PRP4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRP4B_HUMAN
• UniProt AC: Q13523
• Protein Name: Serine/threonine-protein kinase PRP4 homolog
• Gene Name: PRPF4B
• Organism: Homo sapiens (Human).
• Sequence Length: 1007
• Subcellular Localization: Nucleus.
• Protein Description: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF..
• Protein Sequence: MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAETQSL ------CCHHHHHHH	27.04	22223895
6	Phosphorylation	--MAAAETQSLREQP --CCHHHHHHHHHCC	20.80	23401153
8	Phosphorylation	MAAAETQSLREQPEM CCHHHHHHHHHCCCC	36.49	23401153
20	O-linked_Glycosylation	PEMEDANSEKSINEE CCCCCCCCCCCCCCC	48.39	30379171
20	Phosphorylation	PEMEDANSEKSINEE CCCCCCCCCCCCCCC	48.39	29255136
23	Phosphorylation	EDANSEKSINEENGE CCCCCCCCCCCCCCC	26.96	29255136
32	Phosphorylation	NEENGEVSEDQSQNK CCCCCCCCHHHHHCH	31.02	29255136
36	Phosphorylation	GEVSEDQSQNKHSRH CCCCHHHHHCHHHHH	48.30	29255136
41	Phosphorylation	DQSQNKHSRHKKKKH HHHHCHHHHHHHHHH	37.38	28387310
60	Phosphorylation	KHKKHKHSSEEDKDK HHHHCCCCCHHHHHH	44.22	30576142
61	Phosphorylation	HKKHKHSSEEDKDKK HHHCCCCCHHHHHHH	44.73	26657352
87	Phosphorylation	RKEIIDASDKEGMSP HHHHCCCHHCCCCCH	45.53	28176443
93	Phosphorylation	ASDKEGMSPAKRTKL CHHCCCCCHHHHCCH	32.34	23927012
98	Phosphorylation	GMSPAKRTKLDDLAL CCCHHHHCCHHHHHH	34.94	26074081
99	Acetylation	MSPAKRTKLDDLALL CCHHHHCCHHHHHHH	54.69	25953088
99	Sumoylation	MSPAKRTKLDDLALL CCHHHHCCHHHHHHH	54.69	28112733
99	Ubiquitination	MSPAKRTKLDDLALL CCHHHHCCHHHHHHH	54.69	-
111	Acetylation	ALLEDLEKQRALIKA HHHHHHHHHHHHHHH	53.00	26051181
111	Sumoylation	ALLEDLEKQRALIKA HHHHHHHHHHHHHHH	53.00	28112733
111	Ubiquitination	ALLEDLEKQRALIKA HHHHHHHHHHHHHHH	53.00	-
117	Sumoylation	EKQRALIKAELDNEL HHHHHHHHHHHCHHH	36.34	-
117	Sumoylation	EKQRALIKAELDNEL HHHHHHHHHHHCHHH	36.34	25114211
125	Sulfoxidation	AELDNELMEGKVQSG HHHCHHHHHCCCCCC	5.35	21406390
131	Phosphorylation	LMEGKVQSGMGLILQ HHHCCCCCCCEEHHH	33.46	22167270
140	Phosphorylation	MGLILQGYESGSEEE CEEHHHCCCCCCCCC	8.25	29255136
142	Phosphorylation	LILQGYESGSEEEGE EHHHCCCCCCCCCHH	38.85	29255136
144	Phosphorylation	LQGYESGSEEEGEIH HHCCCCCCCCCHHHH	51.63	29255136
162	Phosphorylation	RNGNRSSTRSSSTKG HCCCCCCCCCCCCCC	35.50	-
164	Phosphorylation	GNRSSTRSSSTKGKL CCCCCCCCCCCCCCE	28.82	30108239
165	Phosphorylation	NRSSTRSSSTKGKLE CCCCCCCCCCCCCEE	38.44	30108239
166	Phosphorylation	RSSTRSSSTKGKLEL CCCCCCCCCCCCEEE	35.07	23401153
167	Phosphorylation	SSTRSSSTKGKLELV CCCCCCCCCCCEEEE	45.85	23401153
168	Acetylation	STRSSSTKGKLELVD CCCCCCCCCCEEEEC	56.87	7266923
170	Sumoylation	RSSSTKGKLELVDNK CCCCCCCCEEEECCC	40.10	-
170	Acetylation	RSSSTKGKLELVDNK CCCCCCCCEEEECCC	40.10	23749302
170	Sumoylation	RSSSTKGKLELVDNK CCCCCCCCEEEECCC	40.10	28112733
177	Acetylation	KLELVDNKITTKKRS CEEEECCCCCCCCHH	36.65	12432463
177	Sumoylation	KLELVDNKITTKKRS CEEEECCCCCCCCHH	36.65	28112733
179	Phosphorylation	ELVDNKITTKKRSKS EEECCCCCCCCHHHH	33.88	26074081
180	Phosphorylation	LVDNKITTKKRSKSR EECCCCCCCCHHHHH	37.73	26074081
182	Ubiquitination	DNKITTKKRSKSRSK CCCCCCCCHHHHHCH	60.87	-
184	Phosphorylation	KITTKKRSKSRSKER CCCCCCHHHHHCHHH	43.81	26074081
186	Phosphorylation	TTKKRSKSRSKERTR CCCCHHHHHCHHHHC	42.93	26074081
188	Phosphorylation	KKRSKSRSKERTRHR CCHHHHHCHHHHCCH	46.06	26074081
196	Phosphorylation	KERTRHRSDKKKSKG HHHHCCHHHCCCCCC	47.89	-
200	Acetylation	RHRSDKKKSKGGIEI CCHHHCCCCCCCCCC	64.24	7296833
201	Phosphorylation	HRSDKKKSKGGIEIV CHHHCCCCCCCCCCC	45.47	23312004
202	Acetylation	RSDKKKSKGGIEIVK HHHCCCCCCCCCCCE	70.77	7296845
209	Acetylation	KGGIEIVKEKTTRSK CCCCCCCEECCCCCC	60.19	26051181
230	Phosphorylation	SKSPSKRSKSQDQAR CCCCCHHHHHHHHHH	40.16	30242111
232	Phosphorylation	SPSKRSKSQDQARKS CCCHHHHHHHHHHHC	39.99	30576142
239	Phosphorylation	SQDQARKSKSPTLRR HHHHHHHCCCHHHHH	32.58	30266825
241	Phosphorylation	DQARKSKSPTLRRRS HHHHHCCCHHHHHHH	30.15	30266825
243	Phosphorylation	ARKSKSPTLRRRSQE HHHCCCHHHHHHHHH	39.73	30266825
248	Phosphorylation	SPTLRRRSQEKIGKA CHHHHHHHHHHHHCC	40.66	26074081
257	Phosphorylation	EKIGKARSPTDDKVK HHHHCCCCCCCCCCC	36.69	22167270
259	Phosphorylation	IGKARSPTDDKVKIE HHCCCCCCCCCCCCC	59.06	30266825
277	Phosphorylation	KSKDRKKSPIINESR CCCCCCCCCCCCCHH	25.11	29255136
283	Phosphorylation	KSPIINESRSRDRGK CCCCCCCHHCCCCCC	30.94	29255136
285	Phosphorylation	PIINESRSRDRGKKS CCCCCHHCCCCCCCC	48.05	20363803
292	Phosphorylation	SRDRGKKSRSPVDLR CCCCCCCCCCCCCCC	41.29	29255136
294	Phosphorylation	DRGKKSRSPVDLRGK CCCCCCCCCCCCCCC	36.04	29255136
302	Phosphorylation	PVDLRGKSKDRRSRS CCCCCCCCCCHHHHH	42.48	26437602
314	Phosphorylation	SRSKERKSKRSETDK HHHHHHHHHCCCCHH	39.25	26074081
317	Phosphorylation	KERKSKRSETDKEKK HHHHHHCCCCHHCCC	48.89	26074081
319	Phosphorylation	RKSKRSETDKEKKPI HHHHCCCCHHCCCCC	54.33	26074081
328	Phosphorylation	KEKKPIKSPSKDASS HCCCCCCCCCCCCCC	34.82	22167270
330	Phosphorylation	KKPIKSPSKDASSGK CCCCCCCCCCCCCCC	50.70	22167270
334	Phosphorylation	KSPSKDASSGKENRS CCCCCCCCCCCCCCC	50.16	24732914
335	Phosphorylation	SPSKDASSGKENRSP CCCCCCCCCCCCCCC	56.45	26657352
341	Phosphorylation	SSGKENRSPSRRPGR CCCCCCCCCCCCCCC	38.52	26552605
343	Phosphorylation	GKENRSPSRRPGRSP CCCCCCCCCCCCCCC	42.01	26074081
349	Phosphorylation	PSRRPGRSPKRRSLS CCCCCCCCCCCCCCC	40.46	30266825
354	Phosphorylation	GRSPKRRSLSPKPRD CCCCCCCCCCCCCCC	36.91	22167270
356	O-linked_Glycosylation	SPKRRSLSPKPRDKS CCCCCCCCCCCCCCC	31.93	30379171
356	Phosphorylation	SPKRRSLSPKPRDKS CCCCCCCCCCCCCCC	31.93	22167270
358	Acetylation	KRRSLSPKPRDKSRR CCCCCCCCCCCCCHH	49.67	19608861
366	Phosphorylation	PRDKSRRSRSPLLND CCCCCHHCCCHHHCC	35.68	29255136
368	Phosphorylation	DKSRRSRSPLLNDRR CCCHHCCCHHHCCHH	22.58	29255136
376	Phosphorylation	PLLNDRRSKQSKSPS HHHCCHHHCCCCCCC	35.62	24300666
379	Phosphorylation	NDRRSKQSKSPSRTL CCHHHCCCCCCCCCC	38.55	30576142
381	Phosphorylation	RRSKQSKSPSRTLSP HHHCCCCCCCCCCCC	33.10	28355574
383	Phosphorylation	SKQSKSPSRTLSPGR HCCCCCCCCCCCCCH	45.01	25159151
385	Phosphorylation	QSKSPSRTLSPGRRA CCCCCCCCCCCCHHH	35.61	20164059
387	Phosphorylation	KSPSRTLSPGRRAKS CCCCCCCCCCHHHHH	25.37	30266825
394	Phosphorylation	SPGRRAKSRSLERKR CCCHHHHHHHHHHHH	26.56	22167270
396	Phosphorylation	GRRAKSRSLERKRRE CHHHHHHHHHHHHHH	41.49	22167270
410	Phosphorylation	EPERRRLSSPRTRPR HHHHHHCCCCCCCCH	36.16	23927012
411	Phosphorylation	PERRRLSSPRTRPRD HHHHHCCCCCCCCHH	24.00	23927012
414	Phosphorylation	RRLSSPRTRPRDDIL HHCCCCCCCCHHHHH	48.70	23403867
422	Phosphorylation	RPRDDILSRRERSKD CCHHHHHHHHHHCCC	29.62	20068231
427	Phosphorylation	ILSRRERSKDASPIN HHHHHHHCCCCCCCC	30.09	22167270
431	Phosphorylation	RERSKDASPINRWSP HHHCCCCCCCCCCCC	36.12	29255136
437	Phosphorylation	ASPINRWSPTRRRSR CCCCCCCCCCCCCCC	17.10	22167270
439	Phosphorylation	PINRWSPTRRRSRSP CCCCCCCCCCCCCCC	31.15	22167270
443	Phosphorylation	WSPTRRRSRSPIRRR CCCCCCCCCCCCHHH	34.99	30576142
445	Phosphorylation	PTRRRSRSPIRRRSR CCCCCCCCCCHHHCC	26.40	30576142
451	Phosphorylation	RSPIRRRSRSPLRRS CCCCHHHCCCCCCCC	34.99	22167270
453	Phosphorylation	PIRRRSRSPLRRSRS CCHHHCCCCCCCCCC	29.54	22167270
458	Phosphorylation	SRSPLRRSRSPRRRS CCCCCCCCCCCCCCC	30.58	20068231
460	Phosphorylation	SPLRRSRSPRRRSRS CCCCCCCCCCCCCCC	24.81	20068231
465	Phosphorylation	SRSPRRRSRSPRRRD CCCCCCCCCCCCHHH	34.99	30576142
467	Phosphorylation	SPRRRSRSPRRRDRG CCCCCCCCCCHHHHH	24.81	30576142
485	Phosphorylation	RSRLRRRSRSRGGRR HHHHHHHHHHHCCCC	32.56	26074081
487	Phosphorylation	RLRRRSRSRGGRRRR HHHHHHHHHCCCCCC	36.20	26074081
495	Phosphorylation	RGGRRRRSRSKVKED HCCCCCCCHHHHCCH	38.81	26074081
497	Phosphorylation	GRRRRSRSKVKEDKF CCCCCCHHHHCCHHH	42.94	26074081
505	Methylation	KVKEDKFKGSLSEGM HHCCHHHCCCCCCCC	54.02	115975717
507	Phosphorylation	KEDKFKGSLSEGMKV CCHHHCCCCCCCCCC	29.34	25137130
509	Phosphorylation	DKFKGSLSEGMKVEQ HHHCCCCCCCCCCEE	33.53	25850435
518	Phosphorylation	GMKVEQESSSDDNLE CCCCEECCCCCCCHH	34.53	28102081
519	Phosphorylation	MKVEQESSSDDNLED CCCEECCCCCCCHHH	36.71	28102081
520	Phosphorylation	KVEQESSSDDNLEDF CCEECCCCCCCHHHC	59.26	28102081
551	Ubiquitination	QRQAIVQKYKYLAED HHHHHHHHHHHHHCC	32.58	-
552	Phosphorylation	RQAIVQKYKYLAEDS HHHHHHHHHHHHCCC	6.43	22468782
554	Phosphorylation	AIVQKYKYLAEDSNM HHHHHHHHHHCCCCC	14.19	20068231
559	Phosphorylation	YKYLAEDSNMSVPSE HHHHHCCCCCCCCCC	26.41	23663014
562	Phosphorylation	LAEDSNMSVPSEPSS HHCCCCCCCCCCCCC	34.82	26055452
565	Phosphorylation	DSNMSVPSEPSSPQS CCCCCCCCCCCCCCC	61.04	25159151
568	Phosphorylation	MSVPSEPSSPQSSTR CCCCCCCCCCCCCCC	51.07	25159151
569	Phosphorylation	SVPSEPSSPQSSTRT CCCCCCCCCCCCCCC	37.36	25159151
572	Phosphorylation	SEPSSPQSSTRTRSP CCCCCCCCCCCCCCC	36.74	25159151
573	Phosphorylation	EPSSPQSSTRTRSPS CCCCCCCCCCCCCCC	19.36	22115753
574	Phosphorylation	PSSPQSSTRTRSPSP CCCCCCCCCCCCCCH	41.11	21712546
576	Phosphorylation	SPQSSTRTRSPSPDD CCCCCCCCCCCCHHH	35.27	29255136
578	Phosphorylation	QSSTRTRSPSPDDIL CCCCCCCCCCHHHHH	29.17	29255136
580	Phosphorylation	STRTRSPSPDDILER CCCCCCCCHHHHHHH	42.05	29255136
593	2-Hydroxyisobutyrylation	ERVAADVKEYERENV HHHHHHHHHHHHHCC	55.94	-
593	Sumoylation	ERVAADVKEYERENV HHHHHHHHHHHHHCC	55.94	28112733
595	Phosphorylation	VAADVKEYERENVDT HHHHHHHHHHHCCCC	17.99	28064214
602	Phosphorylation	YERENVDTFEASVKA HHHHCCCCHHHHHHH	21.06	21815630
606	Phosphorylation	NVDTFEASVKAKHNL CCCCHHHHHHHHHHC	19.56	21815630
615	Phosphorylation	KAKHNLMTVEQNNGS HHHHHCEEEEECCCC	24.85	29888752
622	Phosphorylation	TVEQNNGSSQKKLLA EEEECCCCCCCEECC	31.55	20068231
623	Phosphorylation	VEQNNGSSQKKLLAP EEECCCCCCCEECCC	47.63	20068231
625	Acetylation	QNNGSSQKKLLAPDM ECCCCCCCEECCCCC	47.54	25953088
634	Phosphorylation	LLAPDMFTESDDMFA ECCCCCCCCCHHHHH	28.13	28464451
636	Phosphorylation	APDMFTESDDMFAAY CCCCCCCCHHHHHHH	35.53	22115753
643	Phosphorylation	SDDMFAAYFDSARLR CHHHHHHHHHHHHHH	12.42	27732954
646	Phosphorylation	MFAAYFDSARLRAAG HHHHHHHHHHHHHCC	12.85	27732954
656	2-Hydroxyisobutyrylation	LRAAGIGKDFKENPN HHHCCCCCCCCCCCC	59.06	-
656	Acetylation	LRAAGIGKDFKENPN HHHCCCCCCCCCCCC	59.06	23749302
656	Ubiquitination	LRAAGIGKDFKENPN HHHCCCCCCCCCCCC	59.06	-
659	Acetylation	AGIGKDFKENPNLRD CCCCCCCCCCCCCCC	67.71	26051181
659	Sumoylation	AGIGKDFKENPNLRD CCCCCCCCCCCCCCC	67.71	28112733
659	Ubiquitination	AGIGKDFKENPNLRD CCCCCCCCCCCCCCC	67.71	-
674	Phosphorylation	NWTDAEGYYRVNIGE CCCCCCCEEECCHHH	4.60	-
685	2-Hydroxyisobutyrylation	NIGEVLDKRYNVYGY CHHHHHHCCCCEECE	53.25	-
685	Acetylation	NIGEVLDKRYNVYGY CHHHHHHCCCCEECE	53.25	23749302
685	Malonylation	NIGEVLDKRYNVYGY CHHHHHHCCCCEECE	53.25	26320211
685	Ubiquitination	NIGEVLDKRYNVYGY CHHHHHHCCCCEECE	53.25	-
687	Phosphorylation	GEVLDKRYNVYGYTG HHHHHCCCCEECEEC	18.08	28152594
690	Phosphorylation	LDKRYNVYGYTGQGV HHCCCCEECEECCCH	10.77	28152594
717	Acetylation	ANQEVAVKIIRNNEL CCHHHHHHHHHCCHH	23.76	19608861
727	2-Hydroxyisobutyrylation	RNNELMQKTGLKELE HCCHHHHHHCHHHHH	30.51	-
727	Acetylation	RNNELMQKTGLKELE HCCHHHHHHCHHHHH	30.51	25953088
727	Ubiquitination	RNNELMQKTGLKELE HCCHHHHHHCHHHHH	30.51	-
731	Acetylation	LMQKTGLKELEFLKK HHHHHCHHHHHHHHH	62.69	26051181
731	Ubiquitination	LMQKTGLKELEFLKK HHHHHCHHHHHHHHH	62.69	-
737	Acetylation	LKELEFLKKLNDADP HHHHHHHHHHCCCCC	61.61	23749302
747	2-Hydroxyisobutyrylation	NDADPDDKFHCLRLF CCCCCCCHHHHHHHH	44.37	-
747	Acetylation	NDADPDDKFHCLRLF CCCCCCCHHHHHHHH	44.37	25825284
794	Phosphorylation	LHIKAVRSYSQQLFL HHHHHHHHHHHHHHH	23.65	-
795	Phosphorylation	HIKAVRSYSQQLFLA HHHHHHHHHHHHHHH	10.43	22210691
817	Acetylation	NILHADIKPDNILVN CEECCCCCCCCEEEC	47.03	26051181
817	Ubiquitination	NILHADIKPDNILVN CEECCCCCCCCEEEC	47.03	-
837	Phosphorylation	LKLCDFGSASHVADN HHHCCCCCHHHCCCC	26.96	21945579
839	Phosphorylation	LCDFGSASHVADNDI HCCCCCHHHCCCCCC	21.86	21945579
847	Phosphorylation	HVADNDITPYLVSRF HCCCCCCHHHHHHHH	14.56	29255136
848	Phosphorylation	VADNDITPYLVSRFY CCCCCCHHHHHHHHH	22.31	17016520
849	Phosphorylation	ADNDITPYLVSRFYR CCCCCHHHHHHHHHC	15.87	29255136
852	Phosphorylation	DITPYLVSRFYRAPE CCHHHHHHHHHCCCE	17.68	29255136
855	Phosphorylation	PYLVSRFYRAPEIII HHHHHHHHCCCEEEE	12.54	22817900
892	Ubiquitination	GKILFPGKTNNHMLK CCEECCCCCCHHHHH	48.60	-
905	Acetylation	LKLAMDLKGKMPNKM HHHHHHHCCCCCCHH	52.82	19608861
907	Acetylation	LAMDLKGKMPNKMIR HHHHHCCCCCCHHHH	49.99	19608861
938	Phosphorylation	YIEVDKVTEREKVTV EEEEEECCCCEEEEE	34.76	23322592
944	Phosphorylation	VTEREKVTVMSTINP CCCCEEEEEEECCCC	22.89	23322592
946	Sulfoxidation	EREKVTVMSTINPTK CCEEEEEEECCCCCH	1.82	21406390
947	Phosphorylation	REKVTVMSTINPTKD CEEEEEEECCCCCHH	23.07	29978859
948	Phosphorylation	EKVTVMSTINPTKDL EEEEEEECCCCCHHH	13.48	23322592
952	Phosphorylation	VMSTINPTKDLLADL EEECCCCCHHHHHHH	32.47	21601212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRP4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRP4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRP4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PININ_HUMAN	PNN	physical	12077342
PRP8_HUMAN	PRPF8	physical	22939629
U5S1_HUMAN	EFTUD2	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
MK12_HUMAN	MAPK12	physical	23602568
SRRM2_HUMAN	SRRM2	physical	23602568
PININ_HUMAN	PNN	physical	23602568
PRP8_HUMAN	PRPF8	physical	23602568
PRP6_HUMAN	PRPF6	physical	23602568
U520_HUMAN	SNRNP200	physical	23602568
DDX23_HUMAN	DDX23	physical	23602568
U5S1_HUMAN	EFTUD2	physical	23602568
SNUT1_HUMAN	SART1	physical	23602568
SNUT2_HUMAN	USP39	physical	23602568
PRP4_HUMAN	PRPF4	physical	23602568
SNR40_HUMAN	SNRNP40	physical	23602568
PRP31_HUMAN	PRPF31	physical	23602568
RSMB_HUMAN	SNRPB	physical	23602568
SMD1_HUMAN	SNRPD1	physical	23602568
CPSF5_HUMAN	NUDT21	physical	23602568

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-20; SER-23; SER-32; SER-87; SER-93; SER-142 ANDSER-144, AND MASS SPECTROMETRY.
PubMed: 19413330

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6 AND SER-8, ACETYLATION[LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19007248

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-358 AND LYS-717, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-32;TYR-140; SER-142; SER-144; SER-518; SER-519; SER-520; SER-578 ANDSER-580, AND MASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-20; SER-23; SER-32; SER-87; SER-93; SER-142 ANDSER-144, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-32;SER-87; SER-93; TYR-140; SER-142; SER-144; SER-257; SER-277; SER-292;SER-294; SER-427; SER-431; SER-437; SER-518; SER-519; SER-520;SER-569; SER-578; SER-580 AND TYR-849, AND MASS SPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6 AND SER-8, ACETYLATION[LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19007248

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; SER-366 ANDSER-368, AND MASS SPECTROMETRY.
PubMed: 17924679

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578, AND MASSSPECTROMETRY.
PubMed: 16565220

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292 AND SER-294, ANDMASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-32;SER-87; SER-93; SER-239; SER-241; SER-257; SER-277; SER-292; SER-294;SER-328; SER-366; SER-368; SER-381; THR-385; SER-387; SER-410;SER-411; SER-431; SER-437; THR-576; SER-578; SER-580 AND TYR-849, ANDMASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-32;SER-36; SER-277; SER-294; SER-354; SER-356; SER-366; SER-368; SER-387;SER-431; SER-437; SER-569; SER-578 AND SER-580, AND MASS SPECTROMETRY.
PubMed: 15302935

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
PubMed: 19534553

"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
PubMed: 17389395

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
PubMed: 18083107

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
PubMed: 15592455

"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules.";
Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.;
Mol. Cell. Proteomics 4:1240-1250(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
PubMed: 15951569