| UniProt ID | ERG_HUMAN | |
|---|---|---|
| UniProt AC | P11308 | |
| Protein Name | Transcriptional regulator ERG | |
| Gene Name | ERG | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 486 | |
| Subcellular Localization | Nucleus . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. | |
| Protein Description | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.. | |
| Protein Sequence | MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MIQTVPDPAAH ----CCCCCCCHHHH | 24.07 | 25159151 | |
| 30 | Phosphorylation | QSLFECAYGTPHLAK HHHHHHCCCCCCCEE | 32.94 | 23532336 | |
| 32 | Phosphorylation | LFECAYGTPHLAKTE HHHHCCCCCCCEEEE | 8.54 | - | |
| 44 | Phosphorylation | KTEMTASSSSDYGQT EEEECCCCCCCCCCC | 31.25 | - | |
| 45 | Phosphorylation | TEMTASSSSDYGQTS EEECCCCCCCCCCCC | 25.41 | - | |
| 46 | Phosphorylation | EMTASSSSDYGQTSK EECCCCCCCCCCCCC | 36.48 | - | |
| 48 | Phosphorylation | TASSSSDYGQTSKMS CCCCCCCCCCCCCCC | 17.06 | - | |
| 51 | Phosphorylation | SSSDYGQTSKMSPRV CCCCCCCCCCCCCCC | 26.42 | 23403867 | |
| 52 | Phosphorylation | SSDYGQTSKMSPRVP CCCCCCCCCCCCCCC | 20.62 | 23403867 | |
| 55 | Phosphorylation | YGQTSKMSPRVPQQD CCCCCCCCCCCCCCH | 17.19 | 23403867 | |
| 65 | Phosphorylation | VPQQDWLSQPPARVT CCCCHHHCCCCCEEE | 36.07 | 28387310 | |
| 80 | Phosphorylation | IKMECNPSQVNGSRN EEEECCHHHCCCCCC | 32.54 | 22115753 | |
| 81 | Phosphorylation | KMECNPSQVNGSRNS EEECCHHHCCCCCCC | 33.67 | - | |
| 85 | Phosphorylation | NPSQVNGSRNSPDEC CHHHCCCCCCCCCCC | 24.08 | 23401153 | |
| 88 | Phosphorylation | QVNGSRNSPDECSVA HCCCCCCCCCCCCCC | 32.39 | 23401153 | |
| 93 | Phosphorylation | RNSPDECSVAKGGKM CCCCCCCCCCCCCEE | 24.06 | 15302935 | |
| 96 | Phosphorylation | PDECSVAKGGKMVGS CCCCCCCCCCEECCC | 67.07 | - | |
| 96 | Acetylation | PDECSVAKGGKMVGS CCCCCCCCCCEECCC | 67.07 | 112788003 | |
| 99 | Acetylation | CSVAKGGKMVGSPDT CCCCCCCEECCCCCC | 38.80 | 112788001 | |
| 103 | Phosphorylation | KGGKMVGSPDTVGMN CCCEECCCCCCCCCC | 14.27 | 23401153 | |
| 106 | Phosphorylation | KMVGSPDTVGMNYGS EECCCCCCCCCCHHH | 23.49 | 23403867 | |
| 111 | Phosphorylation | PDTVGMNYGSYMEEK CCCCCCCHHHHHHHH | 9.88 | 30301811 | |
| 113 | Phosphorylation | TVGMNYGSYMEEKHM CCCCCHHHHHHHHCC | 15.79 | 30301811 | |
| 114 | Phosphorylation | VGMNYGSYMEEKHMP CCCCHHHHHHHHCCC | 12.27 | 30301811 | |
| 136 (in isoform 2) | Phosphorylation | - | 25.23 | - | |
| 222 | Phosphorylation | VDKALQNSPRLMHAR HHHHHHHCCCCCCCC | 9.84 | 23401153 | |
| 235 (in isoform 1) | Phosphorylation | - | 11.01 | - | |
| 259 | Phosphorylation | TTRPDLPYEPPRRSA CCCCCCCCCCCCCCC | 48.65 | - | |
| 283 | Phosphorylation | QSKAAQPSPSTVPKT CCCCCCCCCCCCCCC | 21.28 | 23403867 | |
| 285 | Phosphorylation | KAAQPSPSTVPKTED CCCCCCCCCCCCCCC | 46.50 | 23403867 | |
| 286 | Phosphorylation | AAQPSPSTVPKTEDQ CCCCCCCCCCCCCCC | 44.18 | 30301811 | |
| 289 | Sumoylation | PSPSTVPKTEDQRPQ CCCCCCCCCCCCCCC | 61.28 | 28112733 | |
| 300 | Phosphorylation | QRPQLDPYQILGPTS CCCCCCCCCCCCCCC | 14.09 | 27642862 | |
| 349 | Phosphorylation | TNGEFKMTDPDEVAR CCCEEEECCHHHHHH | 44.99 | 22591006 | |
| 369 | Phosphorylation | KSKPNMNYDKLSRAL CCCCCCCHHHHHHHH | 12.04 | - | |
| 371 | Acetylation | KPNMNYDKLSRALRY CCCCCHHHHHHHHHH | 37.69 | 22973553 | |
| 382 | Acetylation | ALRYYYDKNIMTKVH HHHHHHHCCCEEEEC | 32.05 | 22973553 | |
| 387 | Acetylation | YDKNIMTKVHGKRYA HHCCCEEEECCEEEE | 18.17 | 22973553 | |
| 413 | Phosphorylation | LQPHPPESSLYKYPS HCCCCCCCHHCCCCC | 31.27 | - | |
| 427 | Phosphorylation | SDLPYMGSYHAHPQK CCCCCCCCCCCCCCC | 9.38 | 23401153 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 37 | S | Phosphorylation | Kinase | CK1A | P48729 | PSP |
| 38 | S | Phosphorylation | Kinase | CK1A | P48729 | PSP |
| 39 | S | Phosphorylation | Kinase | CK1A | P48729 | PSP |
| 44 | S | Phosphorylation | Kinase | CSNK1A1 | P48729 | GPS |
| 45 | S | Phosphorylation | Kinase | CSNK1A1 | P48729 | GPS |
| 46 | S | Phosphorylation | Kinase | CSNK1A1 | P48729 | GPS |
| 96 | S | Phosphorylation | Kinase | ERK2 | P28482 | PSP |
| 103 | S | Phosphorylation | Kinase | MAPK1 | P28482 | GPS |
| 215 | S | Phosphorylation | Kinase | ERK2 | P28482 | PSP |
| 222 | S | Phosphorylation | Kinase | MAPK1 | P28482 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERG_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612219 | Ewing sarcoma (ES) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND MASSSPECTROMETRY. | |
