WDR37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR37_HUMAN
• UniProt AC: Q9Y2I8
• Protein Name: WD repeat-containing protein 37
• Gene Name: WDR37
• Organism: Homo sapiens (Human).
• Sequence Length: 494
• Protein Sequence: MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDTLNERLAAEGQAIDGAELSKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPVCNLFTCGFDRQAIGWNINIPALLQEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	QTKQKRKSHSLSIRR HHHHHHHHHCCEEEC	23.49	23403867
22	Phosphorylation	KQKRKSHSLSIRRTN HHHHHHHCCEEECCC	30.79	23911959
24	Phosphorylation	KRKSHSLSIRRTNSS HHHHHCCEEECCCCC	19.64	23401153
28	Phosphorylation	HSLSIRRTNSSEQER HCCEEECCCCCHHHH	29.60	22617229
30	Phosphorylation	LSIRRTNSSEQERTG CEEECCCCCHHHHHC	34.34	25159151
31	Phosphorylation	SIRRTNSSEQERTGL EEECCCCCHHHHHCC	45.42	22115753
36	Phosphorylation	NSSEQERTGLPRDML CCCHHHHHCCCHHHH	42.17	23090842
49	Ubiquitination	MLEGQDSKLPSSVRS HHCCCCCCCCHHHHH	73.11	-
56	Phosphorylation	KLPSSVRSTLLELFG CCCHHHHHHHHHHHH	22.66	25693802
57	Phosphorylation	LPSSVRSTLLELFGQ CCHHHHHHHHHHHHH	25.46	25693802
73	Phosphorylation	EREFENLYIENLELR HHHHHHHHEECHHHH	20.12	26074081
103	Phosphorylation	AIDGAELSKGQLKTK CCCHHHCCCCCCCHH	26.67	21815630
108	Ubiquitination	ELSKGQLKTKASHST HCCCCCCCHHHCCCH	39.84	30230243
112	Phosphorylation	GQLKTKASHSTSQLS CCCCHHHCCCHHHHH	21.37	30622161
114	Phosphorylation	LKTKASHSTSQLSQK CCHHHCCCHHHHHHH	27.53	25849741
115	Phosphorylation	KTKASHSTSQLSQKL CHHHCCCHHHHHHHH	18.31	30622161
116	Phosphorylation	TKASHSTSQLSQKLK HHHCCCHHHHHHHHH	31.94	28857561
119	Phosphorylation	SHSTSQLSQKLKTTY CCCHHHHHHHHHHHC	20.03	20363803
121	Ubiquitination	STSQLSQKLKTTYKA CHHHHHHHHHHHCHH	48.88	32015554
124	O-linked_Glycosylation	QLSQKLKTTYKASTS HHHHHHHHHCHHHHH	45.88	28411811
125	O-linked_Glycosylation	LSQKLKTTYKASTSK HHHHHHHHCHHHHHH	22.80	28411811
129	Phosphorylation	LKTTYKASTSKIVSS HHHHCHHHHHHHHHC	29.12	28348404
130	Phosphorylation	KTTYKASTSKIVSSF HHHCHHHHHHHHHCC	38.61	28348404
131	Phosphorylation	TTYKASTSKIVSSFK HHCHHHHHHHHHCCC	20.21	28857561
135	Phosphorylation	ASTSKIVSSFKTTTS HHHHHHHHCCCHHHH	33.27	28857561
136	Phosphorylation	STSKIVSSFKTTTSR HHHHHHHCCCHHHHH	21.62	29978859
138	Ubiquitination	SKIVSSFKTTTSRAA HHHHHCCCHHHHHHH	47.08	32015554
139	Phosphorylation	KIVSSFKTTTSRAAC HHHHCCCHHHHHHHH	33.04	26434776
140	Phosphorylation	IVSSFKTTTSRAACQ HHHCCCHHHHHHHHH	24.30	26434776
141	Phosphorylation	VSSFKTTTSRAACQL HHCCCHHHHHHHHHH	22.80	26434776
142	Phosphorylation	SSFKTTTSRAACQLV HCCCHHHHHHHHHHH	20.17	26434776
167	Phosphorylation	WDVSVAKTQPVVLGT CEEEEEECCCEEEEE	28.50	22210691
174	Phosphorylation	TQPVVLGTASADHTA CCCEEEEECCCCCEE	17.18	22210691
188	Phosphorylation	ALLWSIETGKCLVKY EEEEEEHHCCEEEEE	40.03	22210691
195	Phosphorylation	TGKCLVKYAGHVGSV HCCEEEEECCCCCCE	15.44	18452278
201	Phosphorylation	KYAGHVGSVNSIKFH EECCCCCCEEEEEEC	19.62	28857561
228	Phosphorylation	QTAHIWRYAVQLPTP CCEEEEEEEEECCCC	8.98	27251275
234	Phosphorylation	RYAVQLPTPQPVADT EEEEECCCCCCCCCC	43.05	27251275
241	Phosphorylation	TPQPVADTSISGEDE CCCCCCCCCCCCCCC	20.44	27251275
242	Phosphorylation	PQPVADTSISGEDEV CCCCCCCCCCCCCCE	18.46	27251275
244	Phosphorylation	PVADTSISGEDEVEC CCCCCCCCCCCCEEC	35.58	26471730
252	Phosphorylation	GEDEVECSDKDEPDL CCCCEECCCCCCCCC	33.90	30576142
264	Phosphorylation	PDLDGDVSSDCPTIR CCCCCCCCCCCCCEE	25.79	27251275
265	Phosphorylation	DLDGDVSSDCPTIRV CCCCCCCCCCCCEEE	42.98	27251275
275	O-linked_Glycosylation	PTIRVPLTSLKSHQG CCEEEEHHHCCCCCC	26.41	28411811
340	Phosphorylation	PTQRLVVTSSRDTTF CCCEEEEECCCCCEE	17.32	23403867
341	Phosphorylation	TQRLVVTSSRDTTFR CCEEEEECCCCCEEE	16.27	23403867
342	Phosphorylation	QRLVVTSSRDTTFRL CEEEEECCCCCEEEE	25.47	23403867
345	Phosphorylation	VVTSSRDTTFRLWDF EEECCCCCEEEEEEC	27.07	23403867
346	Phosphorylation	VTSSRDTTFRLWDFR EECCCCCEEEEEECC	15.85	23403867
356	Phosphorylation	LWDFRDPSIHSVNVF EEECCCCCCCEEEEE	36.90	22210691
367	Phosphorylation	VNVFQGHTDTVTSAV EEEEECCCCCCEEEE	39.94	22210691
396	Ubiquitination	TVKVWDLKNMRSPIA EEEEEECCCCCCCCE	46.34	-
400	Phosphorylation	WDLKNMRSPIATIRT EECCCCCCCCEEEEC	15.19	23312004
404	Phosphorylation	NMRSPIATIRTDSAI CCCCCCEEEECCCHH	16.23	23312004
407	Phosphorylation	SPIATIRTDSAINRI CCCEEEECCCHHHHE	30.38	23312004
409	Phosphorylation	IATIRTDSAINRINV CEEEECCCHHHHEEE	30.36	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR37_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPG_HUMAN	CCT3	physical	26186194
TCPH_HUMAN	CCT7	physical	26186194
HSP7C_HUMAN	HSPA8	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
TCPZ_HUMAN	CCT6A	physical	26186194
CLU_HUMAN	CLUH	physical	26186194
TCPA_HUMAN	TCP1	physical	26186194
PACS2_HUMAN	PACS2	physical	26186194
PACS1_HUMAN	PACS1	physical	26186194
SETD2_HUMAN	SETD2	physical	26186194
PACS1_HUMAN	PACS1	physical	28514442
PACS2_HUMAN	PACS2	physical	28514442
CLU_HUMAN	CLUH	physical	28514442
SETD2_HUMAN	SETD2	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.