dbPTM

MYCN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYCN_HUMAN
UniProt AC	P04198
Protein Name	N-myc proto-oncogene protein
Gene Name	MYCN
Organism	Homo sapiens (Human).
Sequence Length	464
Subcellular Localization	Nucleus.
Protein Description	Positively regulates the transcription of MYCNOS in neuroblastoma cells..
Protein Sequence	MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSCSTSTMP -----CCCCCCCCCC	21.28	18669648
5	Phosphorylation	---MPSCSTSTMPGM ---CCCCCCCCCCCC	29.72	18669648
6	Phosphorylation	--MPSCSTSTMPGMI --CCCCCCCCCCCCC	32.32	18669648
7	Phosphorylation	-MPSCSTSTMPGMIC -CCCCCCCCCCCCCC	13.35	18669648
8	Phosphorylation	MPSCSTSTMPGMICK CCCCCCCCCCCCCCC	27.72	18669648
52	Ubiquitination	PGEDIWKKFELLPTP CCHHHHHHHCCCCCC	29.13	-
58	Phosphorylation	KKFELLPTPPLSPSR HHHCCCCCCCCCCCC	37.19	29255136
62	Phosphorylation	LLPTPPLSPSRGFAE CCCCCCCCCCCCCCC	26.97	29255136
64	Phosphorylation	PTPPLSPSRGFAEHS CCCCCCCCCCCCCCC	41.48	29255136
65	Methylation	TPPLSPSRGFAEHSS CCCCCCCCCCCCCCC	47.86	118350215
133	Acetylation	LERAVSEKLQHGRGP HHHHHHHHHHCCCCC	46.04	23749302
142	Phosphorylation	QHGRGPPTAGSTAQS HCCCCCCCCCCCCCC	46.94	27732954
145	Phosphorylation	RGPPTAGSTAQSPGA CCCCCCCCCCCCCCC	20.36	27732954
146	Phosphorylation	GPPTAGSTAQSPGAG CCCCCCCCCCCCCCC	28.00	27732954
149	Phosphorylation	TAGSTAQSPGAGAAS CCCCCCCCCCCCCCC	23.88	27732954
156	Phosphorylation	SPGAGAASPAGRGHG CCCCCCCCCCCCCCC	18.10	27732954
238	Methylation	APGVAPPRPGGRQTS CCCCCCCCCCCCCCC	41.24	422795205
242	Methylation	APPRPGGRQTSGGDH CCCCCCCCCCCCCCC	42.38	422795199
253	Phosphorylation	GGDHKALSTSGEDTL CCCCCCCCCCCCCCC	25.95	30177828
254	Phosphorylation	GDHKALSTSGEDTLS CCCCCCCCCCCCCCC	41.42	30177828
255	Phosphorylation	DHKALSTSGEDTLSD CCCCCCCCCCCCCCC	36.49	30177828
259	Phosphorylation	LSTSGEDTLSDSDDE CCCCCCCCCCCCCCC	24.70	30177828
261	Phosphorylation	TSGEDTLSDSDDEDD CCCCCCCCCCCCCCC	36.84	22817900
263	Phosphorylation	GEDTLSDSDDEDDEE CCCCCCCCCCCCCCC	43.52	15821734
287	Phosphorylation	VTVEKRRSSSNTKAV EEEEEECCCCCCCEE	42.00	28270605
288	Phosphorylation	TVEKRRSSSNTKAVT EEEEECCCCCCCEEE	26.29	28152594
289	Phosphorylation	VEKRRSSSNTKAVTT EEEECCCCCCCEEEE	50.17	28152594
291	Phosphorylation	KRRSSSNTKAVTTFT EECCCCCCCEEEEEE	23.48	28152594
295	Phosphorylation	SSNTKAVTTFTITVR CCCCCEEEEEEEEEC	22.50	28270605
296	Phosphorylation	SNTKAVTTFTITVRP CCCCEEEEEEEEECC	16.51	28270605
298	Phosphorylation	TKAVTTFTITVRPKN CCEEEEEEEEECCCC	17.41	28270605
300	Phosphorylation	AVTTFTITVRPKNAA EEEEEEEEECCCCCC	13.86	28270605
315	Phosphorylation	LGPGRAQSSELILKR CCCCCCCCHHHHHHH	25.46	27732954
316	Phosphorylation	GPGRAQSSELILKRC CCCCCCCHHHHHHHH	25.09	27732954
321	Ubiquitination	QSSELILKRCLPIHQ CCHHHHHHHHCHHHH	33.79	-
352	O-linked_Glycosylation	PPQKKIKSEASPRPL CCCHHCCCCCCCCCC	41.70	30379171
355	Phosphorylation	KKIKSEASPRPLKSV HHCCCCCCCCCCHHC	19.86	24667141
361	Phosphorylation	ASPRPLKSVIPPKAK CCCCCCHHCCCCCCC	32.72	28060719
369	Phosphorylation	VIPPKAKSLSPRNSD CCCCCCCCCCCCCCC	38.65	24719451
371	Phosphorylation	PPKAKSLSPRNSDSE CCCCCCCCCCCCCCH	28.98	24719451
375	Phosphorylation	KSLSPRNSDSEDSER CCCCCCCCCCHHHHH	43.74	30177828
377	Phosphorylation	LSPRNSDSEDSERRR CCCCCCCCHHHHHHH	43.02	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
58	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
62	S	Phosphorylation	Kinase	MTOR	P42345	PSP
261	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
261	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
261	S	Phosphorylation	Kinase	CK2	-	Uniprot
261	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
263	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
263	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
263	S	Phosphorylation	Kinase	CK2	-	Uniprot
263	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:23175188
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM32	Q13049	PMID:25100564
-	K	Ubiquitination	E3 ubiquitin ligase	HUWE1	Q7Z6Z7	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:19111882

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYCN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYCN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAX_HUMAN	MAX	physical	2006410
FBXW7_HUMAN	FBXW7	physical	19111882
SP1_HUMAN	SP1	physical	21123453
SIR1_HUMAN	SIRT1	physical	21698133
ZBT17_HUMAN	ZBTB17	physical	21908575
CDN2A_HUMAN	CDKN2A	physical	17289033
ARF_HUMAN	CDKN2A	physical	17289033
MAX_HUMAN	MAX	physical	17289033
NMI_HUMAN	NMI	physical	10597290
HDAC5_HUMAN	HDAC5	physical	23812427
TRI32_HUMAN	TRIM32	physical	25100564
NEDD4_HUMAN	NEDD4	physical	23175188
ZBT17_HUMAN	ZBTB17	physical	21123453
WDR5_HUMAN	WDR5	physical	26471359
HUWE1_HUMAN	HUWE1	physical	18488021
LPPRC_HUMAN	LRPPRC	physical	18488021
MAX_HUMAN	MAX	physical	18488021

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
	Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
164280
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYCN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58 AND SER-62, AND MASSSPECTROMETRY.	15302935 [Abstract]