| UniProt ID | KLD8B_HUMAN | |
|---|---|---|
| UniProt AC | Q8IXV7 | |
| Protein Name | Kelch domain-containing protein 8B {ECO:0000303|PubMed:19706467} | |
| Gene Name | KLHDC8B {ECO:0000303|PubMed:19706467} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 354 | |
| Subcellular Localization | Cytoplasm . Midbody . In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis. | |
| Protein Description | Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. [PubMed: 20107318 Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells] | |
| Protein Sequence | MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | RAGLPLDTAETLDMA CCCCCCCHHHHHHHH | 33.79 | 22210691 | |
| 56 | Phosphorylation | AETLDMASHTWLALA HHHHHHHCCCEEHHC | 18.14 | 22210691 | |
| 58 | Phosphorylation | TLDMASHTWLALAPL HHHHHCCCEEHHCCC | 21.48 | 22210691 | |
| 112 | Phosphorylation | GRWERRATLPQAAMG CCHHCCCCCCCHHHC | 36.84 | 23312004 | |
| 186 | Ubiquitination | VLGGRQGKLPVTAFE EECCCCCCCCEEEEE | 41.08 | 21906983 | |
| 201 | Phosphorylation | AFDLEARTWTRHPSL EEECCCCCCCCCCCC | 37.93 | 22210691 | |
| 210 | Phosphorylation | TRHPSLPSRRAFAGC CCCCCCCCCHHHCCC | 39.43 | 22210691 | |
| 278 | Phosphorylation | RADFVVGSLGGHIVA CCCEEEEECCCEEEE | 16.54 | - | |
| 298 | Phosphorylation | NQPCPLGSVESFSLA CCCCCCCCHHHHHHH | 30.32 | - | |
| 303 | Phosphorylation | LGSVESFSLARRRWE CCCHHHHHHHHHHHH | 30.33 | 22964224 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLD8B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLD8B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLD8B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KLD8B_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 236000 | Lymphoma, Hodgkin, classic (CHL) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
