PREX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PREX2_HUMAN
• UniProt AC: Q70Z35
• Protein Name: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
• Gene Name: PREX2
• Organism: Homo sapiens (Human).
• Sequence Length: 1606
• Protein Description: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase..
• Protein Sequence: MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Ubiquitination	KLLLELNKIRTIRTF HHHHHHHCHHHHHHH	46.30	-
215	Ubiquitination	CSNINEAKRQMEKLE HCCHHHHHHHHHHHH	36.66	29967540
349	Ubiquitination	MAKTPEEKHEWFEAI EECCHHHHHHHHHHH	45.20	29967540
374	Phosphorylation	KLGMEQDTWVMISEQ CCCCCCCEEEEEEHH	21.47	24144214
379	Phosphorylation	QDTWVMISEQGEKLY CCEEEEEEHHHHHHH	13.03	24144214
386	Phosphorylation	SEQGEKLYKMMCRQG EHHHHHHHHHHHHCC	14.12	-
460	Phosphorylation	FKPEQMLYRFRYDDG CCHHHEEEEEECCCC	11.45	26074081
464	Phosphorylation	QMLYRFRYDDGTFYP HEEEEEECCCCCEEC	18.70	26074081
468	Phosphorylation	RFRYDDGTFYPRNEM EEECCCCCEECCHHH	27.30	26074081
470	Phosphorylation	RYDDGTFYPRNEMQD ECCCCCEECCHHHHH	10.91	26074081
480	Phosphorylation	NEMQDVISKGVRLYC HHHHHHHHHHHHHHH	24.17	-
592	Ubiquitination	VVENVIAKSLLIKSN HHHHHHHHHHEEECC	30.43	-
597	Ubiquitination	IAKSLLIKSNEGSYG HHHHHEEECCCCCCC	47.39	29967540
623	Phosphorylation	IKLVEKGSNAEMAGM EEEEECCCCHHHCCC	43.89	23186163
673	Ubiquitination	LRVLVSTKPRETVKI EEEEEECCCCCEEEC	34.27	-
679	Ubiquitination	TKPRETVKIPDSADG CCCCCEEECCCCCCC	56.81	-
901	Phosphorylation	EHLCQRISSYKKFSR HHHHHHHHHHHHHHH	29.79	24719451
903	Phosphorylation	LCQRISSYKKFSRVL HHHHHHHHHHHHHHH	16.06	24719451
907	Phosphorylation	ISSYKKFSRVLKNRA HHHHHHHHHHHHHCC	30.29	24719451
946	Phosphorylation	HVNVMEVSYPKTSTS EEEEEEEECCCCCCC	23.55	24719451
952	Phosphorylation	VSYPKTSTSLGSAFG EECCCCCCCHHHHHC	32.95	-
953	Phosphorylation	SYPKTSTSLGSAFGV ECCCCCCCHHHHHCC	30.42	-
964	Phosphorylation	AFGVQLDSRKHNSHD HHCCCCCCCCCCCCC	52.39	-
1013	Phosphorylation	QDGHGLRYLLKEEDL CCCCHHHHHHHHHHC	22.79	-
1022	Phosphorylation	LKEEDLETQDIYQKL HHHHHCCHHHHHHHH	38.55	-
1026	Phosphorylation	DLETQDIYQKLLGKL HCCHHHHHHHHHHHH	14.11	-
1052	Phosphorylation	CQIDDLLSSITYSPK HCHHHHHHHCCCCCC	27.30	27251275
1053	Phosphorylation	QIDDLLSSITYSPKL CHHHHHHHCCCCCCC	20.94	27251275
1055	Phosphorylation	DDLLSSITYSPKLER HHHHHHCCCCCCCCC	21.64	27251275
1057	Phosphorylation	LLSSITYSPKLERKT HHHHCCCCCCCCCCC	13.60	27251275
1063	Acetylation	YSPKLERKTSEGIIP CCCCCCCCCCCCCCC	47.21	19822241
1064	Phosphorylation	SPKLERKTSEGIIPT CCCCCCCCCCCCCCC	37.93	23403867
1065	Phosphorylation	PKLERKTSEGIIPTD CCCCCCCCCCCCCCC	36.54	28857561
1073	Phosphorylation	EGIIPTDSDNEKGER CCCCCCCCCCCCCCC	44.83	23403867
1082	Phosphorylation	NEKGERNSKRVCFNV CCCCCCCCCEEEEEE	28.23	22210691
1101	Phosphorylation	QEDSGHDTISNRDSY CCCCCCCCCCCCCCC	22.19	22210691
1103	Phosphorylation	DSGHDTISNRDSYSD CCCCCCCCCCCCCCC	28.09	22210691
1107	Phosphorylation	DTISNRDSYSDCNSN CCCCCCCCCCCCCCC	24.25	-
1495	Phosphorylation	SFIRSKRTAACANTA HHHHHCCCHHHHCCC	23.49	22210691
1501	Phosphorylation	RTAACANTACSASGV CCHHHHCCCCCCCCC	15.54	22210691
1504	Phosphorylation	ACANTACSASGVGLL HHHCCCCCCCCCCHH	24.01	22210691
1506	Phosphorylation	ANTACSASGVGLLSV HCCCCCCCCCCHHHH	20.09	22210691
1514	Phosphorylation	GVGLLSVSSELCNRL CCCHHHHCHHHHHHH	18.08	-
1551	O-linked_Glycosylation	QAIILARSHGLPPRY HHHHHHHHCCCCHHH	19.12	31492838
1558	Phosphorylation	SHGLPPRYIMQATDV HCCCCHHHHHHHHHH	13.40	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1107	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
1107	S	Phosphorylation	Kinase	PAK2	Q13177	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PREX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PREX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTOR_HUMAN	MTOR	physical	17565979
GNMT_HUMAN	GNMT	physical	28205209
HUWE1_HUMAN	HUWE1	physical	28205209

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.