dbPTM

ZCH18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZCH18_HUMAN
UniProt AC	Q86VM9
Protein Name	Zinc finger CCCH domain-containing protein 18
Gene Name	ZC3H18
Organism	Homo sapiens (Human).
Sequence Length	953
Subcellular Localization	Nucleus.
Protein Description
Protein Sequence	MDVAESPERDPHSPEDEEQPQGLSDDDILRDSGSDQDLDGAGVRASDLEDEESAARGPSQEEEDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLRDEASSVTRELDEHELDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPREEGKAGVQSVGEKESLEAAKEKKKEDDDGEIDDGEIDDDDLEEGEVKDPSDRKVRPRPTCRFFMKGNCTWGMNCRFIHPGVNDKGNYSLITKADPFPPNGAPPLGPHPLMPANPWGGPVVDEILPPPPPEPPTESAWERGLRHAKEVLKKATIRKEQEPDFEEKRFTVTIGEDEREFDKENEVFRDWNSRIPRDVRDTVLEPYADPYYDYEIERFWRGGQYENFRVQYTETEPYHNYRERERERERENRQRERERERERDRERERRQRERERERERERDKERQRRKEEWERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLSPQSKSSSKVTSVPGKASDPGAASTKSGKASTLSRREELLKQLKAVEDAIARKRAKIPGKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVAESPE -------CCCCCCCC	9.37	21406692
6	Phosphorylation	--MDVAESPERDPHS --CCCCCCCCCCCCC	23.48	23401153
13	Phosphorylation	SPERDPHSPEDEEQP CCCCCCCCCCCCCCC	35.06	29255136
24	Phosphorylation	EEQPQGLSDDDILRD CCCCCCCCHHHHHHC	45.90	29255136
32	Phosphorylation	DDDILRDSGSDQDLD HHHHHHCCCCCCCCC	33.49	29255136
34	Phosphorylation	DILRDSGSDQDLDGA HHHHCCCCCCCCCCC	35.73	29255136
46	Phosphorylation	DGAGVRASDLEDEES CCCCCCHHHHCCHHH	31.97	29255136
53	Phosphorylation	SDLEDEESAARGPSQ HHHCCHHHHHCCCCH	25.77	29255136
59	Phosphorylation	ESAARGPSQEEEDNH HHHHCCCCHHHHCCC	53.71	23927012
67	Phosphorylation	QEEEDNHSDEEDRAS HHHHCCCCCHHHHHC	53.63	29255136
74	Phosphorylation	SDEEDRASEPKSQDQ CCHHHHHCCCCCCCC	56.15	29255136
78	Phosphorylation	DRASEPKSQDQDSEV HHHCCCCCCCCCHHH	50.10	19664994
83	Phosphorylation	PKSQDQDSEVNELSR CCCCCCCHHHHHHHC	37.50	29255136
89	Phosphorylation	DSEVNELSRGPTSSP CHHHHHHHCCCCCCC	29.07	29255136
93	Phosphorylation	NELSRGPTSSPCEEE HHHHCCCCCCCCHHC	44.66	22167270
94	Phosphorylation	ELSRGPTSSPCEEEG HHHCCCCCCCCHHCC	35.10	23401153
95	Phosphorylation	LSRGPTSSPCEEEGD HHCCCCCCCCHHCCC	35.73	22167270
109	Phosphorylation	DEGEEDRTSDLRDEA CCCCCCCCHHHHHHH	38.63	30266825
110	Phosphorylation	EGEEDRTSDLRDEAS CCCCCCCHHHHHHHH	35.23	30266825
117	Phosphorylation	SDLRDEASSVTRELD HHHHHHHHHHHHHHH	24.24	23401153
118	Phosphorylation	DLRDEASSVTRELDE HHHHHHHHHHHHHHH	34.26	23401153
120	Phosphorylation	RDEASSVTRELDEHE HHHHHHHHHHHHHHC	22.00	30266825
130	Phosphorylation	LDEHELDYDEEVPEE HHHHCCCCCCCCCCC	37.57	28796482
162	Phosphorylation	DEEKGEGTPREEGKA HHHCCCCCCHHHCCC	18.18	29255136
168	Acetylation	GTPREEGKAGVQSVG CCCHHHCCCCCCCHH	45.29	26051181
173	Phosphorylation	EGKAGVQSVGEKESL HCCCCCCCHHCHHHH	29.68	23401153
177	2-Hydroxyisobutyrylation	GVQSVGEKESLEAAK CCCCHHCHHHHHHHH	46.83	-
177	Acetylation	GVQSVGEKESLEAAK CCCCHHCHHHHHHHH	46.83	25953088
179	Phosphorylation	QSVGEKESLEAAKEK CCHHCHHHHHHHHHH	42.45	25159151
184	Acetylation	KESLEAAKEKKKEDD HHHHHHHHHHCCCCC	76.69	26051181
211	Acetylation	DLEEGEVKDPSDRKV HHHCCCCCCCCCCCC	60.67	26051181
214	Phosphorylation	EGEVKDPSDRKVRPR CCCCCCCCCCCCCCC	61.25	29214152
229	Methylation	PTCRFFMKGNCTWGM CCEEEEECCCCCCCC	41.64	115978357
239	Methylation	CTWGMNCRFIHPGVN CCCCCCCEEECCCCC	28.66	30989901
248	Methylation	IHPGVNDKGNYSLIT ECCCCCCCCCEEEEE	43.80	115920321
249 (in isoform 2)	Methylation	-	40.97	-
251	Phosphorylation	GVNDKGNYSLITKAD CCCCCCCEEEEECCC	17.33	28796482
252	Phosphorylation	VNDKGNYSLITKADP CCCCCCEEEEECCCC	19.80	28796482
253 (in isoform 2)	Methylation	-	3.99	-
255	Phosphorylation	KGNYSLITKADPFPP CCCEEEEECCCCCCC	26.02	21406692
263	Methylation	KADPFPPNGAPPLGP CCCCCCCCCCCCCCC	60.54	-
272	Methylation	APPLGPHPLMPANPW CCCCCCCCCCCCCCC	33.22	-
275	Phosphorylation	LGPHPLMPANPWGGP CCCCCCCCCCCCCCC	36.25	-
276	Phosphorylation	GPHPLMPANPWGGPV CCCCCCCCCCCCCCC	22.28	-
297	Phosphorylation	PPPPEPPTESAWERG CCCCCCCCHHHHHHH	53.97	-
309	2-Hydroxyisobutyrylation	ERGLRHAKEVLKKAT HHHHHHHHHHHHHHH	42.08	-
316	Phosphorylation	KEVLKKATIRKEQEP HHHHHHHHCCCCCCC	30.14	-
331	Phosphorylation	DFEEKRFTVTIGEDE CCCCCCEEEEECCCH	22.29	28555341
333	Phosphorylation	EEKRFTVTIGEDERE CCCCEEEEECCCHHH	21.87	21815630
343	2-Hydroxyisobutyrylation	EDEREFDKENEVFRD CCHHHHHHHCCHHHC	68.69	-
362	Phosphorylation	IPRDVRDTVLEPYAD CCCCHHHHCCCCCCC	19.20	28796482
367	Phosphorylation	RDTVLEPYADPYYDY HHHCCCCCCCCCCCC	17.79	28796482
371	Phosphorylation	LEPYADPYYDYEIER CCCCCCCCCCCHHHE	14.98	28796482
372	Phosphorylation	EPYADPYYDYEIERF CCCCCCCCCCHHHEE	19.89	28796482
374	Phosphorylation	YADPYYDYEIERFWR CCCCCCCCHHHEECC	11.59	28796482
381	Methylation	YEIERFWRGGQYENF CHHHEECCCCCCCCE	36.33	115920325
385	Phosphorylation	RFWRGGQYENFRVQY EECCCCCCCCEEEEE	19.00	28796482
392	Phosphorylation	YENFRVQYTETEPYH CCCEEEEEECCCCCC	12.04	20860994
393	Phosphorylation	ENFRVQYTETEPYHN CCEEEEEECCCCCCC	21.24	20860994
395	Phosphorylation	FRVQYTETEPYHNYR EEEEEECCCCCCCHH	34.16	20860994
398	Phosphorylation	QYTETEPYHNYRERE EEECCCCCCCHHHHH	9.10	17360941
405	Methylation	YHNYREREREREREN CCCHHHHHHHHHHHH	54.89	-
409	Phosphorylation	RERERERERENRQRE HHHHHHHHHHHHHHH	60.64	-
422	Phosphorylation	RERERERERDRERER HHHHHHHHHHHHHHH	54.93	-
480	Acetylation	EKEREKEKGKPKPRS HHHHHHHCCCCCCCC	81.13	7680129
482	Acetylation	EREKEKGKPKPRSPQ HHHHHCCCCCCCCCC	62.02	7680141
487	Phosphorylation	KGKPKPRSPQPPSRQ CCCCCCCCCCCCCCC	36.09	22167270
492	Phosphorylation	PRSPQPPSRQAEPPK CCCCCCCCCCCCCCC	43.65	22167270
499	Acetylation	SRQAEPPKKEAATTG CCCCCCCCCHHCCCC	74.16	26051181
510	Sumoylation	ATTGPQVKRADEWKD CCCCCCCCCHHHCCC	36.30	-
510	2-Hydroxyisobutyrylation	ATTGPQVKRADEWKD CCCCCCCCCHHHCCC	36.30	-
510	Methylation	ATTGPQVKRADEWKD CCCCCCCCCHHHCCC	36.30	116253093
510	Sumoylation	ATTGPQVKRADEWKD CCCCCCCCCHHHCCC	36.30	28112733
511	Phosphorylation	TTGPQVKRADEWKDP CCCCCCCCHHHCCCC	48.71	15302935
516	Phosphorylation	VKRADEWKDPWRRSK CCCHHHCCCCCCCCC	52.44	20068231
522	Phosphorylation	WKDPWRRSKSPKKKL CCCCCCCCCCCCHHC	28.98	29514088
528	Sumoylation	RSKSPKKKLGVSVSP CCCCCCHHCCCCCCH	57.51	-
532	Phosphorylation	PKKKLGVSVSPSRAR CCHHCCCCCCHHHHH	18.32	29255136
534	Methylation	KKLGVSVSPSRARRR HHCCCCCCHHHHHHH	15.06	-
534	Phosphorylation	KKLGVSVSPSRARRR HHCCCCCCHHHHHHH	15.06	19664994
534	Sumoylation	KKLGVSVSPSRARRR HHCCCCCCHHHHHHH	15.06	-
536	Phosphorylation	LGVSVSPSRARRRRK CCCCCCHHHHHHHHC	30.94	29255136
540	Ubiquitination	VSPSRARRRRKTSAS CCHHHHHHHHCCCCC	41.59	-
544	Phosphorylation	RARRRRKTSASSASA HHHHHHCCCCCCCCC	27.93	24719451
545	Phosphorylation	ARRRRKTSASSASAS HHHHHCCCCCCCCCC	29.23	30631047
546	Phosphorylation	RRRRKTSASSASASN HHHHCCCCCCCCCCC	16.85	-
547	Phosphorylation	RRRKTSASSASASNS HHHCCCCCCCCCCCC	26.63	25849741
548	Phosphorylation	RRKTSASSASASNSS HHCCCCCCCCCCCCC	26.42	30631047
550	Phosphorylation	KTSASSASASNSSRS CCCCCCCCCCCCCCC	33.89	21082442
552	Phosphorylation	SASSASASNSSRSSS CCCCCCCCCCCCCCC	34.45	25849741
552	Sumoylation	SASSASASNSSRSSS CCCCCCCCCCCCCCC	34.45	-
554	Phosphorylation	SSASASNSSRSSSRS CCCCCCCCCCCCCCC	25.32	20860994
555	Phosphorylation	SASASNSSRSSSRSS CCCCCCCCCCCCCCC	40.19	30576142
556	Phosphorylation	ASASNSSRSSSRSSS CCCCCCCCCCCCCCC	40.14	18691976
558	Phosphorylation	ASNSSRSSSRSSSYS CCCCCCCCCCCCCCC	28.76	19664994
559	Phosphorylation	SNSSRSSSRSSSYSG CCCCCCCCCCCCCCC	37.11	30631047
560	Phosphorylation	NSSRSSSRSSSYSGS CCCCCCCCCCCCCCC	42.37	20068231
565	Phosphorylation	SSRSSSYSGSGSSRS CCCCCCCCCCCCCCC	28.56	30576142
567	Phosphorylation	RSSSYSGSGSSRSRS CCCCCCCCCCCCCCC	29.57	30576142
569	Phosphorylation	SSYSGSGSSRSRSRS CCCCCCCCCCCCCCC	25.03	25849741
570	Phosphorylation	SYSGSGSSRSRSRSS CCCCCCCCCCCCCCC	37.49	25849741
571	Phosphorylation	YSGSGSSRSRSRSSS CCCCCCCCCCCCCCC	37.47	15302935
572	Phosphorylation	SGSGSSRSRSRSSSY CCCCCCCCCCCCCCC	36.23	17081983
576	Phosphorylation	SSRSRSRSSSYSSYS CCCCCCCCCCCCCCC	25.53	15302935
577	Phosphorylation	SRSRSRSSSYSSYSS CCCCCCCCCCCCCCC	31.99	20873877
578	Phosphorylation	RSRSRSSSYSSYSSR CCCCCCCCCCCCCCC	30.22	25849741
579	Phosphorylation	SRSRSSSYSSYSSRS CCCCCCCCCCCCCCC	12.00	20873877
580	Phosphorylation	RSRSSSYSSYSSRSS CCCCCCCCCCCCCCC	25.42	20873877
581	Phosphorylation	SRSSSYSSYSSRSSR CCCCCCCCCCCCCCC	22.32	20363803
583	Phosphorylation	SSSYSSYSSRSSRHS CCCCCCCCCCCCCCC	22.63	20363803
586	Phosphorylation	YSSYSSRSSRHSSFS CCCCCCCCCCCCCCC	33.40	17081983
587	Phosphorylation	SSYSSRSSRHSSFSG CCCCCCCCCCCCCCC	32.66	18452278
590	Phosphorylation	SSRSSRHSSFSGSRS CCCCCCCCCCCCCCC	31.78	18452278
591	Phosphorylation	SRSSRHSSFSGSRSR CCCCCCCCCCCCCCC	19.80	20363803
593	Phosphorylation	SSRHSSFSGSRSRSR CCCCCCCCCCCCCCC	37.49	23663014
595	Phosphorylation	RHSSFSGSRSRSRSF CCCCCCCCCCCCCCC	26.36	23663014
597	Phosphorylation	SSFSGSRSRSRSFSS CCCCCCCCCCCCCCC	35.98	20363803
599	Phosphorylation	FSGSRSRSRSFSSSP CCCCCCCCCCCCCCC	33.26	22817900
601	Phosphorylation	GSRSRSRSFSSSPSP CCCCCCCCCCCCCCC	30.63	25022875
603	Phosphorylation	RSRSRSFSSSPSPSP CCCCCCCCCCCCCCC	31.02	25022875
604	Phosphorylation	SRSRSFSSSPSPSPT CCCCCCCCCCCCCCC	44.23	25159151
605	Phosphorylation	RSRSFSSSPSPSPTP CCCCCCCCCCCCCCC	28.35	25022875
607	Phosphorylation	RSFSSSPSPSPTPSP CCCCCCCCCCCCCCC	39.70	30631047
609	Phosphorylation	FSSSPSPSPTPSPHR CCCCCCCCCCCCCCC	45.82	30631047
611	Phosphorylation	SSPSPSPTPSPHRPS CCCCCCCCCCCCCCC	40.51	21082442
613	Phosphorylation	PSPSPTPSPHRPSIR CCCCCCCCCCCCCCC	35.50	25159151
614	Phosphorylation	SPSPTPSPHRPSIRT CCCCCCCCCCCCCCC	28.80	18452278
615	Phosphorylation	PSPTPSPHRPSIRTK CCCCCCCCCCCCCCC	59.63	-
618	Phosphorylation	TPSPHRPSIRTKGEP CCCCCCCCCCCCCCC	25.34	21082442
619	Phosphorylation	PSPHRPSIRTKGEPA CCCCCCCCCCCCCCC	7.80	18452278
621	Phosphorylation	PHRPSIRTKGEPAPP CCCCCCCCCCCCCCC	41.55	-
622	Sumoylation	HRPSIRTKGEPAPPP CCCCCCCCCCCCCCC	51.97	-
622	Acetylation	HRPSIRTKGEPAPPP CCCCCCCCCCCCCCC	51.97	26051181
622	Sumoylation	HRPSIRTKGEPAPPP CCCCCCCCCCCCCCC	51.97	28112733
628	Phosphorylation	TKGEPAPPPGKAGEK CCCCCCCCCCCCCCC	53.00	19651622
631	Acetylation	EPAPPPGKAGEKSVK CCCCCCCCCCCCCCC	60.02	25953088
633	Phosphorylation	APPPGKAGEKSVKKP CCCCCCCCCCCCCCC	46.48	19651622
635	Acetylation	PPGKAGEKSVKKPAP CCCCCCCCCCCCCCC	60.68	26051181
636	Phosphorylation	PGKAGEKSVKKPAPP CCCCCCCCCCCCCCC	34.56	22617229
637	Phosphorylation	GKAGEKSVKKPAPPP CCCCCCCCCCCCCCC	15.93	19651622
638	Acetylation	KAGEKSVKKPAPPPA CCCCCCCCCCCCCCC	61.19	26051181
639	Sumoylation	AGEKSVKKPAPPPAP CCCCCCCCCCCCCCC	44.23	-
645 (in isoform 2)	Phosphorylation	-	33.89	24275569
646	Sumoylation	KPAPPPAPPQATKTT CCCCCCCCCCCCCCC	27.58	-
651	Acetylation	PAPPQATKTTAPVPE CCCCCCCCCCCCCCC	47.06	26051181
653	Phosphorylation	PPQATKTTAPVPEPT CCCCCCCCCCCCCCC	30.44	22817900
660	Phosphorylation	TAPVPEPTKPGDPRE CCCCCCCCCCCCHHH	48.48	-
661	Sumoylation	APVPEPTKPGDPREA CCCCCCCCCCCHHHH	58.69	-
661	Acetylation	APVPEPTKPGDPREA CCCCCCCCCCCHHHH	58.69	25953088
661	Sumoylation	APVPEPTKPGDPREA CCCCCCCCCCCHHHH	58.69	28112733
663	Sumoylation	VPEPTKPGDPREARR CCCCCCCCCHHHHHH	60.14	-
677	Phosphorylation	RKERPARTPPRRRTL HHCCCCCCCCCCCCC	39.49	30266825
683	Phosphorylation	RTPPRRRTLSGSGSG CCCCCCCCCCCCCCC	24.38	28450419
685	Phosphorylation	PPRRRTLSGSGSGSG CCCCCCCCCCCCCCC	30.24	23927012
685	Sumoylation	PPRRRTLSGSGSGSG CCCCCCCCCCCCCCC	30.24	-
687	Phosphorylation	RRRTLSGSGSGSGSS CCCCCCCCCCCCCCC	26.81	25849741
689	Phosphorylation	RTLSGSGSGSGSSYS CCCCCCCCCCCCCCC	31.33	20068231
691	Phosphorylation	LSGSGSGSGSSYSGS CCCCCCCCCCCCCCC	36.88	20873877
693	Phosphorylation	GSGSGSGSSYSGSSS CCCCCCCCCCCCCCC	28.00	20068231
694	Phosphorylation	SGSGSGSSYSGSSSR CCCCCCCCCCCCCCC	27.18	20068231
695	Phosphorylation	GSGSGSSYSGSSSRS CCCCCCCCCCCCCCC	20.81	20068231
696	Phosphorylation	SGSGSSYSGSSSRSR CCCCCCCCCCCCCCC	33.86	20873877
698	Phosphorylation	SGSSYSGSSSRSRSL CCCCCCCCCCCCCEE	21.14	20068231
699	Phosphorylation	GSSYSGSSSRSRSLS CCCCCCCCCCCCEEE	33.04	20068231
700	Phosphorylation	SSYSGSSSRSRSLSV CCCCCCCCCCCEEEE	35.65	20068231
701	Phosphorylation	SYSGSSSRSRSLSVS CCCCCCCCCCEEEEE	37.73	20068231
702	Phosphorylation	YSGSSSRSRSLSVSS CCCCCCCCCEEEEEC	28.33	27486199
709	Phosphorylation	SRSLSVSSVSSVSSA CCEEEEECEEECCCC	24.70	19664995
713	Phosphorylation	SVSSVSSVSSATSSS EEECEEECCCCCCCC	4.00	20068231
717	Phosphorylation	VSSVSSATSSSSSAH EEECCCCCCCCCCCC	30.96	30576142
718	Phosphorylation	SSVSSATSSSSSAHS EECCCCCCCCCCCCC	28.12	20068231
719	Phosphorylation	SVSSATSSSSSAHSV ECCCCCCCCCCCCCC	29.86	20068231
720	Phosphorylation	VSSATSSSSSAHSVD CCCCCCCCCCCCCCC	28.25	30576142
721	Phosphorylation	SSATSSSSSAHSVDS CCCCCCCCCCCCCCC	33.23	22817900
724	Phosphorylation	TSSSSSAHSVDSEDM CCCCCCCCCCCCHHH	30.24	20068231
732	Phosphorylation	SVDSEDMYADLASPV CCCCHHHHHHHHCCC	14.86	20068231
737	Phosphorylation	DMYADLASPVSSASS HHHHHHHCCCCCCCC	32.88	20068231
740	Phosphorylation	ADLASPVSSASSRSP HHHHCCCCCCCCCCC	24.46	23322592
741	Phosphorylation	DLASPVSSASSRSPA HHHCCCCCCCCCCCC	32.19	23322592
743	Phosphorylation	ASPVSSASSRSPAPA HCCCCCCCCCCCCCC	28.38	20068231
744	Phosphorylation	SPVSSASSRSPAPAQ CCCCCCCCCCCCCCC	36.17	20068231
746	Phosphorylation	VSSASSRSPAPAQTR CCCCCCCCCCCCCHH	27.62	30266825
752	Phosphorylation	RSPAPAQTRKEKGKS CCCCCCCHHHHHCCC	45.90	30576142
761	Phosphorylation	KEKGKSKKEDGVKEE HHHCCCCCCCCCCHH	69.04	20068231
766	Sumoylation	SKKEDGVKEEKRKRD CCCCCCCCHHHHHCC	66.73	-
766	Acetylation	SKKEDGVKEEKRKRD CCCCCCCCHHHHHCC	66.73	7483983
766	Sumoylation	SKKEDGVKEEKRKRD CCCCCCCCHHHHHCC	66.73	28112733
767	Phosphorylation	KKEDGVKEEKRKRDS CCCCCCCHHHHHCCC	67.36	20068231
768	Phosphorylation	KEDGVKEEKRKRDSS CCCCCCHHHHHCCCC	53.06	20068231
770	Phosphorylation	DGVKEEKRKRDSSTQ CCCCHHHHHCCCCCC	42.39	15302935
774	Phosphorylation	EEKRKRDSSTQPPKS HHHHHCCCCCCCCCC	39.04	28985074
775	Phosphorylation	EKRKRDSSTQPPKSA HHHHCCCCCCCCCCC	35.04	26133373
776	Phosphorylation	KRKRDSSTQPPKSAK HHHCCCCCCCCCCCC	49.39	20068231
781	Phosphorylation	SSTQPPKSAKPPAGG CCCCCCCCCCCCCCC	47.50	21712546
783	Acetylation	TQPPKSAKPPAGGKS CCCCCCCCCCCCCCC	59.64	26051181
789	Acetylation	AKPPAGGKSSQQPST CCCCCCCCCCCCCCC	46.12	26051181
790	Phosphorylation	KPPAGGKSSQQPSTP CCCCCCCCCCCCCCC	36.33	23927012
790	Sumoylation	KPPAGGKSSQQPSTP CCCCCCCCCCCCCCC	36.33	-
791	Phosphorylation	PPAGGKSSQQPSTPQ CCCCCCCCCCCCCCC	36.00	23927012
795	Phosphorylation	GKSSQQPSTPQQAPP CCCCCCCCCCCCCCC	48.67	23927012
796	Phosphorylation	KSSQQPSTPQQAPPG CCCCCCCCCCCCCCC	31.62	25159151
805	Phosphorylation	QQAPPGQPQQGTFVA CCCCCCCCCCCCEEE	34.08	-
809	Phosphorylation	PGQPQQGTFVAHKEI CCCCCCCCEEEECEE	15.59	23403867
814	Acetylation	QGTFVAHKEIKLTLL CCCEEEECEEHHHHH	51.93	23954790
817	Sumoylation	FVAHKEIKLTLLNKA EEEECEEHHHHHHHH	36.19	-
817	Acetylation	FVAHKEIKLTLLNKA EEEECEEHHHHHHHH	36.19	30593479
817	Sumoylation	FVAHKEIKLTLLNKA EEEECEEHHHHHHHH	36.19	28112733
819	Phosphorylation	AHKEIKLTLLNKAAD EECEEHHHHHHHHHH	24.97	19664995
820	Phosphorylation	HKEIKLTLLNKAADK ECEEHHHHHHHHHHC	7.81	18491316
823	Sumoylation	IKLTLLNKAADKGSR EHHHHHHHHHHCCCC	44.94	-
823	Acetylation	IKLTLLNKAADKGSR EHHHHHHHHHHCCCC	44.94	25953088
833	Phosphorylation	DKGSRKRYEPSDKDR HCCCCCCCCCCCCCC	34.92	22167270
836	Phosphorylation	SRKRYEPSDKDRQSP CCCCCCCCCCCCCCC	45.40	29255136
838	Acetylation	KRYEPSDKDRQSPPP CCCCCCCCCCCCCCC	60.18	19608861
841	Sumoylation	EPSDKDRQSPPPAKR CCCCCCCCCCCCCCC	71.12	-
842	Phosphorylation	PSDKDRQSPPPAKRP CCCCCCCCCCCCCCC	40.02	29255136
847	Sumoylation	RQSPPPAKRPNTSPD CCCCCCCCCCCCCCC	74.33	-
851	Phosphorylation	PPAKRPNTSPDRGSR CCCCCCCCCCCCCCC	44.30	30266825
852	Phosphorylation	PAKRPNTSPDRGSRD CCCCCCCCCCCCCCC	31.29	30266825
857	Phosphorylation	NTSPDRGSRDRKSGG CCCCCCCCCCCCCCC	31.72	28176443
862	Phosphorylation	RGSRDRKSGGRLGSP CCCCCCCCCCCCCCC	47.58	30576142
866	Phosphorylation	DRKSGGRLGSPKPER CCCCCCCCCCCCHHH	10.09	19651622
868	Phosphorylation	KSGGRLGSPKPERQR CCCCCCCCCCHHHHC	34.05	22167270
875	Methylation	SPKPERQRGQNSKAP CCCHHHHCCCCCCCC	55.69	24381585
875	Phosphorylation	SPKPERQRGQNSKAP CCCHHHHCCCCCCCC	55.69	19651622
876	Phosphorylation	PKPERQRGQNSKAPA CCHHHHCCCCCCCCC	23.76	19651622
879	Phosphorylation	ERQRGQNSKAPAAPA HHHCCCCCCCCCCCH	23.47	26074081
881	Phosphorylation	QRGQNSKAPAAPADR HCCCCCCCCCCCHHH	9.97	19651622
886	Phosphorylation	SKAPAAPADRKRQLS CCCCCCCHHHHHCCC	25.23	-
892	Phosphorylation	PADRKRQLSPQSKSS CHHHHHCCCCCCCCC	10.54	19664995
893	Phosphorylation	ADRKRQLSPQSKSSS HHHHHCCCCCCCCCC	16.74	22167270
896	Phosphorylation	KRQLSPQSKSSSKVT HHCCCCCCCCCCCCC	37.58	22167270
898	Phosphorylation	QLSPQSKSSSKVTSV CCCCCCCCCCCCCCC	45.12	26074081
899	Phosphorylation	LSPQSKSSSKVTSVP CCCCCCCCCCCCCCC	37.60	26074081
900	Phosphorylation	SPQSKSSSKVTSVPG CCCCCCCCCCCCCCC	37.93	26074081
901	Sumoylation	PQSKSSSKVTSVPGK CCCCCCCCCCCCCCC	52.02	-
903	Phosphorylation	SKSSSKVTSVPGKAS CCCCCCCCCCCCCCC	27.95	26074081
904	Phosphorylation	KSSSKVTSVPGKASD CCCCCCCCCCCCCCC	29.33	29396449
908	Sumoylation	KVTSVPGKASDPGAA CCCCCCCCCCCCCCC	38.35	-
908	Sumoylation	KVTSVPGKASDPGAA CCCCCCCCCCCCCCC	38.35	28112733
910	Phosphorylation	TSVPGKASDPGAAST CCCCCCCCCCCCCCC	48.07	22199227
916	Phosphorylation	ASDPGAASTKSGKAS CCCCCCCCCCCCCCC	35.51	27251275
917	Phosphorylation	SDPGAASTKSGKAST CCCCCCCCCCCCCCH	25.22	27251275
920	Phosphorylation	GAASTKSGKASTLSR CCCCCCCCCCCHHHH	30.98	20068231
921	Sumoylation	AASTKSGKASTLSRR CCCCCCCCCCHHHHH	46.37	-
921	Acetylation	AASTKSGKASTLSRR CCCCCCCCCCHHHHH	46.37	19829041
925	Sumoylation	KSGKASTLSRREELL CCCCCCHHHHHHHHH	3.29	-
932	Sumoylation	LSRREELLKQLKAVE HHHHHHHHHHHHHHH	3.62	-
934	Phosphorylation	RREELLKQLKAVEDA HHHHHHHHHHHHHHH	48.44	-
945	Sumoylation	VEDAIARKRAKIPGK HHHHHHHHHCCCCCC	47.92	-
952	Acetylation	KRAKIPGKA------ HHCCCCCCC------	45.64	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZCH18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZCH18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZCH18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNPS1_HUMAN	RNPS1	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RTF1_HUMAN	RTF1	physical	26344197
4F2_HUMAN	SLC3A2	physical	26344197
SRRM2_HUMAN	SRRM2	physical	26344197
ZC3HD_HUMAN	ZC3H13	physical	28514442
FNBP4_HUMAN	FNBP4	physical	28514442
VIR_HUMAN	KIAA1429	physical	28514442
CLK4_HUMAN	CLK4	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
RBBP6_HUMAN	RBBP6	physical	28514442
YTDC1_HUMAN	YTHDC1	physical	28514442
PEO1_HUMAN	C10orf2	physical	28514442
PR38B_HUMAN	PRPF38B	physical	28514442
CLK2_HUMAN	CLK2	physical	28514442
RBM7_HUMAN	RBM7	physical	28514442
TOPRS_HUMAN	TOPORS	physical	28514442
CLK1_HUMAN	CLK1	physical	28514442
RB15B_HUMAN	RBM15B	physical	28514442
RMXL1_HUMAN	RBMXL1	physical	28514442
ZCHC8_HUMAN	ZCCHC8	physical	28514442
PRP4B_HUMAN	PRPF4B	physical	28514442
SRS12_HUMAN	SRSF12	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
NKTR_HUMAN	NKTR	physical	28514442
SRSF8_HUMAN	SRSF8	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442
RBM25_HUMAN	RBM25	physical	28514442
CPSF4_HUMAN	CPSF4	physical	28514442
WDR33_HUMAN	WDR33	physical	28514442
ABC3F_HUMAN	APOBEC3F	physical	28514442
RBM6_HUMAN	RBM6	physical	28514442
TSYL1_HUMAN	TSPYL1	physical	28514442
EXOSX_HUMAN	EXOSC10	physical	28514442
SRSF1_HUMAN	SRSF1	physical	28514442
AQR_HUMAN	AQR	physical	28514442
RALY_HUMAN	RALY	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
PPIG_HUMAN	PPIG	physical	28514442
MKRN2_HUMAN	MKRN2	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
U2AF2_HUMAN	U2AF2	physical	28514442
ZC11A_HUMAN	ZC3H11A	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
PI51A_HUMAN	PIP5K1A	physical	28514442
SRS10_HUMAN	SRSF10	physical	28514442
TSYL2_HUMAN	TSPYL2	physical	28514442
RBM15_HUMAN	RBM15	physical	28514442
IKBL1_HUMAN	NFKBIL1	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
FIP1_HUMAN	FIP1L1	physical	28514442
SLTM_HUMAN	SLTM	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
KEAP1_HUMAN	KEAP1	physical	28514442
CTR9_HUMAN	CTR9	physical	28514442
SRRM1_HUMAN	SRRM1	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
VANG1_HUMAN	VANGL1	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
ZCHC3_HUMAN	ZCCHC3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZCH18_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-67 AND SER-534,AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-868, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-532 AND SER-534,AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-67; SER-74;SER-78; SER-95; THR-109; SER-110; SER-532 AND SER-534, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532; SER-534 ANDSER-868, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASSSPECTROMETRY.	19367720 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-868, ANDMASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532 AND SER-534, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-67; SER-74;SER-78; SER-83; SER-487; SER-532; SER-534; SER-599; SER-601; SER-603;SER-604; SER-605; SER-607; SER-609; THR-611; SER-613; THR-677;SER-842; SER-857; SER-868 AND SER-893, AND MASS SPECTROMETRY.	17081983 [Abstract]