TBD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBD_HUMAN
• UniProt AC: Q9UJT1
• Protein Name: Tubulin delta chain
• Gene Name: TUBD1
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, cilium . Associated with centrioles. Both cytoplasmic and nuclear. In the elongating spermatid it is associated with the manchette,
• Protein Description: Acts as a positive regulator of hedgehog signaling and regulates ciliary function..
• Protein Sequence: MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPIARAVLVDMEPKVINQMLSKAAQSGQWKYGQHACFCQKQGSGNNWAYGYSVHGPRHEESIMNIIRKEVEKCDSFSGFFIIMSMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLLHENDAIHKICAKLMNIKQISFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGLLKHLRQMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNKDLHFNTSIANLVILRGKDVQSADVEGFKDPALYTSWLKPVNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	TVQLGQCGNQIGFEV EEEECCCCCCCCHHH	22.61	22817900
47	Ubiquitination	EAYQASCKERFFSEE HHHHHHHHHHHCCHH	49.80	-
52	Phosphorylation	SCKERFFSEEENGVP HHHHHHCCHHHCCCE	41.19	22210691
71	Ubiquitination	VLVDMEPKVINQMLS EEECCCHHHHHHHHH	42.30	29967540
78	Phosphorylation	KVINQMLSKAAQSGQ HHHHHHHHHHHHCCC	18.20	22210691
79 (in isoform 2)	Ubiquitination	-	43.72	21906983
79 (in isoform 1)	Ubiquitination	-	43.72	21906983
79	Ubiquitination	VINQMLSKAAQSGQW HHHHHHHHHHHCCCC	43.72	22817900
87	Ubiquitination	AAQSGQWKYGQHACF HHHCCCCCCCCEEEE	31.45	29967540
96	Ubiquitination	GQHACFCQKQGSGNN CCEEEEEEECCCCCC	22.36	29967540
97	Ubiquitination	QHACFCQKQGSGNNW CEEEEEEECCCCCCE	58.78	-
113	Ubiquitination	YGYSVHGPRHEESIM CEEECCCCCCHHHHH	21.41	29967540
132	Phosphorylation	KEVEKCDSFSGFFII HHHHCCCCCCCEEEE	30.68	22210691
134	Phosphorylation	VEKCDSFSGFFIIMS HHCCCCCCCEEEEEE	38.35	22210691
141	Phosphorylation	SGFFIIMSMAGGTGS CCEEEEEECCCCCCC	8.62	22210691
146	Ubiquitination	IMSMAGGTGSGLGAF EEECCCCCCCCHHHH	27.53	29967540
146	Phosphorylation	IMSMAGGTGSGLGAF EEECCCCCCCCHHHH	27.53	22210691
148	Phosphorylation	SMAGGTGSGLGAFVT ECCCCCCCCHHHHHH	30.59	22210691
155	Phosphorylation	SGLGAFVTQNLEDQY CCHHHHHHCCHHHHH	12.80	22210691
155	Ubiquitination	SGLGAFVTQNLEDQY CCHHHHHHCCHHHHH	12.80	29967540
156	Ubiquitination	GLGAFVTQNLEDQYS CHHHHHHCCHHHHHC	47.40	29967540
165	Ubiquitination	LEDQYSNSLKMNQII HHHHHCCCCCCCEEE	24.35	29967540
172	Ubiquitination	SLKMNQIIWPYGTGE CCCCCEEECCCCCCC	1.87	29967540
188	Ubiquitination	IVQNYNSILTLSHLY EEECCCHHHHHHHHH	2.80	29967540
198	Ubiquitination	LSHLYRSSDALLLHE HHHHHHCCCEEEECC	20.22	29967540
207	Ubiquitination	ALLLHENDAIHKICA EEEECCHHHHHHHHH	43.87	29967540
214	Ubiquitination	DAIHKICAKLMNIKQ HHHHHHHHHHCCCCC	16.10	29967540
215	Ubiquitination	AIHKICAKLMNIKQI HHHHHHHHHCCCCCC	43.81	29967540
274	Ubiquitination	PEFKMLSVRNIPHMS CCCEEEEECCCCCCC	4.84	29967540
279	Ubiquitination	LSVRNIPHMSENSLA EEECCCCCCCCCCHH	28.71	29967540
286	Ubiquitination	HMSENSLAYTTFTWA CCCCCCHHHHHHHHH	10.23	29967540
307	Ubiquitination	RQMLISNAKMEEGID HHHHHHCHHHHCCCH	13.04	29967540
317	Ubiquitination	EEGIDRHVWPPLSGL HCCCHHHCCCCCCCC	9.51	29967540
326	Ubiquitination	PPLSGLPPLSKMSLN CCCCCCCCCHHCCCC	55.07	29967540
329	Ubiquitination	SGLPPLSKMSLNKDL CCCCCCHHCCCCCCC	39.94	29967540
333	Ubiquitination	PLSKMSLNKDLHFNT CCHHCCCCCCCCCCC	28.61	29967540
340	Phosphorylation	NKDLHFNTSIANLVI CCCCCCCCHHHEEEE	22.14	26270265
341	Phosphorylation	KDLHFNTSIANLVIL CCCCCCCHHHEEEEE	22.32	26270265
362	Ubiquitination	SADVEGFKDPALYTS CCCCCCCCCHHHHHH	73.91	29967540
372	Ubiquitination	ALYTSWLKPVNAFNV HHHHHCCCCCCHHHH	40.43	29967540
381	Ubiquitination	VNAFNVWKTQRAFSK CCHHHHHHHHHCHHH	30.42	29967540
388	Ubiquitination	KTQRAFSKYEKSAVL HHHHCHHHHCCEEEE	51.48	29967540
392	Phosphorylation	AFSKYEKSAVLVSNS CHHHHCCEEEEEECC	16.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
79	Ubiquitination	76 (3)	M ⇒ T	rs1292053	Inflammatory bowel disease Crohn's disease	23128233 28067908 26192919
79	Ubiquitination	76 (3)	M ⇒ T	rs1292053	Inflammatory bowel disease Crohn's disease	23128233 28067908 26192919

Protein-Protein Interaction

Oops, there are no PPI records of TBD_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00570: Vinblastine