ZN346_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN346_HUMAN
• UniProt AC: Q9UL40
• Protein Name: Zinc finger protein 346
• Gene Name: ZNF346
• Organism: Homo sapiens (Human).
• Sequence Length: 294
• Subcellular Localization: Nucleus, nucleolus . Cytoplasm . Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
• Protein Description: Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. [PubMed: 24521053 May bind to specific miRNA hairpins]
• Protein Sequence: MEYPAPATVQAADGGAAGPYSSSELLEGQEPDGVRFDRERARRLWEAVSGAQPVGREEVEHMIQKNQCLFTNTQCKVCCALLISESQKLAHYQSKKHANKVKRYLAIHGMETLKGETKKLDSDQKSSRSKDKNQCCPICNMTFSSPVVAQSHYLGKTHAKNLKLKQQSTKVEALHQNREMIDPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKLKLMARYGRLADPAVTDFPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTVASSLGQIPMQRQPIQKDSTTLED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEYPAPAT -------CCCCCCCE	11.40	22814378
49	Phosphorylation	RRLWEAVSGAQPVGR HHHHHHHHCCCCCCH	35.14	28122231
65	Ubiquitination	EVEHMIQKNQCLFTN HHHHHHHHCCCCCCC	37.75	-
114	Acetylation	IHGMETLKGETKKLD HHCHHHCCCCCCCCC	63.22	25953088
114	Sumoylation	IHGMETLKGETKKLD HHCHHHCCCCCCCCC	63.22	28112733
142	Phosphorylation	CCPICNMTFSSPVVA CCCCCCCCCCCCHHH	13.33	28555341
145	Phosphorylation	ICNMTFSSPVVAQSH CCCCCCCCCHHHCHH	19.95	25159151
170	Ubiquitination	KLKQQSTKVEALHQN HHHHHCHHHHHHHHC	43.24	-
170	Sumoylation	KLKQQSTKVEALHQN HHHHHCHHHHHHHHC	43.24	28112733
222	Phosphorylation	KLKLMARYGRLADPA HHHHHHHHCCCCCCC	9.32	-
273	Phosphorylation	QSPKTVASSLGQIPM CCCHHHHHHHCCCCC	23.04	28555341
280	Sulfoxidation	SSLGQIPMQRQPIQK HHHCCCCCCCCCCCC	5.69	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN346_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN346_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN346_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPO5_HUMAN	XPO5	physical	15254228
ILF3_HUMAN	ILF3	physical	15254228
BRX1_HUMAN	BRIX1	physical	24778252
CC124_HUMAN	CCDC124	physical	24778252
NOA1_HUMAN	NOA1	physical	24778252
HP1B3_HUMAN	HP1BP3	physical	24778252
KRR1_HUMAN	KRR1	physical	24778252
NCBP1_HUMAN	NCBP1	physical	24778252
PHAX_HUMAN	PHAX	physical	24778252
PRKRA_HUMAN	PRKRA	physical	24778252
RUXG_HUMAN	SNRPG	physical	24778252
OLA1_HUMAN	OLA1	physical	24778252
EBP2_HUMAN	EBNA1BP2	physical	24778252
RU2B_HUMAN	SNRPB2	physical	24778252
RU2A_HUMAN	SNRPA1	physical	24778252
U3IP2_HUMAN	RRP9	physical	24778252
PP2AA_HUMAN	PPP2CA	physical	24778252

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330