DNJA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJA4_HUMAN
• UniProt AC: Q8WW22
• Protein Name: DnaJ homolog subfamily A member 4
• Gene Name: DNAJA4
• Organism: Homo sapiens (Human).
• Sequence Length: 397
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Sequence: MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMDQVELKEFCPNEQNWRQHREAYEEDEDGPQAGVQCQTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVKETQYYDILG ---CCCCCEEEEECC	19.02	23186163
6 (in isoform 2)	Phosphorylation	-	35.56	25159151
7	Phosphorylation	-MVKETQYYDILGVK -CCCCCEEEEECCCC	15.55	23186163
8	Phosphorylation	MVKETQYYDILGVKP CCCCCEEEEECCCCC	6.16	23186163
8 (in isoform 2)	Phosphorylation	-	6.16	25159151
10 (in isoform 2)	Phosphorylation	-	1.77	28985074
11 (in isoform 2)	Phosphorylation	-	6.19	25627689
16	Phosphorylation	DILGVKPSASPEEIK EECCCCCCCCHHHHH	35.34	20873877
18	Phosphorylation	LGVKPSASPEEIKKA CCCCCCCCHHHHHHH	36.86	20873877
22 (in isoform 2)	Phosphorylation	-	5.45	28985074
23	Acetylation	SASPEEIKKAYRKLA CCCHHHHHHHHHHHH	34.33	25038526
26	Phosphorylation	PEEIKKAYRKLALKY HHHHHHHHHHHHHHH	19.70	24719451
32	Acetylation	AYRKLALKYHPDKNP HHHHHHHHHCCCCCC	35.59	22643467
32	Ubiquitination	AYRKLALKYHPDKNP HHHHHHHHHCCCCCC	35.59	21890473
33	Phosphorylation	YRKLALKYHPDKNPD HHHHHHHHCCCCCCC	21.31	28152594
37	Acetylation	ALKYHPDKNPDEGEK HHHHCCCCCCCCCHH	74.88	26051181
44	Acetylation	KNPDEGEKFKLISQA CCCCCCHHHHHHHHH	59.67	26051181
45 (in isoform 2)	Phosphorylation	-	7.28	24719451
47 (in isoform 2)	Phosphorylation	-	5.25	24719451
49	Phosphorylation	GEKFKLISQAYEVLS CHHHHHHHHHHHHHH	21.13	29083192
52	Phosphorylation	FKLISQAYEVLSDPK HHHHHHHHHHHHCCC	10.03	29083192
55 (in isoform 2)	Phosphorylation	-	3.00	24719451
56	Phosphorylation	SQAYEVLSDPKKRDV HHHHHHHHCCCCCCC	57.98	29083192
61 (in isoform 2)	Ubiquitination	-	44.76	-
61	Ubiquitination	VLSDPKKRDVYDQGG HHHCCCCCCCCCCCH	44.76	21890473
64	Phosphorylation	DPKKRDVYDQGGEQA CCCCCCCCCCCHHHH	13.56	-
77	Phosphorylation	QAIKEGGSGSPSFSS HHHHCCCCCCCCCCC	47.13	26657352
79	Phosphorylation	IKEGGSGSPSFSSPM HHCCCCCCCCCCCCC	21.04	26657352
81	Phosphorylation	EGGSGSPSFSSPMDI CCCCCCCCCCCCCHH	39.18	20873877
83	Phosphorylation	GSGSPSFSSPMDIFD CCCCCCCCCCCHHHH	37.56	20068231
84	Phosphorylation	SGSPSFSSPMDIFDM CCCCCCCCCCHHHHH	23.41	20068231
108 (in isoform 2)	Phosphorylation	-	4.66	27251275
113	Phosphorylation	KNVVHQLSVTLEDLY CCCEEEEECCHHHHH	13.39	28450419
115	Phosphorylation	VVHQLSVTLEDLYNG CEEEEECCHHHHHCC	22.51	28450419
124	Phosphorylation	EDLYNGVTKKLALQK HHHHCCHHHHHHHHC	24.70	-
144 (in isoform 2)	Phosphorylation	-	48.29	27251275
147	Phosphorylation	GVGGKKGSVEKCPLC CCCCCCCCCCCCCCC	35.66	-
155 (in isoform 2)	Ubiquitination	-	60.36	-
196	Phosphorylation	NPKDRCESCSGAKVI CHHHCCCCCCCCCEE	19.74	29691806
198	Phosphorylation	KDRCESCSGAKVIRE HHCCCCCCCCCEEEE	51.57	29691806
236 (in isoform 2)	Ubiquitination	-	45.64	-
262	Ubiquitination	RGHDLIMKMKIQLSE CCHHHHHHHHHHHHH	30.01	-
264	Ubiquitination	HDLIMKMKIQLSEAL HHHHHHHHHHHHHHH	23.06	-
275	Acetylation	SEALCGFKKTIKTLD HHHHHCCHHHHHHCC	34.00	30588265
336	Phosphorylation	FPEKHWLSLEKLPQL CCHHHCCCHHHCCHH	29.32	23403867
365 (in isoform 2)	Phosphorylation	-	34.93	27251275
365	Acetylation	DMDQVELKEFCPNEQ CCCHHHHHHHCCCHH	34.93	25038526
394	Methylation	GPQAGVQCQTA---- CCCCCCCEECC----	3.45	-
394	Farnesylation	GPQAGVQCQTA---- CCCCCCCEECC----	3.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG_HUMAN	ERG	physical	19940115
NUCG_HUMAN	ENDOG	physical	25036637
DNJA2_HUMAN	DNAJA2	physical	25036637
DNJA1_HUMAN	DNAJA1	physical	25036637
TBA1A_HUMAN	TUBA1A	physical	25036637
TBB6_HUMAN	TUBB6	physical	25036637
AF1Q_HUMAN	MLLT11	physical	25036637
TIM50_HUMAN	TIMM50	physical	25036637
CX057_HUMAN	CXorf57	physical	25036637
TBB4A_HUMAN	TUBB4A	physical	25036637
PRPS1_HUMAN	PRPS1	physical	25036637
TCPB_HUMAN	CCT2	physical	26344197
TCPG_HUMAN	CCT3	physical	26344197
GRP78_HUMAN	HSPA5	physical	26344197
HYOU1_HUMAN	HYOU1	physical	26344197
IMA1_HUMAN	KPNA2	physical	26344197
PRS8_HUMAN	PSMC5	physical	26344197
PSD11_HUMAN	PSMD11	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.