| UniProt ID | ILF3_HUMAN | |
|---|---|---|
| UniProt AC | Q12906 | |
| Protein Name | Interleukin enhancer-binding factor 3 | |
| Gene Name | ILF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 894 | |
| Subcellular Localization | Nucleus, nucleolus . Cytoplasm . Nucleus . Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-I | |
| Protein Description | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. [PubMed: 28625552 As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response] | |
| Protein Sequence | MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Methylation | ---MRPMRIFVNDDR ---CCCEEEEECCCC | 23.13 | 115484867 | |
| 12 | Methylation | RIFVNDDRHVMAKHS EEEECCCCCHHHHCC | 27.45 | 115484859 | |
| 15 | Sulfoxidation | VNDDRHVMAKHSSVY ECCCCCHHHHCCCCC | 3.16 | 21406390 | |
| 17 | Acetylation | DDRHVMAKHSSVYPT CCCCHHHHCCCCCCC | 26.39 | 26051181 | |
| 17 | Ubiquitination | DDRHVMAKHSSVYPT CCCCHHHHCCCCCCC | 26.39 | 21890473 | |
| 17 (in isoform 1) | Ubiquitination | - | 26.39 | 21890473 | |
| 17 (in isoform 2) | Ubiquitination | - | 26.39 | 21890473 | |
| 17 (in isoform 3) | Ubiquitination | - | 26.39 | 21890473 | |
| 17 (in isoform 4) | Ubiquitination | - | 26.39 | 21890473 | |
| 17 (in isoform 5) | Ubiquitination | - | 26.39 | 21890473 | |
| 17 (in isoform 6) | Ubiquitination | - | 26.39 | 21890473 | |
| 19 | Phosphorylation | RHVMAKHSSVYPTQE CCHHHHCCCCCCCHH | 22.31 | 22115753 | |
| 20 | Phosphorylation | HVMAKHSSVYPTQEE CHHHHCCCCCCCHHH | 25.95 | 22115753 | |
| 22 | Phosphorylation | MAKHSSVYPTQEELE HHHCCCCCCCHHHHH | 11.51 | 28064214 | |
| 24 | Phosphorylation | KHSSVYPTQEELEAV HCCCCCCCHHHHHHH | 30.81 | 22115753 | |
| 43 | Acetylation | SHTERALKAVSDWID HHHHHHHHHHHHHHH | 45.84 | 26051181 | |
| 46 | Phosphorylation | ERALKAVSDWIDEQE HHHHHHHHHHHHHHH | 31.89 | 30108239 | |
| 54 | Acetylation | DWIDEQEKGSSEQAE HHHHHHHCCCHHHHH | 64.88 | 26051181 | |
| 56 | Phosphorylation | IDEQEKGSSEQAESD HHHHHCCCHHHHHHC | 41.59 | 23401153 | |
| 56 (in isoform 7) | Phosphorylation | - | 41.59 | 27251275 | |
| 57 | Phosphorylation | DEQEKGSSEQAESDN HHHHCCCHHHHHHCC | 42.25 | 25159151 | |
| 62 | Phosphorylation | GSSEQAESDNMDVPP CCHHHHHHCCCCCCC | 36.98 | 23927012 | |
| 62 (in isoform 7) | Phosphorylation | - | 36.98 | 27251275 | |
| 73 | Phosphorylation | DVPPEDDSKEGAGEQ CCCCCCCCCCCCCCH | 44.95 | 23927012 | |
| 73 (in isoform 7) | Phosphorylation | - | 44.95 | 27251275 | |
| 74 | Acetylation | VPPEDDSKEGAGEQK CCCCCCCCCCCCCHH | 68.13 | 26051181 | |
| 81 | Acetylation | KEGAGEQKTEHMTRT CCCCCCHHHHHHHHH | 52.13 | 19608861 | |
| 82 | Phosphorylation | EGAGEQKTEHMTRTL CCCCCHHHHHHHHHH | 30.71 | 23186163 | |
| 86 | Phosphorylation | EQKTEHMTRTLRGVM CHHHHHHHHHHHHHH | 23.55 | 23186163 | |
| 100 | Acetylation | MRVGLVAKGLLLKGD HHHHHHHHCHHHCCC | 42.48 | 19608861 | |
| 100 | Ubiquitination | MRVGLVAKGLLLKGD HHHHHHHHCHHHCCC | 42.48 | 19608861 | |
| 100 (in isoform 1) | Ubiquitination | - | 42.48 | 21890473 | |
| 100 (in isoform 2) | Ubiquitination | - | 42.48 | 21890473 | |
| 100 (in isoform 3) | Ubiquitination | - | 42.48 | 21890473 | |
| 100 (in isoform 4) | Ubiquitination | - | 42.48 | 21890473 | |
| 100 (in isoform 5) | Ubiquitination | - | 42.48 | 21890473 | |
| 100 (in isoform 6) | Ubiquitination | - | 42.48 | 21890473 | |
| 105 | Ubiquitination | VAKGLLLKGDLDLEL HHHCHHHCCCCCEEE | 50.80 | - | |
| 117 | Acetylation | LELVLLCKEKPTTAL EEEEEEECCCCCHHH | 69.60 | 26051181 | |
| 119 | Acetylation | LVLLCKEKPTTALLD EEEEECCCCCHHHHH | 32.91 | 25953088 | |
| 119 | Ubiquitination | LVLLCKEKPTTALLD EEEEECCCCCHHHHH | 32.91 | - | |
| 121 | Phosphorylation | LLCKEKPTTALLDKV EEECCCCCHHHHHHH | 35.45 | 22817901 | |
| 127 | Ubiquitination | PTTALLDKVADNLAI CCHHHHHHHHHHHHH | 39.01 | - | |
| 158 | Ubiquitination | DDAAIVIKNTKEPPL CCEEEEEECCCCCCE | 47.90 | - | |
| 173 | Phosphorylation | SLTIHLTSPVVREEM EEEEEECCHHHHHHH | 23.27 | - | |
| 182 | Acetylation | VVREEMEKVLAGETL HHHHHHHHHHCCCCC | 41.04 | 26051181 | |
| 188 | Phosphorylation | EKVLAGETLSVNDPP HHHHCCCCCCCCCCC | 24.34 | 30266825 | |
| 190 | Phosphorylation | VLAGETLSVNDPPDV HHCCCCCCCCCCCCC | 26.71 | 29255136 | |
| 190 (in isoform 7) | Phosphorylation | - | 26.71 | 24719451 | |
| 202 | Ubiquitination | PDVLDRQKCLAALAS CCCCCHHHHHHHHHH | 31.91 | 21890473 | |
| 202 (in isoform 1) | Ubiquitination | - | 31.91 | 21890473 | |
| 202 (in isoform 2) | Ubiquitination | - | 31.91 | 21890473 | |
| 202 (in isoform 3) | Ubiquitination | - | 31.91 | 21890473 | |
| 202 (in isoform 4) | Ubiquitination | - | 31.91 | 21890473 | |
| 202 (in isoform 5) | Ubiquitination | - | 31.91 | 21890473 | |
| 202 (in isoform 6) | Ubiquitination | - | 31.91 | 21890473 | |
| 203 | Glutathionylation | DVLDRQKCLAALASL CCCCHHHHHHHHHHH | 2.06 | 22555962 | |
| 209 | Phosphorylation | KCLAALASLRHAKWF HHHHHHHHHHHHHHH | 27.13 | 23312004 | |
| 209 (in isoform 7) | Phosphorylation | - | 27.13 | 24719451 | |
| 214 | Acetylation | LASLRHAKWFQARAN HHHHHHHHHHHHHHC | 42.27 | 23954790 | |
| 214 | Malonylation | LASLRHAKWFQARAN HHHHHHHHHHHHHHC | 42.27 | 26320211 | |
| 214 | Ubiquitination | LASLRHAKWFQARAN HHHHHHHHHHHHHHC | 42.27 | - | |
| 224 | Acetylation | QARANGLKSCVIVIR HHHHCCCHHHHHHHH | 43.11 | 26051181 | |
| 257 | Acetylation | PLELLCEKSIGTANR CHHHHHHCCCCCCCC | 46.51 | 26051181 | |
| 257 | Ubiquitination | PLELLCEKSIGTANR CHHHHHHCCCCCCCC | 46.51 | 21890473 | |
| 257 (in isoform 1) | Ubiquitination | - | 46.51 | 21890473 | |
| 257 (in isoform 2) | Ubiquitination | - | 46.51 | 21890473 | |
| 257 (in isoform 3) | Ubiquitination | - | 46.51 | 21890473 | |
| 257 (in isoform 4) | Ubiquitination | - | 46.51 | 21890473 | |
| 257 (in isoform 5) | Ubiquitination | - | 46.51 | 21890473 | |
| 257 (in isoform 6) | Ubiquitination | - | 46.51 | 21890473 | |
| 258 | O-linked_Glycosylation | LELLCEKSIGTANRP HHHHHHCCCCCCCCC | 12.17 | 23301498 | |
| 258 | Phosphorylation | LELLCEKSIGTANRP HHHHHHCCCCCCCCC | 12.17 | - | |
| 261 | Phosphorylation | LCEKSIGTANRPMGA HHHCCCCCCCCCCCH | 21.06 | - | |
| 266 | Sulfoxidation | IGTANRPMGAGEALR CCCCCCCCCHHHHHH | 5.33 | 30846556 | |
| 273 | Methylation | MGAGEALRRVLECLA CCHHHHHHHHHHHHH | 33.44 | 115484891 | |
| 297 | Acetylation | GIYDPCEKEATDAIG CCCCCCHHHHHHHHC | 60.41 | 26051181 | |
| 297 | Ubiquitination | GIYDPCEKEATDAIG CCCCCCHHHHHHHHC | 60.41 | - | |
| 300 | Phosphorylation | DPCEKEATDAIGHLD CCCHHHHHHHHCCCC | 27.36 | 21406692 | |
| 315 | Phosphorylation | RQQREDITQSAQHAL HHHHHHHHHHHHHHH | 28.88 | 21123651 | |
| 323 | Methylation | QSAQHALRLAAFGQL HHHHHHHHHHHHHHH | 24.06 | 115484851 | |
| 332 | Acetylation | AAFGQLHKVLGMDPL HHHHHHHHHHCCCCC | 47.98 | 25953088 | |
| 332 | Ubiquitination | AAFGQLHKVLGMDPL HHHHHHHHHHCCCCC | 47.98 | 21890473 | |
| 332 (in isoform 1) | Ubiquitination | - | 47.98 | 21890473 | |
| 332 (in isoform 2) | Ubiquitination | - | 47.98 | 21890473 | |
| 332 (in isoform 3) | Ubiquitination | - | 47.98 | 21890473 | |
| 332 (in isoform 4) | Ubiquitination | - | 47.98 | 21890473 | |
| 332 (in isoform 5) | Ubiquitination | - | 47.98 | 21890473 | |
| 332 (in isoform 6) | Ubiquitination | - | 47.98 | 21890473 | |
| 336 | Sulfoxidation | QLHKVLGMDPLPSKM HHHHHHCCCCCCCCC | 4.14 | 28183972 | |
| 341 | Phosphorylation | LGMDPLPSKMPKKPK HCCCCCCCCCCCCCC | 49.63 | 21712546 | |
| 342 | Acetylation | GMDPLPSKMPKKPKN CCCCCCCCCCCCCCC | 58.23 | 25953088 | |
| 342 | Malonylation | GMDPLPSKMPKKPKN CCCCCCCCCCCCCCC | 58.23 | 26320211 | |
| 342 | Ubiquitination | GMDPLPSKMPKKPKN CCCCCCCCCCCCCCC | 58.23 | 21890473 | |
| 342 (in isoform 1) | Ubiquitination | - | 58.23 | 21890473 | |
| 342 (in isoform 2) | Ubiquitination | - | 58.23 | 21890473 | |
| 342 (in isoform 3) | Ubiquitination | - | 58.23 | 21890473 | |
| 342 (in isoform 4) | Ubiquitination | - | 58.23 | 21890473 | |
| 342 (in isoform 5) | Ubiquitination | - | 58.23 | 21890473 | |
| 342 (in isoform 6) | Ubiquitination | - | 58.23 | 21890473 | |
| 348 | Sumoylation | SKMPKKPKNENPVDY CCCCCCCCCCCCCCE | 82.72 | 25114211 | |
| 355 | Phosphorylation | KNENPVDYTVQIPPS CCCCCCCEEEECCCC | 14.72 | 23403867 | |
| 356 | Phosphorylation | NENPVDYTVQIPPST CCCCCCEEEECCCCC | 11.06 | 21945579 | |
| 362 | Phosphorylation | YTVQIPPSTTYAITP EEEECCCCCEEEECC | 28.20 | 21945579 | |
| 363 | Phosphorylation | TVQIPPSTTYAITPM EEECCCCCEEEECCC | 29.60 | 21945579 | |
| 364 | Phosphorylation | VQIPPSTTYAITPMK EECCCCCEEEECCCC | 18.45 | 21945579 | |
| 365 | Phosphorylation | QIPPSTTYAITPMKR ECCCCCEEEECCCCC | 8.97 | 21945579 | |
| 368 | Phosphorylation | PSTTYAITPMKRPME CCCEEEECCCCCCCC | 14.79 | 21945579 | |
| 368 (in isoform 7) | Phosphorylation | - | 14.79 | 27251275 | |
| 374 | Sulfoxidation | ITPMKRPMEEDGEEK ECCCCCCCCCCCCCC | 11.63 | 30846556 | |
| 381 | Acetylation | MEEDGEEKSPSKKKK CCCCCCCCCCCHHHH | 64.46 | 26051181 | |
| 382 | Phosphorylation | EEDGEEKSPSKKKKK CCCCCCCCCCHHHHH | 37.37 | 29255136 | |
| 382 (in isoform 7) | Phosphorylation | - | 37.37 | 24719451 | |
| 384 | Phosphorylation | DGEEKSPSKKKKKIQ CCCCCCCCHHHHHHH | 65.29 | 29255136 | |
| 393 | Acetylation | KKKKIQKKEEKAEPP HHHHHHHHHHHCCCH | 55.52 | 25953088 | |
| 396 | Acetylation | KIQKKEEKAEPPQAM HHHHHHHHCCCHHHH | 60.17 | 26051181 | |
| 396 | Sumoylation | KIQKKEEKAEPPQAM HHHHHHHHCCCHHHH | 60.17 | 28112733 | |
| 403 | Sulfoxidation | KAEPPQAMNALMRLN HCCCHHHHHHHHHHH | 2.25 | 21406390 | |
| 413 | Acetylation | LMRLNQLKPGLQYKL HHHHHHCCCCCEEEE | 27.55 | 23749302 | |
| 413 | Ubiquitination | LMRLNQLKPGLQYKL HHHHHHCCCCCEEEE | 27.55 | 21890473 | |
| 413 (in isoform 1) | Ubiquitination | - | 27.55 | 21890473 | |
| 413 (in isoform 2) | Ubiquitination | - | 27.55 | 21890473 | |
| 413 (in isoform 3) | Ubiquitination | - | 27.55 | 21890473 | |
| 413 (in isoform 4) | Ubiquitination | - | 27.55 | 21890473 | |
| 413 (in isoform 5) | Ubiquitination | - | 27.55 | 21890473 | |
| 413 (in isoform 6) | Ubiquitination | - | 27.55 | 21890473 | |
| 419 | Methylation | LKPGLQYKLVSQTGP CCCCCEEEEEECCCC | 29.47 | - | |
| 450 | Acetylation | FEASGPSKKTAKLHV EECCCCCHHHCHHHH | 58.22 | 26051181 | |
| 454 | Acetylation | GPSKKTAKLHVAVKV CCCHHHCHHHHHHHH | 44.34 | 25953088 | |
| 454 | Malonylation | GPSKKTAKLHVAVKV CCCHHHCHHHHHHHH | 44.34 | 26320211 | |
| 454 | Ubiquitination | GPSKKTAKLHVAVKV CCCHHHCHHHHHHHH | 44.34 | - | |
| 460 | Acetylation | AKLHVAVKVLQDMGL CHHHHHHHHHHHCCC | 27.73 | 19608861 | |
| 465 | Sulfoxidation | AVKVLQDMGLPTGAE HHHHHHHCCCCCCCC | 3.71 | 21406390 | |
| 469 | Phosphorylation | LQDMGLPTGAEGRDS HHHCCCCCCCCCCCC | 54.81 | 29255136 | |
| 469 (in isoform 4) | Phosphorylation | - | 54.81 | 25999147 | |
| 469 (in isoform 6) | Phosphorylation | - | 54.81 | 25999147 | |
| 469 (in isoform 7) | Phosphorylation | - | 54.81 | 23927012 | |
| 476 | Phosphorylation | TGAEGRDSSKGEDSA CCCCCCCCCCCCCCC | 32.37 | 29255136 | |
| 476 (in isoform 4) | Phosphorylation | - | 32.37 | 20201521 | |
| 476 (in isoform 6) | Phosphorylation | - | 32.37 | 20201521 | |
| 476 (in isoform 7) | Phosphorylation | - | 32.37 | 20201521 | |
| 477 | Phosphorylation | GAEGRDSSKGEDSAE CCCCCCCCCCCCCCH | 49.31 | 29255136 | |
| 477 (in isoform 4) | Phosphorylation | - | 49.31 | 23927012 | |
| 477 (in isoform 6) | Phosphorylation | - | 49.31 | 23927012 | |
| 477 (in isoform 7) | Phosphorylation | - | 49.31 | 23927012 | |
| 482 | Phosphorylation | DSSKGEDSAEETEAK CCCCCCCCCHHHCCC | 33.02 | 29255136 | |
| 482 (in isoform 4) | Phosphorylation | - | 33.02 | 20201521 | |
| 482 (in isoform 6) | Phosphorylation | - | 33.02 | 20201521 | |
| 482 (in isoform 7) | Phosphorylation | - | 33.02 | 20201521 | |
| 486 | Phosphorylation | GEDSAEETEAKPAVV CCCCCHHHCCCCEEE | 32.52 | 22167270 | |
| 486 (in isoform 4) | Phosphorylation | - | 32.52 | 26503892 | |
| 486 (in isoform 6) | Phosphorylation | - | 32.52 | 26503892 | |
| 486 (in isoform 7) | Phosphorylation | - | 32.52 | 26503892 | |
| 489 | Sumoylation | SAEETEAKPAVVAPA CCHHHCCCCEEEECC | 27.55 | 28112733 | |
| 503 | Phosphorylation | APVVEAVSTPSAAFP CCEEEEECCCCCCCC | 41.47 | 22167270 | |
| 503 (in isoform 4) | Phosphorylation | - | 41.47 | 23927012 | |
| 503 (in isoform 6) | Phosphorylation | - | 41.47 | 23927012 | |
| 503 (in isoform 7) | Phosphorylation | - | 41.47 | 23927012 | |
| 504 | Phosphorylation | PVVEAVSTPSAAFPS CEEEEECCCCCCCCC | 18.05 | 22167270 | |
| 504 (in isoform 4) | Phosphorylation | - | 18.05 | 28355574 | |
| 504 (in isoform 6) | Phosphorylation | - | 18.05 | 28355574 | |
| 504 (in isoform 7) | Phosphorylation | - | 18.05 | 28355574 | |
| 506 | Phosphorylation | VEAVSTPSAAFPSDA EEEECCCCCCCCCCC | 32.11 | 22167270 | |
| 506 (in isoform 4) | Phosphorylation | - | 32.11 | 23927012 | |
| 506 (in isoform 6) | Phosphorylation | - | 32.11 | 23927012 | |
| 506 (in isoform 7) | Phosphorylation | - | 32.11 | 23927012 | |
| 511 | Phosphorylation | TPSAAFPSDATAEQG CCCCCCCCCCCCCCC | 33.16 | 22167270 | |
| 511 (in isoform 4) | Phosphorylation | - | 33.16 | 23927012 | |
| 511 (in isoform 6) | Phosphorylation | - | 33.16 | 23927012 | |
| 511 (in isoform 7) | Phosphorylation | - | 33.16 | 23927012 | |
| 514 | Phosphorylation | AAFPSDATAEQGPIL CCCCCCCCCCCCCCC | 35.40 | 22167270 | |
| 514 (in isoform 4) | Phosphorylation | - | 35.40 | 23927012 | |
| 514 (in isoform 6) | Phosphorylation | - | 35.40 | 23927012 | |
| 514 (in isoform 7) | Phosphorylation | - | 35.40 | 23927012 | |
| 522 | Phosphorylation | AEQGPILTKHGKNPV CCCCCCCCCCCCCCC | 23.01 | 23927012 | |
| 523 | Ubiquitination | EQGPILTKHGKNPVM CCCCCCCCCCCCCCH | 47.09 | - | |
| 526 | Acetylation | PILTKHGKNPVMELN CCCCCCCCCCCHHHH | 58.77 | 26051181 | |
| 530 | Sulfoxidation | KHGKNPVMELNEKRR CCCCCCCHHHHHHHC | 5.24 | 21406390 | |
| 540 | Acetylation | NEKRRGLKYELISET HHHHCCCCEEEEECC | 39.23 | 25953088 | |
| 540 | Malonylation | NEKRRGLKYELISET HHHHCCCCEEEEECC | 39.23 | 26320211 | |
| 540 | Ubiquitination | NEKRRGLKYELISET HHHHCCCCEEEEECC | 39.23 | - | |
| 541 | Phosphorylation | EKRRGLKYELISETG HHHCCCCEEEEECCC | 22.47 | 28152594 | |
| 545 | Phosphorylation | GLKYELISETGGSHD CCCEEEEECCCCCCC | 41.55 | 28555341 | |
| 547 | Phosphorylation | KYELISETGGSHDKR CEEEEECCCCCCCCE | 39.80 | 25159151 | |
| 550 | Phosphorylation | LISETGGSHDKRFVM EEECCCCCCCCEEEE | 29.83 | 27251275 | |
| 553 | Acetylation | ETGGSHDKRFVMEVE CCCCCCCCEEEEEEE | 42.17 | 25953088 | |
| 553 | Ubiquitination | ETGGSHDKRFVMEVE CCCCCCCCEEEEEEE | 42.17 | - | |
| 554 (in isoform 7) | Phosphorylation | - | 35.13 | 27251275 | |
| 557 | Sulfoxidation | SHDKRFVMEVEVDGQ CCCCEEEEEEEECCE | 4.37 | 21406390 | |
| 571 | Phosphorylation | QKFQGAGSNKKVAKA EEECCCCCCHHHHHH | 44.96 | 20068231 | |
| 574 | Malonylation | QGAGSNKKVAKAYAA CCCCCCHHHHHHHHH | 52.23 | 26320211 | |
| 577 | Acetylation | GSNKKVAKAYAALAA CCCHHHHHHHHHHHH | 44.94 | 26051181 | |
| 577 | Malonylation | GSNKKVAKAYAALAA CCCHHHHHHHHHHHH | 44.94 | 33225896 | |
| 577 | Ubiquitination | GSNKKVAKAYAALAA CCCHHHHHHHHHHHH | 44.94 | 21890473 | |
| 577 (in isoform 1) | Ubiquitination | - | 44.94 | 21890473 | |
| 577 (in isoform 2) | Ubiquitination | - | 44.94 | 21890473 | |
| 577 (in isoform 3) | Ubiquitination | - | 44.94 | 21890473 | |
| 577 (in isoform 5) | Ubiquitination | - | 44.94 | 21890473 | |
| 579 | Nitration | NKKVAKAYAALAALE CHHHHHHHHHHHHHH | 7.53 | - | |
| 579 | Phosphorylation | NKKVAKAYAALAALE CHHHHHHHHHHHHHH | 7.53 | 28152594 | |
| 581 (in isoform 4) | Ubiquitination | - | 5.76 | 21890473 | |
| 581 (in isoform 6) | Ubiquitination | - | 5.76 | 21890473 | |
| 587 | Acetylation | AALAALEKLFPDTPL HHHHHHHHHCCCCCC | 57.17 | 155317 | |
| 587 | Ubiquitination | AALAALEKLFPDTPL HHHHHHHHHCCCCCC | 57.17 | - | |
| 592 | Phosphorylation | LEKLFPDTPLALDAN HHHHCCCCCCEECCC | 22.05 | 19664994 | |
| 596 (in isoform 7) | Phosphorylation | - | 9.35 | 24719451 | |
| 600 | Acetylation | PLALDANKKKRAPVP CCEECCCCCCCCCCC | 62.48 | 23236377 | |
| 600 | Malonylation | PLALDANKKKRAPVP CCEECCCCCCCCCCC | 62.48 | 26320211 | |
| 600 | Ubiquitination | PLALDANKKKRAPVP CCEECCCCCCCCCCC | 62.48 | - | |
| 601 | Acetylation | LALDANKKKRAPVPV CEECCCCCCCCCCCC | 47.50 | 30583073 | |
| 609 | Dimethylation | KRAPVPVRGGPKFAA CCCCCCCCCCCCCCC | 37.98 | - | |
| 609 | Methylation | KRAPVPVRGGPKFAA CCCCCCCCCCCCCCC | 37.98 | 15782174 | |
| 613 | Methylation | VPVRGGPKFAAKPHN CCCCCCCCCCCCCCC | 51.41 | 23748837 | |
| 640 | Methylation | VPPPPNLRGRGRGGS CCCCCCCCCCCCCCC | 39.13 | 24395645 | |
| 642 | Methylation | PPPNLRGRGRGGSIR CCCCCCCCCCCCCCC | 25.79 | 24395659 | |
| 647 | Phosphorylation | RGRGRGGSIRGRGRG CCCCCCCCCCCCCCC | 16.37 | 22817900 | |
| 665 | Phosphorylation | GGANHGGYMNAGAGY CCCCCCCCCCCCCCC | 7.56 | 20068231 | |
| 672 | Phosphorylation | YMNAGAGYGSYGYGG CCCCCCCCCCCCCCC | 11.45 | 20068231 | |
| 674 | Phosphorylation | NAGAGYGSYGYGGNS CCCCCCCCCCCCCCC | 13.60 | 20068231 | |
| 675 | Phosphorylation | AGAGYGSYGYGGNSA CCCCCCCCCCCCCCC | 15.25 | 20068231 | |
| 677 | Phosphorylation | AGYGSYGYGGNSATA CCCCCCCCCCCCCCC | 17.39 | 20068231 | |
| 681 | Phosphorylation | SYGYGGNSATAGYSQ CCCCCCCCCCCCCCC | 30.21 | 20068231 | |
| 683 | Phosphorylation | GYGGNSATAGYSQFY CCCCCCCCCCCCCCC | 22.04 | 20068231 | |
| 686 | Phosphorylation | GNSATAGYSQFYSNG CCCCCCCCCCCCCCC | 9.24 | 20068231 | |
| 686 (in isoform 5) | Phosphorylation | - | 9.24 | - | |
| 687 | Phosphorylation | NSATAGYSQFYSNGG CCCCCCCCCCCCCCC | 16.94 | 20068231 | |
| 690 | Phosphorylation | TAGYSQFYSNGGHSG CCCCCCCCCCCCCCC | 8.12 | 20068231 | |
| 691 | Phosphorylation | AGYSQFYSNGGHSGN CCCCCCCCCCCCCCC | 30.22 | 20068231 | |
| 694 (in isoform 2) | Phosphorylation | - | 18.95 | 25884760 | |
| 696 | Phosphorylation | FYSNGGHSGNASGGG CCCCCCCCCCCCCCC | 36.70 | 20068231 | |
| 696 (in isoform 2) | Phosphorylation | - | 36.70 | - | |
| 698 (in isoform 6) | Phosphorylation | - | 33.67 | 25884760 | |
| 700 | Phosphorylation | GGHSGNASGGGGGGG CCCCCCCCCCCCCCC | 41.80 | 20068231 | |
| 700 (in isoform 6) | Phosphorylation | - | 41.80 | - | |
| 710 | Phosphorylation | GGGGGGGSSGYGSYY CCCCCCCCCCCCCCC | 24.70 | 20068231 | |
| 711 | Phosphorylation | GGGGGGSSGYGSYYQ CCCCCCCCCCCCCCC | 39.03 | 20068231 | |
| 713 | Phosphorylation | GGGGSSGYGSYYQGD CCCCCCCCCCCCCCC | 12.59 | 20068231 | |
| 715 | Phosphorylation | GGSSGYGSYYQGDNY CCCCCCCCCCCCCCC | 16.51 | 20068231 | |
| 716 | Phosphorylation | GSSGYGSYYQGDNYN CCCCCCCCCCCCCCC | 8.74 | 20068231 | |
| 717 | Phosphorylation | SSGYGSYYQGDNYNS CCCCCCCCCCCCCCC | 14.02 | 20068231 | |
| 722 | Phosphorylation | SYYQGDNYNSPVPPK CCCCCCCCCCCCCCH | 23.04 | 20068231 | |
| 724 | Phosphorylation | YQGDNYNSPVPPKHA CCCCCCCCCCCCHHC | 19.53 | 20068231 | |
| 734 | Acetylation | PPKHAGKKQPHGGQQ CCHHCCCCCCCCCCC | 69.05 | 7910659 | |
| 742 | Acetylation | QPHGGQQKPSYGSGY CCCCCCCCCCCCCCC | 28.22 | 26051181 | |
| 744 | Phosphorylation | HGGQQKPSYGSGYQS CCCCCCCCCCCCCCC | 49.51 | 28152594 | |
| 745 | Phosphorylation | GGQQKPSYGSGYQSH CCCCCCCCCCCCCCC | 24.68 | 20068231 | |
| 747 | Phosphorylation | QQKPSYGSGYQSHQG CCCCCCCCCCCCCCC | 26.54 | 28152594 | |
| 749 | Phosphorylation | KPSYGSGYQSHQGQQ CCCCCCCCCCCCCCC | 14.45 | 20068231 | |
| 751 | Phosphorylation | SYGSGYQSHQGQQQS CCCCCCCCCCCCCCC | 14.86 | 28152594 | |
| 758 | Phosphorylation | SHQGQQQSYNQSPYS CCCCCCCCCCCCCCC | 23.01 | 28796482 | |
| 759 | Phosphorylation | HQGQQQSYNQSPYSN CCCCCCCCCCCCCCC | 16.94 | 28796482 | |
| 762 | Phosphorylation | QQQSYNQSPYSNYGP CCCCCCCCCCCCCCC | 23.36 | 25159151 | |
| 764 | Phosphorylation | QSYNQSPYSNYGPPQ CCCCCCCCCCCCCCC | 18.13 | 23898821 | |
| 765 | Phosphorylation | SYNQSPYSNYGPPQG CCCCCCCCCCCCCCC | 27.28 | 23898821 | |
| 766 (in isoform 7) | Phosphorylation | - | 39.68 | 27251275 | |
| 767 | Phosphorylation | NQSPYSNYGPPQGKQ CCCCCCCCCCCCCCC | 25.68 | 28122231 | |
| 773 | Acetylation | NYGPPQGKQKGYNHG CCCCCCCCCCCCCCC | 43.52 | 26051181 | |
| 775 | Acetylation | GPPQGKQKGYNHGQG CCCCCCCCCCCCCCC | 67.84 | 26051181 | |
| 777 | Phosphorylation | PQGKQKGYNHGQGSY CCCCCCCCCCCCCCC | 15.83 | 21945579 | |
| 783 | Phosphorylation | GYNHGQGSYSYSNSY CCCCCCCCCCCCCCC | 11.74 | 21945579 | |
| 784 | Phosphorylation | YNHGQGSYSYSNSYN CCCCCCCCCCCCCCC | 20.60 | 21945579 | |
| 785 | Phosphorylation | NHGQGSYSYSNSYNS CCCCCCCCCCCCCCC | 24.63 | 21945579 | |
| 786 | Phosphorylation | HGQGSYSYSNSYNSP CCCCCCCCCCCCCCC | 12.02 | 21945579 | |
| 787 | Phosphorylation | GQGSYSYSNSYNSPG CCCCCCCCCCCCCCC | 17.23 | 21945579 | |
| 789 | O-linked_Glycosylation | GSYSYSNSYNSPGGG CCCCCCCCCCCCCCC | 21.54 | OGP | |
| 789 | Phosphorylation | GSYSYSNSYNSPGGG CCCCCCCCCCCCCCC | 21.54 | 21945579 | |
| 790 | Phosphorylation | SYSYSNSYNSPGGGG CCCCCCCCCCCCCCC | 24.74 | 21945579 | |
| 792 | Phosphorylation | SYSNSYNSPGGGGGS CCCCCCCCCCCCCCC | 19.38 | 21945579 | |
| 796 (in isoform 7) | Phosphorylation | - | 43.11 | 24719451 | |
| 799 | Phosphorylation | SPGGGGGSDYNYESK CCCCCCCCCCCCCCC | 39.95 | 21945579 | |
| 801 | Phosphorylation | GGGGGSDYNYESKFN CCCCCCCCCCCCCCC | 22.72 | 21945579 | |
| 803 | Phosphorylation | GGGSDYNYESKFNYS CCCCCCCCCCCCCCC | 18.49 | 21945579 | |
| 803 (in isoform 7) | Phosphorylation | - | 18.49 | 27251275 | |
| 805 | Phosphorylation | GSDYNYESKFNYSGS CCCCCCCCCCCCCCC | 31.99 | 21945579 | |
| 806 | Acetylation | SDYNYESKFNYSGSG CCCCCCCCCCCCCCC | 26.20 | 26051181 | |
| 809 | Phosphorylation | NYESKFNYSGSGGRS CCCCCCCCCCCCCCC | 19.96 | 21712546 | |
| 810 | Phosphorylation | YESKFNYSGSGGRSG CCCCCCCCCCCCCCC | 27.82 | 30266825 | |
| 812 | Phosphorylation | SKFNYSGSGGRSGGN CCCCCCCCCCCCCCC | 31.94 | 30266825 | |
| 814 (in isoform 7) | Phosphorylation | - | 23.44 | 24719451 | |
| 815 | Methylation | NYSGSGGRSGGNSYG CCCCCCCCCCCCCCC | 35.34 | 80702087 | |
| 816 | Phosphorylation | YSGSGGRSGGNSYGS CCCCCCCCCCCCCCC | 55.09 | 21945579 | |
| 820 | Phosphorylation | GGRSGGNSYGSGGAS CCCCCCCCCCCCCCC | 33.86 | 21945579 | |
| 821 | Phosphorylation | GRSGGNSYGSGGASY CCCCCCCCCCCCCCC | 21.22 | 21945579 | |
| 823 | Phosphorylation | SGGNSYGSGGASYNP CCCCCCCCCCCCCCC | 26.31 | 21945579 | |
| 827 | Phosphorylation | SYGSGGASYNPGSHG CCCCCCCCCCCCCCC | 28.81 | 21945579 | |
| 828 | Phosphorylation | YGSGGASYNPGSHGG CCCCCCCCCCCCCCC | 25.50 | 21945579 | |
| 831 (in isoform 7) | Phosphorylation | - | 28.74 | 24719451 | |
| 832 | Phosphorylation | GASYNPGSHGGYGGG CCCCCCCCCCCCCCC | 21.88 | 21945579 | |
| 836 | Phosphorylation | NPGSHGGYGGGSGGG CCCCCCCCCCCCCCC | 19.72 | 21945579 | |
| 840 | Phosphorylation | HGGYGGGSGGGSSYQ CCCCCCCCCCCCCCC | 37.22 | 21945579 | |
| 844 | Phosphorylation | GGGSGGGSSYQGKQG CCCCCCCCCCCCCCC | 29.19 | 21945579 | |
| 844 (in isoform 7) | Phosphorylation | - | 29.19 | 27251275 | |
| 845 | Phosphorylation | GGSGGGSSYQGKQGG CCCCCCCCCCCCCCC | 25.42 | 21945579 | |
| 846 | Phosphorylation | GSGGGSSYQGKQGGY CCCCCCCCCCCCCCC | 24.00 | 21945579 | |
| 853 | Phosphorylation | YQGKQGGYSQSNYNS CCCCCCCCCCCCCCC | 15.45 | 21945579 | |
| 854 | Phosphorylation | QGKQGGYSQSNYNSP CCCCCCCCCCCCCCC | 30.33 | 21945579 | |
| 856 | Phosphorylation | KQGGYSQSNYNSPGS CCCCCCCCCCCCCCC | 35.03 | 21945579 | |
| 858 | Phosphorylation | GGYSQSNYNSPGSGQ CCCCCCCCCCCCCCC | 23.43 | 21945579 | |
| 860 | Phosphorylation | YSQSNYNSPGSGQNY CCCCCCCCCCCCCCC | 21.93 | 21945579 | |
| 863 | Phosphorylation | SNYNSPGSGQNYSGP CCCCCCCCCCCCCCC | 40.36 | 21945579 | |
| 864 (in isoform 7) | Phosphorylation | - | 26.18 | 24719451 | |
| 867 | Phosphorylation | SPGSGQNYSGPPSSY CCCCCCCCCCCCHHC | 13.71 | 21945579 | |
| 868 | Phosphorylation | PGSGQNYSGPPSSYQ CCCCCCCCCCCHHCC | 52.99 | 21945579 | |
| 872 | Phosphorylation | QNYSGPPSSYQSSQG CCCCCCCHHCCCCCC | 44.82 | 21945579 | |
| 873 | Phosphorylation | NYSGPPSSYQSSQGG CCCCCCHHCCCCCCC | 32.72 | 21945579 | |
| 874 | Phosphorylation | YSGPPSSYQSSQGGY CCCCCHHCCCCCCCC | 19.42 | 21945579 | |
| 876 | Phosphorylation | GPPSSYQSSQGGYGR CCCHHCCCCCCCCCC | 19.18 | 21945579 | |
| 877 | Phosphorylation | PPSSYQSSQGGYGRN CCHHCCCCCCCCCCC | 19.81 | 21945579 | |
| 881 | Phosphorylation | YQSSQGGYGRNADHS CCCCCCCCCCCCCCC | 21.53 | 21945579 | |
| 883 | Methylation | SSQGGYGRNADHSMN CCCCCCCCCCCCCCC | 27.04 | 115484875 | |
| 888 | Phosphorylation | YGRNADHSMNYQYR- CCCCCCCCCCCCCC- | 14.85 | 25159151 | |
| 891 | Phosphorylation | NADHSMNYQYR---- CCCCCCCCCCC---- | 9.78 | 28796482 | |
| 892 (in isoform 7) | Phosphorylation | - | 23.63 | 24719451 | |
| 893 | Phosphorylation | DHSMNYQYR------ CCCCCCCCC------ | 14.13 | 28796482 | |
| 894 | Methylation | HSMNYQYR------- CCCCCCCC------- | 25.25 | 97778515 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 188 | T | Phosphorylation | Kinase | PKR | P19525 | Uniprot |
| 315 | T | Phosphorylation | Kinase | PKR | P19525 | Uniprot |
| 382 | S | Phosphorylation | Kinase | CDK2 | P24941 | PSP |
| 647 | S | Phosphorylation | Kinase | AKT1 | P31749 | PSP |
| 647 | S | Phosphorylation | Kinase | PRKCB | P05771 | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | SPOP | O43791 | PMID:31772275 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ILF3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-81; LYS-100 AND LYS-460, ANDMASS SPECTROMETRY. | |
| Methylation | |
| Reference | PubMed |
| "Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-609, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-482; THR-592 ANDSER-792, AND MASS SPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-368; THR-504; THR-592;SER-792 AND SER-860, AND MASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190; SER-482; TYR-579;THR-592; SER-792; SER-810 AND SER-812, AND MASS SPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND SER-384, ANDMASS SPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-592 AND SER-812, ANDMASS SPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190; SER-382; SER-482AND THR-592, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, AND MASSSPECTROMETRY. | |
| "Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND THR-592, AND MASSSPECTROMETRY. | |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-486, AND MASSSPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-592, AND MASSSPECTROMETRY. | |
