| UniProt ID | HUWE1_HUMAN | |
|---|---|---|
| UniProt AC | Q7Z6Z7 | |
| Protein Name | E3 ubiquitin-protein ligase HUWE1 | |
| Gene Name | HUWE1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 4374 | |
| Subcellular Localization | Cytoplasm . Nucleus . Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells. | |
| Protein Description | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.. | |
| Protein Sequence | MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Ubiquitination | VDRTKLKKTPTEAPA CCCCCCCCCCCCCCH | 70.90 | - | |
| 11 | Phosphorylation | DRTKLKKTPTEAPAD CCCCCCCCCCCCCHH | 33.58 | 20860994 | |
| 13 | Phosphorylation | TKLKKTPTEAPADCR CCCCCCCCCCCHHHH | 50.43 | 20860994 | |
| 25 | Acetylation | DCRALIDKLKVCNDE HHHHHHHHHCCCCHH | 43.12 | 25953088 | |
| 25 | Malonylation | DCRALIDKLKVCNDE HHHHHHHHHCCCCHH | 43.12 | 26320211 | |
| 25 | Succinylation | DCRALIDKLKVCNDE HHHHHHHHHCCCCHH | 43.12 | 23954790 | |
| 25 | Ubiquitination | DCRALIDKLKVCNDE HHHHHHHHHCCCCHH | 43.12 | - | |
| 27 | 2-Hydroxyisobutyrylation | RALIDKLKVCNDEQL HHHHHHHCCCCHHHH | 50.94 | - | |
| 27 | Ubiquitination | RALIDKLKVCNDEQL HHHHHHHCCCCHHHH | 50.94 | - | |
| 145 | Phosphorylation | LYVFSKRSNYITRLG HHHHHCCCCCHHHCC | 37.41 | 26552605 | |
| 147 | Phosphorylation | VFSKRSNYITRLGSD HHHCCCCCHHHCCCC | 12.62 | 26552605 | |
| 149 | Phosphorylation | SKRSNYITRLGSDKR HCCCCCHHHCCCCCC | 14.96 | 26552605 | |
| 153 | Phosphorylation | NYITRLGSDKRTPLL CCHHHCCCCCCCHHH | 44.54 | 21601212 | |
| 157 | Phosphorylation | RLGSDKRTPLLTRLQ HCCCCCCCHHHHHHH | 24.83 | 27174698 | |
| 161 | Phosphorylation | DKRTPLLTRLQHLAE CCCCHHHHHHHHHHH | 36.70 | 27174698 | |
| 173 | Ubiquitination | LAESWGGKENGFGLA HHHHCCCCCCCCCHH | 44.03 | - | |
| 190 | Ubiquitination | CRDLHMMKYPPSATT HHHHCCCCCCCCCCE | 47.21 | - | |
| 216 | Phosphorylation | EVKIEKRTTSNTLHY EEEEEEECCCCCEEE | 45.72 | 23312004 | |
| 217 | Phosphorylation | VKIEKRTTSNTLHYI EEEEEECCCCCEEEE | 24.82 | 23312004 | |
| 218 | Phosphorylation | KIEKRTTSNTLHYIH EEEEECCCCCEEEEE | 27.49 | 23312004 | |
| 220 | Phosphorylation | EKRTTSNTLHYIHIE EEECCCCCEEEEEHH | 18.06 | 23312004 | |
| 223 | Phosphorylation | TTSNTLHYIHIEQLD CCCCCEEEEEHHHHH | 9.41 | 23312004 | |
| 231 | Ubiquitination | IHIEQLDKISESPSE EEHHHHHHHCCCHHH | 57.64 | - | |
| 237 | Phosphorylation | DKISESPSEIMESLT HHHCCCHHHHHHHHH | 49.38 | 28348404 | |
| 245 | Ubiquitination | EIMESLTKMYSIPKD HHHHHHHHHHCCCCH | 40.93 | - | |
| 251 | Ubiquitination | TKMYSIPKDKQMLLF HHHHCCCCHHHHHHH | 75.73 | - | |
| 259 | Phosphorylation | DKQMLLFTHIRLAHG HHHHHHHHHHHHHCC | 19.16 | 27470641 | |
| 324 | 2-Hydroxyisobutyrylation | DKQLMEIKAASLRTL CHHHHHHHHHHHHHH | 25.29 | - | |
| 324 | Ubiquitination | DKQLMEIKAASLRTL CHHHHHHHHHHHHHH | 25.29 | 21890473 | |
| 330 | Phosphorylation | IKAASLRTLTSIVHL HHHHHHHHHHHHHHH | 39.41 | - | |
| 332 | Phosphorylation | AASLRTLTSIVHLER HHHHHHHHHHHHHHC | 18.78 | - | |
| 333 | Phosphorylation | ASLRTLTSIVHLERT HHHHHHHHHHHHHCC | 26.23 | - | |
| 340 | Phosphorylation | SIVHLERTPKLSSII HHHHHHCCCCCHHCE | 18.52 | 30622161 | |
| 342 | Ubiquitination | VHLERTPKLSSIIDC HHHHCCCCCHHCEEC | 61.46 | - | |
| 417 | Ubiquitination | EALLKVIKFLGDEQD HHHHHHHHHHCCCHH | 37.21 | 22053931 | |
| 417 (in isoform 2) | Ubiquitination | - | 37.21 | 21890473 | |
| 468 | Methylation | EHEVDLCRKECPFVI HHHHHHHHCCCCEEE | 45.14 | 115387391 | |
| 476 | Ubiquitination | KECPFVIKPKIQRPN CCCCEEECCCCCCCC | 34.65 | - | |
| 484 | Phosphorylation | PKIQRPNTTQEGEEM CCCCCCCCCCCCCCC | 32.32 | 21712546 | |
| 485 | Phosphorylation | KIQRPNTTQEGEEME CCCCCCCCCCCCCCC | 31.12 | 29214152 | |
| 493 | Phosphorylation | QEGEEMETDMDGVQC CCCCCCCCCCCCCCC | 35.00 | 28555341 | |
| 509 | Acetylation | PQRAALLKSMLNFLK HHHHHHHHHHHHHHH | 34.37 | 19608861 | |
| 509 | Ubiquitination | PQRAALLKSMLNFLK HHHHHHHHHHHHHHH | 34.37 | 19608861 | |
| 516 | Acetylation | KSMLNFLKKAIQDPA HHHHHHHHHHHCCCH | 35.70 | 25953088 | |
| 516 | Ubiquitination | KSMLNFLKKAIQDPA HHHHHHHHHHHCCCH | 35.70 | - | |
| 517 | Ubiquitination | SMLNFLKKAIQDPAF HHHHHHHHHHCCCHH | 53.52 | - | |
| 525 | Phosphorylation | AIQDPAFSDGIRHVM HHCCCHHCCCCHHHH | 36.71 | - | |
| 529 | Methylation | PAFSDGIRHVMDGSL CHHCCCCHHHHCCCC | 23.13 | 115480031 | |
| 632 | Ubiquitination | QPFERLFKVLLSPDY CCHHHHHHHHHCCCC | 36.24 | 21890473 | |
| 636 | Phosphorylation | RLFKVLLSPDYLPAM HHHHHHHCCCCHHHH | 16.15 | - | |
| 648 | Phosphorylation | PAMRRRRSSDPLGDT HHHHHHCCCCCCCHH | 36.96 | 30278072 | |
| 649 | Phosphorylation | AMRRRRSSDPLGDTA HHHHHCCCCCCCHHH | 41.24 | 23401153 | |
| 655 | Phosphorylation | SSDPLGDTASNLGSA CCCCCCHHHHHHHHH | 30.13 | 30278072 | |
| 657 | Phosphorylation | DPLGDTASNLGSAVD CCCCHHHHHHHHHHH | 34.38 | 23927012 | |
| 661 | Phosphorylation | DTASNLGSAVDELMR HHHHHHHHHHHHHHH | 28.43 | 23663014 | |
| 674 | Ubiquitination | MRHQPTLKTDATTAI HHCCCCCCCHHHHHH | 47.00 | 21906983 | |
| 674 (in isoform 1) | Ubiquitination | - | 47.00 | 21890473 | |
| 674 (in isoform 2) | Ubiquitination | - | 47.00 | 21890473 | |
| 674 (in isoform 3) | Ubiquitination | - | 47.00 | 21890473 | |
| 696 | Acetylation | CNLGRDPKYICQKPS HHCCCCHHHHHCCCC | 52.08 | 26051181 | |
| 696 | Ubiquitination | CNLGRDPKYICQKPS HHCCCCHHHHHCCCC | 52.08 | - | |
| 697 | Phosphorylation | NLGRDPKYICQKPSI HCCCCHHHHHCCCCC | 16.59 | 28152594 | |
| 701 | Acetylation | DPKYICQKPSIQKAD CHHHHHCCCCCCCCC | 36.00 | 26822725 | |
| 701 | Ubiquitination | DPKYICQKPSIQKAD CHHHHHCCCCCCCCC | 36.00 | - | |
| 710 | Phosphorylation | SIQKADGTATAPPPR CCCCCCCCCCCCCCC | 22.76 | 21888424 | |
| 718 | Phosphorylation | ATAPPPRSNHAAEEA CCCCCCCCCCCHHHC | 38.45 | 30576142 | |
| 726 | Phosphorylation | NHAAEEASSEDEEEE CCCHHHCCCCCHHHH | 37.22 | 30576142 | |
| 727 | Phosphorylation | HAAEEASSEDEEEEE CCHHHCCCCCHHHHH | 56.99 | 29496963 | |
| 740 | Phosphorylation | EEVQAMQSFNSTQQN HHHHHHHHHCCCCCC | 17.20 | 24275569 | |
| 743 | Phosphorylation | QAMQSFNSTQQNETE HHHHHHCCCCCCCCC | 26.11 | 29496963 | |
| 744 | Phosphorylation | AMQSFNSTQQNETEP HHHHHCCCCCCCCCC | 34.97 | 29496963 | |
| 749 | Phosphorylation | NSTQQNETEPNQQVV CCCCCCCCCCCCCCC | 65.38 | 29496963 | |
| 769 | Phosphorylation | IPIPLMDYILNVMKF CCHHHHHHHHHHHHH | 8.05 | 23403867 | |
| 797 | Ubiquitination | CQEFVNQKGLLPLVT HHHHHHHCCHHHHHH | 46.45 | - | |
| 830 | Phosphorylation | AVAGVCKSILTLSHE HHHHHHHHHHHHCCC | 20.08 | 24719451 | |
| 850 | Phosphorylation | EGLLQLDSILSSLEP HHHHHHHHHHHHCCC | 33.74 | 26074081 | |
| 853 | O-linked_Glycosylation | LQLDSILSSLEPLHR HHHHHHHHHCCCCCC | 31.07 | 30059200 | |
| 853 | Phosphorylation | LQLDSILSSLEPLHR HHHHHHHHHCCCCCC | 31.07 | 26074081 | |
| 854 | O-linked_Glycosylation | QLDSILSSLEPLHRP HHHHHHHHCCCCCCC | 33.05 | 30059200 | |
| 854 | Phosphorylation | QLDSILSSLEPLHRP HHHHHHHHCCCCCCC | 33.05 | 26074081 | |
| 864 | Phosphorylation | PLHRPIESPGGSVLL CCCCCCCCCCHHHHH | 29.57 | 26074081 | |
| 868 | Phosphorylation | PIESPGGSVLLRELA CCCCCCHHHHHHHHH | 18.59 | 26074081 | |
| 927 | Phosphorylation | ISVNQWGSQLGLSVL EEEHHHHHHHHHHHH | 21.19 | 17478428 | |
| 990 | Phosphorylation | TTQGGKRSDGEQDGA CCCCCCCCCCCCCCC | 54.15 | 24043423 | |
| 1000 | Phosphorylation | EQDGAAGSMDASTQG CCCCCCCCCCHHHHH | 14.57 | 24043423 | |
| 1004 | Phosphorylation | AAGSMDASTQGLLEG CCCCCCHHHHHHHHC | 19.59 | 24043423 | |
| 1005 | Phosphorylation | AGSMDASTQGLLEGI CCCCCHHHHHHHHCC | 28.51 | 24043423 | |
| 1018 | Phosphorylation | GIGLDGDTLAPMETD CCCCCCCCCCCCCCC | 30.28 | 28348404 | |
| 1024 | Phosphorylation | DTLAPMETDEPTASD CCCCCCCCCCCCCCC | 39.14 | 24043423 | |
| 1028 | Phosphorylation | PMETDEPTASDSKGK CCCCCCCCCCCCCCC | 36.42 | 24043423 | |
| 1030 | Phosphorylation | ETDEPTASDSKGKSK CCCCCCCCCCCCCCC | 44.91 | 24043423 | |
| 1032 | Phosphorylation | DEPTASDSKGKSKIT CCCCCCCCCCCCCCC | 40.59 | 24043423 | |
| 1037 | Ubiquitination | SDSKGKSKITPAMAA CCCCCCCCCCHHHHH | 54.83 | - | |
| 1039 | Phosphorylation | SKGKSKITPAMAARI CCCCCCCCHHHHHHH | 14.56 | - | |
| 1050 | Ubiquitination | AARIKQIKPLLSASS HHHHHHHHHHHCHHH | 27.41 | 21890473 | |
| 1054 | Phosphorylation | KQIKPLLSASSRLGR HHHHHHHCHHHHHHH | 33.51 | 21406692 | |
| 1056 | Phosphorylation | IKPLLSASSRLGRAL HHHHHCHHHHHHHHH | 16.77 | 21406692 | |
| 1057 | Phosphorylation | KPLLSASSRLGRALA HHHHCHHHHHHHHHH | 31.10 | 21406692 | |
| 1077 | Phosphorylation | LVKLCVGSPVRQRRS HHHHHCCCHHHHCCC | 10.38 | 29116813 | |
| 1084 | Phosphorylation | SPVRQRRSHHAASTT CHHHHCCCCCCCCCC | 23.08 | 20201521 | |
| 1089 | Phosphorylation | RRSHHAASTTTAPTP CCCCCCCCCCCCCCH | 27.37 | 30266825 | |
| 1090 | Phosphorylation | RSHHAASTTTAPTPA CCCCCCCCCCCCCHH | 24.36 | 30266825 | |
| 1091 | Phosphorylation | SHHAASTTTAPTPAA CCCCCCCCCCCCHHH | 20.61 | 30266825 | |
| 1092 | Phosphorylation | HHAASTTTAPTPAAR CCCCCCCCCCCHHHH | 30.63 | 30266825 | |
| 1095 | Phosphorylation | ASTTTAPTPAARSTA CCCCCCCCHHHHHHH | 24.09 | 28450419 | |
| 1098 (in isoform 3) | Ubiquitination | - | 13.73 | 21890473 | |
| 1102 (in isoform 3) | Ubiquitination | - | 8.28 | 21890473 | |
| 1107 | Acetylation | STASALTKLLTKGLS HHHHHHHHHHHCCCC | 42.20 | 25953088 | |
| 1107 | Ubiquitination | STASALTKLLTKGLS HHHHHHHHHHHCCCC | 42.20 | 21906983 | |
| 1107 (in isoform 1) | Ubiquitination | - | 42.20 | 21890473 | |
| 1107 (in isoform 2) | Ubiquitination | - | 42.20 | 21890473 | |
| 1111 | Ubiquitination | ALTKLLTKGLSWQPP HHHHHHHCCCCCCCC | 58.80 | 21906983 | |
| 1111 (in isoform 1) | Ubiquitination | - | 58.80 | 21890473 | |
| 1111 (in isoform 2) | Ubiquitination | - | 58.80 | 21890473 | |
| 1147 | Ubiquitination | PMLFDERKYPYHLML CHHCCCCCCCHHHHH | 48.83 | 21890473 | |
| 1148 | Phosphorylation | MLFDERKYPYHLMLQ HHCCCCCCCHHHHHH | 18.42 | 22912867 | |
| 1150 | Phosphorylation | FDERKYPYHLMLQKF CCCCCCCHHHHHHHH | 12.42 | 22912867 | |
| 1153 | Sulfoxidation | RKYPYHLMLQKFLCS CCCCHHHHHHHHHHC | 2.07 | 30846556 | |
| 1156 | Ubiquitination | PYHLMLQKFLCSGGH CHHHHHHHHHHCCHH | 36.02 | - | |
| 1160 | Phosphorylation | MLQKFLCSGGHNALF HHHHHHHCCHHHHHH | 50.37 | 22912867 | |
| 1169 | Phosphorylation | GHNALFETFNWALSM HHHHHHHHHHHHHHC | 18.22 | 22912867 | |
| 1175 | Phosphorylation | ETFNWALSMGGKVPV HHHHHHHHCCCCEEC | 13.97 | 22912867 | |
| 1183 | Phosphorylation | MGGKVPVSEGLEHSD CCCCEECCCCCCCCC | 21.63 | 29759185 | |
| 1189 | Phosphorylation | VSEGLEHSDLPDGTG CCCCCCCCCCCCCCH | 31.31 | 29759185 | |
| 1195 | Phosphorylation | HSDLPDGTGEFLDAW CCCCCCCCHHHHHHH | 40.70 | 29759185 | |
| 1204 | Sulfoxidation | EFLDAWLMLVEKMVN HHHHHHHHHHHHHCC | 2.48 | 30846556 | |
| 1213 | Phosphorylation | VEKMVNPTTVLESPH HHHHCCCCCCCCCCC | 25.08 | 23312004 | |
| 1214 | Phosphorylation | EKMVNPTTVLESPHS HHHCCCCCCCCCCCC | 25.09 | 23312004 | |
| 1216 (in isoform 3) | Ubiquitination | - | 5.18 | 21890473 | |
| 1218 | Phosphorylation | NPTTVLESPHSLPAK CCCCCCCCCCCCCCC | 24.61 | 25159151 | |
| 1221 | Phosphorylation | TVLESPHSLPAKLPG CCCCCCCCCCCCCCC | 39.16 | 23312004 | |
| 1225 | Ubiquitination | SPHSLPAKLPGGVQN CCCCCCCCCCCCCCC | 53.96 | 21906983 | |
| 1225 (in isoform 1) | Ubiquitination | - | 53.96 | 21890473 | |
| 1225 (in isoform 2) | Ubiquitination | - | 53.96 | 21890473 | |
| 1238 (in isoform 3) | Ubiquitination | - | 12.21 | 21890473 | |
| 1247 | Ubiquitination | RFLVVTQKAAFTCIK HHHHHHHHHHHHHHH | 32.11 | 21906983 | |
| 1247 (in isoform 1) | Ubiquitination | - | 32.11 | 21890473 | |
| 1247 (in isoform 2) | Ubiquitination | - | 32.11 | 21890473 | |
| 1254 | Ubiquitination | KAAFTCIKNLWNRKP HHHHHHHHHHHCCCC | 48.40 | - | |
| 1286 (in isoform 3) | Ubiquitination | - | 5.84 | 21890473 | |
| 1295 | Ubiquitination | RERLSKEKEGSRGEE HHHHHCCCCCCCCCC | 71.73 | 21906983 | |
| 1295 (in isoform 1) | Ubiquitination | - | 71.73 | 21890473 | |
| 1295 (in isoform 2) | Ubiquitination | - | 71.73 | 21890473 | |
| 1298 | Phosphorylation | LSKEKEGSRGEEDTG HHCCCCCCCCCCCCC | 37.90 | 29255136 | |
| 1304 | Phosphorylation | GSRGEEDTGQEEGGS CCCCCCCCCCCCCCC | 44.00 | 20873877 | |
| 1342 | Phosphorylation | AMEALLNTSTMEQAT HHHHHHCCCCHHHHH | 26.08 | 25627689 | |
| 1343 | Phosphorylation | MEALLNTSTMEQATE HHHHHCCCCHHHHHH | 25.36 | 25627689 | |
| 1344 | Phosphorylation | EALLNTSTMEQATEY HHHHCCCCHHHHHHH | 23.76 | 25627689 | |
| 1351 | Phosphorylation | TMEQATEYLLTHPPP CHHHHHHHHHHCCCC | 11.58 | 27642862 | |
| 1354 | Phosphorylation | QATEYLLTHPPPIMG HHHHHHHHCCCCCCC | 29.73 | - | |
| 1368 | Phosphorylation | GGVVRDLSMSEEDQM CCHHCCCCCCHHHHH | 25.26 | 23927012 | |
| 1369 | Sulfoxidation | GVVRDLSMSEEDQMM CHHCCCCCCHHHHHH | 8.32 | 21406390 | |
| 1370 | Phosphorylation | VVRDLSMSEEDQMMR HHCCCCCCHHHHHHH | 34.16 | 23927012 | |
| 1382 | Phosphorylation | MMRAIAMSLGQDIPM HHHHHHHHCCCCCCC | 21.96 | 23927012 | |
| 1395 | Phosphorylation | PMDQRAESPEEVACR CCHHCCCCHHHHHHC | 36.30 | 19664994 | |
| 1403 | Ubiquitination | PEEVACRKEEEERKA HHHHHHCHHHHHHHH | 70.16 | - | |
| 1413 | Ubiquitination | EERKAREKQEEEEAK HHHHHHHHHHHHHHH | 58.41 | - | |
| 1420 | Ubiquitination | KQEEEEAKCLEKFQD HHHHHHHHHHHHHCC | 42.50 | - | |
| 1424 | Ubiquitination | EEAKCLEKFQDADPL HHHHHHHHHCCCCCC | 35.06 | - | |
| 1443 | Sulfoxidation | LHTFTDTMLPGCFHL HHHCCCCCCCHHHHH | 4.78 | 30846556 | |
| 1466 | Sulfoxidation | YRVCDLIMTAIKRNG HHHHHHHHHHHHHCC | 2.42 | 21406390 | |
| 1470 | Ubiquitination | DLIMTAIKRNGADYR HHHHHHHHHCCCCHH | 37.03 | - | |
| 1470 (in isoform 2) | Ubiquitination | - | 37.03 | - | |
| 1476 | Phosphorylation | IKRNGADYRDMILKQ HHHCCCCHHHHHHHH | 14.15 | - | |
| 1482 | Acetylation | DYRDMILKQVVNQVW CHHHHHHHHHHHHHH | 30.07 | 7923563 | |
| 1505 | Phosphorylation | AALPLTTSDTKTVSE HHCCCCCCCCHHHHH | 37.74 | 25627689 | |
| 1507 | Phosphorylation | LPLTTSDTKTVSEWI CCCCCCCCHHHHHHH | 28.51 | 30576142 | |
| 1509 | Phosphorylation | LTTSDTKTVSEWISQ CCCCCCHHHHHHHHH | 31.21 | - | |
| 1511 | Phosphorylation | TSDTKTVSEWISQMA CCCCHHHHHHHHHHC | 32.23 | - | |
| 1519 | Phosphorylation | EWISQMATLPQASNL HHHHHHCCCHHHHHH | 33.36 | - | |
| 1572 | Ubiquitination | QPCLQAAKEQKEVQT HHHHHHHHHHCCCCC | 64.79 | - | |
| 1599 (in isoform 3) | Ubiquitination | - | 27.61 | 21890473 | |
| 1601 | Ubiquitination | EKTAISSKRRAQMTK HHHHHCHHHHHHHHH | 38.83 | - | |
| 1608 | Ubiquitination | KRRAQMTKYLQSNSN HHHHHHHHHHHHCCC | 38.32 | 21906983 | |
| 1608 (in isoform 1) | Ubiquitination | - | 38.32 | 21890473 | |
| 1608 (in isoform 2) | Ubiquitination | - | 38.32 | 21890473 | |
| 1643 | Ubiquitination | STIDSAWKSGETSVR CCCCCCHHCCCCEEE | 48.58 | - | |
| 1658 | Phosphorylation | FTAGRRRYTVQFTTM EECCCEEEEEEEEEE | 14.95 | - | |
| 1684 (in isoform 3) | Ubiquitination | - | 39.23 | 21890473 | |
| 1693 | Acetylation | PRLNKNSKNSNGQEL CCCCCCCCCCCHHHH | 74.02 | 25953088 | |
| 1693 | Ubiquitination | PRLNKNSKNSNGQEL CCCCCCCCCCCHHHH | 74.02 | 21906983 | |
| 1693 (in isoform 1) | Ubiquitination | - | 74.02 | 21890473 | |
| 1693 (in isoform 2) | Ubiquitination | - | 74.02 | 21890473 | |
| 1693 (in isoform 3) | Ubiquitination | - | 74.02 | 21890473 | |
| 1695 | Phosphorylation | LNKNSKNSNGQELEK CCCCCCCCCHHHHHH | 46.18 | 29083192 | |
| 1699 (in isoform 3) | Ubiquitination | - | 61.36 | 21890473 | |
| 1702 | Ubiquitination | SNGQELEKTLEESKE CCHHHHHHHHHHHHH | 71.66 | 21906983 | |
| 1702 (in isoform 1) | Ubiquitination | - | 71.66 | 21890473 | |
| 1702 (in isoform 2) | Ubiquitination | - | 71.66 | 21890473 | |
| 1703 | Phosphorylation | NGQELEKTLEESKEM CHHHHHHHHHHHHHH | 29.99 | 26074081 | |
| 1707 | Phosphorylation | LEKTLEESKEMDIKR HHHHHHHHHHHHHHC | 25.25 | 26074081 | |
| 1708 | 2-Hydroxyisobutyrylation | EKTLEESKEMDIKRK HHHHHHHHHHHHHCH | 61.41 | - | |
| 1708 | Ubiquitination | EKTLEESKEMDIKRK HHHHHHHHHHHHHCH | 61.41 | 21906983 | |
| 1708 (in isoform 1) | Ubiquitination | - | 61.41 | 21890473 | |
| 1708 (in isoform 2) | Ubiquitination | - | 61.41 | 21890473 | |
| 1709 (in isoform 3) | Ubiquitination | - | 51.90 | 21890473 | |
| 1710 | Sulfoxidation | TLEESKEMDIKRKEN HHHHHHHHHHHCHHC | 8.09 | 21406390 | |
| 1713 | Ubiquitination | ESKEMDIKRKENKGN HHHHHHHHCHHCCCC | 53.83 | - | |
| 1718 | Ubiquitination | DIKRKENKGNDTPLA HHHCHHCCCCCCCCC | 61.25 | 21906983 | |
| 1718 (in isoform 1) | Ubiquitination | - | 61.25 | 21890473 | |
| 1718 (in isoform 2) | Ubiquitination | - | 61.25 | 21890473 | |
| 1722 | Phosphorylation | KENKGNDTPLALEST HHCCCCCCCCCCCCC | 24.97 | 29255136 | |
| 1724 (in isoform 3) | Ubiquitination | - | 10.36 | 21890473 | |
| 1728 | Phosphorylation | DTPLALESTNTEKET CCCCCCCCCCCCCCC | 28.01 | 30108239 | |
| 1729 | Phosphorylation | TPLALESTNTEKETS CCCCCCCCCCCCCCC | 36.46 | 21815630 | |
| 1731 | Phosphorylation | LALESTNTEKETSLE CCCCCCCCCCCCCCC | 48.82 | 30108239 | |
| 1733 | Ubiquitination | LESTNTEKETSLEET CCCCCCCCCCCCCCC | 65.34 | 21906983 | |
| 1733 (in isoform 1) | Ubiquitination | - | 65.34 | 21890473 | |
| 1733 (in isoform 2) | Ubiquitination | - | 65.34 | 21890473 | |
| 1735 | Phosphorylation | STNTEKETSLEETKI CCCCCCCCCCCCCCH | 50.07 | 26657352 | |
| 1736 | Phosphorylation | TNTEKETSLEETKIG CCCCCCCCCCCCCHH | 34.57 | 21815630 | |
| 1740 | Phosphorylation | KETSLEETKIGEILI CCCCCCCCCHHHHHH | 20.70 | 30108239 | |
| 1774 | Phosphorylation | GVPVDPDTLHATLRL CCCCCHHHHHHHHHH | 26.32 | 26091039 | |
| 1778 | Phosphorylation | DPDTLHATLRLCLRL CHHHHHHHHHHHHHH | 11.15 | 26091039 | |
| 1790 (in isoform 3) | Ubiquitination | - | 38.71 | 21890473 | |
| 1799 | Ubiquitination | AMMFAELKSTRMILN HHHHHHHHHCHHHHH | 41.09 | 21906983 | |
| 1799 (in isoform 1) | Ubiquitination | - | 41.09 | 21890473 | |
| 1799 (in isoform 2) | Ubiquitination | - | 41.09 | 21890473 | |
| 1831 (in isoform 3) | Ubiquitination | - | 10.53 | 21890473 | |
| 1840 | Acetylation | TLRHTMEKVVRSAAT HHHHHHHHHHHHHHH | 34.90 | 19608861 | |
| 1840 | Ubiquitination | TLRHTMEKVVRSAAT HHHHHHHHHHHHHHH | 34.90 | 21906983 | |
| 1840 (in isoform 1) | Ubiquitination | - | 34.90 | 21890473 | |
| 1840 (in isoform 2) | Ubiquitination | - | 34.90 | 21890473 | |
| 1844 | Phosphorylation | TMEKVVRSAATSGAG HHHHHHHHHHHCCCC | 15.62 | 25693802 | |
| 1847 | Phosphorylation | KVVRSAATSGAGSTT HHHHHHHHCCCCCCC | 27.66 | 25693802 | |
| 1848 | Phosphorylation | VVRSAATSGAGSTTS HHHHHHHCCCCCCCC | 23.17 | 25693802 | |
| 1852 | Phosphorylation | AATSGAGSTTSGVVS HHHCCCCCCCCCCCC | 28.16 | 25693802 | |
| 1853 | Phosphorylation | ATSGAGSTTSGVVSG HHCCCCCCCCCCCCC | 24.86 | 25693802 | |
| 1854 | Phosphorylation | TSGAGSTTSGVVSGS HCCCCCCCCCCCCCC | 25.77 | 25693802 | |
| 1855 | Phosphorylation | SGAGSTTSGVVSGSL CCCCCCCCCCCCCCC | 29.67 | 22210691 | |
| 1859 | Phosphorylation | STTSGVVSGSLGSRE CCCCCCCCCCCCHHH | 21.91 | - | |
| 1869 | Phosphorylation | LGSREINYILRVLGP CCHHHHHHHHHHHCH | 13.64 | 20068231 | |
| 1901 | Methylation | RIALPAPRGSGTASD EEECCCCCCCCCCCH | 54.75 | 115480035 | |
| 1903 | Phosphorylation | ALPAPRGSGTASDDE ECCCCCCCCCCCHHH | 33.96 | 29255136 | |
| 1905 | Phosphorylation | PAPRGSGTASDDEFE CCCCCCCCCCHHHHH | 25.37 | 29255136 | |
| 1907 | Phosphorylation | PRGSGTASDDEFENL CCCCCCCCHHHHHCC | 45.49 | 19664994 | |
| 1908 (in isoform 3) | Ubiquitination | - | 57.93 | 21890473 | |
| 1917 | Ubiquitination | EFENLRIKGPNAVQL HHHCCEECCCCCEEE | 62.98 | 21906983 | |
| 1917 (in isoform 1) | Ubiquitination | - | 62.98 | 21890473 | |
| 1917 (in isoform 2) | Ubiquitination | - | 62.98 | 21890473 | |
| 1917 (in isoform 3) | Ubiquitination | - | 62.98 | 21890473 | |
| 1922 (in isoform 3) | Ubiquitination | - | 6.01 | 21890473 | |
| 1926 | Ubiquitination | PNAVQLVKTTPLKPS CCCEEEEECCCCCCC | 56.10 | 21906983 | |
| 1926 (in isoform 1) | Ubiquitination | - | 56.10 | 21890473 | |
| 1926 (in isoform 2) | Ubiquitination | - | 56.10 | 21890473 | |
| 1927 | Phosphorylation | NAVQLVKTTPLKPSP CCEEEEECCCCCCCC | 26.60 | 25159151 | |
| 1928 | Phosphorylation | AVQLVKTTPLKPSPL CEEEEECCCCCCCCC | 22.39 | 25159151 | |
| 1931 | Acetylation | LVKTTPLKPSPLPVI EEECCCCCCCCCCCC | 44.65 | 26051181 | |
| 1931 | Ubiquitination | LVKTTPLKPSPLPVI EEECCCCCCCCCCCC | 44.65 | 21906983 | |
| 1931 (in isoform 1) | Ubiquitination | - | 44.65 | 21890473 | |
| 1931 (in isoform 2) | Ubiquitination | - | 44.65 | 21890473 | |
| 1933 | Phosphorylation | KTTPLKPSPLPVIPD ECCCCCCCCCCCCCH | 37.17 | 28450419 | |
| 1941 | Phosphorylation | PLPVIPDTIKEVIYD CCCCCCHHHHHHHHH | 28.70 | 29396449 | |
| 1968 | Ubiquitination | EADKSDPKPGVMTQE HHCCCCCCCCCCHHH | 60.43 | - | |
| 1988 | Phosphorylation | QDMGDDVYQQYRSLT HHHCHHHHHHHHHHH | 9.26 | 28796482 | |
| 1991 | Phosphorylation | GDDVYQQYRSLTRQS CHHHHHHHHHHHCCC | 6.14 | 28796482 | |
| 1993 | Phosphorylation | DVYQQYRSLTRQSSD HHHHHHHHHHCCCCC | 29.20 | 25159151 | |
| 1995 | Phosphorylation | YQQYRSLTRQSSDFD HHHHHHHHCCCCCCC | 28.10 | 26074081 | |
| 1998 | Phosphorylation | YRSLTRQSSDFDTQS HHHHHCCCCCCCCCC | 28.69 | 26074081 | |
| 1999 | Phosphorylation | RSLTRQSSDFDTQSG HHHHCCCCCCCCCCC | 33.68 | 29116813 | |
| 2003 | Phosphorylation | RQSSDFDTQSGFSIN CCCCCCCCCCCCEEC | 25.32 | 29116813 | |
| 2005 | Phosphorylation | SSDFDTQSGFSINSQ CCCCCCCCCCEECCE | 43.85 | 28348404 | |
| 2008 | Phosphorylation | FDTQSGFSINSQVFA CCCCCCCEECCEEEE | 25.12 | 28348404 | |
| 2011 | Phosphorylation | QSGFSINSQVFAADG CCCCEECCEEEECCC | 26.50 | 28348404 | |
| 2020 | Phosphorylation | VFAADGASTETSASG EEECCCCCCCCCCCC | 32.10 | 29449344 | |
| 2021 | Phosphorylation | FAADGASTETSASGT EECCCCCCCCCCCCC | 42.63 | 29449344 | |
| 2034 | Phosphorylation | GTSQGEASTPEESRD CCCCCCCCCCHHCCC | 39.94 | 24275569 | |
| 2035 | Phosphorylation | TSQGEASTPEESRDG CCCCCCCCCHHCCCC | 41.59 | 24275569 | |
| 2046 | Ubiquitination | SRDGKKDKEGDRASE CCCCCCCCCCCCCCH | 72.91 | - | |
| 2052 | Phosphorylation | DKEGDRASEEGKQKG CCCCCCCCHHHHHCC | 36.75 | 25849741 | |
| 2060 | Acetylation | EEGKQKGKGSKPLMP HHHHHCCCCCCCCCC | 68.03 | 19821007 | |
| 2062 | Phosphorylation | GKQKGKGSKPLMPTS HHHCCCCCCCCCCHH | 34.29 | 24719451 | |
| 2068 | Phosphorylation | GSKPLMPTSTILRLL CCCCCCCHHHHHHHH | 25.24 | 20860994 | |
| 2069 | Phosphorylation | SKPLMPTSTILRLLA CCCCCCHHHHHHHHH | 13.95 | 20860994 | |
| 2070 | Phosphorylation | KPLMPTSTILRLLAE CCCCCHHHHHHHHHH | 26.89 | 20860994 | |
| 2157 | Ubiquitination | VALVNEVKAALGRAL HHHHHHHHHHHHHHH | 23.05 | - | |
| 2166 | Sulfoxidation | ALGRALAMAESTEKH HHHHHHHHHHHHHHH | 4.40 | 30846556 | |
| 2172 | 2-Hydroxyisobutyrylation | AMAESTEKHARLQAV HHHHHHHHHHHHHHH | 42.53 | - | |
| 2172 | Ubiquitination | AMAESTEKHARLQAV HHHHHHHHHHHHHHH | 42.53 | - | |
| 2197 | Phosphorylation | CPSTSSFYSSATAKT CCCCHHHCCCCCCCC | 12.03 | - | |
| 2198 | Phosphorylation | PSTSSFYSSATAKTQ CCCHHHCCCCCCCCC | 16.10 | - | |
| 2209 (in isoform 3) | Ubiquitination | - | 4.16 | 21890473 | |
| 2210 (in isoform 3) | Ubiquitination | - | 37.64 | 21890473 | |
| 2218 | Ubiquitination | NIIRLFLKKGLVNDL HHHHHHHHCCCHHHH | 37.14 | 21906983 | |
| 2218 (in isoform 1) | Ubiquitination | - | 37.14 | 21890473 | |
| 2218 (in isoform 2) | Ubiquitination | - | 37.14 | 21890473 | |
| 2219 | Malonylation | IIRLFLKKGLVNDLA HHHHHHHCCCHHHHH | 60.67 | 26320211 | |
| 2219 | Ubiquitination | IIRLFLKKGLVNDLA HHHHHHHCCCHHHHH | 60.67 | - | |
| 2219 (in isoform 1) | Ubiquitination | - | 60.67 | 21890473 | |
| 2219 (in isoform 2) | Ubiquitination | - | 60.67 | 21890473 | |
| 2235 | Phosphorylation | VPHSLDLSSPNMANT CCCCCCCCCCCHHHH | 43.33 | 28348404 | |
| 2236 | Phosphorylation | PHSLDLSSPNMANTV CCCCCCCCCCHHHHH | 27.82 | 28348404 | |
| 2239 (in isoform 3) | Ubiquitination | - | 3.27 | 21890473 | |
| 2248 | Acetylation | NTVNAALKPLETLSR HHHHHHHHHHHHHHH | 42.71 | 23954790 | |
| 2248 | Malonylation | NTVNAALKPLETLSR HHHHHHHHHHHHHHH | 42.71 | 26320211 | |
| 2248 | Ubiquitination | NTVNAALKPLETLSR HHHHHHHHHHHHHHH | 42.71 | 21890473 | |
| 2248 (in isoform 1) | Ubiquitination | - | 42.71 | 21890473 | |
| 2248 (in isoform 2) | Ubiquitination | - | 42.71 | 21890473 | |
| 2258 (in isoform 3) | Ubiquitination | - | 45.75 | 21890473 | |
| 2261 | Phosphorylation | SRIVNQPSSLFGSKS HHHHCCCHHHHCCCC | 29.88 | 30108239 | |
| 2262 | Phosphorylation | RIVNQPSSLFGSKSA HHHCCCHHHHCCCCC | 34.11 | 25693802 | |
| 2266 | Phosphorylation | QPSSLFGSKSASSKN CCHHHHCCCCCCCCC | 18.99 | 23911959 | |
| 2267 | Acetylation | PSSLFGSKSASSKNK CHHHHCCCCCCCCCC | 50.88 | 25953088 | |
| 2267 | Ubiquitination | PSSLFGSKSASSKNK CHHHHCCCCCCCCCC | 50.88 | 21906983 | |
| 2267 (in isoform 1) | Ubiquitination | - | 50.88 | 21890473 | |
| 2267 (in isoform 2) | Ubiquitination | - | 50.88 | 21890473 | |
| 2268 | Phosphorylation | SSLFGSKSASSKNKS HHHHCCCCCCCCCCC | 34.77 | 23312004 | |
| 2275 | Phosphorylation | SASSKNKSEQDAQGA CCCCCCCCHHHHCCC | 50.30 | 28787133 | |
| 2287 | Phosphorylation | QGASQDSSSNQQDPG CCCCCCCCCCCCCCC | 41.41 | 28787133 | |
| 2339 | Phosphorylation | GQPEVLSSQEMQVEN CCCHHCCCCHHHHHH | 26.46 | 17478428 | |
| 2362 | Phosphorylation | LLERDGGSGNSTIIV HHHHCCCCCCCEEEE | 40.09 | 19664994 | |
| 2365 | Phosphorylation | RDGGSGNSTIIVSRS HCCCCCCCEEEEECC | 25.22 | 29255136 | |
| 2366 | Phosphorylation | DGGSGNSTIIVSRSG CCCCCCCEEEEECCC | 20.79 | 29255136 | |
| 2370 | Phosphorylation | GNSTIIVSRSGEDES CCCEEEEECCCCCCC | 15.43 | 29255136 | |
| 2372 | Phosphorylation | STIIVSRSGEDESQE CEEEEECCCCCCCHH | 38.74 | 30266825 | |
| 2377 | Phosphorylation | SRSGEDESQEDVLMD ECCCCCCCHHHHCCC | 51.71 | 17525332 | |
| 2388 | Phosphorylation | VLMDEAPSNLSQAST HCCCCCCCCHHHHHH | 58.41 | 23663014 | |
| 2391 | Phosphorylation | DEAPSNLSQASTLQA CCCCCCHHHHHHHHC | 28.13 | 30278072 | |
| 2394 | Phosphorylation | PSNLSQASTLQANRE CCCHHHHHHHHCCCH | 23.24 | 23663014 | |
| 2395 | Phosphorylation | SNLSQASTLQANRED CCHHHHHHHHCCCHH | 26.38 | 23663014 | |
| 2471 | Phosphorylation | EMELDEDYPDMNASP EEECCCCCCCCCCCC | 10.09 | - | |
| 2477 | Phosphorylation | DYPDMNASPLVRFER CCCCCCCCCCEEEEC | 17.48 | 26074081 | |
| 2500 | Phosphorylation | IEFDNMFSSATDIPP EEECCCCCCCCCCCC | 14.32 | 26074081 | |
| 2508 | Phosphorylation | SATDIPPSPGNIPTT CCCCCCCCCCCCCCC | 39.83 | 26074081 | |
| 2514 | Phosphorylation | PSPGNIPTTHPLMVR CCCCCCCCCCCEEEE | 33.66 | 26074081 | |
| 2515 | Phosphorylation | SPGNIPTTHPLMVRH CCCCCCCCCCEEEEE | 19.01 | 26074081 | |
| 2526 | Phosphorylation | MVRHADHSSLTLGSG EEEECCCCCEECCCC | 27.82 | 21712546 | |
| 2527 | Phosphorylation | VRHADHSSLTLGSGS EEECCCCCEECCCCC | 23.19 | 21712546 | |
| 2529 | Phosphorylation | HADHSSLTLGSGSST ECCCCCEECCCCCCH | 30.90 | 25867546 | |
| 2532 | Phosphorylation | HSSLTLGSGSSTTRL CCCEECCCCCCHHHC | 38.32 | 26055452 | |
| 2534 | Phosphorylation | SLTLGSGSSTTRLTQ CEECCCCCCHHHCCC | 26.63 | 25867546 | |
| 2535 | Phosphorylation | LTLGSGSSTTRLTQG EECCCCCCHHHCCCC | 37.01 | 25867546 | |
| 2536 | Phosphorylation | TLGSGSSTTRLTQGI ECCCCCCHHHCCCCC | 20.03 | 25867546 | |
| 2537 | Phosphorylation | LGSGSSTTRLTQGIG CCCCCCHHHCCCCCC | 26.15 | 25867546 | |
| 2540 | Phosphorylation | GSSTTRLTQGIGRSQ CCCHHHCCCCCCCCH | 22.81 | 23090842 | |
| 2545 | Methylation | RLTQGIGRSQRTLRQ HCCCCCCCCHHHHHH | 27.91 | 24381559 | |
| 2546 | Phosphorylation | LTQGIGRSQRTLRQL CCCCCCCCHHHHHHH | 20.85 | 23090842 | |
| 2554 | Phosphorylation | QRTLRQLTANTGHTI HHHHHHHHCCCCCEE | 14.99 | 20873877 | |
| 2557 | Phosphorylation | LRQLTANTGHTIHVH HHHHHCCCCCEEEEE | 28.07 | 20873877 | |
| 2560 | Phosphorylation | LTANTGHTIHVHYPG HHCCCCCEEEEECCC | 17.70 | 28152594 | |
| 2565 | Phosphorylation | GHTIHVHYPGNRQPN CCEEEEECCCCCCCC | 16.25 | 28152594 | |
| 2584 | Phosphorylation | LQRLLGPSAAADILQ HHHHHCHHHHHHHHH | 28.83 | 28102081 | |
| 2593 | Phosphorylation | AADILQLSSSLPLQS HHHHHHHHCCCCCCC | 12.62 | 26846344 | |
| 2594 | Phosphorylation | ADILQLSSSLPLQSR HHHHHHHCCCCCCCC | 44.48 | 26846344 | |
| 2595 | Phosphorylation | DILQLSSSLPLQSRG HHHHHHCCCCCCCCC | 30.54 | 26846344 | |
| 2600 | Phosphorylation | SSSLPLQSRGRARLL HCCCCCCCCCCEEEE | 44.37 | 21712546 | |
| 2619 | Phosphorylation | DVHIIARSDDELLDD CEEEEECCCCHHHHH | 40.15 | 22167270 | |
| 2632 | Phosphorylation | DDFFHDQSTATSQAG HHHCCCCCCCCCCCC | 26.52 | 23663014 | |
| 2633 | Phosphorylation | DFFHDQSTATSQAGT HHCCCCCCCCCCCCC | 28.46 | 23663014 | |
| 2635 | Phosphorylation | FHDQSTATSQAGTLS CCCCCCCCCCCCCCH | 22.81 | 23663014 | |
| 2636 | Phosphorylation | HDQSTATSQAGTLSS CCCCCCCCCCCCCHH | 18.64 | 23663014 | |
| 2640 | Phosphorylation | TATSQAGTLSSIPTA CCCCCCCCCHHHCHH | 26.87 | 23663014 | |
| 2642 | Phosphorylation | TSQAGTLSSIPTALT CCCCCCCHHHCHHHH | 26.51 | 27080861 | |
| 2643 | Phosphorylation | SQAGTLSSIPTALTR CCCCCCHHHCHHHHH | 35.38 | 27080861 | |
| 2656 | Ubiquitination | TRWTEECKVLDAESM HHCCCCCEECCCCHH | 49.46 | - | |
| 2662 | Phosphorylation | CKVLDAESMHDCVSV CEECCCCHHCCCEEE | 24.12 | 26074081 | |
| 2668 | Phosphorylation | ESMHDCVSVVKVSIV CHHCCCEEEEEHHHH | 27.76 | 26074081 | |
| 2671 | Ubiquitination | HDCVSVVKVSIVNHL CCCEEEEEHHHHHHH | 28.27 | - | |
| 2673 | Phosphorylation | CVSVVKVSIVNHLEF CEEEEEHHHHHHHHH | 18.33 | 26074081 | |
| 2682 | Methylation | VNHLEFLRDEELEER HHHHHHHCHHHHHHH | 55.40 | 115480043 | |
| 2686 (in isoform 3) | Ubiquitination | - | 8.56 | 21890473 | |
| 2694 (in isoform 3) | Ubiquitination | - | 41.98 | 21890473 | |
| 2695 | Ubiquitination | ERREKRRKQLAEEET HHHHHHHHHHHHHHH | 54.41 | 21906983 | |
| 2695 (in isoform 1) | Ubiquitination | - | 54.41 | 21890473 | |
| 2695 (in isoform 2) | Ubiquitination | - | 54.41 | 21890473 | |
| 2703 | Ubiquitination | QLAEEETKITDKGKE HHHHHHHHCCCCCHH | 47.06 | 21906983 | |
| 2703 (in isoform 1) | Ubiquitination | - | 47.06 | 21890473 | |
| 2703 (in isoform 2) | Ubiquitination | - | 47.06 | 21890473 | |
| 2705 | Phosphorylation | AEEETKITDKGKEDK HHHHHHCCCCCHHCC | 32.96 | - | |
| 2709 | Ubiquitination | TKITDKGKEDKENRD HHCCCCCHHCCCCCC | 69.36 | - | |
| 2712 | Ubiquitination | TDKGKEDKENRDQSA CCCCHHCCCCCCCHH | 58.96 | - | |
| 2718 | Phosphorylation | DKENRDQSAQCTASK CCCCCCCHHCCCCCC | 25.29 | 27251275 | |
| 2725 | Ubiquitination | SAQCTASKSNDSTEQ HHCCCCCCCCCCCCC | 51.30 | - | |
| 2726 | Phosphorylation | AQCTASKSNDSTEQN HCCCCCCCCCCCCCC | 43.29 | 30576142 | |
| 2729 | Phosphorylation | TASKSNDSTEQNLSD CCCCCCCCCCCCCCC | 37.79 | 30576142 | |
| 2730 | Phosphorylation | ASKSNDSTEQNLSDG CCCCCCCCCCCCCCC | 44.44 | 30278072 | |
| 2735 | Phosphorylation | DSTEQNLSDGTPMPD CCCCCCCCCCCCCCC | 41.36 | 30576142 | |
| 2738 | Phosphorylation | EQNLSDGTPMPDSYP CCCCCCCCCCCCCCC | 22.77 | 30576142 | |
| 2743 | Phosphorylation | DGTPMPDSYPTTPSS CCCCCCCCCCCCCCC | 27.43 | 30278072 | |
| 2744 | Phosphorylation | GTPMPDSYPTTPSST CCCCCCCCCCCCCCC | 16.39 | 30576142 | |
| 2746 | Phosphorylation | PMPDSYPTTPSSTDA CCCCCCCCCCCCCCC | 43.01 | 30278072 | |
| 2747 | Phosphorylation | MPDSYPTTPSSTDAA CCCCCCCCCCCCCCC | 19.37 | 30278072 | |
| 2749 | Phosphorylation | DSYPTTPSSTDAATS CCCCCCCCCCCCCCC | 43.72 | 30576142 | |
| 2750 | Phosphorylation | SYPTTPSSTDAATSE CCCCCCCCCCCCCCC | 31.35 | 30576142 | |
| 2751 | Phosphorylation | YPTTPSSTDAATSES CCCCCCCCCCCCCCC | 33.71 | 30278072 | |
| 2755 | Phosphorylation | PSSTDAATSESKETL CCCCCCCCCCCHHHH | 34.45 | 22199227 | |
| 2756 | Phosphorylation | SSTDAATSESKETLG CCCCCCCCCCHHHHH | 34.84 | 22199227 | |
| 2758 | Phosphorylation | TDAATSESKETLGTL CCCCCCCCHHHHHHC | 35.24 | 22199227 | |
| 2821 | Phosphorylation | PSGEAETTQMELSPA CCCCCCCCEEECCCC | 19.88 | 27732954 | |
| 2826 | Phosphorylation | ETTQMELSPAPTITS CCCEEECCCCCCCCC | 13.00 | 26074081 | |
| 2830 | Phosphorylation | MELSPAPTITSLSPE EECCCCCCCCCCCHH | 38.71 | 26074081 | |
| 2832 | Phosphorylation | LSPAPTITSLSPERA CCCCCCCCCCCHHHH | 26.54 | 26074081 | |
| 2833 | Phosphorylation | SPAPTITSLSPERAE CCCCCCCCCCHHHHC | 24.01 | 25850435 | |
| 2835 | Phosphorylation | APTITSLSPERAEDS CCCCCCCCHHHHCCC | 25.20 | 25850435 | |
| 2842 | Phosphorylation | SPERAEDSDALTAVS CHHHHCCCCHHHHHH | 19.11 | 26074081 | |
| 2846 | Phosphorylation | AEDSDALTAVSSQLE HCCCCHHHHHHHHHC | 27.08 | 26074081 | |
| 2849 | Phosphorylation | SDALTAVSSQLEGSP CCHHHHHHHHHCCCC | 15.20 | 26074081 | |
| 2850 | Phosphorylation | DALTAVSSQLEGSPM CHHHHHHHHHCCCCC | 31.99 | 26074081 | |
| 2855 | Phosphorylation | VSSQLEGSPMDTSSL HHHHHCCCCCCHHHH | 14.00 | 30278072 | |
| 2859 | Phosphorylation | LEGSPMDTSSLASCT HCCCCCCHHHHHHCC | 17.60 | 26074081 | |
| 2860 | Phosphorylation | EGSPMDTSSLASCTL CCCCCCHHHHHHCCH | 21.06 | 30278072 | |
| 2861 | Phosphorylation | GSPMDTSSLASCTLE CCCCCHHHHHHCCHH | 30.01 | 26074081 | |
| 2864 | Phosphorylation | MDTSSLASCTLEEAV CCHHHHHHCCHHHHH | 16.96 | 28348404 | |
| 2866 | Phosphorylation | TSSLASCTLEEAVGD HHHHHHCCHHHHHCC | 34.41 | 29802988 | |
| 2887 | Phosphorylation | SEQPRAGSSTPGDAP CCCCCCCCCCCCCCC | 30.01 | 29255136 | |
| 2888 | Phosphorylation | EQPRAGSSTPGDAPP CCCCCCCCCCCCCCC | 37.39 | 29255136 | |
| 2889 | Phosphorylation | QPRAGSSTPGDAPPA CCCCCCCCCCCCCCC | 32.75 | 29255136 | |
| 2904 | Phosphorylation | VAEVQGRSDGSGESA EEEECCCCCCCCCCC | 53.82 | 27251789 | |
| 2907 | Phosphorylation | VQGRSDGSGESAQPP ECCCCCCCCCCCCCC | 44.36 | 20873877 | |
| 2910 | Phosphorylation | RSDGSGESAQPPEDS CCCCCCCCCCCCCCC | 35.41 | 30108239 | |
| 2917 | Phosphorylation | SAQPPEDSSPPASSE CCCCCCCCCCCCCCC | 42.98 | 30278072 | |
| 2918 | Phosphorylation | AQPPEDSSPPASSES CCCCCCCCCCCCCCC | 47.42 | 30278072 | |
| 2922 | O-linked_Glycosylation | EDSSPPASSESSSTR CCCCCCCCCCCCCCH | 40.17 | 30059200 | |
| 2922 | Phosphorylation | EDSSPPASSESSSTR CCCCCCCCCCCCCCH | 40.17 | 28176443 | |
| 2923 | Phosphorylation | DSSPPASSESSSTRD CCCCCCCCCCCCCHH | 43.53 | 28176443 | |
| 2925 | Phosphorylation | SPPASSESSSTRDSA CCCCCCCCCCCHHHC | 31.38 | 28176443 | |
| 2926 | Phosphorylation | PPASSESSSTRDSAV CCCCCCCCCCHHHCE | 31.51 | 30108239 | |
| 2927 | Phosphorylation | PASSESSSTRDSAVA CCCCCCCCCHHHCEE | 36.42 | 28176443 | |
| 2928 | Phosphorylation | ASSESSSTRDSAVAI CCCCCCCCHHHCEEE | 40.21 | 28176443 | |
| 2931 | Phosphorylation | ESSSTRDSAVAISGA CCCCCHHHCEEECCC | 22.73 | 21815630 | |
| 2936 | O-linked_Glycosylation | RDSAVAISGADSRGI HHHCEEECCCCCCCC | 20.42 | 30059200 | |
| 2936 | Phosphorylation | RDSAVAISGADSRGI HHHCEEECCCCCCCC | 20.42 | 29255136 | |
| 2940 | Phosphorylation | VAISGADSRGILEEP EEECCCCCCCCCCCC | 31.69 | 25849741 | |
| 2950 | Phosphorylation | ILEEPLPSTSSEEED CCCCCCCCCCCCCCC | 48.91 | 20873877 | |
| 2951 | Phosphorylation | LEEPLPSTSSEEEDP CCCCCCCCCCCCCCC | 34.04 | 20873877 | |
| 2952 | Phosphorylation | EEPLPSTSSEEEDPL CCCCCCCCCCCCCCC | 39.84 | 28464451 | |
| 2953 | Phosphorylation | EPLPSTSSEEEDPLA CCCCCCCCCCCCCCC | 49.46 | 26657352 | |
| 2963 | Phosphorylation | EDPLAGISLPEGVDP CCCCCCCCCCCCCCH | 36.63 | 24144214 | |
| 2971 | Phosphorylation | LPEGVDPSFLAALPD CCCCCCHHHHHHCCH | 28.55 | 24144214 | |
| 2995 | Phosphorylation | QLGIRPPTRTAPSTN CCCCCCCCCCCCCCC | 43.25 | 27690223 | |
| 2997 | Phosphorylation | GIRPPTRTAPSTNSS CCCCCCCCCCCCCCC | 45.45 | 24173317 | |
| 3000 | Phosphorylation | PPTRTAPSTNSSAPA CCCCCCCCCCCCCCC | 37.44 | 24173317 | |
| 3001 | Phosphorylation | PTRTAPSTNSSAPAV CCCCCCCCCCCCCCC | 37.75 | 24173317 | |
| 3004 | Phosphorylation | TAPSTNSSAPAVVGN CCCCCCCCCCCCCCC | 40.10 | 24173317 | |
| 3015 | Phosphorylation | VVGNPGVTEVSPEFL CCCCCCCEECCHHHH | 36.26 | 28348404 | |
| 3018 | Phosphorylation | NPGVTEVSPEFLAAL CCCCEECCHHHHHCC | 16.69 | 28348404 | |
| 3051 | Phosphorylation | RELAQNASSDTPMDP HHHHHHCCCCCCCCH | 35.97 | 28348404 | |
| 3052 | Phosphorylation | ELAQNASSDTPMDPV HHHHHCCCCCCCCHH | 42.99 | 28348404 | |
| 3054 | Phosphorylation | AQNASSDTPMDPVTF HHHCCCCCCCCHHHH | 23.59 | 28348404 | |
| 3056 | Sulfoxidation | NASSDTPMDPVTFIQ HCCCCCCCCHHHHHH | 11.18 | 30846556 | |
| 3060 | Phosphorylation | DTPMDPVTFIQTLPS CCCCCHHHHHHCCCH | 22.02 | 27251275 | |
| 3064 | Phosphorylation | DPVTFIQTLPSDLRR CHHHHHHCCCHHHHH | 35.50 | 27251275 | |
| 3067 | Phosphorylation | TFIQTLPSDLRRSVL HHHHCCCHHHHHHHH | 53.00 | 27251275 | |
| 3072 | Phosphorylation | LPSDLRRSVLEDMED CCHHHHHHHHHHCCC | 25.31 | 22199227 | |
| 3080 | Phosphorylation | VLEDMEDSVLAVMPP HHHHCCCCEEEECCH | 13.01 | 22115753 | |
| 3116 | Phosphorylation | HERLFGHSSTSALSA HHHHHCCCHHHHHHH | 35.37 | 22617229 | |
| 3117 | O-linked_Glycosylation | ERLFGHSSTSALSAI HHHHCCCHHHHHHHH | 22.25 | 30059200 | |
| 3117 | Phosphorylation | ERLFGHSSTSALSAI HHHHCCCHHHHHHHH | 22.25 | 21712546 | |
| 3118 | O-linked_Glycosylation | RLFGHSSTSALSAIL HHHCCCHHHHHHHHH | 22.49 | 30059200 | |
| 3118 | Phosphorylation | RLFGHSSTSALSAIL HHHCCCHHHHHHHHH | 22.49 | 21712546 | |
| 3119 | Phosphorylation | LFGHSSTSALSAILR HHCCCHHHHHHHHHC | 29.21 | 21712546 | |
| 3122 | O-linked_Glycosylation | HSSTSALSAILRSPA CCHHHHHHHHHCCHH | 16.99 | 30059200 | |
| 3122 | Phosphorylation | HSSTSALSAILRSPA CCHHHHHHHHHCCHH | 16.99 | 22617229 | |
| 3127 | Phosphorylation | ALSAILRSPAFTSRL HHHHHHCCHHHHHHC | 19.69 | 30266825 | |
| 3131 | Phosphorylation | ILRSPAFTSRLSGNR HHCCHHHHHHCCCCC | 18.29 | 30266825 | |
| 3132 | Phosphorylation | LRSPAFTSRLSGNRG HCCHHHHHHCCCCCC | 25.44 | 21712546 | |
| 3135 | Phosphorylation | PAFTSRLSGNRGVQY HHHHHHCCCCCCCCE | 32.67 | 26055452 | |
| 3138 | Methylation | TSRLSGNRGVQYTRL HHHCCCCCCCCEEEE | 50.62 | 82797073 | |
| 3142 | Phosphorylation | SGNRGVQYTRLAVQR CCCCCCCEEEEEEEC | 7.45 | 23917254 | |
| 3143 | Phosphorylation | GNRGVQYTRLAVQRG CCCCCCEEEEEEECC | 11.34 | - | |
| 3149 | Methylation | YTRLAVQRGGTFQMG EEEEEEECCCCEECC | 38.62 | 30760053 | |
| 3152 | Phosphorylation | LAVQRGGTFQMGGSS EEEECCCCEECCCCC | 17.33 | 23401153 | |
| 3158 | Phosphorylation | GTFQMGGSSSHNRPS CCEECCCCCCCCCCC | 23.96 | 20873877 | |
| 3159 | O-linked_Glycosylation | TFQMGGSSSHNRPSG CEECCCCCCCCCCCC | 38.60 | 30059200 | |
| 3159 | Phosphorylation | TFQMGGSSSHNRPSG CEECCCCCCCCCCCC | 38.60 | 23401153 | |
| 3160 | O-linked_Glycosylation | FQMGGSSSHNRPSGS EECCCCCCCCCCCCC | 26.86 | 30059200 | |
| 3160 | Phosphorylation | FQMGGSSSHNRPSGS EECCCCCCCCCCCCC | 26.86 | 20873877 | |
| 3165 | Phosphorylation | SSSHNRPSGSNVDTL CCCCCCCCCCCHHHH | 52.17 | 20873877 | |
| 3167 | Phosphorylation | SHNRPSGSNVDTLLR CCCCCCCCCHHHHHH | 37.71 | 20873877 | |
| 3171 | Phosphorylation | PSGSNVDTLLRLRGR CCCCCHHHHHHHHCH | 24.33 | 30576142 | |
| 3214 | Phosphorylation | RVLRNLCYHAQTRHW HHHHHHHHHHHHHHH | 11.89 | 25839225 | |
| 3225 | Phosphorylation | TRHWVIRSLLSILQR HHHHHHHHHHHHHHH | 23.65 | 21712546 | |
| 3228 (in isoform 2) | Ubiquitination | - | 26.92 | 21890473 | |
| 3235 (in isoform 3) | Ubiquitination | - | 49.86 | 21890473 | |
| 3242 | Phosphorylation | ESELCIETPKLTTSE CCCCEEECCCCCCCH | 13.05 | 21815630 | |
| 3244 | Ubiquitination | ELCIETPKLTTSEEK CCEEECCCCCCCHHH | 66.92 | 21906983 | |
| 3244 (in isoform 1) | Ubiquitination | - | 66.92 | 21890473 | |
| 3246 | Phosphorylation | CIETPKLTTSEEKGK EEECCCCCCCHHHCC | 34.11 | - | |
| 3247 | Phosphorylation | IETPKLTTSEEKGKK EECCCCCCCHHHCCC | 44.57 | - | |
| 3248 | Phosphorylation | ETPKLTTSEEKGKKS ECCCCCCCHHHCCCC | 38.22 | 21815630 | |
| 3251 | Ubiquitination | KLTTSEEKGKKSSKS CCCCCHHHCCCCCCC | 72.48 | - | |
| 3257 | Ubiquitination | EKGKKSSKSCGSSSH HHCCCCCCCCCCCCC | 57.78 | - | |
| 3258 | Phosphorylation | KGKKSSKSCGSSSHE HCCCCCCCCCCCCCC | 26.17 | 27251275 | |
| 3261 | Phosphorylation | KSSKSCGSSSHENRP CCCCCCCCCCCCCCC | 32.75 | 25159151 | |
| 3262 | Phosphorylation | SSKSCGSSSHENRPL CCCCCCCCCCCCCCH | 22.46 | 25159151 | |
| 3263 | Phosphorylation | SKSCGSSSHENRPLD CCCCCCCCCCCCCHH | 36.20 | 25159151 | |
| 3274 | Ubiquitination | RPLDLLHKMESKSSN CCHHHHHHHCCCCCC | 44.31 | - | |
| 3279 | Phosphorylation | LHKMESKSSNQLSWL HHHHCCCCCCCCEEE | 43.74 | 27251275 | |
| 3280 | Phosphorylation | HKMESKSSNQLSWLS HHHCCCCCCCCEEEH | 32.12 | 27251275 | |
| 3312 | Phosphorylation | RSGGRKHTEKHASGG CCCCCCCCCCCCCCC | 50.17 | 21601212 | |
| 3314 | Ubiquitination | GGRKHTEKHASGGST CCCCCCCCCCCCCCE | 45.70 | - | |
| 3317 | Phosphorylation | KHTEKHASGGSTVHI CCCCCCCCCCCEEEE | 43.32 | 29214152 | |
| 3320 | Phosphorylation | EKHASGGSTVHIHPQ CCCCCCCCEEEECCC | 30.68 | 25159151 | |
| 3321 | Phosphorylation | KHASGGSTVHIHPQA CCCCCCCEEEECCCC | 21.27 | 25159151 | |
| 3329 (in isoform 2) | Ubiquitination | - | 7.68 | 21890473 | |
| 3336 (in isoform 3) | Ubiquitination | - | 2.40 | 21890473 | |
| 3345 | Ubiquitination | DTLIQLAKVFPSHFT HHHHHHHHHCHHHHC | 53.66 | 21906983 | |
| 3345 (in isoform 1) | Ubiquitination | - | 53.66 | 21890473 | |
| 3357 | Ubiquitination | HFTQQRTKETNCESD HHCCHHHCCCCCCCH | 65.81 | - | |
| 3359 | Phosphorylation | TQQRTKETNCESDRE CCHHHCCCCCCCHHH | 46.88 | 28102081 | |
| 3363 | Phosphorylation | TKETNCESDRERGNK HCCCCCCCHHHCCCC | 44.14 | 28102081 | |
| 3370 | Ubiquitination | SDRERGNKACSPCSS CHHHCCCCCCCCCCC | 54.30 | - | |
| 3373 | Phosphorylation | ERGNKACSPCSSQSS HCCCCCCCCCCCCCC | 33.53 | 23401153 | |
| 3376 | Phosphorylation | NKACSPCSSQSSSSG CCCCCCCCCCCCCCC | 34.49 | 30278072 | |
| 3377 | Phosphorylation | KACSPCSSQSSSSGI CCCCCCCCCCCCCCC | 40.58 | 19413330 | |
| 3379 | Phosphorylation | CSPCSSQSSSSGICT CCCCCCCCCCCCCCH | 33.85 | 23898821 | |
| 3380 | Phosphorylation | SPCSSQSSSSGICTD CCCCCCCCCCCCCHH | 22.38 | 23898821 | |
| 3381 | Phosphorylation | PCSSQSSSSGICTDF CCCCCCCCCCCCHHH | 37.52 | 23898821 | |
| 3382 | Phosphorylation | CSSQSSSSGICTDFW CCCCCCCCCCCHHHH | 33.84 | 23898821 | |
| 3386 | Phosphorylation | SSSSGICTDFWDLLV CCCCCCCHHHHHHHH | 32.10 | 23663014 | |
| 3393 (in isoform 2) | Ubiquitination | - | 8.22 | - | |
| 3409 | Ubiquitination | RKGKNSVKSVPVSAG CCCCCCCEECCCCCC | 45.62 | - | |
| 3421 | Phosphorylation | SAGGEGETSPYSLEA CCCCCCCCCCCCCCC | 45.95 | 24719451 | |
| 3422 | Phosphorylation | AGGEGETSPYSLEAS CCCCCCCCCCCCCCC | 19.96 | 28348404 | |
| 3424 | Phosphorylation | GEGETSPYSLEASPL CCCCCCCCCCCCCHH | 26.17 | - | |
| 3436 (in isoform 2) | Ubiquitination | - | 36.51 | 21890473 | |
| 3443 (in isoform 3) | Ubiquitination | - | 3.40 | 21890473 | |
| 3446 | Phosphorylation | SHPVIRRSSLLTEKL CCHHHHCHHHHHHHH | 18.58 | 30108239 | |
| 3447 | Phosphorylation | HPVIRRSSLLTEKLL CHHHHCHHHHHHHHH | 26.11 | 27273156 | |
| 3450 | Phosphorylation | IRRSSLLTEKLLRLL HHCHHHHHHHHHHHH | 36.05 | 28102081 | |
| 3452 | 2-Hydroxyisobutyrylation | RSSLLTEKLLRLLSL CHHHHHHHHHHHHHH | 47.81 | - | |
| 3452 | Ubiquitination | RSSLLTEKLLRLLSL CHHHHHHHHHHHHHH | 47.81 | 21906983 | |
| 3452 (in isoform 1) | Ubiquitination | - | 47.81 | 21890473 | |
| 3542 (in isoform 2) | Ubiquitination | - | 23.80 | 21890473 | |
| 3549 (in isoform 3) | Ubiquitination | - | 34.06 | 21890473 | |
| 3553 | Phosphorylation | ISPTTKGSKSPAKVS ECCCCCCCCCCCCCC | 31.36 | 23927012 | |
| 3555 | Phosphorylation | PTTKGSKSPAKVSDG CCCCCCCCCCCCCCC | 31.61 | 23401153 | |
| 3558 | Ubiquitination | KGSKSPAKVSDGGSS CCCCCCCCCCCCCCC | 45.73 | 21906983 | |
| 3558 (in isoform 1) | Ubiquitination | - | 45.73 | 21890473 | |
| 3560 | Phosphorylation | SKSPAKVSDGGSSST CCCCCCCCCCCCCCC | 29.81 | 23927012 | |
| 3564 | Phosphorylation | AKVSDGGSSSTDFKM CCCCCCCCCCCCCEE | 27.01 | 23927012 | |
| 3565 | Phosphorylation | KVSDGGSSSTDFKMV CCCCCCCCCCCCEEC | 40.30 | 23927012 | |
| 3566 | Phosphorylation | VSDGGSSSTDFKMVS CCCCCCCCCCCEECC | 33.42 | 21815630 | |
| 3567 | Phosphorylation | SDGGSSSTDFKMVSS CCCCCCCCCCEECCC | 47.61 | 23927012 | |
| 3605 (in isoform 2) | Ubiquitination | - | 2.24 | 21890473 | |
| 3612 (in isoform 3) | Ubiquitination | - | 42.66 | 21890473 | |
| 3620 (in isoform 2) | Ubiquitination | - | 3.34 | 21890473 | |
| 3621 | Ubiquitination | GTRDTVLKLLLNGAR CCHHHHHHHHHHHHH | 32.52 | 21906983 | |
| 3621 (in isoform 1) | Ubiquitination | - | 32.52 | 21890473 | |
| 3627 (in isoform 3) | Ubiquitination | - | 8.47 | 21890473 | |
| 3636 | Ubiquitination | HLGYTLCKQIGTLLA HHHHHHHHHHHHHHH | 48.33 | 21906983 | |
| 3636 (in isoform 1) | Ubiquitination | - | 48.33 | 21890473 | |
| 3659 (in isoform 2) | Ubiquitination | - | 40.48 | 21890473 | |
| 3660 | Phosphorylation | QRRAQCETLSPDGLP HHHHHCCCCCCCCCC | 39.91 | 30266825 | |
| 3662 | Phosphorylation | RAQCETLSPDGLPEE HHHCCCCCCCCCCCC | 28.50 | 23927012 | |
| 3673 | Phosphorylation | LPEEQPQTTKLKGKM CCCCCCCCCCCCCHH | 32.36 | 30266825 | |
| 3674 | Phosphorylation | PEEQPQTTKLKGKMQ CCCCCCCCCCCCHHH | 29.18 | 30266825 | |
| 3675 | Ubiquitination | EEQPQTTKLKGKMQS CCCCCCCCCCCHHHH | 52.14 | 21906983 | |
| 3677 | Ubiquitination | QPQTTKLKGKMQSRF CCCCCCCCCHHHHCC | 59.03 | - | |
| 3681 (in isoform 2) | Ubiquitination | - | 34.63 | 21890473 | |
| 3682 | Phosphorylation | KLKGKMQSRFDMAEN CCCCHHHHCCCCCCC | 31.27 | 28348404 | |
| 3686 | Sulfoxidation | KMQSRFDMAENVVIV HHHHCCCCCCCEEEE | 4.66 | 21406390 | |
| 3688 (in isoform 3) | Ubiquitination | - | 43.87 | 21890473 | |
| 3695 | Phosphorylation | ENVVIVASQKRPLGG CCEEEEEECCCCCCC | 25.91 | 17478428 | |
| 3697 | Ubiquitination | VVIVASQKRPLGGRE EEEEEECCCCCCCCC | 54.19 | 21906983 | |
| 3697 (in isoform 1) | Ubiquitination | - | 54.19 | 21890473 | |
| 3716 | Ubiquitination | SMSMLTSKTSTQKFF CHHHHCCCCHHHHHH | 41.06 | - | |
| 3721 | Ubiquitination | TSKTSTQKFFLRVLQ CCCCHHHHHHHHHHH | 37.87 | - | |
| 3747 | Phosphorylation | ANKKAKQTGRLGSSG HHHHHHHHCCCCCCC | 24.46 | - | |
| 3752 | Phosphorylation | KQTGRLGSSGLGSAS HHHCCCCCCCCCCHH | 26.31 | 29255136 | |
| 3753 | Phosphorylation | QTGRLGSSGLGSASS HHCCCCCCCCCCHHH | 35.92 | 29255136 | |
| 3757 | Phosphorylation | LGSSGLGSASSIQAA CCCCCCCCHHHHHHH | 29.98 | 29255136 | |
| 3759 | Phosphorylation | SSGLGSASSIQAAVR CCCCCCHHHHHHHHH | 29.66 | 30266825 | |
| 3760 | Phosphorylation | SGLGSASSIQAAVRQ CCCCCHHHHHHHHHH | 20.59 | 28176443 | |
| 3778 | Sulfoxidation | EADAIIQMVREGQRA HHHHHHHHHHHHHHH | 1.85 | 30846556 | |
| 3793 | Phosphorylation | RRQQQAATSESSQSE HHHHHHHCCCCHHHH | 35.72 | 28450419 | |
| 3794 | O-linked_Glycosylation | RQQQAATSESSQSEA HHHHHHCCCCHHHHH | 30.65 | 30059200 | |
| 3794 | Phosphorylation | RQQQAATSESSQSEA HHHHHHCCCCHHHHH | 30.65 | 23403867 | |
| 3796 | Phosphorylation | QQAATSESSQSEASV HHHHCCCCHHHHHHH | 33.18 | 25849741 | |
| 3797 | Phosphorylation | QAATSESSQSEASVR HHHCCCCHHHHHHHC | 33.40 | 17525332 | |
| 3799 | Phosphorylation | ATSESSQSEASVRRE HCCCCHHHHHHHCCC | 36.76 | 29523821 | |
| 3802 | Phosphorylation | ESSQSEASVRREESP CCHHHHHHHCCCCCC | 16.47 | 26074081 | |
| 3808 | Phosphorylation | ASVRREESPMDVDQP HHHCCCCCCCCCCCC | 22.29 | 29255136 | |
| 3816 | Phosphorylation | PMDVDQPSPSAQDTQ CCCCCCCCCCCHHHH | 26.34 | 19664994 | |
| 3818 | Phosphorylation | DVDQPSPSAQDTQSI CCCCCCCCCHHHHHH | 42.79 | 29255136 | |
| 3819 (in isoform 2) | Ubiquitination | - | 18.04 | 21890473 | |
| 3822 | Phosphorylation | PSPSAQDTQSIASDG CCCCCHHHHHHCCCC | 16.49 | 29255136 | |
| 3824 | Phosphorylation | PSAQDTQSIASDGTP CCCHHHHHHCCCCCC | 23.39 | 30266825 | |
| 3826 (in isoform 3) | Ubiquitination | - | 13.55 | 21890473 | |
| 3827 | Phosphorylation | QDTQSIASDGTPQGE HHHHHHCCCCCCCCH | 34.60 | 30266825 | |
| 3830 | Phosphorylation | QSIASDGTPQGEKEK HHHCCCCCCCCHHHH | 19.89 | 30266825 | |
| 3835 | Ubiquitination | DGTPQGEKEKEERPP CCCCCCHHHHCCCCC | 79.50 | 21906983 | |
| 3835 (in isoform 1) | Ubiquitination | - | 79.50 | 21890473 | |
| 3837 | Ubiquitination | TPQGEKEKEERPPEL CCCCHHHHCCCCCCC | 75.77 | - | |
| 3840 | Dimethylation | GEKEKEERPPELPLL CHHHHCCCCCCCCCH | 53.84 | - | |
| 3840 | Methylation | GEKEKEERPPELPLL CHHHHCCCCCCCCCH | 53.84 | 115390693 | |
| 3896 (in isoform 2) | Ubiquitination | - | 57.60 | 21890473 | |
| 3903 (in isoform 3) | Ubiquitination | - | 26.27 | 21890473 | |
| 3906 | Phosphorylation | PVRDTRESQLAHIKD CCCCCCHHHHHHCCC | 27.48 | 27273156 | |
| 3912 | Ubiquitination | ESQLAHIKDEPPPLS HHHHHHCCCCCCCCC | 46.29 | 21906983 | |
| 3912 (in isoform 1) | Ubiquitination | - | 46.29 | 21890473 | |
| 3919 | Phosphorylation | KDEPPPLSPAPLTPA CCCCCCCCCCCCCCC | 25.45 | 29255136 | |
| 3924 | Phosphorylation | PLSPAPLTPATPSSL CCCCCCCCCCCCHHC | 15.15 | 29255136 | |
| 3927 | Phosphorylation | PAPLTPATPSSLDPF CCCCCCCCCHHCCCC | 25.55 | 29255136 | |
| 3929 | Phosphorylation | PLTPATPSSLDPFFS CCCCCCCHHCCCCCC | 38.90 | 27273156 | |
| 3930 | Phosphorylation | LTPATPSSLDPFFSR CCCCCCHHCCCCCCC | 37.69 | 27273156 | |
| 3936 | Phosphorylation | SSLDPFFSREPSSMH HHCCCCCCCCCCCCC | 35.79 | 23927012 | |
| 3941 | Phosphorylation | FFSREPSSMHISSSL CCCCCCCCCCCCCCC | 25.70 | 28464451 | |
| 3945 | Phosphorylation | EPSSMHISSSLPPDT CCCCCCCCCCCCCCH | 10.13 | 23836654 | |
| 3947 | Phosphorylation | SSMHISSSLPPDTQK CCCCCCCCCCCCHHH | 37.80 | - | |
| 3954 | Ubiquitination | SLPPDTQKFLRFAET CCCCCHHHHHHHHHH | 48.75 | 21890473 | |
| 3975 | Phosphorylation | QILRQSTTHLADGPF HHHHHCCCCCCCCCC | 21.82 | - | |
| 3997 | 2-Hydroxyisobutyrylation | RVLDFDVKRKYFRQE EECCHHHHHHHHHHH | 45.04 | - | |
| 3997 | Ubiquitination | RVLDFDVKRKYFRQE EECCHHHHHHHHHHH | 45.04 | - | |
| 3999 | Ubiquitination | LDFDVKRKYFRQELE CCHHHHHHHHHHHHH | 42.92 | - | |
| 4014 | Ubiquitination | RLDEGLRKEDMAVHV HHHHHCCHHHCCHHH | 64.21 | - | |
| 4037 | Acetylation | SYRELHRKSPEEMKN HHHHHHHCCHHHHHH | 60.66 | 19807431 | |
| 4038 | Phosphorylation | YRELHRKSPEEMKNR HHHHHHCCHHHHHHC | 37.18 | 27174698 | |
| 4043 | Ubiquitination | RKSPEEMKNRLYIVF HCCHHHHHHCEEEEE | 42.04 | - | |
| 4047 | Phosphorylation | EEMKNRLYIVFEGEE HHHHHCEEEEEECCC | 7.57 | 27174698 | |
| 4066 | Phosphorylation | GGLLREWYMIISREM HHHHHHHHHHHCHHH | 3.60 | 27174698 | |
| 4070 | Phosphorylation | REWYMIISREMFNPM HHHHHHHCHHHHCCH | 15.97 | 27174698 | |
| 4078 | Phosphorylation | REMFNPMYALFRTSP HHHHCCHHHHCCCCC | 11.04 | 21406692 | |
| 4083 | Phosphorylation | PMYALFRTSPGDRVT CHHHHCCCCCCCCEE | 31.75 | - | |
| 4084 | Phosphorylation | MYALFRTSPGDRVTY HHHHCCCCCCCCEEE | 23.72 | - | |
| 4100 (in isoform 2) | Ubiquitination | - | 34.68 | 21890473 | |
| 4107 (in isoform 3) | Ubiquitination | - | 4.44 | 21890473 | |
| 4116 | Ubiquitination | FVGRIVAKAVYDNRL HHHHHHHHHHHCCCH | 27.73 | 21906983 | |
| 4116 (in isoform 1) | Ubiquitination | - | 27.73 | 21890473 | |
| 4139 | Ubiquitination | FYKHILGKSVRYTDM HHHHHHCCCEECCCC | 42.19 | - | |
| 4174 (in isoform 2) | Ubiquitination | - | 12.67 | 21890473 | |
| 4181 (in isoform 3) | Ubiquitination | - | 5.06 | 21890473 | |
| 4190 | Ubiquitination | VCEVRDLKPNGANIL EEEEECCCCCCCCEE | 40.50 | 21906983 | |
| 4190 (in isoform 1) | Ubiquitination | - | 40.50 | 21890473 | |
| 4206 | Phosphorylation | TEENKKEYVHLVCQM ECCCHHHHHHHHHHH | 11.31 | 27642862 | |
| 4221 | Ubiquitination | RMTGAIRKQLAAFLE HHHHHHHHHHHHHHH | 43.48 | - | |
| 4271 | Phosphorylation | SNTEYHKYQSNSIQI CCCCEEECCCCCHHH | 12.12 | - | |
| 4279 (in isoform 2) | Ubiquitination | - | 16.97 | 21890473 | |
| 4286 (in isoform 3) | Ubiquitination | - | 34.00 | 21890473 | |
| 4287 | Phosphorylation | WFWRALRSFDQADRA HHHHHHHCCCHHHHH | 33.74 | 23322592 | |
| 4295 | Ubiquitination | FDQADRAKFLQFVTG CCHHHHHHHHHHHHC | 47.72 | 21906983 | |
| 4295 (in isoform 1) | Ubiquitination | - | 47.72 | 21890473 | |
| 4296 (in isoform 3) | Ubiquitination | - | 6.73 | 21890473 | |
| 4301 | Phosphorylation | AKFLQFVTGTSKVPL HHHHHHHHCCCCCCC | 35.71 | 23911959 | |
| 4304 | Phosphorylation | LQFVTGTSKVPLQGF HHHHHCCCCCCCCHH | 32.76 | 23911959 | |
| 4305 | Ubiquitination | QFVTGTSKVPLQGFA HHHHCCCCCCCCHHH | 47.94 | 21890473 | |
| 4305 (in isoform 1) | Ubiquitination | - | 47.94 | 21890473 | |
| 4313 (in isoform 3) | Ubiquitination | - | 12.13 | 21890473 | |
| 4317 | Sulfoxidation | GFAALEGMNGIQKFQ HHHHHHCCCCEEEEE | 2.79 | 21406390 | |
| 4322 | Ubiquitination | EGMNGIQKFQIHRDD HCCCCEEEEEEECCC | 37.00 | 21890473 | |
| 4322 (in isoform 1) | Ubiquitination | - | 37.00 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 927 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 2339 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 2391 | S | Phosphorylation | Kinase | ATR | Q13535 | PSP |
| 2636 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 3377 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 3695 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 3797 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | HUWE1 | Q7Z6Z7 | PMID:17580310 |
| - | K | Ubiquitination | E3 ubiquitin ligase | MDM2 | Q00987 | PMID:30818224 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HUWE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HUWE1_HUMAN !! | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-509; LYS-1840 AND LYS-2248,AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1368; SER-1370;SER-1395; SER-1907; SER-2362; SER-2391; SER-2595; SER-2619; THR-2751;SER-2887; SER-2918; SER-3116; SER-3752; SER-3757; SER-3808; SER-3816;SER-3919 AND THR-3924, AND MASS SPECTROMETRY. | |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1903 AND SER-1907, ANDMASS SPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395; SER-1907;SER-2362; SER-2365; THR-2366; THR-2746; SER-2887; SER-2888; THR-2889;SER-2918; SER-3373; SER-3377; SER-3757 AND SER-3759, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1368; SER-1395;SER-1907; SER-2362; SER-2365; SER-2887; SER-3662; SER-3919; THR-3924AND THR-3927, AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907 AND SER-2362, ANDMASS SPECTROMETRY. | |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084 AND SER-2526, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907, AND MASSSPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907, AND MASSSPECTROMETRY. | |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2377; SER-3797; SER-3816AND THR-3822, AND MASS SPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395; SER-1907;SER-2362; SER-2887 AND SER-2918, AND MASS SPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907; SER-2362;SER-3808; SER-3816; SER-3919; THR-3924 AND THR-3927, AND MASSSPECTROMETRY. | |
| "Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395; SER-1907 ANDSER-2362, AND MASS SPECTROMETRY. | |
