dbPTM

TCPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TCPH_HUMAN
UniProt AC	Q99832
Protein Name	T-complex protein 1 subunit eta
Gene Name	CCT7
Organism	Homo sapiens (Human).
Sequence Length	543
Subcellular Localization	Cytoplasm.
Protein Description	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)..
Protein Sequence	MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMPTPVIL -------CCCCCEEE	7.01	19413330
1 (in isoform 3)	Acetylation	-	7.01	22814378
3 (in isoform 3)	Ubiquitination	-	32.05	-
4	Phosphorylation	----MMPTPVILLKE ----CCCCCEEEEEC	16.58	29255136
4 (in isoform 2)	Phosphorylation	-	16.58	-
7 (in isoform 4)	Phosphorylation	-	3.82	22210691
8 (in isoform 4)	Phosphorylation	-	5.94	22210691
9 (in isoform 4)	Phosphorylation	-	3.05	22210691
10	Ubiquitination	PTPVILLKEGTDSSQ CCCEEEEECCCCCCC	51.13	33845483
11	Ubiquitination	TPVILLKEGTDSSQG CCEEEEECCCCCCCC	68.26	21890473
11	Ubiquitination	TPVILLKEGTDSSQG CCEEEEECCCCCCCC	68.26	23000965
11 (in isoform 4)	Phosphorylation	-	68.26	22210691
13	Phosphorylation	VILLKEGTDSSQGIP EEEEECCCCCCCCHH	33.52	21712546
13	Ubiquitination	VILLKEGTDSSQGIP EEEEECCCCCCCCHH	33.52	23000965
14	Ubiquitination	ILLKEGTDSSQGIPQ EEEECCCCCCCCHHH	58.09	23000965
16	Phosphorylation	LKEGTDSSQGIPQLV EECCCCCCCCHHHHH	34.92	21712546
19	Ubiquitination	GTDSSQGIPQLVSNI CCCCCCCHHHHHHHH	1.20	23503661
22	Ubiquitination	SSQGIPQLVSNISAC CCCCHHHHHHHHHHH	3.70	23503661
23	Ubiquitination	SQGIPQLVSNISACQ CCCHHHHHHHHHHHH	3.29	21890473
23	Acetylation	SQGIPQLVSNISACQ CCCHHHHHHHHHHHH	3.29	19608861
23	Ubiquitination	SQGIPQLVSNISACQ CCCHHHHHHHHHHHH	3.29	23000965
24	Phosphorylation	QGIPQLVSNISACQV CCHHHHHHHHHHHHH	36.72	21712546
26	Ubiquitination	IPQLVSNISACQVIA HHHHHHHHHHHHHHH	1.84	32015554
27	Phosphorylation	PQLVSNISACQVIAE HHHHHHHHHHHHHHH	27.52	21712546
29	Glutathionylation	LVSNISACQVIAEAV HHHHHHHHHHHHHHH	2.37	22555962
33	Ubiquitination	ISACQVIAEAVRTTL HHHHHHHHHHHHHCC	10.39	21890473
33	Ubiquitination	ISACQVIAEAVRTTL HHHHHHHHHHHHHCC	10.39	23000965
43	Methylation	VRTTLGPRGMDKLIV HHHCCCCCCCCEEEE	51.80	-
43	Neddylation	VRTTLGPRGMDKLIV HHHCCCCCCCCEEEE	51.80	32015554
43	Ubiquitination	VRTTLGPRGMDKLIV HHHCCCCCCCCEEEE	51.80	33845483
46	Ubiquitination	TLGPRGMDKLIVDGR CCCCCCCCEEEECCC	45.49	22053931
47	Ubiquitination	LGPRGMDKLIVDGRG CCCCCCCEEEECCCC	31.08	21890473
47	2-Hydroxyisobutyrylation	LGPRGMDKLIVDGRG CCCCCCCEEEECCCC	31.08	-
47	Acetylation	LGPRGMDKLIVDGRG CCCCCCCEEEECCCC	31.08	25953088
47	Neddylation	LGPRGMDKLIVDGRG CCCCCCCEEEECCCC	31.08	32015554
47	Ubiquitination	LGPRGMDKLIVDGRG CCCCCCCEEEECCCC	31.08	23000965
48	Ubiquitination	GPRGMDKLIVDGRGK CCCCCCEEEECCCCC	3.93	33845483
50	Ubiquitination	RGMDKLIVDGRGKAT CCCCEEEECCCCCEE	10.40	33845483
53	Methylation	DKLIVDGRGKATISN CEEEECCCCCEEECC	38.69	-
55	Ubiquitination	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	21890473
55	2-Hydroxyisobutyrylation	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	-
55	Malonylation	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	26320211
55	Ubiquitination	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	23000965
57	Phosphorylation	VDGRGKATISNDGAT ECCCCCEEECCCHHH	28.55	-
57	Ubiquitination	VDGRGKATISNDGAT ECCCCCEEECCCHHH	28.55	27667366
58	Ubiquitination	DGRGKATISNDGATI CCCCCEEECCCHHHH	4.29	33845483
59	Phosphorylation	GRGKATISNDGATIL CCCCEEECCCHHHHH	25.23	21712546
62	Ubiquitination	KATISNDGATILKLL CEEECCCHHHHHHHH	28.95	23503661
64	Phosphorylation	TISNDGATILKLLDV EECCCHHHHHHHHHH	32.16	22496350
65	Ubiquitination	ISNDGATILKLLDVV ECCCHHHHHHHHHHH	2.94	23503661
67	Ubiquitination	NDGATILKLLDVVHP CCHHHHHHHHHHHCH	43.06	21890473
67	Acetylation	NDGATILKLLDVVHP CCHHHHHHHHHHHCH	43.06	19608861
67	Ubiquitination	NDGATILKLLDVVHP CCHHHHHHHHHHHCH	43.06	23000965
70	Ubiquitination	ATILKLLDVVHPAAK HHHHHHHHHHCHHHH	51.32	29967540
73	Ubiquitination	LKLLDVVHPAAKTLV HHHHHHHCHHHHHHH	13.21	32015554
76	Ubiquitination	LDVVHPAAKTLVDIA HHHHCHHHHHHHHHH	15.15	29967540
77	Ubiquitination	DVVHPAAKTLVDIAK HHHCHHHHHHHHHHH	44.49	21890473
77	2-Hydroxyisobutyrylation	DVVHPAAKTLVDIAK HHHCHHHHHHHHHHH	44.49	-
77	Acetylation	DVVHPAAKTLVDIAK HHHCHHHHHHHHHHH	44.49	25953088
77	Ubiquitination	DVVHPAAKTLVDIAK HHHCHHHHHHHHHHH	44.49	23000965
79	Ubiquitination	VHPAAKTLVDIAKSQ HCHHHHHHHHHHHCC	3.00	23000965
83	Ubiquitination	AKTLVDIAKSQDAEV HHHHHHHHHCCCCCC	10.86	23503661
84	Ubiquitination	KTLVDIAKSQDAEVG HHHHHHHHCCCCCCC	49.32	-
85	Ubiquitination	TLVDIAKSQDAEVGD HHHHHHHCCCCCCCC	25.03	21890473
85	Ubiquitination	TLVDIAKSQDAEVGD HHHHHHHCCCCCCCC	25.03	23000965
88	Ubiquitination	DIAKSQDAEVGDGTT HHHHCCCCCCCCCHH	13.02	21890473
91	Ubiquitination	KSQDAEVGDGTTSVT HCCCCCCCCCHHHHH	21.09	33845483
93	Ubiquitination	QDAEVGDGTTSVTLL CCCCCCCCHHHHHHH	25.60	33845483
95	Phosphorylation	AEVGDGTTSVTLLAA CCCCCCHHHHHHHHH	27.08	21712546
96	Phosphorylation	EVGDGTTSVTLLAAE CCCCCHHHHHHHHHH	16.97	21712546
100	Ubiquitination	GTTSVTLLAAEFLKQ CHHHHHHHHHHHHHH	2.87	27667366
101	Ubiquitination	TTSVTLLAAEFLKQV HHHHHHHHHHHHHHH	14.20	33845483
106	Ubiquitination	LLAAEFLKQVKPYVE HHHHHHHHHHHHHHH	59.37	23503661
109	Acetylation	AEFLKQVKPYVEEGL HHHHHHHHHHHHCCC	28.30	26051181
109	Ubiquitination	AEFLKQVKPYVEEGL HHHHHHHHHHHHCCC	28.30	23503661
111	Phosphorylation	FLKQVKPYVEEGLHP HHHHHHHHHHCCCCH	18.12	28152594
112	Ubiquitination	LKQVKPYVEEGLHPQ HHHHHHHHHCCCCHH	7.97	29967540
113	Ubiquitination	KQVKPYVEEGLHPQI HHHHHHHHCCCCHHH	40.27	29967540
116	Acetylation	KPYVEEGLHPQIIIR HHHHHCCCCHHHHHH	6.36	19608861
116	Ubiquitination	KPYVEEGLHPQIIIR HHHHHCCCCHHHHHH	6.36	27667366
122	Ubiquitination	GLHPQIIIRAFRTAT CCCHHHHHHHHHHHH	2.51	23000965
127	Phosphorylation	IIIRAFRTATQLAVN HHHHHHHHHHHHHHH	27.83	21601212
128	Ubiquitination	IIRAFRTATQLAVNK HHHHHHHHHHHHHHH	6.78	21890473
128	Ubiquitination	IIRAFRTATQLAVNK HHHHHHHHHHHHHHH	6.78	23000965
129	Phosphorylation	IRAFRTATQLAVNKI HHHHHHHHHHHHHHH	24.41	27273156
130	Ubiquitination	RAFRTATQLAVNKIK HHHHHHHHHHHHHHH	25.59	21890473
130	Ubiquitination	RAFRTATQLAVNKIK HHHHHHHHHHHHHHH	25.59	23000965
131	Ubiquitination	AFRTATQLAVNKIKE HHHHHHHHHHHHHHH	5.09	21890473
131	Ubiquitination	AFRTATQLAVNKIKE HHHHHHHHHHHHHHH	5.09	23000965
135	2-Hydroxyisobutyrylation	ATQLAVNKIKEIAVT HHHHHHHHHHHHEEE	48.86	-
135	Acetylation	ATQLAVNKIKEIAVT HHHHHHHHHHHHEEE	48.86	25953088
135	Ubiquitination	ATQLAVNKIKEIAVT HHHHHHHHHHHHEEE	48.86	21906983
137	Acetylation	QLAVNKIKEIAVTVK HHHHHHHHHHEEEEE	44.68	26051181
137	Ubiquitination	QLAVNKIKEIAVTVK HHHHHHHHHHEEEEE	44.68	33845483
143	Ubiquitination	IKEIAVTVKKADKVE HHHHEEEEECCCHHH	4.87	32015554
144	2-Hydroxyisobutyrylation	KEIAVTVKKADKVEQ HHHEEEEECCCHHHH	32.64	-
144	Acetylation	KEIAVTVKKADKVEQ HHHEEEEECCCHHHH	32.64	25953088
144	Ubiquitination	KEIAVTVKKADKVEQ HHHEEEEECCCHHHH	32.64	27667366
145	Ubiquitination	EIAVTVKKADKVEQR HHEEEEECCCHHHHH	58.44	33845483
153	Acetylation	ADKVEQRKLLEKCAM CCHHHHHHHHHHHHH	58.06	25953088
155	Ubiquitination	KVEQRKLLEKCAMTA HHHHHHHHHHHHHHH	7.11	29967540
157	Acetylation	EQRKLLEKCAMTALS HHHHHHHHHHHHHHH	27.54	23236377
157	Malonylation	EQRKLLEKCAMTALS HHHHHHHHHHHHHHH	27.54	26320211
157	Ubiquitination	EQRKLLEKCAMTALS HHHHHHHHHHHHHHH	27.54	29967540
160	Neddylation	KLLEKCAMTALSSKL HHHHHHHHHHHHHHH	2.93	32015554
160	Sulfoxidation	KLLEKCAMTALSSKL HHHHHHHHHHHHHHH	2.93	30846556
160	Ubiquitination	KLLEKCAMTALSSKL HHHHHHHHHHHHHHH	2.93	33845483
161	Phosphorylation	LLEKCAMTALSSKLI HHHHHHHHHHHHHHH	13.11	29083192
162	Ubiquitination	LEKCAMTALSSKLIS HHHHHHHHHHHHHHH	7.74	33845483
163	Ubiquitination	EKCAMTALSSKLISQ HHHHHHHHHHHHHHH	4.34	22053931
164	Phosphorylation	KCAMTALSSKLISQQ HHHHHHHHHHHHHHH	23.98	29083192
164	Ubiquitination	KCAMTALSSKLISQQ HHHHHHHHHHHHHHH	23.98	33845483
165	Phosphorylation	CAMTALSSKLISQQK HHHHHHHHHHHHHHH	32.12	29083192
166	Acetylation	AMTALSSKLISQQKA HHHHHHHHHHHHHHH	46.60	25953088
166	Ubiquitination	AMTALSSKLISQQKA HHHHHHHHHHHHHHH	46.60	23000965
172	2-Hydroxyisobutyrylation	SKLISQQKAFFAKMV HHHHHHHHHHHHHHH	39.25	-
172	Acetylation	SKLISQQKAFFAKMV HHHHHHHHHHHHHHH	39.25	23954790
172	Succinylation	SKLISQQKAFFAKMV HHHHHHHHHHHHHHH	39.25	23954790
172	Ubiquitination	SKLISQQKAFFAKMV HHHHHHHHHHHHHHH	39.25	23000965
173	Ubiquitination	KLISQQKAFFAKMVV HHHHHHHHHHHHHHH	10.64	23000965
174	Ubiquitination	LISQQKAFFAKMVVD HHHHHHHHHHHHHHH	8.67	21890473
174	Ubiquitination	LISQQKAFFAKMVVD HHHHHHHHHHHHHHH	8.67	23000965
176	Ubiquitination	SQQKAFFAKMVVDAV HHHHHHHHHHHHHHH	7.80	21890473
186	Ubiquitination	VVDAVMMLDDLLQLK HHHHHHHHHHHHHHH	2.21	32015554
190	Ubiquitination	VMMLDDLLQLKMIGI HHHHHHHHHHHHHCC	7.83	32015554
193	Ubiquitination	LDDLLQLKMIGIKKV HHHHHHHHHHCCEEE	18.60	29967540
199	2-Hydroxyisobutyrylation	LKMIGIKKVQGGALE HHHHCCEEECCCCCC	37.56	-
199	Acetylation	LKMIGIKKVQGGALE HHHHCCEEECCCCCC	37.56	26051181
199	Ubiquitination	LKMIGIKKVQGGALE HHHHCCEEECCCCCC	37.56	29967540
200	Ubiquitination	KMIGIKKVQGGALED HHHCCEEECCCCCCC	5.62	23503661
203	Neddylation	GIKKVQGGALEDSQL CCEEECCCCCCCHHE	15.19	32015554
203	Ubiquitination	GIKKVQGGALEDSQL CCEEECCCCCCCHHE	15.19	33845483
205	Ubiquitination	KKVQGGALEDSQLVA EEECCCCCCCHHEEE	9.45	21890473
205	Ubiquitination	KKVQGGALEDSQLVA EEECCCCCCCHHEEE	9.45	21890473
206	Ubiquitination	KVQGGALEDSQLVAG EECCCCCCCHHEEEE	55.90	22053931
214	Ubiquitination	DSQLVAGVAFKKTFS CHHEEEEEEEEEECC	4.00	21963094
217	Acetylation	LVAGVAFKKTFSYAG EEEEEEEEEECCCCC	40.96	25953088
217	Ubiquitination	LVAGVAFKKTFSYAG EEEEEEEEEECCCCC	40.96	23000965
218	2-Hydroxyisobutyrylation	VAGVAFKKTFSYAGF EEEEEEEEECCCCCE	48.63	-
218	Acetylation	VAGVAFKKTFSYAGF EEEEEEEEECCCCCE	48.63	6570511
218	Ubiquitination	VAGVAFKKTFSYAGF EEEEEEEEECCCCCE	48.63	23000965
219	Phosphorylation	AGVAFKKTFSYAGFE EEEEEEEECCCCCEE	20.57	28258704
221	Phosphorylation	VAFKKTFSYAGFEMQ EEEEEECCCCCEECC	21.21	29978859
222	Nitration	AFKKTFSYAGFEMQP EEEEECCCCCEECCC	13.42	-
222	Phosphorylation	AFKKTFSYAGFEMQP EEEEECCCCCEECCC	13.42	28258704
226	Ubiquitination	TFSYAGFEMQPKKYH ECCCCCEECCCCCCC	35.67	23000965
227	Sulfoxidation	FSYAGFEMQPKKYHN CCCCCEECCCCCCCC	8.47	30846556
230	2-Hydroxyisobutyrylation	AGFEMQPKKYHNPKI CCEECCCCCCCCCCE	49.42	-
230	Acetylation	AGFEMQPKKYHNPKI CCEECCCCCCCCCCE	49.42	26051181
230	Succinylation	AGFEMQPKKYHNPKI CCEECCCCCCCCCCE	49.42	23954790
230	Ubiquitination	AGFEMQPKKYHNPKI CCEECCCCCCCCCCE	49.42	33845483
231	Acetylation	GFEMQPKKYHNPKIA CEECCCCCCCCCCEE	59.43	30584175
231	Ubiquitination	GFEMQPKKYHNPKIA CEECCCCCCCCCCEE	59.43	-
233	Acetylation	EMQPKKYHNPKIALL ECCCCCCCCCCEEEE	53.66	19608861
233	Ubiquitination	EMQPKKYHNPKIALL ECCCCCCCCCCEEEE	53.66	27667366
236	Ubiquitination	PKKYHNPKIALLNVE CCCCCCCCEEEEEEE	46.02	21963094
243	Ubiquitination	KIALLNVELELKAEK CEEEEEEEEEEEECC	35.14	23503661
247	Neddylation	LNVELELKAEKDNAE EEEEEEEEECCCCCE	45.16	32015554
247	Ubiquitination	LNVELELKAEKDNAE EEEEEEEEECCCCCE	45.16	33845483
248	Ubiquitination	NVELELKAEKDNAEI EEEEEEEECCCCCEE	41.52	21890473
248	Ubiquitination	NVELELKAEKDNAEI EEEEEEEECCCCCEE	41.52	21890473
250	Ubiquitination	ELELKAEKDNAEIRV EEEEEECCCCCEEEE	62.23	21890473
250	Acetylation	ELELKAEKDNAEIRV EEEEEECCCCCEEEE	62.23	23749302
250	Succinylation	ELELKAEKDNAEIRV EEEEEECCCCCEEEE	62.23	23954790
250	Ubiquitination	ELELKAEKDNAEIRV EEEEEECCCCCEEEE	62.23	33845483
259	Phosphorylation	NAEIRVHTVEDYQAI CCEEEEEEHHCHHHH	23.80	27642862
259	Ubiquitination	NAEIRVHTVEDYQAI CCEEEEEEHHCHHHH	23.80	21963094
263	Phosphorylation	RVHTVEDYQAIVDAE EEEEHHCHHHHCCCH	6.07	28796482
275	Phosphorylation	DAEWNILYDKLEKIH CCHHHHHHHHHHHHH	13.77	29496907
276	Acetylation	AEWNILYDKLEKIHH CHHHHHHHHHHHHHC	45.69	19608861
276	Ubiquitination	AEWNILYDKLEKIHH CHHHHHHHHHHHHHC	45.69	27667366
277	Ubiquitination	EWNILYDKLEKIHHS HHHHHHHHHHHHHCC	45.01	32015554
279	Ubiquitination	NILYDKLEKIHHSGA HHHHHHHHHHHCCCC	56.56	21890473
279	Ubiquitination	NILYDKLEKIHHSGA HHHHHHHHHHHCCCC	56.56	33845483
280	2-Hydroxyisobutyrylation	ILYDKLEKIHHSGAK HHHHHHHHHHCCCCE	58.75	-
280	Ubiquitination	ILYDKLEKIHHSGAK HHHHHHHHHHCCCCE	58.75	29967540
281	Ubiquitination	LYDKLEKIHHSGAKV HHHHHHHHHCCCCEE	2.29	33845483
287	2-Hydroxyisobutyrylation	KIHHSGAKVVLSKLP HHHCCCCEEEEECCC	36.08	-
287	Acetylation	KIHHSGAKVVLSKLP HHHCCCCEEEEECCC	36.08	23749302
287	Ubiquitination	KIHHSGAKVVLSKLP HHHCCCCEEEEECCC	36.08	23503661
292	2-Hydroxyisobutyrylation	GAKVVLSKLPIGDVA CCEEEEECCCCCCHH	54.87	-
292	Acetylation	GAKVVLSKLPIGDVA CCEEEEECCCCCCHH	54.87	23954790
292	Ubiquitination	GAKVVLSKLPIGDVA CCEEEEECCCCCCHH	54.87	21906983
300	Phosphorylation	LPIGDVATQYFADRD CCCCCHHHHHHCCCC	24.53	28152594
302	Phosphorylation	IGDVATQYFADRDMF CCCHHHHHHCCCCCC	9.07	28152594
306	Methylation	ATQYFADRDMFCAGR HHHHHCCCCCCCCCC	33.59	-
310	Glutathionylation	FADRDMFCAGRVPEE HCCCCCCCCCCCCHH	2.93	22555962
317	Ubiquitination	CAGRVPEEDLKRTMM CCCCCCHHHHHHHHH	63.67	22053931
320	Acetylation	RVPEEDLKRTMMACG CCCHHHHHHHHHHCC	59.13	19608861
320	Malonylation	RVPEEDLKRTMMACG CCCHHHHHHHHHHCC	59.13	26320211
320	Ubiquitination	RVPEEDLKRTMMACG CCCHHHHHHHHHHCC	59.13	21906983
322	Ubiquitination	PEEDLKRTMMACGGS CHHHHHHHHHHCCCH	15.09	21890473
322	Phosphorylation	PEEDLKRTMMACGGS CHHHHHHHHHHCCCH	15.09	28509920
322	Ubiquitination	PEEDLKRTMMACGGS CHHHHHHHHHHCCCH	15.09	33845483
324	Ubiquitination	EDLKRTMMACGGSIQ HHHHHHHHHCCCHHH	2.49	21890473
324	Ubiquitination	EDLKRTMMACGGSIQ HHHHHHHHHCCCHHH	2.49	33845483
329	Phosphorylation	TMMACGGSIQTSVNA HHHHCCCHHHHHHHH	9.23	26126808
331	Ubiquitination	MACGGSIQTSVNALS HHCCCHHHHHHHHHC	29.44	21890473
331	Ubiquitination	MACGGSIQTSVNALS HHCCCHHHHHHHHHC	29.44	21963094
332	Phosphorylation	ACGGSIQTSVNALSA HCCCHHHHHHHHHCH	32.73	26126808
333	Phosphorylation	CGGSIQTSVNALSAD CCCHHHHHHHHHCHH	9.30	26126808
338	Phosphorylation	QTSVNALSADVLGRC HHHHHHHCHHHHCCC	21.73	28509920
343	Ubiquitination	ALSADVLGRCQVFEE HHCHHHHCCCEEEEE	28.32	21890473
343	Ubiquitination	ALSADVLGRCQVFEE HHCHHHHCCCEEEEE	28.32	23000965
345	Glutathionylation	SADVLGRCQVFEETQ CHHHHCCCEEEEEEE	3.72	22555962
353	Ubiquitination	QVFEETQIGGERYNF EEEEEEEECCEEEEE	11.33	21890473
353	Ubiquitination	QVFEETQIGGERYNF EEEEEEEECCEEEEE	11.33	21890473
358	Phosphorylation	TQIGGERYNFFTGCP EEECCEEEEECCCCC	16.42	28152594
364	S-nitrosocysteine	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	-
364	Glutathionylation	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	22555962
364	S-nitrosylation	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	22178444
366	Acetylation	NFFTGCPKAKTCTFI EECCCCCCCCEEEEE	67.60	26051181
366	Succinylation	NFFTGCPKAKTCTFI EECCCCCCCCEEEEE	67.60	23954790
366	Ubiquitination	NFFTGCPKAKTCTFI EECCCCCCCCEEEEE	67.60	33845483
368	Ubiquitination	FTGCPKAKTCTFILR CCCCCCCCEEEEEEC	50.70	33845483
370	Glutathionylation	GCPKAKTCTFILRGG CCCCCCEEEEEECCC	2.63	22555962
370	S-nitrosylation	GCPKAKTCTFILRGG CCCCCCEEEEEECCC	2.63	2212679
371	Phosphorylation	CPKAKTCTFILRGGA CCCCCEEEEEECCCH	20.95	-
374	Ubiquitination	AKTCTFILRGGAEQF CCEEEEEECCCHHHH	3.48	21890473
374	Ubiquitination	AKTCTFILRGGAEQF CCEEEEEECCCHHHH	3.48	21963094
375	Methylation	KTCTFILRGGAEQFM CEEEEEECCCHHHHH	36.36	-
376	Ubiquitination	TCTFILRGGAEQFME EEEEEECCCHHHHHH	35.90	21890473
376	Ubiquitination	TCTFILRGGAEQFME EEEEEECCCHHHHHH	35.90	21890473
376	Ubiquitination	TCTFILRGGAEQFME EEEEEECCCHHHHHH	35.90	21963094
382	Sulfoxidation	RGGAEQFMEETERSL CCCHHHHHHHHHHHH	4.55	21406390
386	Ubiquitination	EQFMEETERSLHDAI HHHHHHHHHHHHHHH	43.48	21890473
386	Ubiquitination	EQFMEETERSLHDAI HHHHHHHHHHHHHHH	43.48	23000965
388	Ubiquitination	FMEETERSLHDAIMI HHHHHHHHHHHHHHH	24.67	21890473
394	Sulfoxidation	RSLHDAIMIVRRAIK HHHHHHHHHHHHHHH	2.19	21406390
396	Ubiquitination	LHDAIMIVRRAIKND HHHHHHHHHHHHHCC	1.55	21890473
396	Ubiquitination	LHDAIMIVRRAIKND HHHHHHHHHHHHHCC	1.55	21890473
398	Ubiquitination	DAIMIVRRAIKNDSV HHHHHHHHHHHCCCC	29.75	21890473
401	Ubiquitination	MIVRRAIKNDSVVAG HHHHHHHHCCCCCCC	54.43	21906983
414	Sulfoxidation	AGGGAIEMELSKYLR CCCCHHHHHHHHHHH	5.26	21406390
418	Ubiquitination	AIEMELSKYLRDYSR HHHHHHHHHHHHHCC	62.01	21963094
419	Ubiquitination	IEMELSKYLRDYSRT HHHHHHHHHHHHCCC	12.00	21890473
419	Phosphorylation	IEMELSKYLRDYSRT HHHHHHHHHHHHCCC	12.00	23882029
419	Ubiquitination	IEMELSKYLRDYSRT HHHHHHHHHHHHCCC	12.00	21963094
421	Ubiquitination	MELSKYLRDYSRTIP HHHHHHHHHHCCCCC	37.42	21890473
423	Phosphorylation	LSKYLRDYSRTIPGK HHHHHHHHCCCCCCH	8.13	28152594
424	Phosphorylation	SKYLRDYSRTIPGKQ HHHHHHHCCCCCCHH	27.51	29496907
426	Phosphorylation	YLRDYSRTIPGKQQL HHHHHCCCCCCHHHH	26.11	28387310
430	Methylation	YSRTIPGKQQLLIGA HCCCCCCHHHHHHHH	29.53	-
430	Sumoylation	YSRTIPGKQQLLIGA HCCCCCCHHHHHHHH	29.53	28112733
430	Ubiquitination	YSRTIPGKQQLLIGA HCCCCCCHHHHHHHH	29.53	23000965
434	Ubiquitination	IPGKQQLLIGAYAKA CCCHHHHHHHHHHHH	2.70	22053931
438	Phosphorylation	QQLLIGAYAKALEII HHHHHHHHHHHHHHC	11.92	28152594
440	Ubiquitination	LLIGAYAKALEIIPR HHHHHHHHHHHHCHH	40.61	21906983
450	S-nitrosocysteine	EIIPRQLCDNAGFDA HHCHHHHHCCCCCCH	2.61	-
450	Glutathionylation	EIIPRQLCDNAGFDA HHCHHHHHCCCCCCH	2.61	22555962
450	S-nitrosylation	EIIPRQLCDNAGFDA HHCHHHHHCCCCCCH	2.61	22178444
458	Phosphorylation	DNAGFDATNILNKLR CCCCCCHHHHHHHHH	25.33	28387310
463	Acetylation	DATNILNKLRARHAQ CHHHHHHHHHHHHCC	35.59	23749302
463	Ubiquitination	DATNILNKLRARHAQ CHHHHHHHHHHHHCC	35.59	21963094
477	Ubiquitination	QGGTWYGVDINNEDI CCCCEEEEECCCHHH	3.81	22053931
504	Phosphorylation	MVRINALTAASEAAC HHHHHHHHHHHHHHH	20.12	-
507	Phosphorylation	INALTAASEAACLIV HHHHHHHHHHHHEEE	25.88	-
511	Glutathionylation	TAASEAACLIVSVDE HHHHHHHHEEEEHHH	3.25	22555962
521	Ubiquitination	VSVDETIKNPRSTVD EEHHHHCCCCCCCCC	69.21	22053931
524	Methylation	DETIKNPRSTVDAPT HHHCCCCCCCCCCCC	55.12	-
526	Phosphorylation	TIKNPRSTVDAPTAA HCCCCCCCCCCCCCC	24.55	-
531	Phosphorylation	RSTVDAPTAAGRGRG CCCCCCCCCCCCCCC	30.75	-
535	Dimethylation	DAPTAAGRGRGRGRP CCCCCCCCCCCCCCC	27.23	-
535	Methylation	DAPTAAGRGRGRGRP CCCCCCCCCCCCCCC	27.23	24129315
537	Dimethylation	PTAAGRGRGRGRPH- CCCCCCCCCCCCCC-	30.21	-
537	Methylation	PTAAGRGRGRGRPH- CCCCCCCCCCCCCC-	30.21	-
539	Dimethylation	AAGRGRGRGRPH--- CCCCCCCCCCCC---	36.26	-
539	Methylation	AAGRGRGRGRPH--- CCCCCCCCCCCC---	36.26	-
541	Methylation	GRGRGRGRPH----- CCCCCCCCCC-----	25.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TCPH_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TCPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TCPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED31_HUMAN	MED31	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
A4_HUMAN	APP	physical	21832049
TCPQ_HUMAN	CCT8	physical	22939629
TCPZ_HUMAN	CCT6A	physical	22939629
TIF1B_HUMAN	TRIM28	physical	22939629
CEBPE_HUMAN	CEBPE	physical	21988832
TCPD_HUMAN	CCT4	physical	22863883
TCPE_HUMAN	CCT5	physical	22863883
TCPZ_HUMAN	CCT6A	physical	22863883
TCPQ_HUMAN	CCT8	physical	22863883
TCPA_HUMAN	TCP1	physical	22863883
TCPB_HUMAN	CCT2	physical	26344197
TCPQ_HUMAN	CCT8	physical	26344197
IMA3_HUMAN	KPNA4	physical	26344197
LAGE3_HUMAN	LAGE3	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
DCA12_HUMAN	DCAF12	physical	28514442
KLD8B_HUMAN	KLHDC8B	physical	28514442
WDR70_HUMAN	WDR70	physical	28514442
TBD_HUMAN	TUBD1	physical	28514442
WDR46_HUMAN	WDR46	physical	28514442
DCA13_HUMAN	DCAF13	physical	28514442
WDR24_HUMAN	WDR24	physical	28514442
FBXW8_HUMAN	FBXW8	physical	28514442
RFWD3_HUMAN	RFWD3	physical	28514442
DTL_HUMAN	DTL	physical	28514442
KTNB1_HUMAN	KATNB1	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
KLHL8_HUMAN	KLHL8	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
NEDD1_HUMAN	NEDD1	physical	28514442
UTP18_HUMAN	UTP18	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442
TAF1C_HUMAN	TAF1C	physical	28514442
BUB3_HUMAN	BUB3	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
MEP50_HUMAN	WDR77	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
WDTC1_HUMAN	WDTC1	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
MIO_HUMAN	MIOS	physical	28514442
PDCL3_HUMAN	PDCL3	physical	28514442
HDAC3_HUMAN	HDAC3	physical	28514442
TLE4_HUMAN	TLE4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TCPH_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-67 AND LYS-320, AND MASSSPECTROMETRY.	19608861 [Abstract]