DET1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DET1_HUMAN
• UniProt AC: Q7L5Y6
• Protein Name: DET1 homolog
• Gene Name: DET1
• Organism: Homo sapiens (Human).
• Sequence Length: 550
• Subcellular Localization: Nucleus .
• Protein Description: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation..
• Protein Sequence: MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	Phosphorylation	KNILAILSVQQQTIH HHHHHHHCCCCCEEE	16.27	24043423
238	Phosphorylation	ILSVQQQTIHVFQVT HHCCCCCEEEEEEEC	14.54	24043423
245	Phosphorylation	TIHVFQVTPEGTFID EEEEEEECCCCCEEE	12.58	24043423
249	Phosphorylation	FQVTPEGTFIDVRTI EEECCCCCEEEEEEE	18.76	24043423
333	Acetylation	LRQLRMWKMQLLDEN HHHHHHHHHHHHCCC	13.87	30588111
348	Phosphorylation	HLFIKYTSEDVVTLR CEEEEEECCCEEEEE	28.80	-
353	Phosphorylation	YTSEDVVTLRVTDPS EECCCEEEEEECCHH	14.54	-
426	Ubiquitination	RQIQRRFKDTIINAK HHHHHHHHHHHHHCC	52.75	-
437 (in isoform 2)	Ubiquitination	-	19.03	-
481	Phosphorylation	SVMERPKTCGDHPIR EEECCCCCCCCCCEE	25.14	23532336
492	Phosphorylation	HPIRFYARDSGLLKF CCEEEEEECCCCEEE	27.52	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DET1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DET1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DET1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDB1_HUMAN	DDB1	physical	14739464
CUL4A_HUMAN	CUL4A	physical	14739464
RFWD2_HUMAN	RFWD2	physical	14739464
RBX1_HUMAN	RBX1	physical	14739464
DDA1_HUMAN	DDA1	physical	17452440
DDB1_HUMAN	DDB1	physical	17452440
UB2E3_HUMAN	UBE2E3	physical	17452440
UB2E1_HUMAN	UBE2E1	physical	17452440
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
CUL4B_HUMAN	CUL4B	physical	16949367
CUL4A_HUMAN	CUL4A	physical	17452440
RFWD2_HUMAN	RFWD2	physical	17452440
MDM2_HUMAN	MDM2	physical	17452440
RNF14_HUMAN	RNF14	physical	17452440
RFWD2_HUMAN	RFWD2	physical	28514442
UB2E2_HUMAN	UBE2E2	physical	28514442
UB2E3_HUMAN	UBE2E3	physical	28514442
CUL4A_HUMAN	CUL4A	physical	28514442
STK40_HUMAN	STK40	physical	28514442
CUL4B_HUMAN	CUL4B	physical	28514442
DDA1_HUMAN	DDA1	physical	28514442
DDB1_HUMAN	DDB1	physical	28514442
CSN2_HUMAN	COPS2	physical	28514442
CSN7B_HUMAN	COPS7B	physical	28514442
UB2E1_HUMAN	UBE2E1	physical	28514442
CSN5_HUMAN	COPS5	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442
CSN4_HUMAN	COPS4	physical	28514442
CSN7A_HUMAN	COPS7A	physical	28514442
CSN1_HUMAN	GPS1	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
CSN3_HUMAN	COPS3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.