dbPTM

ETV1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ETV1_HUMAN
UniProt AC	P50549
Protein Name	ETS translocation variant 1
Gene Name	ETV1
Organism	Homo sapiens (Human).
Sequence Length	477
Subcellular Localization	Nucleus .
Protein Description	Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'..
Protein Sequence	MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDGFYDQQVPYM ---CCCCCCCCCCEE	20.55	-
33	Acetylation	PTNVRKRKFINRDLA CCCHHHHHHCCCCCC	54.34	12917345
58	Acetylation	SQLQETWLAEAQVPD HHHHHHHHHHCCCCC	3.94	12917345
89	Sumoylation	HGLPLKIKKEPHSPC CCCCCEECCCCCCCH	49.88	-
94	Phosphorylation	KIKKEPHSPCSEISS EECCCCCCCHHHHHH	38.01	25850435
97	Phosphorylation	KEPHSPCSEISSACS CCCCCCHHHHHHHHC	41.15	25850435
98	Acetylation	EPHSPCSEISSACSQ CCCCCHHHHHHHHCC	54.32	12917345
100	Phosphorylation	HSPCSEISSACSQEQ CCCHHHHHHHHCCCC	14.08	25002506
101	Phosphorylation	SPCSEISSACSQEQP CCHHHHHHHHCCCCC	38.67	25002506
104	Phosphorylation	SEISSACSQEQPFKF HHHHHHHCCCCCCCC	36.15	22210691
116	Acetylation	FKFSYGEKCLYNVSA CCCCCCCEEEEEEEC	25.77	12917345
139	Phosphorylation	MRPSNPPTPSSTPVS CCCCCCCCCCCCCCC	36.74	12917345
143	Phosphorylation	NPPTPSSTPVSPLHH CCCCCCCCCCCCCCC	31.86	12917345
146	Phosphorylation	TPSSTPVSPLHHASP CCCCCCCCCCCCCCC	23.97	12917345
191	Phosphorylation	HRFRRQLSEPCNSFP HHHHHHHCCCHHCCC	31.02	12569367
196	Phosphorylation	QLSEPCNSFPPLPTM HHCCCHHCCCCCCCC	45.94	27251275
216	Phosphorylation	PMYQRQMSEPNIPFP CCCCCCCCCCCCCCC	41.38	28112733
317	Sumoylation	EKFDGDIKQEPGMYR CCCCCCCCCCCCCCC	54.04	28112733
334	Phosphorylation	PTYQRRGSLQLWQFL CCCCCCCHHHHHHHH	15.90	12569367
386	Phosphorylation	KNRPAMNYDKLSRSL CCCCCCCHHHHHHHH	11.02	26657352
390	Phosphorylation	AMNYDKLSRSLRYYY CCCHHHHHHHHHHHH	26.09	26657352
392	Phosphorylation	NYDKLSRSLRYYYEK CHHHHHHHHHHHHHH	17.52	25954137
410	Phosphorylation	QKVAGERYVYKFVCD HHHCCCCEEEEEEEC	12.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
191	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
191	S	Phosphorylation	Kinase	KS6A1	Q15418	PhosphoELM
191	S	Phosphorylation	Kinase	RPS6KA1	Q63531	GPS
191	S	Phosphorylation	Kinase	RPS6KA5	O75582	Uniprot
216	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
216	S	Phosphorylation	Kinase	KS6A1	Q15418	PhosphoELM
216	S	Phosphorylation	Kinase	RPS6KA1	Q63531	GPS
216	S	Phosphorylation	Kinase	RPS6KA5	O75582	Uniprot
334	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
334	S	Phosphorylation	Kinase	PKACA	P17612	PSP
334	S	Phosphorylation	Kinase	KS6A1	Q15418	PhosphoELM
334	S	Phosphorylation	Kinase	RPS6KA1	Q63531	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	Q8NHY2	PMID:20062082

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
191	S	Phosphorylation	12213813
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.
216	S	Phosphorylation	12213813
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ETV1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT2B_HUMAN	KAT2B	physical	12917345
NCOA3_HUMAN	NCOA3	physical	14747462
STK40_HUMAN	STK40	physical	26186194
RFWD2_HUMAN	RFWD2	physical	26186194
DET1_HUMAN	DET1	physical	26186194
TERT_HUMAN	TERT	genetic	23284306
RFWD2_HUMAN	RFWD2	physical	28514442
STK40_HUMAN	STK40	physical	28514442
DET1_HUMAN	DET1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612219	Ewing sarcoma (ES)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ETV1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Regulation of the ER81 transcription factor and its coactivators bymitogen- and stress-activated protein kinase 1 (MSK1)."; Janknecht R.; Oncogene 22:746-755(2003). Cited for: PHOSPHORYLATION AT SER-191 AND SER-216, AND MUTAGENESIS OF SER-191 ANDSER-216.	12569367 [Abstract]
"Regulation of the ETS transcription factor ER81 by the 90-kDaribosomal S6 kinase 1 and protein kinase A."; Wu J., Janknecht R.; J. Biol. Chem. 277:42669-42679(2002). Cited for: PHOSPHORYLATION AT SER-191 AND SER-216.	12213813 [Abstract]