HSP7C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP7C_HUMAN
• UniProt AC: P11142
• Protein Name: Heat shock cognate 71 kDa protein
• Gene Name: HSPA8
• Organism: Homo sapiens (Human).
• Sequence Length: 646
• Subcellular Localization: Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
• Protein Description: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. [PubMed: 21150129]
• Protein Sequence: MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKGPAVGI ------CCCCCEEEE	46.44	19413330
2	Phosphorylation	------MSKGPAVGI ------CCCCCEEEE	46.44	23401153
2 (in isoform 2)	Acetylation	-	46.44	-
3	Acetylation	-----MSKGPAVGID -----CCCCCEEEEE	68.56	23236377
3	Ubiquitination	-----MSKGPAVGID -----CCCCCEEEEE	68.56	21890473
13	Phosphorylation	AVGIDLGTTYSCVGV EEEEECCCCEEEEEE	29.83	28152594
14	Phosphorylation	VGIDLGTTYSCVGVF EEEECCCCEEEEEEE	16.19	28464451
15	Phosphorylation	GIDLGTTYSCVGVFQ EEECCCCEEEEEEEE	10.42	28152594
16	Phosphorylation	IDLGTTYSCVGVFQH EECCCCEEEEEEEEC	10.55	28152594
17	Glutathionylation	DLGTTYSCVGVFQHG ECCCCEEEEEEEECC	1.86	22555962
17	S-palmitoylation	DLGTTYSCVGVFQHG ECCCCEEEEEEEECC	1.86	29575903
25	Ubiquitination	VGVFQHGKVEIIAND EEEEECCEEEEEECC	34.27	-
37	Phosphorylation	ANDQGNRTTPSYVAF ECCCCCCCCCCEEEE	47.24	21945579
38	Phosphorylation	NDQGNRTTPSYVAFT CCCCCCCCCCEEEEE	13.65	21945579
40	Phosphorylation	QGNRTTPSYVAFTDT CCCCCCCCEEEEECH	30.10	21945579
41	Nitration	GNRTTPSYVAFTDTE CCCCCCCEEEEECHH	9.30	-
41	Phosphorylation	GNRTTPSYVAFTDTE CCCCCCCEEEEECHH	9.30	21945579
45	Phosphorylation	TPSYVAFTDTERLIG CCCEEEEECHHHHHH	32.07	21945579
47	Phosphorylation	SYVAFTDTERLIGDA CEEEEECHHHHHHHH	21.68	21945579
49	Methylation	VAFTDTERLIGDAAK EEEECHHHHHHHHHH	33.43	-
56	Acetylation	RLIGDAAKNQVAMNP HHHHHHHHCCCCCCC	50.02	23954790
56	Malonylation	RLIGDAAKNQVAMNP HHHHHHHHCCCCCCC	50.02	26320211
56	Ubiquitination	RLIGDAAKNQVAMNP HHHHHHHHCCCCCCC	50.02	21890473
56 (in isoform 1)	Ubiquitination	-	50.02	21890473
56 (in isoform 2)	Ubiquitination	-	50.02	21890473
61	Sulfoxidation	AAKNQVAMNPTNTVF HHHCCCCCCCCCCHH	6.92	28465586
64	Phosphorylation	NQVAMNPTNTVFDAK CCCCCCCCCCHHHHH	38.22	23911959
66	Phosphorylation	VAMNPTNTVFDAKRL CCCCCCCCHHHHHHH	25.65	22817900
71	Acetylation	TNTVFDAKRLIGRRF CCCHHHHHHHHCCCC	49.97	25825284
71	Succinylation	TNTVFDAKRLIGRRF CCCHHHHHHHHCCCC	49.97	23954790
71	Ubiquitination	TNTVFDAKRLIGRRF CCCHHHHHHHHCCCC	49.97	21890473
71 (in isoform 1)	Ubiquitination	-	49.97	21890473
71 (in isoform 2)	Ubiquitination	-	49.97	21890473
85	Phosphorylation	FDDAVVQSDMKHWPF CCCHHHCCCCCCCCE	28.23	30266825
87	Sulfoxidation	DAVVQSDMKHWPFMV CHHHCCCCCCCCEEE	4.10	21406390
88	Trimethylation	AVVQSDMKHWPFMVV HHHCCCCCCCCEEEE	47.73	-
88	Acetylation	AVVQSDMKHWPFMVV HHHCCCCCCCCEEEE	47.73	21466224
88	Methylation	AVVQSDMKHWPFMVV HHHCCCCCCCCEEEE	47.73	-
88	Ubiquitination	AVVQSDMKHWPFMVV HHHCCCCCCCCEEEE	47.73	21890473
88 (in isoform 1)	Ubiquitination	-	47.73	21890473
88 (in isoform 2)	Acetylation	-	47.73	-
88 (in isoform 2)	Ubiquitination	-	47.73	21890473
93	Sulfoxidation	DMKHWPFMVVNDAGR CCCCCCEEEECCCCC	2.63	30846556
102	Ubiquitination	VNDAGRPKVQVEYKG ECCCCCCEEEEEECC	43.89	-
107	Phosphorylation	RPKVQVEYKGETKSF CCEEEEEECCCEECC	25.99	20090780
108	Acetylation	PKVQVEYKGETKSFY CEEEEEECCCEECCC	36.44	23749302
108	Malonylation	PKVQVEYKGETKSFY CEEEEEECCCEECCC	36.44	26320211
108	Ubiquitination	PKVQVEYKGETKSFY CEEEEEECCCEECCC	36.44	19608861
108 (in isoform 1)	Ubiquitination	-	36.44	21890473
108 (in isoform 2)	Acetylation	-	36.44	-
108 (in isoform 2)	Ubiquitination	-	36.44	21890473
111	Phosphorylation	QVEYKGETKSFYPEE EEEECCCEECCCHHH	40.43	28152594
112	Acetylation	VEYKGETKSFYPEEV EEECCCEECCCHHHH	33.98	23954790
112	Ubiquitination	VEYKGETKSFYPEEV EEECCCEECCCHHHH	33.98	21890473
112 (in isoform 1)	Ubiquitination	-	33.98	21890473
112 (in isoform 2)	Ubiquitination	-	33.98	21890473
113	Phosphorylation	EYKGETKSFYPEEVS EECCCEECCCHHHHH	37.12	21712546
115	Nitration	KGETKSFYPEEVSSM CCCEECCCHHHHHHH	19.47	-
115	Phosphorylation	KGETKSFYPEEVSSM CCCEECCCHHHHHHH	19.47	28152594
120	Phosphorylation	SFYPEEVSSMVLTKM CCCHHHHHHHHHHHH	18.92	28152594
121	Phosphorylation	FYPEEVSSMVLTKMK CCHHHHHHHHHHHHH	20.34	28152594
122	Sulfoxidation	YPEEVSSMVLTKMKE CHHHHHHHHHHHHHH	1.92	30846556
125	Phosphorylation	EVSSMVLTKMKEIAE HHHHHHHHHHHHHHH	20.06	28152594
126	Acetylation	VSSMVLTKMKEIAEA HHHHHHHHHHHHHHH	43.76	25953088
126	Ubiquitination	VSSMVLTKMKEIAEA HHHHHHHHHHHHHHH	43.76	21890473
126 (in isoform 1)	Ubiquitination	-	43.76	21890473
126 (in isoform 2)	Ubiquitination	-	43.76	21890473
127	Sulfoxidation	SSMVLTKMKEIAEAY HHHHHHHHHHHHHHH	3.87	21406390
128	Acetylation	SMVLTKMKEIAEAYL HHHHHHHHHHHHHHC	47.74	72627929
128	Ubiquitination	SMVLTKMKEIAEAYL HHHHHHHHHHHHHHC	47.74	21906983
128 (in isoform 1)	Ubiquitination	-	47.74	21890473
128 (in isoform 2)	Ubiquitination	-	47.74	21890473
134	Phosphorylation	MKEIAEAYLGKTVTN HHHHHHHHCCCCCCC	13.90	28152594
137	Acetylation	IAEAYLGKTVTNAVV HHHHHCCCCCCCEEE	36.91	23954790
137	Ubiquitination	IAEAYLGKTVTNAVV HHHHHCCCCCCCEEE	36.91	21890473
137 (in isoform 1)	Ubiquitination	-	36.91	21890473
137 (in isoform 2)	Acetylation	-	36.91	-
137 (in isoform 2)	Ubiquitination	-	36.91	21890473
138	Phosphorylation	AEAYLGKTVTNAVVT HHHHCCCCCCCEEEE	30.66	28152594
140	Phosphorylation	AYLGKTVTNAVVTVP HHCCCCCCCEEEEEE	23.77	28152594
145	Phosphorylation	TVTNAVVTVPAYFND CCCCEEEEEECCCCH	17.74	28152594
149	Phosphorylation	AVVTVPAYFNDSQRQ EEEEEECCCCHHHCC	9.24	28152594
153	Phosphorylation	VPAYFNDSQRQATKD EECCCCHHHCCHHCC	28.50	17525332
153 (in isoform 2)	Phosphorylation	-	28.50	-
158	Phosphorylation	NDSQRQATKDAGTIA CHHHCCHHCCCCCCC	22.56	25159151
159	Acetylation	DSQRQATKDAGTIAG HHHCCHHCCCCCCCC	48.90	23749302
159	Malonylation	DSQRQATKDAGTIAG HHHCCHHCCCCCCCC	48.90	26320211
159	Ubiquitination	DSQRQATKDAGTIAG HHHCCHHCCCCCCCC	48.90	21890473
159 (in isoform 1)	Ubiquitination	-	48.90	21890473
159 (in isoform 2)	Ubiquitination	-	48.90	21890473
163	Phosphorylation	QATKDAGTIAGLNVL CHHCCCCCCCCCHHH	14.90	23911959
177	Phosphorylation	LRIINEPTAAAIAYG HHHCCCHHHHHHHHC	23.81	28152594
183	Nitration	PTAAAIAYGLDKKVG HHHHHHHHCCCCCCC	16.47	-
183	Phosphorylation	PTAAAIAYGLDKKVG HHHHHHHHCCCCCCC	16.47	28152594
187	Acetylation	AIAYGLDKKVGAERN HHHHCCCCCCCCCCC	55.17	23954790
187	Malonylation	AIAYGLDKKVGAERN HHHHCCCCCCCCCCC	55.17	26320211
187	Ubiquitination	AIAYGLDKKVGAERN HHHHCCCCCCCCCCC	55.17	21890473
187 (in isoform 1)	Ubiquitination	-	55.17	21890473
187 (in isoform 2)	Ubiquitination	-	55.17	21890473
188	Ubiquitination	IAYGLDKKVGAERNV HHHCCCCCCCCCCCE	45.64	22053931
188 (in isoform 1)	Ubiquitination	-	45.64	21890473
188 (in isoform 2)	Ubiquitination	-	45.64	21890473
220	Ubiquitination	EDGIFEVKSTAGDTH CCCEEEEEECCCCCC	34.59	-
221	Phosphorylation	DGIFEVKSTAGDTHL CCEEEEEECCCCCCC	28.76	25850435
222	Phosphorylation	GIFEVKSTAGDTHLG CEEEEEECCCCCCCC	29.01	25850435
226	Phosphorylation	VKSTAGDTHLGGEDF EEECCCCCCCCCCCC	20.34	26329039
237	Sulfoxidation	GEDFDNRMVNHFIAE CCCCCHHHHHHHHHH	4.42	30846556
246	Acetylation	NHFIAEFKRKHKKDI HHHHHHHHHHHHCCC	52.63	19608861
246	Malonylation	NHFIAEFKRKHKKDI HHHHHHHHHHHHCCC	52.63	26320211
246	Methylation	NHFIAEFKRKHKKDI HHHHHHHHHHHHCCC	52.63	19608861
246	Ubiquitination	NHFIAEFKRKHKKDI HHHHHHHHHHHHCCC	52.63	21890473
246 (in isoform 1)	Ubiquitination	-	52.63	21890473
246 (in isoform 2)	Acetylation	-	52.63	-
246 (in isoform 2)	Ubiquitination	-	52.63	21890473
248	Ubiquitination	FIAEFKRKHKKDISE HHHHHHHHHHCCCHH	61.44	-
251	Ubiquitination	EFKRKHKKDISENKR HHHHHHHCCCHHHHH	61.07	21906983
251 (in isoform 1)	Ubiquitination	-	61.07	21890473
251 (in isoform 2)	Ubiquitination	-	61.07	21890473
254	Phosphorylation	RKHKKDISENKRAVR HHHHCCCHHHHHHHH	45.29	26055452
254 (in isoform 2)	Phosphorylation	-	45.29	-
257	Acetylation	KKDISENKRAVRRLR HCCCHHHHHHHHHHH	37.37	23749302
257	Sumoylation	KKDISENKRAVRRLR HCCCHHHHHHHHHHH	37.37	-
257	Ubiquitination	KKDISENKRAVRRLR HCCCHHHHHHHHHHH	37.37	21890473
257 (in isoform 1)	Ubiquitination	-	37.37	21890473
257 (in isoform 2)	Ubiquitination	-	37.37	21890473
265	Phosphorylation	RAVRRLRTACERAKR HHHHHHHHHHHHHHH	40.01	27273156
273	Phosphorylation	ACERAKRTLSSSTQA HHHHHHHHHCCCCCE	30.22	-
277	Phosphorylation	AKRTLSSSTQASIEI HHHHHCCCCCEEEEH	22.59	22817900
296	Phosphorylation	EGIDFYTSITRARFE CCCCHHHHHHHHHHH	15.58	20860994
298	Phosphorylation	IDFYTSITRARFEEL CCHHHHHHHHHHHHH	20.31	20860994
313	Phosphorylation	NADLFRGTLDPVEKA CHHHHCCCCCHHHHH	24.59	22817900
319	Acetylation	GTLDPVEKALRDAKL CCCCHHHHHHHHCCC	53.61	19608861
319	Malonylation	GTLDPVEKALRDAKL CCCCHHHHHHHHCCC	53.61	26320211
319	Succinylation	GTLDPVEKALRDAKL CCCCHHHHHHHHCCC	53.61	-
319	Succinylation	GTLDPVEKALRDAKL CCCCHHHHHHHHCCC	53.61	-
319	Ubiquitination	GTLDPVEKALRDAKL CCCCHHHHHHHHCCC	53.61	21890473
319 (in isoform 1)	Ubiquitination	-	53.61	21890473
319 (in isoform 2)	Acetylation	-	53.61	-
319 (in isoform 2)	Ubiquitination	-	53.61	21890473
325	Acetylation	EKALRDAKLDKSQIH HHHHHHCCCCHHHCC	62.60	25953088
325	Malonylation	EKALRDAKLDKSQIH HHHHHHCCCCHHHCC	62.60	26320211
325	Ubiquitination	EKALRDAKLDKSQIH HHHHHHCCCCHHHCC	62.60	-
325 (in isoform 1)	Ubiquitination	-	62.60	21890473
325 (in isoform 2)	Ubiquitination	-	62.60	21890473
328	Acetylation	LRDAKLDKSQIHDIV HHHCCCCHHHCCEEE	55.48	23954790
328	Malonylation	LRDAKLDKSQIHDIV HHHCCCCHHHCCEEE	55.48	26320211
328	Ubiquitination	LRDAKLDKSQIHDIV HHHCCCCHHHCCEEE	55.48	21890473
328 (in isoform 1)	Ubiquitination	-	55.48	21890473
328 (in isoform 2)	Ubiquitination	-	55.48	21890473
329	Phosphorylation	RDAKLDKSQIHDIVL HHCCCCHHHCCEEEE	33.75	26055452
329 (in isoform 2)	Phosphorylation	-	33.75	-
340	Phosphorylation	DIVLVGGSTRIPKIQ EEEEECCCCCCHHHH	14.48	20873877
341	Phosphorylation	IVLVGGSTRIPKIQK EEEECCCCCCHHHHH	35.57	20873877
345	Ubiquitination	GGSTRIPKIQKLLQD CCCCCCHHHHHHHHH	56.23	-
348	Acetylation	TRIPKIQKLLQDFFN CCCHHHHHHHHHHHC	55.42	23954790
348	Succinylation	TRIPKIQKLLQDFFN CCCHHHHHHHHHHHC	55.42	23954790
348	Ubiquitination	TRIPKIQKLLQDFFN CCCHHHHHHHHHHHC	55.42	21890473
348 (in isoform 1)	Ubiquitination	-	55.42	21890473
348 (in isoform 2)	Acetylation	-	55.42	-
348 (in isoform 2)	Ubiquitination	-	55.42	21890473
357	Acetylation	LQDFFNGKELNKSIN HHHHHCCCCCCCCCC	61.20	23749302
357	Succinylation	LQDFFNGKELNKSIN HHHHHCCCCCCCCCC	61.20	23954790
357	Sumoylation	LQDFFNGKELNKSIN HHHHHCCCCCCCCCC	61.20	-
357	Ubiquitination	LQDFFNGKELNKSIN HHHHHCCCCCCCCCC	61.20	21890473
357 (in isoform 1)	Ubiquitination	-	61.20	21890473
357 (in isoform 2)	Ubiquitination	-	61.20	21890473
361	Acetylation	FNGKELNKSINPDEA HCCCCCCCCCCHHHH	66.39	23954790
361	Sumoylation	FNGKELNKSINPDEA HCCCCCCCCCCHHHH	66.39	-
361	Ubiquitination	FNGKELNKSINPDEA HCCCCCCCCCCHHHH	66.39	21890473
361 (in isoform 1)	Ubiquitination	-	66.39	21890473
361 (in isoform 2)	Ubiquitination	-	66.39	21890473
362	Phosphorylation	NGKELNKSINPDEAV CCCCCCCCCCHHHHH	26.90	30278072
362 (in isoform 2)	Phosphorylation	-	26.90	-
371	Nitration	NPDEAVAYGAAVQAA CHHHHHHHHHHHHHH	10.74	-
371	Phosphorylation	NPDEAVAYGAAVQAA CHHHHHHHHHHHHHH	10.74	18669648
381	Phosphorylation	AVQAAILSGDKSENV HHHHHHHCCCCCCCH	38.54	19060867
385	Phosphorylation	AILSGDKSENVQDLL HHHCCCCCCCHHHEE	38.86	20068231
385 (in isoform 2)	Phosphorylation	-	38.86	-
397	Phosphorylation	DLLLLDVTPLSLGIE HEEEEECCCCCCCCE	20.41	20068231
397 (in isoform 2)	Phosphorylation	-	20.41	-
400	Phosphorylation	LLDVTPLSLGIETAG EEECCCCCCCCEECC	26.25	20068231
405	Phosphorylation	PLSLGIETAGGVMTV CCCCCCEECCCEEEE	28.78	20068231
411	Phosphorylation	ETAGGVMTVLIKRNT EECCCEEEEEEECCC	15.11	20068231
415	Ubiquitination	GVMTVLIKRNTTIPT CEEEEEEECCCCCCC	35.12	-
418	Phosphorylation	TVLIKRNTTIPTKQT EEEEECCCCCCCCEE	30.09	26437602
419	Phosphorylation	VLIKRNTTIPTKQTQ EEEECCCCCCCCEEE	28.63	27251275
423	Ubiquitination	RNTTIPTKQTQTFTT CCCCCCCCEEEEEEE	46.09	22053931
423 (in isoform 1)	Ubiquitination	-	46.09	21890473
423 (in isoform 2)	Ubiquitination	-	46.09	21890473
425	Phosphorylation	TTIPTKQTQTFTTYS CCCCCCEEEEEEEEC	31.00	28152594
427	Phosphorylation	IPTKQTQTFTTYSDN CCCCEEEEEEEECCC	26.74	28152594
429	Phosphorylation	TKQTQTFTTYSDNQP CCEEEEEEEECCCCC	28.36	28152594
430	O-linked_Glycosylation	KQTQTFTTYSDNQPG CEEEEEEEECCCCCE	19.48	26374642
430	Phosphorylation	KQTQTFTTYSDNQPG CEEEEEEEECCCCCE	19.48	28152594
431	Phosphorylation	QTQTFTTYSDNQPGV EEEEEEEECCCCCEE	15.80	28152594
432	Phosphorylation	TQTFTTYSDNQPGVL EEEEEEECCCCCEEE	28.17	28152594
443	Phosphorylation	PGVLIQVYEGERAMT CEEEEEEEECCCCCC	11.22	28152594
450	Phosphorylation	YEGERAMTKDNNLLG EECCCCCCCCCCCCC	33.97	25849741
451	Acetylation	EGERAMTKDNNLLGK ECCCCCCCCCCCCCE	45.43	23749302
451	Malonylation	EGERAMTKDNNLLGK ECCCCCCCCCCCCCE	45.43	26320211
451	Ubiquitination	EGERAMTKDNNLLGK ECCCCCCCCCCCCCE	45.43	21890473
451 (in isoform 1)	Ubiquitination	-	45.43	21890473
451 (in isoform 2)	Ubiquitination	-	45.43	21890473
458	Ubiquitination	KDNNLLGKFELTGIP CCCCCCCEEEEECCC	35.32	21890473
458 (in isoform 1)	Ubiquitination	-	35.32	21890473
462	Phosphorylation	LLGKFELTGIPPAPR CCCEEEEECCCCCCC	26.35	26552605
469	Dimethylation	TGIPPAPRGVPQIEV ECCCCCCCCCCEEEE	61.93	-
469	Methylation	TGIPPAPRGVPQIEV ECCCCCCCCCCEEEE	61.93	24129315
477	Phosphorylation	GVPQIEVTFDIDANG CCCEEEEEEEECCCC	11.64	22817900
495	Phosphorylation	VSAVDKSTGKENKIT EEEEECCCCCCCCEE	59.00	-
497	Acetylation	AVDKSTGKENKITIT EEECCCCCCCCEEEE	59.19	25953088
497	Ubiquitination	AVDKSTGKENKITIT EEECCCCCCCCEEEE	59.19	-
500	Acetylation	KSTGKENKITITNDK CCCCCCCCEEEECCC	42.17	25953088
500	Ubiquitination	KSTGKENKITITNDK CCCCCCCCEEEECCC	42.17	21906983
500 (in isoform 1)	Ubiquitination	-	42.17	21890473
502	Phosphorylation	TGKENKITITNDKGR CCCCCCEEEECCCCC	24.29	25159151
504	Phosphorylation	KENKITITNDKGRLS CCCCEEEECCCCCCC	28.81	23312004
507	Sumoylation	KITITNDKGRLSKED CEEEECCCCCCCHHH	48.26	-
507	Acetylation	KITITNDKGRLSKED CEEEECCCCCCCHHH	48.26	23749302
507	Succinylation	KITITNDKGRLSKED CEEEECCCCCCCHHH	48.26	23954790
507	Sumoylation	KITITNDKGRLSKED CEEEECCCCCCCHHH	48.26	-
507	Ubiquitination	KITITNDKGRLSKED CEEEECCCCCCCHHH	48.26	21890473
507 (in isoform 1)	Ubiquitination	-	48.26	21890473
511	Phosphorylation	TNDKGRLSKEDIERM ECCCCCCCHHHHHHH	32.41	29255136
512	Acetylation	NDKGRLSKEDIERMV CCCCCCCHHHHHHHH	65.09	25825284
512	Malonylation	NDKGRLSKEDIERMV CCCCCCCHHHHHHHH	65.09	26320211
512	Succinylation	NDKGRLSKEDIERMV CCCCCCCHHHHHHHH	65.09	-
512	Succinylation	NDKGRLSKEDIERMV CCCCCCCHHHHHHHH	65.09	-
512	Sumoylation	NDKGRLSKEDIERMV CCCCCCCHHHHHHHH	65.09	19608861
512	Ubiquitination	NDKGRLSKEDIERMV CCCCCCCHHHHHHHH	65.09	21890473
512 (in isoform 1)	Ubiquitination	-	65.09	21890473
524	Acetylation	RMVQEAEKYKAEDEK HHHHHHHHHCHHCHH	60.13	23749302
524	Ubiquitination	RMVQEAEKYKAEDEK HHHHHHHHHCHHCHH	60.13	19608861
524 (in isoform 1)	Ubiquitination	-	60.13	21890473
525	Phosphorylation	MVQEAEKYKAEDEKQ HHHHHHHHCHHCHHH	13.61	-
526	Acetylation	VQEAEKYKAEDEKQR HHHHHHHCHHCHHHH	57.26	25953088
526	Ubiquitination	VQEAEKYKAEDEKQR HHHHHHHCHHCHHHH	57.26	21906983
526 (in isoform 1)	Ubiquitination	-	57.26	21890473
531	Acetylation	KYKAEDEKQRDKVSS HHCHHCHHHHHHCCC	64.06	23749302
531	Ubiquitination	KYKAEDEKQRDKVSS HHCHHCHHHHHHCCC	64.06	21906983
531 (in isoform 1)	Ubiquitination	-	64.06	21890473
535	Ubiquitination	EDEKQRDKVSSKNSL HCHHHHHHCCCCHHH	46.32	-
537	Phosphorylation	EKQRDKVSSKNSLES HHHHHHCCCCHHHHH	41.14	23403867
538	Phosphorylation	KQRDKVSSKNSLESY HHHHHCCCCHHHHHH	38.55	23403867
539	Acetylation	QRDKVSSKNSLESYA HHHHCCCCHHHHHHH	42.95	7925255
539	Ubiquitination	QRDKVSSKNSLESYA HHHHCCCCHHHHHHH	42.95	21890473
539 (in isoform 1)	Ubiquitination	-	42.95	21890473
541	Phosphorylation	DKVSSKNSLESYAFN HHCCCCHHHHHHHHE	36.93	23401153
544	Phosphorylation	SSKNSLESYAFNMKA CCCHHHHHHHHEEEC	27.36	25159151
545	Phosphorylation	SKNSLESYAFNMKAT CCHHHHHHHHEEECE	13.06	23403867
549	Sulfoxidation	LESYAFNMKATVEDE HHHHHHEEECEECCH	2.23	21406390
550	Acetylation	ESYAFNMKATVEDEK HHHHHEEECEECCHH	41.85	25953088
550	Ubiquitination	ESYAFNMKATVEDEK HHHHHEEECEECCHH	41.85	21906983
550 (in isoform 1)	Ubiquitination	-	41.85	21890473
557	"N6,N6-dimethyllysine"	KATVEDEKLQGKIND ECEECCHHHCCCCCH	59.43	-
557	Acetylation	KATVEDEKLQGKIND ECEECCHHHCCCCCH	59.43	21466224
557	Methylation	KATVEDEKLQGKIND ECEECCHHHCCCCCH	59.43	24129315
557	Ubiquitination	KATVEDEKLQGKIND ECEECCHHHCCCCCH	59.43	21906983
557 (in isoform 1)	Ubiquitination	-	59.43	21890473
561	"N6,N6,N6-trimethyllysine"	EDEKLQGKINDEDKQ CCHHHCCCCCHHHHH	25.94	-
561	Acetylation	EDEKLQGKINDEDKQ CCHHHCCCCCHHHHH	25.94	21466224
561	Methylation	EDEKLQGKINDEDKQ CCHHHCCCCCHHHHH	25.94	23349634
561	Ubiquitination	EDEKLQGKINDEDKQ CCHHHCCCCCHHHHH	25.94	21906983
561 (in isoform 1)	Ubiquitination	-	25.94	21890473
567	"N6,N6-dimethyllysine"	GKINDEDKQKILDKC CCCCHHHHHHHHHHH	51.98	-
567	Acetylation	GKINDEDKQKILDKC CCCCHHHHHHHHHHH	51.98	21466224
567	Methylation	GKINDEDKQKILDKC CCCCHHHHHHHHHHH	51.98	23748837
569	"N6,N6-dimethyllysine"	INDEDKQKILDKCNE CCHHHHHHHHHHHHH	51.48	-
569	Acetylation	INDEDKQKILDKCNE CCHHHHHHHHHHHHH	51.48	21466224
569	Methylation	INDEDKQKILDKCNE CCHHHHHHHHHHHHH	51.48	23748837
573	Acetylation	DKQKILDKCNEIINW HHHHHHHHHHHHHHH	35.20	25953088
573	Ubiquitination	DKQKILDKCNEIINW HHHHHHHHHHHHHHH	35.20	21906983
573 (in isoform 1)	Ubiquitination	-	35.20	21890473
574	S-nitrosocysteine	KQKILDKCNEIINWL HHHHHHHHHHHHHHH	5.73	-
574	Glutathionylation	KQKILDKCNEIINWL HHHHHHHHHHHHHHH	5.73	22555962
574	S-nitrosylation	KQKILDKCNEIINWL HHHHHHHHHHHHHHH	5.73	22178444
583	Acetylation	EIINWLDKNQTAEKE HHHHHHCCCCHHHHH	49.11	23749302
583	Sumoylation	EIINWLDKNQTAEKE HHHHHHCCCCHHHHH	49.11	-
583	Ubiquitination	EIINWLDKNQTAEKE HHHHHHCCCCHHHHH	49.11	21890473
583 (in isoform 1)	Ubiquitination	-	49.11	21890473
589	Acetylation	DKNQTAEKEEFEHQQ CCCCHHHHHHHHHHH	61.14	19608861
589	Ubiquitination	DKNQTAEKEEFEHQQ CCCCHHHHHHHHHHH	61.14	21906983
589 (in isoform 1)	Ubiquitination	-	61.14	21890473
597	Acetylation	EEFEHQQKELEKVCN HHHHHHHHHHHHHHH	58.66	19608861
597	Malonylation	EEFEHQQKELEKVCN HHHHHHHHHHHHHHH	58.66	26320211
597	Ubiquitination	EEFEHQQKELEKVCN HHHHHHHHHHHHHHH	58.66	21890473
597 (in isoform 1)	Ubiquitination	-	58.66	21890473
601	Acetylation	HQQKELEKVCNPIIT HHHHHHHHHHHHHHH	65.79	19608861
601	Malonylation	HQQKELEKVCNPIIT HHHHHHHHHHHHHHH	65.79	26320211
601	Methylation	HQQKELEKVCNPIIT HHHHHHHHHHHHHHH	65.79	19608861
601	Ubiquitination	HQQKELEKVCNPIIT HHHHHHHHHHHHHHH	65.79	21890473
601 (in isoform 1)	Ubiquitination	-	65.79	21890473
603	S-nitrosocysteine	QKELEKVCNPIITKL HHHHHHHHHHHHHHH	8.10	-
603	Glutathionylation	QKELEKVCNPIITKL HHHHHHHHHHHHHHH	8.10	22555962
603	S-nitrosylation	QKELEKVCNPIITKL HHHHHHHHHHHHHHH	8.10	22178444
603	S-palmitoylation	QKELEKVCNPIITKL HHHHHHHHHHHHHHH	8.10	29575903
608	Phosphorylation	KVCNPIITKLYQSAG HHHHHHHHHHHHHCC	18.73	21712546
609	Ubiquitination	VCNPIITKLYQSAGG HHHHHHHHHHHHCCC	34.49	-
611	Phosphorylation	NPIITKLYQSAGGMP HHHHHHHHHHCCCCC	11.28	18691976
613	Phosphorylation	IITKLYQSAGGMPGG HHHHHHHHCCCCCCC	18.48	21406692
633	Phosphorylation	PGGGAPPSGGASSGP CCCCCCCCCCCCCCC	49.12	27134283
637	Phosphorylation	APPSGGASSGPTIEE CCCCCCCCCCCCCCC	38.82	19413330
638	Phosphorylation	PPSGGASSGPTIEEV CCCCCCCCCCCCCCC	48.54	19413330
641	Phosphorylation	GGASSGPTIEEVD-- CCCCCCCCCCCCC--	44.54	27134283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:11146634

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
561	K	Methylation	Trimethylation at Lys-561 reduces fibrillar SNCA binding.	23349634

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP7C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HPBP1_HUMAN	HSPBP1	physical	16189514
NOA1_HUMAN	NOA1	physical	16169070
T4S1_HUMAN	TM4SF1	physical	16169070
ERH_HUMAN	ERH	physical	16169070
F16P1_HUMAN	FBP1	physical	16169070
UBC_HUMAN	UBC	physical	16169070
DNJA3_HUMAN	DNAJA3	physical	11679576
HS90A_HUMAN	HSP90AA1	physical	9269769
PP1A_HUMAN	PPP1CA	physical	9269769
MYPT2_HUMAN	PPP1R12B	physical	9269769
BAG2_HUMAN	BAG2	physical	9873016
BAG3_HUMAN	BAG3	physical	9873016
BAG4_HUMAN	BAG4	physical	11909948
TERA_HUMAN	VCP	physical	16621797
CCND1_HUMAN	CCND1	physical	18537972
CDK4_HUMAN	CDK4	physical	18537972
BAG1_HUMAN	BAG1	physical	12297498
CFTR_HUMAN	CFTR	physical	10982807
CFTR_HUMAN	CFTR	physical	10666020
CHIP_HUMAN	STUB1	physical	21454478
CFTR_HUMAN	CFTR	physical	21697503
ERG_HUMAN	ERG	physical	21183741
HD_HUMAN	HTT	physical	20026656
UBE3A_HUMAN	UBE3A	physical	19233847
BCR_HUMAN	BCR	physical	20675402
ABL1_HUMAN	ABL1	physical	20675402
P53_HUMAN	TP53	physical	8729618
BAG1_HUMAN	BAG1	physical	11741305
CFTR_HUMAN	CFTR	physical	11146634
CAPZB_HUMAN	CAPZB	physical	20884878
CAZA1_HUMAN	CAPZA1	physical	20884878
SYUA_HUMAN	SNCA	physical	22776201
TERA_HUMAN	VCP	physical	22939629
VAMP2_HUMAN	VAMP2	physical	22939629
PRKDC_HUMAN	PRKDC	physical	22939629
RNPS1_HUMAN	RNPS1	physical	22939629
PDIA3_HUMAN	PDIA3	physical	22939629
ROA3_HUMAN	HNRNPA3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629
SC24C_HUMAN	SEC24C	physical	22939629
STIP1_HUMAN	STIP1	physical	22939629
SSBP_HUMAN	SSBP1	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RL18A_HUMAN	RPL18A	physical	22939629
NECP2_HUMAN	NECAP2	physical	22939629
SON_HUMAN	SON	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
SC31A_HUMAN	SEC31A	physical	22939629
PO2F1_HUMAN	POU2F1	physical	22939629
NAL12_HUMAN	NLRP12	physical	17947705
MIPT3_HUMAN	TRAF3IP1	physical	20391533
KCNQ4_HUMAN	KCNQ4	physical	23431407
SRRT_HUMAN	SRRT	physical	22365833
CCAR2_HUMAN	CCAR2	physical	22365833
BAG2_HUMAN	BAG2	physical	22365833
CCND1_HUMAN	CCND1	physical	23217712
BAG1_HUMAN	BAG1	physical	19800331
RAF1_HUMAN	RAF1	physical	16093354
ESR1_HUMAN	ESR1	physical	9774640
STIP1_HUMAN	STIP1	physical	9774640
DNJC7_HUMAN	DNAJC7	physical	10567422
TTC1_HUMAN	TTC1	physical	10567422
SGTA_HUMAN	SGTA	physical	10567422
STIP1_HUMAN	STIP1	physical	10567422
CHIP_HUMAN	STUB1	physical	23865999
STIP1_HUMAN	STIP1	physical	11093761
DNJB1_HUMAN	DNAJB1	physical	11093761
F10A1_HUMAN	ST13	physical	11093761
TGM2_HUMAN	TGM2	physical	21988832
SGTA_HUMAN	SGTA	physical	21988832
CFTR_HUMAN	CFTR	physical	23990462
TF65_HUMAN	RELA	physical	24175631
ASNA_HUMAN	ASNA1	physical	22863883
SYYC_HUMAN	YARS	physical	22863883
BAG2_HUMAN	BAG2	physical	25036637
HS105_HUMAN	HSPH1	physical	25036637
BAG3_HUMAN	BAG3	physical	25036637
HSP72_HUMAN	HSPA2	physical	25036637
BAG4_HUMAN	BAG4	physical	25036637
DNJB6_HUMAN	DNAJB6	physical	25036637
EDRF1_HUMAN	EDRF1	physical	25036637
DNJC9_HUMAN	DNAJC9	physical	25036637
GBRB1_HUMAN	GABRB1	physical	25036637
HSP74_HUMAN	HSPA4	physical	25036637
HS74L_HUMAN	HSPA4L	physical	25036637
HPBP1_HUMAN	HSPBP1	physical	25036637
HYOU1_HUMAN	HYOU1	physical	25036637
TBA1A_HUMAN	TUBA1A	physical	25036637
F10A1_HUMAN	ST13	physical	25036637
DNJA1_HUMAN	DNAJA1	physical	25036637
CHIP_HUMAN	STUB1	physical	25036637
DJB12_HUMAN	DNAJB12	physical	25036637
GCST_HUMAN	AMT	physical	25036637
DNJA2_HUMAN	DNAJA2	physical	25036637
SC24C_HUMAN	SEC24C	physical	25036637
FWCH2_HUMAN	FLYWCH2	physical	25036637
CHIP_HUMAN	STUB1	physical	16275660
NMI_HUMAN	NMI	physical	25416956
BAG3_HUMAN	BAG3	physical	25416956
TRI38_HUMAN	TRIM38	physical	25416956
HPBP1_HUMAN	HSPBP1	physical	25416956
BAG1_HUMAN	BAG1	physical	25535373
NNRE_HUMAN	APOA1BP	physical	26344197
BAG2_HUMAN	BAG2	physical	26344197
DNJA4_HUMAN	DNAJA4	physical	26344197
DNJB4_HUMAN	DNAJB4	physical	26344197
DNJC1_HUMAN	DNAJC1	physical	26344197
DJC13_HUMAN	DNAJC13	physical	26344197
DNJC2_HUMAN	DNAJC2	physical	26344197
DUT_HUMAN	DUT	physical	26344197
FPPS_HUMAN	FDPS	physical	26344197
G3P_HUMAN	GAPDH	physical	26344197
HNRPD_HUMAN	HNRNPD	physical	26344197
HSP74_HUMAN	HSPA4	physical	26344197
HS74L_HUMAN	HSPA4L	physical	26344197
HS105_HUMAN	HSPH1	physical	26344197
IPO7_HUMAN	IPO7	physical	26344197
LMNB1_HUMAN	LMNB1	physical	26344197
NACAM_HUMAN	NACA	physical	26344197
NACA_HUMAN	NACA	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
TBB5_HUMAN	TUBB	physical	26344197
RN207_HUMAN	RNF207	physical	25281747
HIS3_HUMAN	HTN3	physical	26775844
P53_HUMAN	TP53	physical	7954368
HS90A_HUMAN	HSP90AA1	physical	22504172
CLC4K_HUMAN	CD207	physical	28514442
HSF1_HUMAN	HSF1	physical	28514442
ABL2_HUMAN	ABL2	physical	28514442
EDRF1_HUMAN	EDRF1	physical	28514442
DJC13_HUMAN	DNAJC13	physical	28514442
GAK_HUMAN	GAK	physical	28514442
ARFP1_HUMAN	ARFIP1	physical	28514442
SF3A2_HUMAN	SF3A2	physical	28514442
RPRD2_HUMAN	RPRD2	physical	28514442
TBCE_HUMAN	TBCE	physical	28514442
HPBP1_HUMAN	HSPBP1	physical	28514442
CF106_HUMAN	C6orf106	physical	28514442
EP300_HUMAN	EP300	physical	28514442
SRP54_HUMAN	SRP54	physical	28514442
TACC3_HUMAN	TACC3	physical	28514442
MARE2_HUMAN	MAPRE2	physical	28514442
A1AT_HUMAN	SERPINA1	physical	28514442
HSP72_HUMAN	HSPA2	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442
KCD15_HUMAN	KCTD15	physical	28514442
HBB_HUMAN	HBB	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
TAU_HUMAN	MAPT	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
H15_HUMAN	HIST1H1B	physical	28514442
NFS1_HUMAN	NFS1	physical	28514442
MP2K2_HUMAN	MAP2K2	physical	28514442
QRIC1_HUMAN	QRICH1	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
WNK1_HUMAN	WNK1	physical	28514442
NUCG_HUMAN	ENDOG	physical	28514442
CKAP5_HUMAN	CKAP5	physical	28514442
GANAB_HUMAN	GANAB	physical	28514442
PP1R8_HUMAN	PPP1R8	physical	28514442
MAVS_HUMAN	MAVS	physical	28514442
RNF25_HUMAN	RNF25	physical	28514442
MD1L1_HUMAN	MAD1L1	physical	28514442
FOXC1_HUMAN	FOXC1	physical	28514442
ATF1_HUMAN	ATF1	physical	28514442
CSTF3_HUMAN	CSTF3	physical	28514442
ALBU_HUMAN	ALB	physical	28514442
NB5R3_HUMAN	CYB5R3	physical	28514442
CSDE1_HUMAN	CSDE1	physical	28514442
GLIP1_HUMAN	GLIPR1	physical	23333597
SP1_HUMAN	SP1	physical	23333597
MYB_HUMAN	MYB	physical	23333597
FANCA_HUMAN	FANCA	physical	28215707
P53_HUMAN	TP53	physical	28215707
BAG1_HUMAN	BAG1	physical	28215707
SODC_HUMAN	SOD1	physical	28215707
LAMP2_HUMAN	LAMP2	physical	28465257
EP300_HUMAN	EP300	physical	28465257
CBP_HUMAN	CREBBP	physical	28465257
UBQL2_HUMAN	UBQLN2	physical	27477512

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-88; LYS-108; LYS-246;LYS-319; LYS-348; LYS-512; LYS-524; LYS-589; LYS-597 AND LYS-601, ANDMASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541; SER-637 ANDSER-638, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; TYR-115; SER-120AND SER-121, AND MASS SPECTROMETRY.
PubMed: 18669648

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND MASSSPECTROMETRY.
PubMed: 17525332

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-477, AND MASSSPECTROMETRY.
PubMed: 15302935

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-41 AND TYR-107, AND MASSSPECTROMETRY.
PubMed: 18083107

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15, AND MASSSPECTROMETRY.
PubMed: 15592455