TAP26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAP26_HUMAN
• UniProt AC: Q9P031
• Protein Name: Thyroid transcription factor 1-associated protein 26
• Gene Name: CCDC59
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Subcellular Localization: Nucleus .
• Protein Description: Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities..
• Protein Sequence: MAPVRRSAKWRPGGIEARGEGVSTVGYRNKNVRQKTWRPNHPQAFVGSVREGQGFAFRRKLKIQQSYKKLLRKEKKAQTSLESQFTDRYPDNLKHLYLAEEERHRKQARKVDHPLSEQVHQPLLEEQCSIDEPLFEDQCSFDQPQPEEQCIKTVNSFTIPKKNKKKTSNQKAQEEYEQIQAKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQEKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAPVRRSAKWRPGG -CCCCCCCCCCCCCC	24.52	26074081
9	Sumoylation	APVRRSAKWRPGGIE CCCCCCCCCCCCCCC	45.01	-
9	Acetylation	APVRRSAKWRPGGIE CCCCCCCCCCCCCCC	45.01	25953088
9	Sumoylation	APVRRSAKWRPGGIE CCCCCCCCCCCCCCC	45.01	-
36	Phosphorylation	NKNVRQKTWRPNHPQ CCCCCCCCCCCCCCC	20.54	28555341
48	Phosphorylation	HPQAFVGSVREGQGF CCCCCCCCCCCCCCC	16.82	28555341
68	Acetylation	LKIQQSYKKLLRKEK HHHHHHHHHHHHHHH	42.04	25953088
88	Methylation	LESQFTDRYPDNLKH HHHHHCCCCCCCHHH	41.65	-
94	Ubiquitination	DRYPDNLKHLYLAEE CCCCCCHHHHHHHHH	37.51	29967540
97	Phosphorylation	PDNLKHLYLAEEERH CCCHHHHHHHHHHHH	12.00	28152594
116	Phosphorylation	RKVDHPLSEQVHQPL HHCCCCCHHHCCHHH	30.36	30576142
129	Phosphorylation	PLLEEQCSIDEPLFE HHHHHHCCCCCCCCC	32.54	29496963
156	Phosphorylation	QCIKTVNSFTIPKKN HHCHHHHHHCCCCCC	21.30	25159151
158	Phosphorylation	IKTVNSFTIPKKNKK CHHHHHHCCCCCCCC	35.87	27134283
167	Phosphorylation	PKKNKKKTSNQKAQE CCCCCCCCCCHHHHH	41.61	-
168	Phosphorylation	KKNKKKTSNQKAQEE CCCCCCCCCHHHHHH	46.25	-
176	Phosphorylation	NQKAQEEYEQIQAKR CHHHHHHHHHHHHHH	16.63	28796482
182	Ubiquitination	EYEQIQAKRAAKKQE HHHHHHHHHHHHHHH	26.62	32015554
182	Acetylation	EYEQIQAKRAAKKQE HHHHHHHHHHHHHHH	26.62	26051181
187	Ubiquitination	QAKRAAKKQEFERRK HHHHHHHHHHHHHHH	50.78	24816145
208	Ubiquitination	QRQYKKKKMEVFKIL HHHHHHHHHHHHHHH	49.53	30230243
232	Phosphorylation	NLNVQMEYLLQKIQE CHHHCHHHHHHHHHH	13.84	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAP26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAP26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
167	Phosphorylation	167 (0)	T ⇒ P;A	rs143136847	Hypospadias	25108383
168	Phosphorylation	167 (1)	T ⇒ P;A	rs143136847	Hypospadias	25108383
176	Phosphorylation	167 (9)	T ⇒ P;A	rs143136847	Hypospadias	25108383

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TUT7_HUMAN	ZCCHC6	physical	28514442
HAUS4_HUMAN	HAUS4	physical	28514442
HAUS1_HUMAN	HAUS1	physical	28514442
CENPB_HUMAN	CENPB	physical	28514442
NPA1P_HUMAN	URB1	physical	28514442
EDC3_HUMAN	EDC3	physical	28514442
LRP2_HUMAN	LRP2	physical	28514442
COG4_HUMAN	COG4	physical	28514442
RNBP6_HUMAN	RANBP6	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
LENG8_HUMAN	LENG8	physical	28514442
DDX52_HUMAN	DDX52	physical	28514442
ARMX3_HUMAN	ARMCX3	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
ZN346_HUMAN	ZNF346	physical	28514442
POP7_HUMAN	POP7	physical	28514442
NOA1_HUMAN	NOA1	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
DDX51_HUMAN	DDX51	physical	28514442
RT18C_HUMAN	MRPS18C	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
ZN483_HUMAN	ZNF483	physical	28514442
HERC5_HUMAN	HERC5	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
URB2_HUMAN	URB2	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
DCP1A_HUMAN	DCP1A	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
SRBD1_HUMAN	SRBD1	physical	28514442
IPO5_HUMAN	IPO5	physical	28514442
ZN638_HUMAN	ZNF638	physical	28514442
CI114_HUMAN	C9orf114	physical	28514442
HNRPQ_HUMAN	SYNCRIP	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
RT24_HUMAN	MRPS24	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.