dbPTM

PRP8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRP8_HUMAN
UniProt AC	Q6P2Q9
Protein Name	Pre-mRNA-processing-splicing factor 8
Gene Name	PRPF8
Organism	Homo sapiens (Human).
Sequence Length	2335
Subcellular Localization	Nucleus speckle.
Protein Description	Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site..
Protein Sequence	MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGVFPYRG ------CCCCCCCCC	33.87	22223895
7	Phosphorylation	-MAGVFPYRGPGNPV -CCCCCCCCCCCCCC	19.41	26074081
8	Methylation	MAGVFPYRGPGNPVP CCCCCCCCCCCCCCC	45.10	115387181
24	Phosphorylation	PLAPLPDYMSEEKLQ CCCCCCCCCCHHHHH	10.70	27642862
26	Phosphorylation	APLPDYMSEEKLQEK CCCCCCCCHHHHHHH	36.05	25159151
29	Acetylation	PDYMSEEKLQEKARK CCCCCHHHHHHHHHH	51.96	26051181
29	Ubiquitination	PDYMSEEKLQEKARK CCCCCHHHHHHHHHH	51.96	21906983
33	Ubiquitination	SEEKLQEKARKWQQL CHHHHHHHHHHHHHH	40.30	22817900
36	Acetylation	KLQEKARKWQQLQAK HHHHHHHHHHHHHHH	54.97	25953088
36	Malonylation	KLQEKARKWQQLQAK HHHHHHHHHHHHHHH	54.97	26320211
36	Ubiquitination	KLQEKARKWQQLQAK HHHHHHHHHHHHHHH	54.97	29967540
43	2-Hydroxyisobutyrylation	KWQQLQAKRYAEKRK HHHHHHHHHHHHHHC	32.74	-
43	Acetylation	KWQQLQAKRYAEKRK HHHHHHHHHHHHHHC	32.74	25953088
43	Ubiquitination	KWQQLQAKRYAEKRK HHHHHHHHHHHHHHC	32.74	29967540
50	Ubiquitination	KRYAEKRKFGFVDAQ HHHHHHHCCCCCCCC	61.99	24816145
58	Acetylation	FGFVDAQKEDMPPEH CCCCCCCCCCCCHHH	58.35	26051181
68	Ubiquitination	MPPEHVRKIIRDHGD CCHHHHHHHHHHCCC	41.20	-
79	Methylation	DHGDMTNRKFRHDKR HCCCCCCCCCCCCCH	30.26	115489055
80	Ubiquitination	HGDMTNRKFRHDKRV CCCCCCCCCCCCCHH	49.14	29967540
93	Acetylation	RVYLGALKYMPHAVL HHHHHHHHHCHHHHH	38.68	26051181
93	Ubiquitination	RVYLGALKYMPHAVL HHHHHHHHHCHHHHH	38.68	21963094
94	Phosphorylation	VYLGALKYMPHAVLK HHHHHHHHCHHHHHH	19.41	24719451
218	Acetylation	QPLRDSRKYVNGSTY CCCCCCCCCCCCCCC	58.46	26051181
218	Ubiquitination	QPLRDSRKYVNGSTY CCCCCCCCCCCCCCC	58.46	21906983
223	Phosphorylation	SRKYVNGSTYQRWQF CCCCCCCCCCCEEEE	20.81	28152594
224	Phosphorylation	RKYVNGSTYQRWQFT CCCCCCCCCCEEEEH	25.68	28152594
225	Phosphorylation	KYVNGSTYQRWQFTL CCCCCCCCCEEEEHH	9.59	28152594
231	Phosphorylation	TYQRWQFTLPMMSTL CCCEEEEHHHHHHHH	18.17	20068231
236	Phosphorylation	QFTLPMMSTLYRLAN EEHHHHHHHHHHHHH	14.70	20068231
237	Phosphorylation	FTLPMMSTLYRLANQ EHHHHHHHHHHHHHH	15.20	20068231
239	Phosphorylation	LPMMSTLYRLANQLL HHHHHHHHHHHHHHH	12.04	20068231
247	Phosphorylation	RLANQLLTDLVDDNY HHHHHHHHHHCCCCC	35.56	20068231
254	Phosphorylation	TDLVDDNYFYLFDLK HHHCCCCCEEEEEHH	10.70	20068231
256	Phosphorylation	LVDDNYFYLFDLKAF HCCCCCEEEEEHHHH	8.97	20068231
261	Ubiquitination	YFYLFDLKAFFTSKA CEEEEEHHHHHHHHH	45.02	23000965
267	Ubiquitination	LKAFFTSKALNMAIP HHHHHHHHHHHCCCC	54.56	23000965
271	Sulfoxidation	FTSKALNMAIPGGPK HHHHHHHCCCCCCCC	3.58	28183972
278	Ubiquitination	MAIPGGPKFEPLVRD CCCCCCCCCHHCCCC	66.68	23000965
301	Ubiquitination	NEFNDINKIIIRQPI HHCCCCCHHHCCCCC	35.30	21906983
342	Phosphorylation	PNVVFIKTEDPDLPA CCEEEEECCCCCCCC	40.58	23312004
351	Phosphorylation	DPDLPAFYFDPLINP CCCCCCCCCCCCCCC	14.80	23312004
360	Phosphorylation	DPLINPISHRHSVKS CCCCCCCCCCCCCCC	18.74	23312004
364	Phosphorylation	NPISHRHSVKSQEPL CCCCCCCCCCCCCCC	31.06	23312004
366	Acetylation	ISHRHSVKSQEPLPD CCCCCCCCCCCCCCC	49.81	26051181
366	Sumoylation	ISHRHSVKSQEPLPD CCCCCCCCCCCCCCC	49.81	-
366	Ubiquitination	ISHRHSVKSQEPLPD CCCCCCCCCCCCCCC	49.81	21906983
394	Phosphorylation	FLKDTPLYTDNTANG HHCCCCCCCCCCCCC	17.16	22817900
428	Acetylation	ALDIPLVKNWYREHC CCCCCHHHCHHHHHC	49.82	26051181
428	Ubiquitination	ALDIPLVKNWYREHC CCCCCHHHCHHHHHC	49.82	23000965
442	2-Hydroxyisobutyrylation	CPAGQPVKVRVSYQK CCCCCCEEEEEEHHH	30.89	-
442	Ubiquitination	CPAGQPVKVRVSYQK CCCCCCEEEEEEHHH	30.89	27667366
449	Acetylation	KVRVSYQKLLKYYVL EEEEEHHHHHHHHHH	47.78	26051181
449	Ubiquitination	KVRVSYQKLLKYYVL EEEEEHHHHHHHHHH	47.78	21906983
452	Acetylation	VSYQKLLKYYVLNAL EEHHHHHHHHHHHHH	45.00	26051181
452	Ubiquitination	VSYQKLLKYYVLNAL EEHHHHHHHHHHHHH	45.00	21963094
453	Phosphorylation	SYQKLLKYYVLNALK EHHHHHHHHHHHHHC	9.97	28152594
454	Phosphorylation	YQKLLKYYVLNALKH HHHHHHHHHHHHHCC	9.25	28152594
460	Ubiquitination	YYVLNALKHRPPKAQ HHHHHHHCCCCCHHH	34.85	21963094
465	Ubiquitination	ALKHRPPKAQKKRYL HHCCCCCHHHHHHHH	67.16	22817900
477	Ubiquitination	RYLFRSFKATKFFQS HHHHHHHCHHHHHCC	57.29	22817900
480	2-Hydroxyisobutyrylation	FRSFKATKFFQSTKL HHHHCHHHHHCCCCC	49.38	-
480	Acetylation	FRSFKATKFFQSTKL HHHHCHHHHHCCCCC	49.38	26051181
480	Ubiquitination	FRSFKATKFFQSTKL HHHHCHHHHHCCCCC	49.38	22817900
486	Ubiquitination	TKFFQSTKLDWVEVG HHHHCCCCCCHHHHH	50.09	21963094
501	Phosphorylation	LQVCRQGYNMLNLLI HHHHHHCHHHHHHHH	6.78	-
511	Ubiquitination	LNLLIHRKNLNYLHL HHHHHHHCCCCEEEE	52.18	-
515	Phosphorylation	IHRKNLNYLHLDYNF HHHCCCCEEEEEECC	9.92	28152594
520	Phosphorylation	LNYLHLDYNFNLKPV CCEEEEEECCCCCCC	28.19	28152594
525	Acetylation	LDYNFNLKPVKTLTT EEECCCCCCCCCCCC	49.20	26051181
525	Ubiquitination	LDYNFNLKPVKTLTT EEECCCCCCCCCCCC	49.20	22817900
528	Ubiquitination	NFNLKPVKTLTTKER CCCCCCCCCCCCHHH	46.47	22817900
533	Ubiquitination	PVKTLTTKERKKSRF CCCCCCCHHHHHHCC	50.73	32015554
555	Ubiquitination	REVLRLTKLVVDSHV HHHHHHHHHHHCCCH	43.82	21906983
591	Sulfoxidation	HVGQLTGMYRYKYKL HHHHHHCHHHHHHHH	1.13	28183972
606	Ubiquitination	MRQIRMCKDLKHLIY HHHHHCCCCCCHHHE	57.67	23000965
609	2-Hydroxyisobutyrylation	IRMCKDLKHLIYYRF HHCCCCCCHHHEEEC	46.64	-
609	Acetylation	IRMCKDLKHLIYYRF HHCCCCCCHHHEEEC	46.64	25825284
609	Ubiquitination	IRMCKDLKHLIYYRF HHCCCCCCHHHEEEC	46.64	23000965
618	Phosphorylation	LIYYRFNTGPVGKGP HHEEECCCCCCCCCC	39.90	21815630
623	Ubiquitination	FNTGPVGKGPGCGFW CCCCCCCCCCCCCHH	63.27	21963094
645	Phosphorylation	LFFMRGITPLLERWL HHHHCCCHHHHHHHH	15.65	-
666	Ubiquitination	QFEGRHSKGVAKTVT HHCCCCCCCCCEECH	51.81	22817900
670	Acetylation	RHSKGVAKTVTKQRV CCCCCCCEECHHHHH	40.91	25953088
670	Ubiquitination	RHSKGVAKTVTKQRV CCCCCCCEECHHHHH	40.91	21906983
674	Ubiquitination	GVAKTVTKQRVESHF CCCEECHHHHHHHHC	31.60	21906983
679	Phosphorylation	VTKQRVESHFDLELR CHHHHHHHHCCHHHH	26.96	20068231
702	2-Hydroxyisobutyrylation	DMMPEGIKQNKARTI HHCCHHHHHHHHHHH	59.69	-
702	Ubiquitination	DMMPEGIKQNKARTI HHCCHHHHHHHHHHH	59.69	23000965
705	Ubiquitination	PEGIKQNKARTILQH CHHHHHHHHHHHHHH	36.43	23000965
721	Ubiquitination	SEAWRCWKANIPWKV HHHHHHHHCCCCCCC	34.87	23503661
727	Ubiquitination	WKANIPWKVPGLPTP HHCCCCCCCCCCCCC	32.95	21906983
733	Phosphorylation	WKVPGLPTPIENMIL CCCCCCCCCHHHHHH	41.77	-
738	Sulfoxidation	LPTPIENMILRYVKA CCCCHHHHHHHHHHH	1.66	28183972
742	Phosphorylation	IENMILRYVKAKADW HHHHHHHHHHHHCCC	11.67	-
744	Ubiquitination	NMILRYVKAKADWWT HHHHHHHHHHCCCCC	34.92	22817900
746	2-Hydroxyisobutyrylation	ILRYVKAKADWWTNT HHHHHHHHCCCCCCC	40.95	-
746	Malonylation	ILRYVKAKADWWTNT HHHHHHHHCCCCCCC	40.95	26320211
746	Ubiquitination	ILRYVKAKADWWTNT HHHHHHHHCCCCCCC	40.95	21963094
769	2-Hydroxyisobutyrylation	RRGATVDKTVCKKNL HCCCCCCHHHHHHHH	38.22	-
769	Acetylation	RRGATVDKTVCKKNL HCCCCCCHHHHHHHH	38.22	25953088
769	Ubiquitination	RRGATVDKTVCKKNL HCCCCCCHHHHHHHH	38.22	33845483
773	Ubiquitination	TVDKTVCKKNLGRLT CCCHHHHHHHHHHHH	40.12	24816145
785	Ubiquitination	RLTRLYLKAEQERQH HHHHHHHHHHHHHHC	36.00	21906983
800	Phosphorylation	NYLKDGPYITAEEAV CCCCCCCEECHHHHH	19.21	24144214
802	Phosphorylation	LKDGPYITAEEAVAV CCCCCEECHHHHHHH	23.36	28509920
810	Phosphorylation	AEEAVAVYTTTVHWL HHHHHHHHHEEHHHH	6.66	24144214
811	Phosphorylation	EEAVAVYTTTVHWLE HHHHHHHHEEHHHHH	14.91	24144214
812	Phosphorylation	EAVAVYTTTVHWLES HHHHHHHEEHHHHHH	14.77	28509920
813	Phosphorylation	AVAVYTTTVHWLESR HHHHHHEEHHHHHHC	11.54	28509920
819	Phosphorylation	TTVHWLESRRFSPIP EEHHHHHHCCCCCCC	26.96	24144214
833	Ubiquitination	PFPPLSYKHDTKLLI CCCCCCCCCCHHHHH	31.46	21890473
837	Acetylation	LSYKHDTKLLILALE CCCCCCHHHHHHHHH	47.56	26051181
837	Ubiquitination	LSYKHDTKLLILALE CCCCCCHHHHHHHHH	47.56	21963094
847	Ubiquitination	ILALERLKEAYSVKS HHHHHHHHHHHHHHH	46.66	27667366
850	Phosphorylation	LERLKEAYSVKSRLN HHHHHHHHHHHHHCC	18.32	25367160
851	Phosphorylation	ERLKEAYSVKSRLNQ HHHHHHHHHHHHCCH	30.07	25367160
853	2-Hydroxyisobutyrylation	LKEAYSVKSRLNQSQ HHHHHHHHHHCCHHH	24.74	-
853	Acetylation	LKEAYSVKSRLNQSQ HHHHHHHHHHCCHHH	24.74	25953088
853	Ubiquitination	LKEAYSVKSRLNQSQ HHHHHHHHHHCCHHH	24.74	27667366
854	Phosphorylation	KEAYSVKSRLNQSQR HHHHHHHHHCCHHHH	39.58	23403867
859	Phosphorylation	VKSRLNQSQREELGL HHHHCCHHHHHHHCH	30.08	20068231
871	Phosphorylation	LGLIEQAYDNPHEAL HCHHHHHHCCHHHHH	18.89	25147952
928	Phosphorylation	YLDQYLWYEADKRRL HHHHHHCHHHHHCCC	9.92	25147952
932	Ubiquitination	YLWYEADKRRLFPPW HHCHHHHHCCCCCCC	46.60	21906983
941	Ubiquitination	RLFPPWIKPADTEPP CCCCCCCCCCCCCCC	30.22	21906983
983	2-Hydroxyisobutyrylation	MLESRFEKMYEKIDL EEHHHHHHHHHHCCH	44.03	-
983	Acetylation	MLESRFEKMYEKIDL EEHHHHHHHHHHCCH	44.03	26051181
983	Ubiquitination	MLESRFEKMYEKIDL EEHHHHHHHHHHCCH	44.03	21906983
987	2-Hydroxyisobutyrylation	RFEKMYEKIDLTLLN HHHHHHHHCCHHHHH	24.83	-
987	Acetylation	RFEKMYEKIDLTLLN HHHHHHHHCCHHHHH	24.83	26051181
987	Ubiquitination	RFEKMYEKIDLTLLN HHHHHHHHCCHHHHH	24.83	21906983
1008	Phosphorylation	VDHNIADYMTAKNNV HCCCHHHHHCCCCCE	6.32	-
1010	Phosphorylation	HNIADYMTAKNNVVI CCHHHHHCCCCCEEE	28.40	-
1012	2-Hydroxyisobutyrylation	IADYMTAKNNVVINY HHHHHCCCCCEEEEE	39.63	-
1012	Ubiquitination	IADYMTAKNNVVINY HHHHHCCCCCEEEEE	39.63	21906983
1020	Acetylation	NNVVINYKDMNHTNS CCEEEEECCCCCCCC	46.11	26051181
1020	Methylation	NNVVINYKDMNHTNS CCEEEEECCCCCCCC	46.11	42364821
1020	Ubiquitination	NNVVINYKDMNHTNS CCEEEEECCCCCCCC	46.11	21906983
1025	Phosphorylation	NYKDMNHTNSYGIIR EECCCCCCCCHHHHH	22.36	20068231
1027	Phosphorylation	KDMNHTNSYGIIRGL CCCCCCCCHHHHHHH	26.37	20068231
1028	Phosphorylation	DMNHTNSYGIIRGLQ CCCCCCCHHHHHHHH	17.89	20068231
1059	Phosphorylation	VLGLHRASEMAGPPQ HHHHHHHHHHCCCCC	28.06	22210691
1073	Phosphorylation	QMPNDFLSFQDIATE CCCCCCCCHHHHHHH	22.36	22210691
1091	Phosphorylation	PIRLFCRYIDRIHIF HHHHHHHHHCEEEEE	14.35	-
1113	Phosphorylation	ARDLIQRYLTEHPDP HHHHHHHHHHHCCCC	11.12	28152594
1115	Phosphorylation	DLIQRYLTEHPDPNN HHHHHHHHHCCCCCC	24.26	28152594
1128	Phosphorylation	NNENIVGYNNKKCWP CCCCCCCCCCCCCCC	12.50	28152594
1131	Acetylation	NIVGYNNKKCWPRDA CCCCCCCCCCCCHHH	45.75	26051181
1131	Ubiquitination	NIVGYNNKKCWPRDA CCCCCCCCCCCCHHH	45.75	21906983
1132	Ubiquitination	IVGYNNKKCWPRDAR CCCCCCCCCCCHHHH	43.59	22817900
1144	Ubiquitination	DARMRLMKHDVNLGR HHHHHHHHHCCCCCH	41.04	21906983
1151	Dimethylation	KHDVNLGRAVFWDIK HHCCCCCHHHHHHHH	30.64	-
1151	Methylation	KHDVNLGRAVFWDIK HHCCCCCHHHHHHHH	30.64	115372751
1158	Acetylation	RAVFWDIKNRLPRSV HHHHHHHHHCCCCCE	33.28	26051181
1158	Ubiquitination	RAVFWDIKNRLPRSV HHHHHHHHHCCCCCE	33.28	23000965
1201	Methylation	CRILPKCRTSYEEFT EEECCCCCCCHHHHC	32.60	115489047
1204	Nitration	LPKCRTSYEEFTHKD CCCCCCCHHHHCCCC	20.90	-
1204	Phosphorylation	LPKCRTSYEEFTHKD CCCCCCCHHHHCCCC	20.90	27642862
1210	2-Hydroxyisobutyrylation	SYEEFTHKDGVWNLQ CHHHHCCCCCCHHCC	53.79	-
1210	Acetylation	SYEEFTHKDGVWNLQ CHHHHCCCCCCHHCC	53.79	26051181
1210	Ubiquitination	SYEEFTHKDGVWNLQ CHHHHCCCCCCHHCC	53.79	21906983
1222	Acetylation	NLQNEVTKERTAQCF HCCCCCCHHHEEEEE	50.83	26051181
1222	Ubiquitination	NLQNEVTKERTAQCF HCCCCCCHHHEEEEE	50.83	21906983
1290	Acetylation	ELLDLLVKCENKIQT HHHHHHHHCCCHHCH	35.48	26051181
1290	Ubiquitination	ELLDLLVKCENKIQT HHHHHHHHCCCHHCH	35.48	21963094
1294	Acetylation	LLVKCENKIQTRIKI HHHHCCCHHCHHEEC	17.56	26051181
1294	Ubiquitination	LLVKCENKIQTRIKI HHHHCCCHHCHHEEC	17.56	21963094
1300	2-Hydroxyisobutyrylation	NKIQTRIKIGLNSKM CHHCHHEECCCCCCC	27.68	-
1300	Ubiquitination	NKIQTRIKIGLNSKM CHHCHHEECCCCCCC	27.68	21963094
1306	Acetylation	IKIGLNSKMPSRFPP EECCCCCCCCCCCCC	54.48	25953088
1306	Malonylation	IKIGLNSKMPSRFPP EECCCCCCCCCCCCC	54.48	32601280
1306	Ubiquitination	IKIGLNSKMPSRFPP EECCCCCCCCCCCCC	54.48	21906983
1318	Phosphorylation	FPPVVFYTPKELGGL CCCEEEECCHHHCCC	19.20	21082442
1338	Phosphorylation	GHVLIPQSDLRWSKQ CCEEEEHHHCCHHHC	33.00	27251275
1344	Ubiquitination	QSDLRWSKQTDVGIT HHHCCHHHCCCCCCC	50.70	23000965
1346	Phosphorylation	DLRWSKQTDVGITHF HCCHHHCCCCCCCEE	36.07	28555341
1355	Phosphorylation	VGITHFRSGMSHEED CCCCEECCCCCCCHH	37.59	25159151
1358	Phosphorylation	THFRSGMSHEEDQLI CEECCCCCCCHHCCC	31.13	25159151
1369	Phosphorylation	DQLIPNLYRYIQPWE HCCCHHHHHHHCCCC	14.17	19651622
1371	Phosphorylation	LIPNLYRYIQPWESE CCHHHHHHHCCCCCC	7.14	28152594
1392	Acetylation	VWAEYALKRQEAIAQ HHHHHHHHHHHHHHH	43.81	26051181
1392	Ubiquitination	VWAEYALKRQEAIAQ HHHHHHHHHHHHHHH	43.81	21906983
1401	Methylation	QEAIAQNRRLTLEDL HHHHHHCCCCCHHHH	23.94	115489063
1404	Phosphorylation	IAQNRRLTLEDLEDS HHHCCCCCHHHHHHH	26.70	28450419
1414	Methylation	DLEDSWDRGIPRINT HHHHHHHCCCCHHHH	38.39	115387165
1418	Methylation	SWDRGIPRINTLFQK HHHCCCCHHHHHHHC	32.63	115387173
1425	"N6,N6-dimethyllysine"	RINTLFQKDRHTLAY HHHHHHHCCCCCCCC	49.77	-
1425	Methylation	RINTLFQKDRHTLAY HHHHHHHCCCCCCCC	49.77	24129315
1425	Ubiquitination	RINTLFQKDRHTLAY HHHHHHHCCCCCCCC	49.77	-
1432	Phosphorylation	KDRHTLAYDKGWRVR CCCCCCCCCCCCEEE	22.69	25839225
1434	2-Hydroxyisobutyrylation	RHTLAYDKGWRVRTD CCCCCCCCCCEEECC	47.93	-
1434	Ubiquitination	RHTLAYDKGWRVRTD CCCCCCCCCCEEECC	47.93	23000965
1443	2-Hydroxyisobutyrylation	WRVRTDFKQYQVLKQ CEEECCHHHHHHHHC	51.40	-
1443	Acetylation	WRVRTDFKQYQVLKQ CEEECCHHHHHHHHC	51.40	25953088
1443	Methylation	WRVRTDFKQYQVLKQ CEEECCHHHHHHHHC	51.40	42364833
1443	Ubiquitination	WRVRTDFKQYQVLKQ CEEECCHHHHHHHHC	51.40	23000965
1449	Acetylation	FKQYQVLKQNPFWWT HHHHHHHHCCCCCEE	49.53	25953088
1449	Ubiquitination	FKQYQVLKQNPFWWT HHHHHHHHCCCCCEE	49.53	23000965
1463	Acetylation	THQRHDGKLWNLNNY EEECCCCEEEECCHH	57.28	19608861
1463	Ubiquitination	THQRHDGKLWNLNNY EEECCCCEEEECCHH	57.28	22817900
1470	Phosphorylation	KLWNLNNYRTDMIQA EEEECCHHHHHHHHH	17.51	20068231
1505	Ubiquitination	WEGLFWEKASGFEES CHHHHHHHCCCHHHH	38.15	21987572
1507	Phosphorylation	GLFWEKASGFEESMK HHHHHHCCCHHHHHH	55.90	20860994
1512	Phosphorylation	KASGFEESMKWKKLT HCCCHHHHHHHHHHH	20.61	25159151
1516	Trimethylation	FEESMKWKKLTNAQR HHHHHHHHHHHHHHH	32.18	-
1516	Methylation	FEESMKWKKLTNAQR HHHHHHHHHHHHHHH	32.18	23644510
1517	Trimethylation	EESMKWKKLTNAQRS HHHHHHHHHHHHHHC	60.47	-
1517	Methylation	EESMKWKKLTNAQRS HHHHHHHHHHHHHHC	60.47	23644510
1519	Phosphorylation	SMKWKKLTNAQRSGL HHHHHHHHHHHHCCC	37.07	25348772
1524	Phosphorylation	KLTNAQRSGLNQIPN HHHHHHHCCCCCCCC	35.24	25348772
1535	Phosphorylation	QIPNRRFTLWWSPTI CCCCCCEEEEECCCC	21.47	21815630
1539	Phosphorylation	RRFTLWWSPTINRAN CCEEEEECCCCCCCC	10.69	21815630
1541	Phosphorylation	FTLWWSPTINRANVY EEEEECCCCCCCCEE	25.93	26270265
1608	Phosphorylation	LDALEIETVQKETIH CCCCEEEEECCCCCC	33.62	-
1635	Phosphorylation	DILLFASYKWNVSRP HHHHHHHHCCCCCCH	19.32	29759185
1649	Acetylation	PSLLADSKDVMDSTT HHHCCCCCCCCCCCC	55.69	26051181
1649	Ubiquitination	PSLLADSKDVMDSTT HHHCCCCCCCCCCCC	55.69	21906983
1671	Phosphorylation	IQLRWGDYDSHDIER EEEECCCCCHHHHHH	18.53	-
1722	Phosphorylation	YGNWFPGSKPLIQQA HCCCCCCCHHHHHHH	31.19	24719451
1732	Ubiquitination	LIQQAMAKIMKANPA HHHHHHHHHHHHCHH	30.19	22817900
1735	Ubiquitination	QAMAKIMKANPALYV HHHHHHHHHCHHHHH	48.78	27667366
1741	Phosphorylation	MKANPALYVLRERIR HHHCHHHHHHHHHHH	10.27	28152594
1792	Ubiquitination	VYRVTIHKTFEGNLT EEEEEEEEEECCCEE	51.57	21906983
1801	Acetylation	FEGNLTTKPINGAIF ECCCEEECEECCEEE	38.37	26051181
1801	Ubiquitination	FEGNLTTKPINGAIF ECCCEEECEECCEEE	38.37	21906983
1831	Ubiquitination	TSVWAGQKRLGQLAK HHHHCCCHHHHHHCC	48.99	21963094
1838	Acetylation	KRLGQLAKWKTAEEV HHHHHHCCCCCHHHH	58.79	25953088
1838	Ubiquitination	KRLGQLAKWKTAEEV HHHHHHCCCCCHHHH	58.79	29967540
1840	2-Hydroxyisobutyrylation	LGQLAKWKTAEEVAA HHHHCCCCCHHHHHH	36.83	-
1840	Ubiquitination	LGQLAKWKTAEEVAA HHHHCCCCCHHHHHH	36.83	29967540
1851	Phosphorylation	EVAALIRSLPVEEQP HHHHHHHCCCCCCCC	29.99	21712546
1859	2-Hydroxyisobutyrylation	LPVEEQPKQIIVTRK CCCCCCCCEEEEECC	54.55	-
1859	Acetylation	LPVEEQPKQIIVTRK CCCCCCCCEEEEECC	54.55	26051181
1859	Ubiquitination	LPVEEQPKQIIVTRK CCCCCCCCEEEEECC	54.55	21906983
1866	Ubiquitination	KQIIVTRKGMLDPLE CEEEEECCCCCCCEE	39.03	21906983
1887	Phosphorylation	PNIVIKGSELQLPFQ CCEEEECCCCCCCHH	30.08	21712546
1898	Acetylation	LPFQACLKVEKFGDL CCHHHHEEHHHHCCE	48.51	26051181
1898	Ubiquitination	LPFQACLKVEKFGDL CCHHHHEEHHHHCCE	48.51	21963094
1901	Acetylation	QACLKVEKFGDLILK HHHEEHHHHCCEEHH	58.60	26051181
1901	Ubiquitination	QACLKVEKFGDLILK HHHEEHHHHCCEEHH	58.60	22817900
1955	Ubiquitination	DRAKVILKPDKTTIT CCCCEEECCCCCCCC	39.79	29967540
1958	Ubiquitination	KVILKPDKTTITEPH CEEECCCCCCCCCCC	56.97	21890473
1972	Phosphorylation	HHIWPTLTDEEWIKV CCCCCCCCCHHHEEE	43.79	-
1984	2-Hydroxyisobutyrylation	IKVEVQLKDLILADY EEEEEEHHHHHHHHH	33.14	-
1984	Ubiquitination	IKVEVQLKDLILADY EEEEEEHHHHHHHHH	33.14	29967540
1991	Phosphorylation	KDLILADYGKKNNVN HHHHHHHHCCCCCCC	25.82	20068231
1993	2-Hydroxyisobutyrylation	LILADYGKKNNVNVA HHHHHHCCCCCCCHH	46.21	-
1993	Acetylation	LILADYGKKNNVNVA HHHHHHCCCCCCCHH	46.21	26051181
1993	Succinylation	LILADYGKKNNVNVA HHHHHHCCCCCCCHH	46.21	23954790
1993	Ubiquitination	LILADYGKKNNVNVA HHHHHHCCCCCCCHH	46.21	27667366
1994	Ubiquitination	ILADYGKKNNVNVAS HHHHHCCCCCCCHHH	49.76	21906983
2014	Sulfoxidation	IRDIILGMEISAPSQ HHHHHHCCCCCCCHH	3.56	21406390
2031	Acetylation	QQIAEIEKQTKEQSQ HHHHHHHHHHHHHHC	69.77	26051181
2031	Ubiquitination	QQIAEIEKQTKEQSQ HHHHHHHHHHHHHHC	69.77	21906983
2034	Ubiquitination	AEIEKQTKEQSQLTA HHHHHHHHHHHCCCC	51.79	21906983
2037	Phosphorylation	EKQTKEQSQLTATQT HHHHHHHHCCCCEEE	28.40	29978859
2040	Phosphorylation	TKEQSQLTATQTRTV HHHHHCCCCEEEEEC	21.74	25072903
2042	Phosphorylation	EQSQLTATQTRTVNK HHHCCCCEEEEECCC	25.82	17525332
2044	Phosphorylation	SQLTATQTRTVNKHG HCCCCEEEEECCCCC	24.77	25072903
2046	Phosphorylation	LTATQTRTVNKHGDE CCCEEEEECCCCCCE	31.64	24173317
2049	Acetylation	TQTRTVNKHGDEIIT EEEEECCCCCCEEEE	44.63	26051181
2049	Malonylation	TQTRTVNKHGDEIIT EEEEECCCCCCEEEE	44.63	26320211
2049	Ubiquitination	TQTRTVNKHGDEIIT EEEEECCCCCCEEEE	44.63	22817900
2056	Phosphorylation	KHGDEIITSTTSNYE CCCCEEEEECCCCCC	26.19	23186163
2057	Phosphorylation	HGDEIITSTTSNYET CCCEEEEECCCCCCE	21.19	20873877
2058	Phosphorylation	GDEIITSTTSNYETQ CCEEEEECCCCCCEE	26.12	28152594
2059	Phosphorylation	DEIITSTTSNYETQT CEEEEECCCCCCEEC	18.10	28152594
2060	Phosphorylation	EIITSTTSNYETQTF EEEEECCCCCCEECC	37.19	28152594
2062	Phosphorylation	ITSTTSNYETQTFSS EEECCCCCCEECCCC	21.81	28152594
2064	Phosphorylation	STTSNYETQTFSSKT ECCCCCCEECCCCCC	23.66	17525332
2066	Phosphorylation	TSNYETQTFSSKTEW CCCCCEECCCCCCCH	32.67	28442448
2070	Acetylation	ETQTFSSKTEWRVRA CEECCCCCCCHHHHH	49.63	26051181
2070	Ubiquitination	ETQTFSSKTEWRVRA CEECCCCCCCHHHHH	49.63	21963094
2079	Phosphorylation	EWRVRAISAANLHLR CHHHHHHHHCCCEEE	21.97	25159151
2086	Methylation	SAANLHLRTNHIYVS HHCCCEEEECEEEEE	23.80	115489039
2087	Phosphorylation	AANLHLRTNHIYVSS HCCCEEEECEEEEEH	37.19	19664994
2091	Phosphorylation	HLRTNHIYVSSDDIK EEEECEEEEEHHHHH	6.17	28796482
2093	Phosphorylation	RTNHIYVSSDDIKET EECEEEEEHHHHHHH	15.86	28796482
2094	Phosphorylation	TNHIYVSSDDIKETG ECEEEEEHHHHHHHC	29.29	28796482
2098	Acetylation	YVSSDDIKETGYTYI EEEHHHHHHHCCEEE	57.10	26051181
2098	Ubiquitination	YVSSDDIKETGYTYI EEEHHHHHHHCCEEE	57.10	-
2100	Phosphorylation	SSDDIKETGYTYILP EHHHHHHHCCEEEEE	30.41	28152594
2102	Phosphorylation	DDIKETGYTYILPKN HHHHHHCCEEEEEHH	12.09	28152594
2103	Phosphorylation	DIKETGYTYILPKNV HHHHHCCEEEEEHHH	12.87	28152594
2104	Phosphorylation	IKETGYTYILPKNVL HHHHCCEEEEEHHHH	7.62	28152594
2108	Acetylation	GYTYILPKNVLKKFI CCEEEEEHHHHHHEE	57.13	26051181
2108	Ubiquitination	GYTYILPKNVLKKFI CCEEEEEHHHHHHEE	57.13	27667366
2112	Ubiquitination	ILPKNVLKKFICISD EEEHHHHHHEECHHH	41.16	-
2113	2-Hydroxyisobutyrylation	LPKNVLKKFICISDL EEHHHHHHEECHHHH	35.48	-
2113	Acetylation	LPKNVLKKFICISDL EEHHHHHHEECHHHH	35.48	25953088
2113	Ubiquitination	LPKNVLKKFICISDL EEHHHHHHEECHHHH	35.48	-
2118	Phosphorylation	LKKFICISDLRAQIA HHHEECHHHHHHHHH	26.61	24719451
2127	Phosphorylation	LRAQIAGYLYGVSPP HHHHHHHHHHCCCCC	6.42	28152594
2129	Phosphorylation	AQIAGYLYGVSPPDN HHHHHHHHCCCCCCC	13.65	28152594
2132	Phosphorylation	AGYLYGVSPPDNPQV HHHHHCCCCCCCCCC	26.76	20068231
2140	Acetylation	PPDNPQVKEIRCIVM CCCCCCCCEEEEEEE	42.02	26051181
2140	Ubiquitination	PPDNPQVKEIRCIVM CCCCCCCCEEEEEEE	42.02	21906983
2189	Phosphorylation	PNESPQLSPQDVTTH CCCCCCCCHHHCHHC	18.44	-
2198	Ubiquitination	QDVTTHAKIMADNPS HHCHHCCEEECCCCC	25.96	29967540
2205	Phosphorylation	KIMADNPSWDGEKTI EEECCCCCCCCCCEE	44.01	21406692
2216	S-palmitoylation	EKTIIITCSFTPGSC CCEEEEEEEECCCCE	1.91	29575903
2223	S-palmitoylation	CSFTPGSCTLTAYKL EEECCCCEEEEEEEE	4.47	29575903
2244	Ubiquitination	WGRQNTDKGNNPKGY HCCCCCCCCCCCCCC	62.59	29967540
2249	Ubiquitination	TDKGNNPKGYLPSHY CCCCCCCCCCCCHHH	63.41	27667366
2251	Phosphorylation	KGNNPKGYLPSHYER CCCCCCCCCCHHHHH	22.90	28152594
2254	Phosphorylation	NPKGYLPSHYERVQM CCCCCCCHHHHHHHH	35.79	28152594
2256	Phosphorylation	KGYLPSHYERVQMLL CCCCCHHHHHHHHHH	15.12	28152594
2277	Phosphorylation	FFMVPAQSSWNYNFM EEEEECCCCCCCCCC	39.15	27251275
2278	Phosphorylation	FMVPAQSSWNYNFMG EEEECCCCCCCCCCC	13.78	27251275
2281	Phosphorylation	PAQSSWNYNFMGVRH ECCCCCCCCCCCCCC	11.97	27251275
2293	Acetylation	VRHDPNMKYELQLAN CCCCCCCCEEEEECC	42.06	25953088
2293	Ubiquitination	VRHDPNMKYELQLAN CCCCCCCCEEEEECC	42.06	21906983
2294	Phosphorylation	RHDPNMKYELQLANP CCCCCCCEEEEECCH	15.88	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRP8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRP8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRP8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U5S1_HUMAN	EFTUD2	physical	9774689
SNR40_HUMAN	SNRNP40	physical	9774689
PRPF3_HUMAN	PRPF3	physical	20595234
UBC_HUMAN	UBC	physical	20595234
U5S1_HUMAN	EFTUD2	physical	16723661
U520_HUMAN	SNRNP200	physical	16723661
PRP8_HUMAN	PRPF8	physical	16723661
SNR40_HUMAN	SNRNP40	physical	16723661
U5S1_HUMAN	EFTUD2	physical	22939629
U520_HUMAN	SNRNP200	physical	22939629
SNR40_HUMAN	SNRNP40	physical	22939629
SMD3_HUMAN	SNRPD3	physical	22939629
RUXE_HUMAN	SNRPE	physical	22939629
SMD1_HUMAN	SNRPD1	physical	22939629
SF3B3_HUMAN	SF3B3	physical	22939629
SMD2_HUMAN	SNRPD2	physical	22939629
SF3B1_HUMAN	SF3B1	physical	22939629
RU2A_HUMAN	SNRPA1	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
RU17_HUMAN	SNRNP70	physical	22939629
SF3A1_HUMAN	SF3A1	physical	22939629
SNUT1_HUMAN	SART1	physical	22939629
PRPF3_HUMAN	PRPF3	physical	22939629
SF3A2_HUMAN	SF3A2	physical	22939629
SMU1_HUMAN	SMU1	physical	22939629
ECD_HUMAN	ECD	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
TRI55_HUMAN	TRIM55	physical	22939629
SART3_HUMAN	SART3	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
RAGP1_HUMAN	RANGAP1	physical	22939629
RS14_HUMAN	RPS14	physical	22939629
S10A9_HUMAN	S100A9	physical	22939629
SEPT7_HUMAN	SEPT7	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
SEPT2_HUMAN	SEPT2	physical	22939629
SF3B2_HUMAN	SF3B2	physical	22365833
SF3B4_HUMAN	SF3B4	physical	22365833
PRP19_HUMAN	PRPF19	physical	22365833
SPF27_HUMAN	BCAS2	physical	22365833
SLU7_HUMAN	SLU7	physical	22365833
WDR83_HUMAN	WDR83	physical	22365833
ZN830_HUMAN	ZNF830	physical	22365833
PCBP1_HUMAN	PCBP1	physical	22365833
HNRH2_HUMAN	HNRNPH2	physical	22365833
GPKOW_HUMAN	GPKOW	physical	22365833
PRP8_HUMAN	PRPF8	physical	17317632
GABT_HUMAN	ABAT	physical	26344197
PRP17_HUMAN	CDC40	physical	26344197
CDC5L_HUMAN	CDC5L	physical	26344197
CRNL1_HUMAN	CRNKL1	physical	26344197
U5S1_HUMAN	EFTUD2	physical	26344197
G3BP2_HUMAN	G3BP2	physical	26344197
ISY1_HUMAN	ISY1	physical	26344197
IMA3_HUMAN	KPNA4	physical	26344197
LC7L2_HUMAN	LUC7L2	physical	26344197
MED13_HUMAN	MED13	physical	26344197
NACAM_HUMAN	NACA	physical	26344197
NACA_HUMAN	NACA	physical	26344197
PI42A_HUMAN	PIP4K2A	physical	26344197
PI42B_HUMAN	PIP4K2B	physical	26344197
PI42C_HUMAN	PIP4K2C	physical	26344197
PLRG1_HUMAN	PLRG1	physical	26344197
PRP19_HUMAN	PRPF19	physical	26344197
PRPF3_HUMAN	PRPF3	physical	26344197
RBP2_HUMAN	RANBP2	physical	26344197
RNPS1_HUMAN	RNPS1	physical	26344197
SNUT1_HUMAN	SART1	physical	26344197
SF3B3_HUMAN	SF3B3	physical	26344197
U520_HUMAN	SNRNP200	physical	26344197
SMD3_HUMAN	SNRPD3	physical	26344197
RUXE_HUMAN	SNRPE	physical	26344197
SNW1_HUMAN	SNW1	physical	26344197
PRP31_HUMAN	PRPF31	physical	28088760
U520_HUMAN	SNRNP200	physical	27173435
SMU1_HUMAN	SMU1	physical	27173435
RIOK1_HUMAN	RIOK1	physical	27173435
PRP6_HUMAN	PRPF6	physical	27173435
U5S1_HUMAN	EFTUD2	physical	27173435
CD2B2_HUMAN	CD2BP2	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
600059	Retinitis pigmentosa 13 (RP13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRP8_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1463, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2079, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1539, AND MASSSPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2042 AND THR-2064, ANDMASS SPECTROMETRY.	17525332 [Abstract]