| UniProt ID | NXF1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UBU9 | |
| Protein Name | Nuclear RNA export factor 1 | |
| Gene Name | NXF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 619 | |
| Subcellular Localization | Nucleus . Nucleus, nucleoplasm . Nucleus speckle . Cytoplasm . Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the | |
| Protein Description | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). [PubMed: 10924507 The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex] | |
| Protein Sequence | MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDTWHDRDRIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSIPFIPQNPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASSEEIQRAFAMPAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MADEGKSYS ------CCCCCCCCC | 24.46 | 19413330 | |
| 6 | Ubiquitination | --MADEGKSYSEHDD --CCCCCCCCCCCCC | 44.14 | - | |
| 7 | Phosphorylation | -MADEGKSYSEHDDE -CCCCCCCCCCCCCC | 44.76 | 30266825 | |
| 8 | Phosphorylation | MADEGKSYSEHDDER CCCCCCCCCCCCCCC | 22.89 | 30266825 | |
| 9 | Phosphorylation | ADEGKSYSEHDDERV CCCCCCCCCCCCCCC | 35.23 | 30266825 | |
| 33 | Phosphorylation | RGPFRWKYGEGNRRS CCCCCCCCCCCCCCC | 17.28 | - | |
| 42 | Asymmetric dimethylarginine | EGNRRSGRGGSGIRS CCCCCCCCCCCCCCC | 47.77 | - | |
| 42 | Methylation | EGNRRSGRGGSGIRS CCCCCCCCCCCCCCC | 47.77 | - | |
| 61 | Sulfoxidation | EDDGDVAMSDAQDGP CCCCCCCCCCCCCCC | 3.61 | 21406390 | |
| 62 | O-linked_Glycosylation | DDGDVAMSDAQDGPR CCCCCCCCCCCCCCC | 21.76 | 30379171 | |
| 62 | Phosphorylation | DDGDVAMSDAQDGPR CCCCCCCCCCCCCCC | 21.76 | 30576142 | |
| 72 | Phosphorylation | QDGPRVRYNPYTTRP CCCCCEECCCCCCCC | 20.03 | - | |
| 75 | Phosphorylation | PRVRYNPYTTRPNRR CCEECCCCCCCCCCC | 19.67 | 25839225 | |
| 76 | Phosphorylation | RVRYNPYTTRPNRRG CEECCCCCCCCCCCC | 20.00 | 26330541 | |
| 77 | Phosphorylation | VRYNPYTTRPNRRGD EECCCCCCCCCCCCC | 37.98 | - | |
| 82 | Methylation | YTTRPNRRGDTWHDR CCCCCCCCCCCCCCC | 54.71 | 54557755 | |
| 85 | Phosphorylation | RPNRRGDTWHDRDRI CCCCCCCCCCCCCCE | 27.76 | 29449344 | |
| 95 | Phosphorylation | DRDRIHVTVRRDRAP CCCCEEEEEECCCCC | 8.30 | 26546556 | |
| 105 | Methylation | RDRAPPERGGAGTSQ CCCCCCCCCCCCCCC | 55.40 | 115485963 | |
| 115 | Phosphorylation | AGTSQDGTSKNWFKI CCCCCCCCCCCEEEE | 44.83 | 28985074 | |
| 117 | Ubiquitination | TSQDGTSKNWFKITI CCCCCCCCCEEEEEE | 59.02 | - | |
| 121 | Ubiquitination | GTSKNWFKITIPYGR CCCCCEEEEEEECCC | 30.47 | - | |
| 126 | Nitrated tyrosine | WFKITIPYGRKYDKA EEEEEEECCCCCCHH | 26.22 | - | |
| 126 | Nitration | WFKITIPYGRKYDKA EEEEEEECCCCCCHH | 26.22 | - | |
| 137 | Phosphorylation | YDKAWLLSMIQSKCS CCHHHHHHHHHHHCC | 16.21 | 28842319 | |
| 143 | S-nitrosylation | LSMIQSKCSVPFTPI HHHHHHHCCCCCCCE | 6.33 | 24105792 | |
| 148 | Phosphorylation | SKCSVPFTPIEFHYE HHCCCCCCCEEEEEE | 19.79 | - | |
| 154 | Phosphorylation | FTPIEFHYENTRAQF CCCEEEEEECCCEEE | 19.05 | 27642862 | |
| 167 | Phosphorylation | QFFVEDASTASALKA EEEEECCHHHHHHHH | 36.51 | 21406692 | |
| 168 | Phosphorylation | FFVEDASTASALKAV EEEECCHHHHHHHHH | 26.76 | 21406692 | |
| 170 | Phosphorylation | VEDASTASALKAVNY EECCHHHHHHHHHCC | 33.93 | 21406692 | |
| 173 | Ubiquitination | ASTASALKAVNYKIL CHHHHHHHHHCCEEC | 50.43 | 21890473 | |
| 173 | Ubiquitination | ASTASALKAVNYKIL CHHHHHHHHHCCEEC | 50.43 | 21890473 | |
| 178 | Malonylation | ALKAVNYKILDRENR HHHHHCCEECCCCCC | 31.43 | 26320211 | |
| 178 | Ubiquitination | ALKAVNYKILDRENR HHHHHCCEECCCCCC | 31.43 | - | |
| 188 | Phosphorylation | DRENRRISIIINSSA CCCCCEEEEEECCCC | 13.11 | 25159151 | |
| 193 | Phosphorylation | RISIIINSSAPPHTI EEEEEECCCCCCCCH | 19.91 | 28348404 | |
| 194 | Phosphorylation | ISIIINSSAPPHTIL EEEEECCCCCCCCHH | 40.06 | 28348404 | |
| 205 | Ubiquitination | HTILNELKPEQVEQL CCHHHCCCHHHHHHH | 40.09 | - | |
| 218 | Ubiquitination | QLKLIMSKRYDGSQQ HHHHHHHHCCCCCCC | 37.28 | - | |
| 220 | Phosphorylation | KLIMSKRYDGSQQAL HHHHHHCCCCCCCCC | 28.52 | 29449344 | |
| 223 | Phosphorylation | MSKRYDGSQQALDLK HHHCCCCCCCCCCCC | 19.07 | 28450419 | |
| 230 | Ubiquitination | SQQALDLKGLRSDPD CCCCCCCCCCCCCHH | 56.41 | 21890473 | |
| 230 | Methylation | SQQALDLKGLRSDPD CCCCCCCCCCCCCHH | 56.41 | 44497577 | |
| 230 | Ubiquitination | SQQALDLKGLRSDPD CCCCCCCCCCCCCHH | 56.41 | 21890473 | |
| 251 | Phosphorylation | DVVLNRRSCMAATLR HHHHCHHHHHHHHHH | 12.66 | 30266825 | |
| 284 | Phosphorylation | LYRLDDMSSIVQKAP EEEHHHHHHHHHHCC | 24.73 | 25003641 | |
| 285 | Phosphorylation | YRLDDMSSIVQKAPN EEHHHHHHHHHHCCC | 21.82 | 29083192 | |
| 289 | Ubiquitination | DMSSIVQKAPNLKIL HHHHHHHHCCCCEEE | 55.72 | - | |
| 294 | Ubiquitination | VQKAPNLKILNLSGN HHHCCCCEEEECCCC | 52.35 | - | |
| 299 | Phosphorylation | NLKILNLSGNELKSE CCEEEECCCCHHCCH | 38.20 | 25159151 | |
| 304 | Sumoylation | NLSGNELKSERELDK ECCCCHHCCHHHHHH | 44.06 | - | |
| 304 | Ubiquitination | NLSGNELKSERELDK ECCCCHHCCHHHHHH | 44.06 | - | |
| 304 | Sumoylation | NLSGNELKSERELDK ECCCCHHCCHHHHHH | 44.06 | - | |
| 304 | Acetylation | NLSGNELKSERELDK ECCCCHHCCHHHHHH | 44.06 | 25953088 | |
| 347 | Ubiquitination | AIRERFPKLLRLDGH HHHHHCCHHHCCCCC | 58.40 | - | |
| 374 | Ubiquitination | PTTLPPCKGSYFGTE CCCCCCCCCCCCCCH | 57.58 | - | |
| 430 | Phosphorylation | IPQNPARSSLAEYFK CCCCCCCHHHHHHHH | 31.63 | 28555341 | |
| 431 | Phosphorylation | PQNPARSSLAEYFKD CCCCCCHHHHHHHHH | 26.50 | 27134283 | |
| 437 | Ubiquitination | SSLAEYFKDSRNVKK HHHHHHHHHCCCHHH | 54.62 | - | |
| 437 | Acetylation | SSLAEYFKDSRNVKK HHHHHHHHHCCCHHH | 54.62 | 26051181 | |
| 528 | S-palmitoylation | PASNSGLCIVNDELF ECCCCCEEEECCEEE | 3.58 | 29575903 | |
| 554 | Phosphorylation | AFAMPAPTPSSSPVP HHCCCCCCCCCCCCC | 37.60 | 20068231 | |
| 556 | Phosphorylation | AMPAPTPSSSPVPTL CCCCCCCCCCCCCCC | 46.02 | 18691976 | |
| 557 | Phosphorylation | MPAPTPSSSPVPTLS CCCCCCCCCCCCCCC | 39.60 | 20068231 | |
| 558 | Phosphorylation | PAPTPSSSPVPTLSP CCCCCCCCCCCCCCH | 33.96 | 28464451 | |
| 562 | Phosphorylation | PSSSPVPTLSPEQQE CCCCCCCCCCHHHHH | 39.85 | 29116813 | |
| 564 | Phosphorylation | SSPVPTLSPEQQEML CCCCCCCCHHHHHHH | 28.95 | 28464451 | |
| 575 | Phosphorylation | QEMLQAFSTQSGMNL HHHHHHHHHCCCCCH | 28.66 | 20068231 | |
| 576 | Phosphorylation | EMLQAFSTQSGMNLE HHHHHHHHCCCCCHH | 21.94 | 20068231 | |
| 578 | Phosphorylation | LQAFSTQSGMNLEWS HHHHHHCCCCCHHHH | 39.85 | 27080861 | |
| 585 | Phosphorylation | SGMNLEWSQKCLQDN CCCCHHHHHHHHHCC | 15.47 | 27080861 | |
| 607 | Ubiquitination | AQAFTHLKAKGEIPE HHHHHHHHHCCCCCC | 40.21 | - | |
| 609 | Ubiquitination | AFTHLKAKGEIPEVA HHHHHHHCCCCCCCC | 56.33 | 19413330 | |
| 609 | Acetylation | AFTHLKAKGEIPEVA HHHHHHHCCCCCCCC | 56.33 | 26051181 | |
| 618 | Sulfoxidation | EIPEVAFMK------ CCCCCCCCC------ | 3.47 | 21406390 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NXF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NXF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NXF1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |