UniProt ID | EBP2_HUMAN | |
---|---|---|
UniProt AC | Q99848 | |
Protein Name | Probable rRNA-processing protein EBP2 | |
Gene Name | EBNA1BP2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 306 | |
Subcellular Localization | Nucleus, nucleolus . Associated with the nucleolus in an RNA-dependent manner. | |
Protein Description | Required for the processing of the 27S pre-rRNA.. | |
Protein Sequence | MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQKPLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTAHGRGLKRPGKKGSNKRPGKRTREKMKNRTH | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
1 | Acetylation | -------MDTPPLSD -------CCCCCCCC | 13.45 | 22814378 | |
3 | Phosphorylation | -----MDTPPLSDSE -----CCCCCCCCCC | 26.05 | 17081983 | |
7 | Phosphorylation | -MDTPPLSDSESESD -CCCCCCCCCCCCCC | 44.88 | 17081983 | |
9 | Phosphorylation | DTPPLSDSESESDES CCCCCCCCCCCCCHH | 39.38 | 17081983 | |
11 | Phosphorylation | PPLSDSESESDESLV CCCCCCCCCCCHHCC | 46.48 | 17081983 | |
13 | Phosphorylation | LSDSESESDESLVTD CCCCCCCCCHHCCCH | 56.83 | 20068231 | |
16 | Phosphorylation | SESESDESLVTDREL CCCCCCHHCCCHHHH | 32.88 | 17081983 | |
19 | Phosphorylation | ESDESLVTDRELQDA CCCHHCCCHHHHHHH | 34.33 | 20068231 | |
28 | Phosphorylation | RELQDAFSRGLLKPG HHHHHHHHCCCCCCC | 27.45 | 30177828 | |
33 | Ubiquitination | AFSRGLLKPGLNVVL HHHCCCCCCCCEEEE | 41.92 | 21890473 | |
33 | Acetylation | AFSRGLLKPGLNVVL HHHCCCCCCCCEEEE | 41.92 | 25953088 | |
44 | Acetylation | NVVLEGPKKAVNDVN EEEEECCHHHHHCCC | 65.31 | 26051181 | |
45 | 2-Hydroxyisobutyrylation | VVLEGPKKAVNDVNG EEEECCHHHHHCCCH | 61.78 | - | |
45 | Acetylation | VVLEGPKKAVNDVNG EEEECCHHHHHCCCH | 61.78 | 26051181 | |
54 | Acetylation | VNDVNGLKQCLAEFK HHCCCHHHHHHHHHH | 40.12 | 26051181 | |
54 | 2-Hydroxyisobutyrylation | VNDVNGLKQCLAEFK HHCCCHHHHHHHHHH | 40.12 | - | |
61 | Acetylation | KQCLAEFKRDLEWVE HHHHHHHHHHHHHHH | 36.19 | 25825284 | |
61 | 2-Hydroxyisobutyrylation | KQCLAEFKRDLEWVE HHHHHHHHHHHHHHH | 36.19 | - | |
64 | Phosphorylation | LAEFKRDLEWVERLD HHHHHHHHHHHHHCC | 6.92 | 17081983 | |
66 | Phosphorylation | EFKRDLEWVERLDVT HHHHHHHHHHHCCCE | 12.45 | 17081983 | |
68 | Phosphorylation | KRDLEWVERLDVTLG HHHHHHHHHCCCEEC | 48.91 | 17081983 | |
71 | Phosphorylation | LEWVERLDVTLGPVP HHHHHHCCCEECCCC | 37.26 | 17081983 | |
73 | Phosphorylation | WVERLDVTLGPVPEI HHHHCCCEECCCCCC | 26.18 | - | |
74 | Phosphorylation | VERLDVTLGPVPEIG HHHCCCEECCCCCCC | 7.98 | 17081983 | |
83 | Phosphorylation | PVPEIGGSEAPAPQN CCCCCCCCCCCCCCC | 25.93 | 20068231 | |
88 | Ubiquitination | GGSEAPAPQNKDQKA CCCCCCCCCCCCCCC | 36.90 | - | |
91 | Acetylation | EAPAPQNKDQKAVDP CCCCCCCCCCCCCCC | 57.18 | 26051181 | |
94 | Ubiquitination | APQNKDQKAVDPEDD CCCCCCCCCCCCCHH | 61.58 | 21890473 | |
94 | Sumoylation | APQNKDQKAVDPEDD CCCCCCCCCCCCCHH | 61.58 | 28112733 | |
94 | Acetylation | APQNKDQKAVDPEDD CCCCCCCCCCCCCHH | 61.58 | 26051181 | |
109 | Ubiquitination | FQREMSFYRQAQAAV HHHHHHHHHHHHHHH | 8.43 | - | |
116 | Acetylation | YRQAQAAVLAVLPRL HHHHHHHHHHHHHHH | 3.85 | - | |
127 | Acetylation | LPRLHQLKVPTKRPT HHHHHHCCCCCCCCC | 39.33 | 25953088 | |
131 | Acetylation | HQLKVPTKRPTDYFA HHCCCCCCCCCHHHH | 50.76 | 25953088 | |
134 | Phosphorylation | KVPTKRPTDYFAEMA CCCCCCCCHHHHHHH | 47.57 | 20860994 | |
136 | Phosphorylation | PTKRPTDYFAEMAKS CCCCCCHHHHHHHHH | 13.73 | - | |
143 | Phosphorylation | YFAEMAKSDLQMQKI HHHHHHHHHHHHHHH | 33.73 | 21712546 | |
149 | Acetylation | KSDLQMQKIRQKLQT HHHHHHHHHHHHHHH | 34.22 | 26051181 | |
149 | Ubiquitination | KSDLQMQKIRQKLQT HHHHHHHHHHHHHHH | 34.22 | - | |
157 | Ubiquitination | IRQKLQTKQAAMERS HHHHHHHHHHHHHHH | 25.61 | - | |
157 | 2-Hydroxyisobutyrylation | IRQKLQTKQAAMERS HHHHHHHHHHHHHHH | 25.61 | - | |
166 | Acetylation | AAMERSEKAKQLRAL HHHHHHHHHHHHHHH | 63.23 | 18603147 | |
168 | Acetylation | MERSEKAKQLRALRK HHHHHHHHHHHHHHH | 62.02 | 18603157 | |
175 | Acetylation | KQLRALRKYGKKVQT HHHHHHHHHHHHHHH | 60.24 | 7825407 | |
179 | Sumoylation | ALRKYGKKVQTEVLQ HHHHHHHHHHHHHHH | 34.90 | 28112733 | |
179 | Acetylation | ALRKYGKKVQTEVLQ HHHHHHHHHHHHHHH | 34.90 | 7369625 | |
182 | Phosphorylation | KYGKKVQTEVLQKRQ HHHHHHHHHHHHHHH | 30.92 | 28555341 | |
186 | Ubiquitination | KVQTEVLQKRQQEKA HHHHHHHHHHHHHHH | 44.02 | - | |
187 | Ubiquitination | VQTEVLQKRQQEKAH HHHHHHHHHHHHHHH | 48.27 | - | |
187 | Acetylation | VQTEVLQKRQQEKAH HHHHHHHHHHHHHHH | 48.27 | 26051181 | |
187 | 2-Hydroxyisobutyrylation | VQTEVLQKRQQEKAH HHHHHHHHHHHHHHH | 48.27 | - | |
191 | Phosphorylation | VLQKRQQEKAHMMNA HHHHHHHHHHHHHHH | 43.82 | - | |
198 | Phosphorylation | EKAHMMNAIKKYQKG HHHHHHHHHHHHHCC | 9.33 | - | |
200 | 2-Hydroxyisobutyrylation | AHMMNAIKKYQKGFS HHHHHHHHHHHCCCC | 42.91 | - | |
204 | Ubiquitination | NAIKKYQKGFSDKLD HHHHHHHCCCCCHHH | 59.85 | - | |
207 | Phosphorylation | KKYQKGFSDKLDFLE HHHHCCCCCHHHHHC | 42.37 | 25159151 | |
209 | Ubiquitination | YQKGFSDKLDFLEGD HHCCCCCHHHHHCCC | 49.08 | 21890473 | |
209 | 2-Hydroxyisobutyrylation | YQKGFSDKLDFLEGD HHCCCCCHHHHHCCC | 49.08 | - | |
209 | Acetylation | YQKGFSDKLDFLEGD HHCCCCCHHHHHCCC | 49.08 | 23749302 | |
212 | Ubiquitination | GFSDKLDFLEGDQKP CCCCHHHHHCCCCCH | 10.96 | - | |
218 | Sumoylation | DFLEGDQKPLAQRKK HHHCCCCCHHHHHHH | 46.90 | - | |
218 | Acetylation | DFLEGDQKPLAQRKK HHHCCCCCHHHHHHH | 46.90 | 26051181 | |
218 | Sumoylation | DFLEGDQKPLAQRKK HHHCCCCCHHHHHHH | 46.90 | 28112733 | |
218 | Ubiquitination | DFLEGDQKPLAQRKK HHHCCCCCHHHHHHH | 46.90 | - | |
224 | Methylation | QKPLAQRKKAGAKGQ CCHHHHHHHHCHHHH | 34.59 | - | |
229 | Acetylation | QRKKAGAKGQQMRKG HHHHHCHHHHHHCCC | 57.23 | 26051181 | |
234 | Ubiquitination | GAKGQQMRKGPSAKR CHHHHHHCCCCCHHH | 36.12 | - | |
235 | Acetylation | AKGQQMRKGPSAKRR HHHHHHCCCCCHHHH | 70.59 | 7296959 | |
237 | Phosphorylation | GQQMRKGPSAKRRYK HHHHCCCCCHHHHHC | 33.86 | - | |
242 | Ubiquitination | KGPSAKRRYKNQKFG CCCCHHHHHCCCCCC | 46.18 | - | |
247 | Acetylation | KRRYKNQKFGFGGKK HHHHCCCCCCCCCCC | 57.77 | 26051181 | |
247 | Ubiquitination | KRRYKNQKFGFGGKK HHHHCCCCCCCCCCC | 57.77 | - | |
253 | Acetylation | QKFGFGGKKKGSKWN CCCCCCCCCCCCCCC | 52.25 | 25953088 | |
256 | Ubiquitination | GFGGKKKGSKWNTRE CCCCCCCCCCCCCCC | 43.25 | - | |
258 | Acetylation | GGKKKGSKWNTRESY CCCCCCCCCCCCCCC | 53.80 | 25953088 | |
261 | Phosphorylation | KKGSKWNTRESYDDV CCCCCCCCCCCCCCH | 34.40 | 22199227 | |
262 | Phosphorylation | KGSKWNTRESYDDVS CCCCCCCCCCCCCHH | 27.87 | - | |
264 | Acetylation | SKWNTRESYDDVSSF CCCCCCCCCCCHHHH | 30.48 | - | |
264 | Ubiquitination | SKWNTRESYDDVSSF CCCCCCCCCCCHHHH | 30.48 | - | |
264 | Phosphorylation | SKWNTRESYDDVSSF CCCCCCCCCCCHHHH | 30.48 | 25159151 | |
265 | Phosphorylation | KWNTRESYDDVSSFR CCCCCCCCCCHHHHH | 16.06 | 19691289 | |
269 | Phosphorylation | RESYDDVSSFRAKTA CCCCCCHHHHHHHCC | 30.65 | 25627689 | |
270 | Phosphorylation | ESYDDVSSFRAKTAH CCCCCHHHHHHHCCC | 20.71 | 25159151 | |
273 | Sumoylation | DDVSSFRAKTAHGRG CCHHHHHHHCCCCCC | 16.13 | - | |
273 | Ubiquitination | DDVSSFRAKTAHGRG CCHHHHHHHCCCCCC | 16.13 | - | |
279 | Methylation | RAKTAHGRGLKRPGK HHHCCCCCCCCCCCC | 37.09 | - | |
302 | Ubiquitination | KRTREKMKNRTH--- HHHHHHHHHCCC--- | 55.11 | - | |
313 | Ubiquitination | H-------------- C-------------- | - | ||
319 | Phosphorylation | -------------------- -------------------- | 24719451 | ||
320 | Phosphorylation | --------------------- --------------------- | 27642862 | ||
325 | Phosphorylation | -------------------------- -------------------------- | 18669648 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EBP2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EBP2_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND MASSSPECTROMETRY. |