| UniProt ID | FBXW7_HUMAN | |
|---|---|---|
| UniProt AC | Q969H0 | |
| Protein Name | F-box/WD repeat-containing protein 7 {ECO:0000305} | |
| Gene Name | FBXW7 {ECO:0000312|HGNC:HGNC:16712} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 707 | |
| Subcellular Localization |
Isoform 1: Nucleus, nucleoplasm . Isoform 2: Cytoplasm . Isoform 3: Nucleus, nucleolus . |
|
| Protein Description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. [PubMed: 17434132 Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1] | |
| Protein Sequence | MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | QELLSVGSKRRRTGG HHHHCCCCCCCCCCC | 22.34 | 20815813 | |
| 11 | Acetylation | ELLSVGSKRRRTGGS HHHCCCCCCCCCCCC | 43.95 | 25953088 | |
| 18 | Phosphorylation | KRRRTGGSLRGNPSS CCCCCCCCCCCCCCH | 19.08 | 20815813 | |
| 25 | Phosphorylation | SLRGNPSSSQVDEEQ CCCCCCCHHHCCHHH | 26.50 | 22399798 | |
| 26 | Phosphorylation | LRGNPSSSQVDEEQM CCCCCCHHHCCHHHH | 38.26 | 17525332 | |
| 176 | Phosphorylation | KRKLDHGSEVRSFSL CCCCCCCCCCCEEEC | 29.51 | 22399798 | |
| 180 | O-linked_Glycosylation | DHGSEVRSFSLGKKP CCCCCCCEEECCCCC | 25.10 | 30379171 | |
| 185 | Acetylation | VRSFSLGKKPCKVSE CCEEECCCCCCEECC | 59.85 | 25953088 | |
| 205 | Phosphorylation | GLVPCSATPTTFGDL CCEECCCCCCCHHHH | 12.60 | 22608923 | |
| 227 | Phosphorylation | QQRRRITSVQPPTGL CCCCCCCCCCCCCCH | 19.18 | 10531037 | |
| 243 | Phosphorylation | EWLKMFQSWSGPEKL HHHHHHHHCCCHHHH | 16.37 | 25690035 | |
| 349 | Phosphorylation | IKPGFIHSPWKSAYI CCCCCCCCCCCHHHH | 27.86 | 22399798 | |
| 372 | Phosphorylation | WRRGELKSPKVLKGH CCCCCCCCCHHHCCC | 42.45 | 24719451 | |
| 412 | Ubiquitination | VWSAVTGKCLRTLVG HHHHHHHHHHHHHHC | 22.26 | - | |
| 678 | Phosphorylation | VVWRIRASNTKLVCA EEEEEEECCCEEEEE | 34.87 | - | |
| 680 | Phosphorylation | WRIRASNTKLVCAVG EEEEECCCEEEEEEE | 24.22 | - | |
| 688 | Phosphorylation | KLVCAVGSRNGTEET EEEEEEECCCCCCEE | 18.90 | - | |
| 692 | Phosphorylation | AVGSRNGTEETKLLV EEECCCCCCEEEEEE | 33.91 | - | |
| 695 | Phosphorylation | SRNGTEETKLLVLDF CCCCCCEEEEEEEEE | 22.29 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 10 | S | Phosphorylation | Kinase | PRKCA | P17252 | GPS |
| 10 | S | Phosphorylation | Kinase | PRKCE | P16054 | GPS |
| 10 | S | Phosphorylation | Kinase | PRKCI | P41743 | GPS |
| 18 | S | Phosphorylation | Kinase | PRKCA | P17252 | GPS |
| 18 | S | Phosphorylation | Kinase | PRKCE | P16054 | GPS |
| 18 | S | Phosphorylation | Kinase | PRKCI | P41743 | GPS |
| 25 | S | Phosphorylation | Kinase | PLK2 | Q9NYY3 | PSP |
| 26 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 176 | S | Phosphorylation | Kinase | PLK2 | Q9NYY3 | PSP |
| 205 | T | Phosphorylation | Kinase | MAPK1 | P28482 | GPS |
| 205 | T | Phosphorylation | Kinase | MAPK3 | P27361 | GPS |
| 227 | S | Phosphorylation | Kinase | AKT1 | P31749 | PSP |
| 227 | S | Phosphorylation | Kinase | SGK1 | O00141 | Uniprot |
| 349 | S | Phosphorylation | Kinase | PLK2 | Q9NYY3 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | TRP120 | - | PMID:32353058 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBXW7_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1signaling by downregulation of protein stability through Fbw7ubiquitin ligase."; Mo J.S., Ann E.J., Yoon J.H., Jung J., Choi Y.H., Kim H.Y., Ahn J.S.,Kim S.M., Kim M.Y., Hong J.A., Seo M.S., Lang F., Choi E.J.,Park H.S.; J. Cell Sci. 124:100-112(2011). Cited for: PHOSPHORYLATION AT SER-227 BY SGK1, AND INTERACTION WITH SGK1 ANDNOTCH1. | |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND MASSSPECTROMETRY. | |
