GNMT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNMT_HUMAN
• UniProt AC: Q14749
• Protein Name: Glycine N-methyltransferase
• Gene Name: GNMT
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine..
• Protein Sequence: MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVDSVYRTR ------CCCCEEHHH	8.26	-
10	Phosphorylation	DSVYRTRSLGVAAEG CCEEHHHHHCCCCCC	28.94	22798277
22	Phosphorylation	AEGLPDQYADGEAAR CCCCCHHCCCCHHHE	17.65	-
34	Phosphorylation	AARVWQLYIGDTRSR HHEEEEEEECCCCCC	6.43	-
46	Succinylation	RSRTAEYKAWLLGLL CCCCHHHHHHHHHHH	25.29	-
46	Succinylation	RSRTAEYKAWLLGLL CCCCHHHHHHHHHHH	25.29	-
81	Phosphorylation	MLVEEGFSVTSVDAS EEEECCCCCEEECCC	35.03	24275569
97	Acetylation	KMLKYALKERWNRRH HHHHHHHHHHHHHCC	36.74	7674065
193	Succinylation	TGCAPPGKNIYYKSD CCCCCCCCCEEECCC	46.04	-
193	Succinylation	TGCAPPGKNIYYKSD CCCCCCCCCEEECCC	46.04	-
196	Phosphorylation	APPGKNIYYKSDLTK CCCCCCEEECCCCCC	17.77	-
197	Phosphorylation	PPGKNIYYKSDLTKD CCCCCEEECCCCCCC	10.54	21253578
198	Succinylation	PGKNIYYKSDLTKDV CCCCEEECCCCCCCC	22.11	-
198	Succinylation	PGKNIYYKSDLTKDV CCCCEEECCCCCCCC	22.11	-
199	Phosphorylation	GKNIYYKSDLTKDVT CCCEEECCCCCCCCE	23.02	-
203	Succinylation	YYKSDLTKDVTTSVL EECCCCCCCCEEEEE	58.46	-
203	Succinylation	YYKSDLTKDVTTSVL EECCCCCCCCEEEEE	58.46	-
220	Phosphorylation	NNKAHMVTLDYTVQV CCCEEEEEEEEEEEC	13.31	25693802
224	Phosphorylation	HMVTLDYTVQVPGAG EEEEEEEEEECCCCC	12.25	-
235	Phosphorylation	PGAGQDGSPGLSKFR CCCCCCCCCCHHHHH	24.88	19060867
239	Phosphorylation	QDGSPGLSKFRLSYY CCCCCCHHHHHHHCC	35.35	25693802
252	Phosphorylation	YYPHCLASFTELLQA CCHHHHHHHHHHHHH	21.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	PKCA	P17252	PSP
10	S	Phosphorylation	Kinase	JNK1	P45983	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNMT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNMT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKHF2_HUMAN	PLEKHF2	physical	16189514
NIF3L_HUMAN	NIF3L1	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
GNMT_HUMAN	GNMT	physical	16189514
RSSA_HUMAN	RPSA	physical	21988832
GNMT_HUMAN	GNMT	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
KRA42_HUMAN	KRTAP4-2	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
HDAC7_HUMAN	HDAC7	physical	21516116
PREX2_HUMAN	PREX2	physical	28205209

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606664: Glycine N-methyltransferase deficiency (GNMT deficiency)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine
• DB00118: S-Adenosylmethionine