SOX7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX7_HUMAN
• UniProt AC: Q9BT81
• Protein Name: Transcription factor SOX-7
• Gene Name: SOX7
• Organism: Homo sapiens (Human).
• Sequence Length: 388
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'..
• Protein Sequence: MASLLGAYPWPEGLECPALDAELSDGQSPPAVPRPPGDKGSESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKKQAKRLCKRVDPGFLLSSLSRDQNALPEKRSGSRGALGEKEDRGEYSPGTALPSLRGCYHEGPAGGGGGGTPSSVDTYPYGLPTPPEMSPLDVLEPEQTFFSSPCQEEHGHPRRIPHLPGHPYSPEYAPSPLHCSHPLGSLALGQSPGVSMMSPVPGCPPSPAYYSPATYHPLHSNLQAHLGQLSPPPEHPGFDALDQLSQVELLGDMDRNEFDQYLNTPGHPDSATGAMALSGHVPVSQVTPTGPTETSLISVLADATATYYNSYSVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	DLHNAELSKMLGKSW CCCHHHHHHHHCHHH	13.92	-
89	Phosphorylation	SWKALTLSQKRPYVD HHHHHHHCCCCCCCC	28.55	25159151
137	Phosphorylation	DPGFLLSSLSRDQNA CHHHHHHHHCCCCCC	30.27	25159151
139	Phosphorylation	GFLLSSLSRDQNALP HHHHHHHCCCCCCCC	35.44	25627689
150	Phosphorylation	NALPEKRSGSRGALG CCCCCCCCCCCCCCC	52.79	26074081
152	Phosphorylation	LPEKRSGSRGALGEK CCCCCCCCCCCCCCC	28.87	26074081
165	Phosphorylation	EKEDRGEYSPGTALP CCCCCCCCCCCCCCH	24.00	27732954
166	Phosphorylation	KEDRGEYSPGTALPS CCCCCCCCCCCCCHH	16.73	21815630
169	Phosphorylation	RGEYSPGTALPSLRG CCCCCCCCCCHHHCC	28.53	23186163
173	Phosphorylation	SPGTALPSLRGCYHE CCCCCCHHHCCCCCC	31.39	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.