dbPTM

WDR70_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR70_HUMAN
UniProt AC	Q9NW82
Protein Name	WD repeat-containing protein 70
Gene Name	WDR70
Organism	Homo sapiens (Human).
Sequence Length	654
Subcellular Localization
Protein Description
Protein Sequence	MERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAEEEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVSPAYSKTQPKTMFAQVESDDEEAKNEPEWKKRKI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MERSGPSEVTG ----CCCCCCCCCCC	41.57	28555341
6	Ubiquitination	--MERSGPSEVTGSD --CCCCCCCCCCCCC	28.67	22817900
32	Methylation	MGFTGFGKKARTFDL ECCCCCCCHHHEECH	40.78	30593423
32	Acetylation	MGFTGFGKKARTFDL ECCCCCCCHHHEECH	40.78	25953088
33	Ubiquitination	GFTGFGKKARTFDLE CCCCCCCHHHEECHH	43.40	-
36	Phosphorylation	GFGKKARTFDLEAMF CCCCHHHEECHHHHH	26.76	20860994
52	Ubiquitination	QTRRTAVERSRKTLE HHHHHHHHHHHHHHH	42.34	23000965
54	Phosphorylation	RRTAVERSRKTLEAR HHHHHHHHHHHHHHH	25.32	23312004
54	Ubiquitination	RRTAVERSRKTLEAR HHHHHHHHHHHHHHH	25.32	23000965
56	Acetylation	TAVERSRKTLEAREK HHHHHHHHHHHHHHH	59.72	26051181
57	Phosphorylation	AVERSRKTLEAREKE HHHHHHHHHHHHHHH	28.81	20068231
81	Ubiquitination	RRQNEDIEPTSSRSN HHCCCCCCCCCCCCC	55.64	23000965
83	Ubiquitination	QNEDIEPTSSRSNVV CCCCCCCCCCCCCHH	26.92	23000965
84	Phosphorylation	NEDIEPTSSRSNVVR CCCCCCCCCCCCHHH	34.17	28555341
87	Phosphorylation	IEPTSSRSNVVRDCS CCCCCCCCCHHHCHH	35.60	28555341
98	Phosphorylation	RDCSKSSSRDTSSSE HCHHCCCCCCCCCCC	41.07	30576142
109	Phosphorylation	SSSESEQSSDSSDDE CCCCCCCCCCCCCCC	31.87	30576142
110	Phosphorylation	SSESEQSSDSSDDEL CCCCCCCCCCCCCCC	41.00	30576142
157	Ubiquitination	EEEAEEEEEEEEEEE HHHHHHHHHHHHHHC	74.18	29967540
161	Ubiquitination	EEEEEEEEEEENPVH HHHHHHHHHHCCCCC	74.18	22817900
178	Ubiquitination	PDSHEITLKHGTKTV CCCCEEEECCCCEEE	4.78	29967540
179	Ubiquitination	DSHEITLKHGTKTVS CCCEEEECCCCEEEE	31.19	29967540
182	Ubiquitination	EITLKHGTKTVSALG EEEECCCCEEEEECC	24.22	29967540
183	Ubiquitination	ITLKHGTKTVSALGL EEECCCCEEEEECCC	52.07	29967540
184	Phosphorylation	TLKHGTKTVSALGLD EECCCCEEEEECCCC	21.38	20860994
190	Ubiquitination	KTVSALGLDPSGARL EEEEECCCCCCCCEE	10.21	22817900
197	Ubiquitination	LDPSGARLVTGGYDY CCCCCCEEEECCCCC	3.92	21963094
217	Phosphorylation	DFAGMDASFKAFRSL CCCCCCHHHHHHHCC	24.02	24719451
218	Ubiquitination	FAGMDASFKAFRSLQ CCCCCHHHHHHHCCC	7.68	21963094
219	Ubiquitination	AGMDASFKAFRSLQP CCCCHHHHHHHCCCC	44.08	21963094
258	Ubiquitination	SQAKVIDRDGFEVME CCEEEECCCCCEEEE	34.52	29967540
272	Ubiquitination	ECIKGDQYIVDMANT EEECCCEEEEECCCC	13.98	23000965
274	Ubiquitination	IKGDQYIVDMANTKG ECCCEEEEECCCCCC	3.33	23000965
279	Ubiquitination	YIVDMANTKGHTAML EEEECCCCCCCEEEE	28.94	29967540
279	Phosphorylation	YIVDMANTKGHTAML EEEECCCCCCCEEEE	28.94	22210691
280	Ubiquitination	IVDMANTKGHTAMLH EEECCCCCCCEEEEE	48.80	29967540
293	Ubiquitination	LHTGSWHPKIKGEFM EECCCCCCCCCCEEE	33.53	23000965
294	Ubiquitination	HTGSWHPKIKGEFMT ECCCCCCCCCCEEEE	44.13	23000965
295	Ubiquitination	TGSWHPKIKGEFMTC CCCCCCCCCCEEEEE	9.03	23000965
296	Sumoylation	GSWHPKIKGEFMTCS CCCCCCCCCEEEEEC	59.52	-
296	Sumoylation	GSWHPKIKGEFMTCS CCCCCCCCCEEEEEC	59.52	25218447
296	Ubiquitination	GSWHPKIKGEFMTCS CCCCCCCCCEEEEEC	59.52	23000965
310	Ubiquitination	SNDATVRTWEVENPK CCCCEEEEEEECCCC	22.95	29967540
318	Ubiquitination	WEVENPKKQKSVFKP EEECCCCCCCCCCCC	65.30	-
321	O-linked_Glycosylation	ENPKKQKSVFKPRTM CCCCCCCCCCCCCCC	30.23	30379171
331	Ubiquitination	KPRTMQGKKVIPTTC CCCCCCCCEEECCEE	27.29	29967540
332	Sumoylation	PRTMQGKKVIPTTCT CCCCCCCEEECCEEE	52.82	-
332	Sumoylation	PRTMQGKKVIPTTCT CCCCCCCEEECCEEE	52.82	-
332	Ubiquitination	PRTMQGKKVIPTTCT CCCCCCCEEECCEEE	52.82	29967540
336	Phosphorylation	QGKKVIPTTCTYSRD CCCEEECCEEEEECC	24.31	29759185
337	Phosphorylation	GKKVIPTTCTYSRDG CCEEECCEEEEECCC	9.48	29759185
339	Phosphorylation	KVIPTTCTYSRDGNL EEECCEEEEECCCCE	23.57	29759185
340	Phosphorylation	VIPTTCTYSRDGNLI EECCEEEEECCCCEE	12.12	29759185
341	Phosphorylation	IPTTCTYSRDGNLIA ECCEEEEECCCCEEE	13.02	29759185
346	Ubiquitination	TYSRDGNLIAAACQN EEECCCCEEEEEEEC	3.26	29967540
367	Ubiquitination	DRNLTVHPKFHYKQA ECCEEECCCCEEEEC	36.35	29967540
368	Ubiquitination	RNLTVHPKFHYKQAH CCEEECCCCEEEECC	29.87	29967540
371	Phosphorylation	TVHPKFHYKQAHDSG EECCCCEEEECCCCC	14.13	-
381	Ubiquitination	AHDSGTDTSCVTFSY CCCCCCCCCEEEEEE	24.70	22817900
401	Phosphorylation	ASRGGDDSLKLWDIR ECCCCCCCCEEECHH	31.95	-
402	Ubiquitination	SRGGDDSLKLWDIRQ CCCCCCCCEEECHHH	7.32	22817900
403	Sumoylation	RGGDDSLKLWDIRQF CCCCCCCEEECHHHC	52.03	-
403	Ubiquitination	RGGDDSLKLWDIRQF CCCCCCCEEECHHHC	52.03	22817900
403	Sumoylation	RGGDDSLKLWDIRQF CCCCCCCEEECHHHC	52.03	-
432	Phosphorylation	PMTDCCFSPDDKLIV CCCCCCCCCCCCEEE	17.32	21815630
452	Acetylation	QRGCGSGKLVFFERR ECCCCCCCEEEEECC	43.08	19608861
452	Ubiquitination	QRGCGSGKLVFFERR ECCCCCCCEEEEECC	43.08	19608861
465	Phosphorylation	RRTFQRVYEIDITDA CCCCCEEEEEECCCH	14.89	-
474	Ubiquitination	IDITDASVVRCLWHP EECCCHHHHHHHCCC	3.18	29967540
481	Ubiquitination	VVRCLWHPKLNQIMV HHHHHCCCCCCEEEE	31.11	29967540
482	Ubiquitination	VRCLWHPKLNQIMVG HHHHCCCCCCEEEEE	47.37	-
482	Acetylation	VRCLWHPKLNQIMVG HHHHCCCCCCEEEEE	47.37	25953088
487	Ubiquitination	HPKLNQIMVGTGNGL CCCCCEEEEECCCCE	1.31	29967540
492	Ubiquitination	QIMVGTGNGLAKVYY EEEEECCCCEEEEEE	41.99	29967540
495	Ubiquitination	VGTGNGLAKVYYDPN EECCCCEEEEEECCC	10.73	29967540
496	Ubiquitination	GTGNGLAKVYYDPNK ECCCCEEEEEECCCC	35.49	29967540
502	Ubiquitination	AKVYYDPNKSQRGAK EEEEECCCCCCCCCE	54.43	29967540
503	Ubiquitination	KVYYDPNKSQRGAKL EEEECCCCCCCCCEE	54.04	29967540
504	Phosphorylation	VYYDPNKSQRGAKLC EEECCCCCCCCCEEE	31.58	-
508	Ubiquitination	PNKSQRGAKLCVVKT CCCCCCCCEEEEEEC	12.11	29967540
509	Acetylation	NKSQRGAKLCVVKTQ CCCCCCCEEEEEECH	45.29	23749302
509	Sumoylation	NKSQRGAKLCVVKTQ CCCCCCCEEEEEECH	45.29	-
509	Sumoylation	NKSQRGAKLCVVKTQ CCCCCCCEEEEEECH	45.29	-
509	Ubiquitination	NKSQRGAKLCVVKTQ CCCCCCCEEEEEECH	45.29	29967540
513	Ubiquitination	RGAKLCVVKTQRKAK CCCEEEEEECHHHHH	5.61	29967540
514	Ubiquitination	GAKLCVVKTQRKAKQ CCEEEEEECHHHHHH	20.67	29967540
514	Acetylation	GAKLCVVKTQRKAKQ CCEEEEEECHHHHHH	20.67	25953088
520	Acetylation	VKTQRKAKQAETLTQ EECHHHHHHCCCCCC	53.74	19608861
524	Phosphorylation	RKAKQAETLTQDYII HHHHHCCCCCCCEEC	37.81	21406692
526	Phosphorylation	AKQAETLTQDYIITP HHHCCCCCCCEECCC	27.15	21406692
529	Phosphorylation	AETLTQDYIITPHAL CCCCCCCEECCCCHH	5.61	21406692
532	Phosphorylation	LTQDYIITPHALPMF CCCCEECCCCHHHCC	10.24	21406692
563	Sumoylation	LDPLKSHKPEPPVAG CCHHHHCCCCCCCCC	59.16	-
563	Sumoylation	LDPLKSHKPEPPVAG CCHHHHCCCCCCCCC	59.16	-
563	Acetylation	LDPLKSHKPEPPVAG CCHHHHCCCCCCCCC	59.16	26051181
573	Methylation	PPVAGPGRGGRVGTH CCCCCCCCCCCCCCC	47.75	12020327
576	Methylation	AGPGRGGRVGTHGGT CCCCCCCCCCCCCCC	26.90	26494429
579	Phosphorylation	GRGGRVGTHGGTLSS CCCCCCCCCCCCHHH	17.94	23917254
583	Phosphorylation	RVGTHGGTLSSYIVK CCCCCCCCHHHEEEE	28.23	28555341
585	Phosphorylation	GTHGGTLSSYIVKNI CCCCCCHHHEEEEEE	22.42	28555341
587	Phosphorylation	HGGTLSSYIVKNIAL CCCCHHHEEEEEEEC	13.32	27642862
589	Ubiquitination	GTLSSYIVKNIALDK CCHHHEEEEEEECCC	2.70	29967540
590	Sumoylation	TLSSYIVKNIALDKT CHHHEEEEEEECCCC	32.83	-
590	Sumoylation	TLSSYIVKNIALDKT CHHHEEEEEEECCCC	32.83	28112733
596	Sumoylation	VKNIALDKTDDSNPR EEEEECCCCCCCCHH	55.49	-
596	Sumoylation	VKNIALDKTDDSNPR EEEEECCCCCCCCHH	55.49	28112733
600	Phosphorylation	ALDKTDDSNPREAIL ECCCCCCCCHHHHHH	52.09	28555341
604	Ubiquitination	TDDSNPREAILRHAK CCCCCHHHHHHHHHH	41.12	32015554
610	Ubiquitination	REAILRHAKAAEDSP HHHHHHHHHHHCCCC	9.21	29967540
611	Acetylation	EAILRHAKAAEDSPY HHHHHHHHHHCCCCC	41.84	20167786
611	Sumoylation	EAILRHAKAAEDSPY HHHHHHHHHHCCCCC	41.84	-
611	Sumoylation	EAILRHAKAAEDSPY HHHHHHHHHHCCCCC	41.84	-
611	Ubiquitination	EAILRHAKAAEDSPY HHHHHHHHHHCCCCC	41.84	29967540
616	Phosphorylation	HAKAAEDSPYWVSPA HHHHHCCCCCCCCCC	16.05	21945579
618	Phosphorylation	KAAEDSPYWVSPAYS HHHCCCCCCCCCCCC	23.53	21945579
621	Phosphorylation	EDSPYWVSPAYSKTQ CCCCCCCCCCCCCCC	6.94	21945579
624	Phosphorylation	PYWVSPAYSKTQPKT CCCCCCCCCCCCCCC	17.68	21945579
625	Phosphorylation	YWVSPAYSKTQPKTM CCCCCCCCCCCCCCE	31.19	21945579
625	Ubiquitination	YWVSPAYSKTQPKTM CCCCCCCCCCCCCCE	31.19	32015554
626	Acetylation	WVSPAYSKTQPKTMF CCCCCCCCCCCCCEE	38.20	20167786
626	Ubiquitination	WVSPAYSKTQPKTMF CCCCCCCCCCCCCEE	38.20	32015554
627	Phosphorylation	VSPAYSKTQPKTMFA CCCCCCCCCCCCEEE	44.13	26074081
631	Phosphorylation	YSKTQPKTMFAQVES CCCCCCCCEEEEECC	24.97	23927012
637	Phosphorylation	KTMFAQVESDDEEAK CCEEEEECCCCHHHH	36.05	32645325
638	Phosphorylation	TMFAQVESDDEEAKN CEEEEECCCCHHHHC	52.05	19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WDR70_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR70_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR70_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ZCH18_HUMAN	ZC3H18	physical	22939629
PR38A_HUMAN	PRPF38A	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR70_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-452 AND LYS-520, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638, AND MASSSPECTROMETRY.	17081983 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-621, AND MASSSPECTROMETRY.	16964243 [Abstract]