dbPTM

RS14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS14_HUMAN
UniProt AC	P62263
Protein Name	40S ribosomal protein S14
Gene Name	RPS14
Organism	Homo sapiens (Human).
Sequence Length	151
Subcellular Localization
Protein Description
Protein Sequence	MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KKEEQVISLGPQVAE CCHHHEEECCCCCCC	28.54	24275569
50	Acetylation	HVTDLSGKETICRVT EEEECCCCEEEEEEC	48.59	155863
61	2-Hydroxyisobutyrylation	CRVTGGMKVKADRDE EEECCCCEEEECCCC	43.81	-
61	Sumoylation	CRVTGGMKVKADRDE EEECCCCEEEECCCC	43.81	28112733
61	Ubiquitination	CRVTGGMKVKADRDE EEECCCCEEEECCCC	43.81	23000965
63	Ubiquitination	VTGGMKVKADRDESS ECCCCEEEECCCCCC	38.77	23000965
63	Malonylation	VTGGMKVKADRDESS ECCCCEEEECCCCCC	38.77	26320211
63	2-Hydroxyisobutyrylation	VTGGMKVKADRDESS ECCCCEEEECCCCCC	38.77	-
63	Acetylation	VTGGMKVKADRDESS ECCCCEEEECCCCCC	38.77	26051181
63	Sumoylation	VTGGMKVKADRDESS ECCCCEEEECCCCCC	38.77	28112733
63	Sumoylation	VTGGMKVKADRDESS ECCCCEEEECCCCCC	38.77	-
69	Phosphorylation	VKADRDESSPYAAML EEECCCCCCHHHHHH	40.68	18691976
70	Phosphorylation	KADRDESSPYAAMLA EECCCCCCHHHHHHH	21.63	22199227
72	Nitration	DRDESSPYAAMLAAQ CCCCCCHHHHHHHHH	14.67	-
72	Phosphorylation	DRDESSPYAAMLAAQ CCCCCCHHHHHHHHH	14.67	30576142
75	Sulfoxidation	ESSPYAAMLAAQDVA CCCHHHHHHHHHHHH	1.67	28465586
85	Glutathionylation	AQDVAQRCKELGITA HHHHHHHHHHHCCEE	2.39	22555962
86	Acetylation	QDVAQRCKELGITAL HHHHHHHHHHCCEEE	59.15	26051181
86	Ubiquitination	QDVAQRCKELGITAL HHHHHHHHHHCCEEE	59.15	23000965
96	2-Hydroxyisobutyrylation	GITALHIKLRATGGN CCEEEEEEEEECCCC	22.60	-
96	Acetylation	GITALHIKLRATGGN CCEEEEEEEEECCCC	22.60	25953088
96	Ubiquitination	GITALHIKLRATGGN CCEEEEEEEEECCCC	22.60	23000965
105	Phosphorylation	RATGGNRTKTPGPGA EECCCCCCCCCCCCH	43.18	28450419
106	Sumoylation	ATGGNRTKTPGPGAQ ECCCCCCCCCCCCHH	49.86	28112733
106	Sumoylation	ATGGNRTKTPGPGAQ ECCCCCCCCCCCCHH	49.86	-
106	Acetylation	ATGGNRTKTPGPGAQ ECCCCCCCCCCCCHH	49.86	26051181
106	Ubiquitination	ATGGNRTKTPGPGAQ ECCCCCCCCCCCCHH	49.86	23000965
107	Phosphorylation	TGGNRTKTPGPGAQS CCCCCCCCCCCCHHH	32.63	23882029
114	Phosphorylation	TPGPGAQSALRALAR CCCCCHHHHHHHHHH	28.83	20860994
117	Methylation	PGAQSALRALARSGM CCHHHHHHHHHHCCC	27.54	115492439
125	Acetylation	ALARSGMKIGRIEDV HHHHCCCCCCCEEEC	45.60	25953088
125	2-Hydroxyisobutyrylation	ALARSGMKIGRIEDV HHHHCCCCCCCEEEC	45.60	-
125	Ubiquitination	ALARSGMKIGRIEDV HHHHCCCCCCCEEEC	45.60	27667366
125	Sumoylation	ALARSGMKIGRIEDV HHHHCCCCCCCEEEC	45.60	-
125	Sumoylation	ALARSGMKIGRIEDV HHHHCCCCCCCEEEC	45.60	-
133	Phosphorylation	IGRIEDVTPIPSDST CCCEEECCCCCCCCC	28.02	23927012
137	Phosphorylation	EDVTPIPSDSTRRKG EECCCCCCCCCCCCC	44.93	23401153
139	Phosphorylation	VTPIPSDSTRRKGGR CCCCCCCCCCCCCCC	28.31	29255136
140	Phosphorylation	TPIPSDSTRRKGGRR CCCCCCCCCCCCCCC	39.21	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS14_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF9_HUMAN	TAF9	physical	16189514
MDM2_HUMAN	MDM2	physical	22391559
A4_HUMAN	APP	physical	21832049
RS15A_HUMAN	RPS15A	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS29_HUMAN	RPS29	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
TOP1_HUMAN	TOP1	physical	22939629
TAF9_HUMAN	TAF9	physical	23246961
MDM2_HUMAN	MDM2	physical	23246961
TMM33_HUMAN	TMEM33	physical	21988832
LARP1_HUMAN	LARP1	physical	22863883
RS15A_HUMAN	RPS15A	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
RS6_HUMAN	RPS6	physical	22863883
RS8_HUMAN	RPS8	physical	22863883
PAIRB_HUMAN	SERBP1	physical	22863883
TSR1_HUMAN	TSR1	physical	22863883
TAF9_HUMAN	TAF9	physical	25416956
HNRL2_HUMAN	HNRNPUL2	physical	26344197
NDUS4_HUMAN	NDUFS4	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL28_HUMAN	RPL28	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS20_HUMAN	RPS20	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS25_HUMAN	RPS25	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS27_HUMAN	RPS27	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197
S61A1_HUMAN	SEC61A1	physical	26344197
RL40_HUMAN	UBA52	physical	26344197
P73_HUMAN	TP73	physical	25301064
MDM2_HUMAN	MDM2	physical	27336364
PCMD1_HUMAN	PCMTD1	physical	28514442
TAF9_HUMAN	TAF9	physical	28514442
NOB1_HUMAN	NOB1	physical	28514442
FRMD8_HUMAN	FRMD8	physical	28514442
CENPV_HUMAN	CENPV	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
ZN430_HUMAN	ZNF430	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
CCZ1B_HUMAN	CCZ1	physical	28514442
CCZ1_HUMAN	CCZ1	physical	28514442
TAF1D_HUMAN	TAF1D	physical	28514442
SDA1_HUMAN	SDAD1	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
TAF1C_HUMAN	TAF1C	physical	28514442
KRR1_HUMAN	KRR1	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
NAT10_HUMAN	NAT10	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
KRI1_HUMAN	KRI1	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
BMS1_HUMAN	BMS1	physical	28514442
YTDC2_HUMAN	YTHDC2	physical	28514442
DDX18_HUMAN	DDX18	physical	28514442
LTV1_HUMAN	LTV1	physical	28514442
ZN121_HUMAN	ZNF121	physical	28514442
RRP5_HUMAN	PDCD11	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
NGDN_HUMAN	NGDN	physical	28514442
P52K_HUMAN	PRKRIR	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
NOP14_HUMAN	NOP14	physical	28514442
PRP4B_HUMAN	PRPF4B	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
DCAF5_HUMAN	DCAF5	physical	28514442
RL32_HUMAN	RPL32	physical	28514442
CDK12_HUMAN	CDK12	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
NKTR_HUMAN	NKTR	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
SPT2_HUMAN	SPTY2D1	physical	28514442
RL15_HUMAN	RPL15	physical	28514442
ZN574_HUMAN	ZNF574	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
SRPK1_HUMAN	SRPK1	physical	28514442
TTF1_HUMAN	TTF1	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
RS13_HUMAN	RPS13	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RBM42_HUMAN	RBM42	physical	28514442
RBMX2_HUMAN	RBMX2	physical	28514442
ZBT24_HUMAN	ZBTB24	physical	28514442
TAP26_HUMAN	CCDC59	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
RL4_HUMAN	RPL4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS14_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-133 AND SER-139, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-105 AND THR-107, ANDMASS SPECTROMETRY.	18088087 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, AND MASSSPECTROMETRY.	17287340 [Abstract]