MTOR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTOR_HUMAN
• UniProt AC: P42345
• Protein Name: Serine/threonine-protein kinase mTOR
• Gene Name: MTOR
• Organism: Homo sapiens (Human).
• Sequence Length: 2549
• Subcellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytopl
• Protein Description: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'. [PubMed: 12087098]
• Protein Sequence: MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLGTGPAA -------CCCCCCCC	35.87	22814378
4	Phosphorylation	----MLGTGPAAATT ----CCCCCCCCCCC	53.26	24532841
10	Phosphorylation	GTGPAAATTAATTSS CCCCCCCCCCCCCCC	16.55	25954137
11	Phosphorylation	TGPAAATTAATTSSN CCCCCCCCCCCCCCC	15.01	25954137
14	Phosphorylation	AAATTAATTSSNVSV CCCCCCCCCCCCHHH	25.42	21964256
15	Phosphorylation	AATTAATTSSNVSVL CCCCCCCCCCCHHHH	25.98	20071362
16	Phosphorylation	ATTAATTSSNVSVLQ CCCCCCCCCCHHHHH	18.63	25954137
16	Ubiquitination	ATTAATTSSNVSVLQ CCCCCCCCCCHHHHH	18.63	22817900
17	Phosphorylation	TTAATTSSNVSVLQQ CCCCCCCCCHHHHHH	38.88	20071362
24	Ubiquitination	SNVSVLQQFASGLKS CCHHHHHHHHHHCCC	31.54	22817900
26	Ubiquitination	VSVLQQFASGLKSRN HHHHHHHHHHCCCCC	9.80	22817900
27	Phosphorylation	SVLQQFASGLKSRNE HHHHHHHHHCCCCCH	46.04	20071362
31	Phosphorylation	QFASGLKSRNEETRA HHHHHCCCCCHHHHH	45.43	25954137
42	Ubiquitination	ETRAKAAKELQHYVT HHHHHHHHHHHHHHH	64.91	-
60	Phosphorylation	REMSQEESTRFYDQL HHCCHHHHHHHHHHH	24.91	26657352
77	Phosphorylation	HIFELVSSSDANERK HHHHHHCCCCCCCCC	25.43	26657352
78	Phosphorylation	IFELVSSSDANERKG HHHHHCCCCCCCCCC	32.98	26657352
84	Ubiquitination	SSDANERKGGILAIA CCCCCCCCCCEEEEE	56.14	-
92	Phosphorylation	GGILAIASLIGVEGG CCEEEEEHHHCCCCC	17.88	-
102	Phosphorylation	GVEGGNATRIGRFAN CCCCCCHHHHHHHHH	27.15	-
110	Phosphorylation	RIGRFANYLRNLLPS HHHHHHHHHHHHCCC	12.01	21712546
128	Ubiquitination	VVMEMASKAIGRLAM HHHHHHHHHHHHHHH	34.19	-
230	Acetylation	REPKEMQKPQWYRHT CCCHHHCCCHHHHHH	37.55	25953088
230	Malonylation	REPKEMQKPQWYRHT CCCHHHCCCHHHHHH	37.55	26320211
230	Ubiquitination	REPKEMQKPQWYRHT CCCHHHCCCHHHHHH	37.55	29967540
243	Ubiquitination	HTFEEAEKGFDETLA HHHHHHHHCCCHHHH	72.44	21906983
248	Phosphorylation	AEKGFDETLAKEKGM HHHCCCHHHHHHCCC	33.58	26091039
251	Ubiquitination	GFDETLAKEKGMNRD CCCHHHHHHCCCCCH	64.17	21906983
253	Ubiquitination	DETLAKEKGMNRDDR CHHHHHHCCCCCHHH	63.85	22817900
298	Ubiquitination	QQQLVHDKYCKDLMG HHHHHCHHHHHHHCC	37.36	-
301	Ubiquitination	LVHDKYCKDLMGFGT HHCHHHHHHHCCCCC	51.29	29967540
308	Phosphorylation	KDLMGFGTKPRHITP HHHCCCCCCCCCCCC	35.30	-
309	Acetylation	DLMGFGTKPRHITPF HHCCCCCCCCCCCCC	40.20	27452117
309	Malonylation	DLMGFGTKPRHITPF HHCCCCCCCCCCCCC	40.20	26320211
309	Ubiquitination	DLMGFGTKPRHITPF HHCCCCCCCCCCCCC	40.20	32015554
314	Phosphorylation	GTKPRHITPFTSFQA CCCCCCCCCCCCCCC	13.26	-
369	Ubiquitination	CRDLMEEKFDQVCQW HHHHHHHHHHHHHHH	40.72	29967540
379	Ubiquitination	QVCQWVLKCRNSKNS HHHHHHHHCCCCCCC	22.87	-
384	Ubiquitination	VLKCRNSKNSLIQMT HHHCCCCCCCHHHHH	54.85	-
426	Ubiquitination	HVLSCVKKEKERTAA HHHHHHHHHHHHHHH	54.33	-
449	Ubiquitination	VAVRSEFKVYLPRVL HHHHHHCCHHHHHHH	26.39	-
482	Ubiquitination	AMQVDATVFTCISML HHHCCHHHHHHHHHH	3.92	21890473
484	Ubiquitination	QVDATVFTCISMLAR HCCHHHHHHHHHHHH	12.47	22817900
532	2-Hydroxyisobutyrylation	SRQIPQLKKDIQDGL HHCCHHHHHHHHHHH	43.05	-
533	Ubiquitination	RQIPQLKKDIQDGLL HCCHHHHHHHHHHHH	69.52	29967540
567	Phosphorylation	GLAHQLASPGLTTLP CHHHHHCCCCCCCCC	28.26	29255136
571	Phosphorylation	QLASPGLTTLPEASD HHCCCCCCCCCCCCC	32.00	29255136
572	Phosphorylation	LASPGLTTLPEASDV HCCCCCCCCCCCCCH	45.41	29255136
577	Phosphorylation	LTTLPEASDVGSITL CCCCCCCCCHHHHHH	31.03	27251275
581	Phosphorylation	PEASDVGSITLALRT CCCCCHHHHHHEEHH	16.55	27251275
583	Phosphorylation	ASDVGSITLALRTLG CCCHHHHHHEEHHCC	14.00	27251275
616	Ubiquitination	HFLNSEHKEIRMEAA HHHCCCCHHHHHHHH	51.27	-
631	Phosphorylation	RTCSRLLTPSIHLIS HHHHHHHCCCEEEEC	21.41	-
665	Phosphorylation	KLLVVGITDPDPDIR HHCCCCCCCCCCCHH	35.23	20071362
671	Ubiquitination	ITDPDPDIRYCVLAS CCCCCCCHHHHHHHC	4.04	21890473
673	Ubiquitination	DPDPDIRYCVLASLD CCCCCHHHHHHHCHH	6.30	22817900
714	Phosphorylation	IRELAICTVGRLSSM HHHHHHHHHHHHHCC	21.63	22210691
719	Phosphorylation	ICTVGRLSSMNPAFV HHHHHHHHCCCHHHH	26.61	22210691
720	Phosphorylation	CTVGRLSSMNPAFVM HHHHHHHCCCHHHHH	27.46	22210691
770	Ubiquitination	NAPRLIRPYMEPILK CCCHHCHHHHHHHHH	26.31	23503661
771	Ubiquitination	APRLIRPYMEPILKA CCHHCHHHHHHHHHH	12.31	23503661
777	Ubiquitination	PYMEPILKALILKLK HHHHHHHHHHHHHCC	41.70	-
802	Ubiquitination	INNVLATIGELAQVS HHHHHHHHHHHHHHC	3.16	22817900
831	Phosphorylation	IMDMLQDSSLLAKRQ HHHHCCCCHHHHHHH	15.21	23090842
832	Phosphorylation	MDMLQDSSLLAKRQV HHHCCCCHHHHHHHH	35.37	23090842
840	Ubiquitination	LLAKRQVALWTLGQL HHHHHHHHHHHHHHH	6.77	22817900
841	Ubiquitination	LAKRQVALWTLGQLV HHHHHHHHHHHHHHH	3.64	22817900
861	Phosphorylation	VVEPYRKYPTLLEVL CCCCHHHCHHHHHHH	7.76	24719451
877	Ubiquitination	NFLKTEQNQGTRREA HHHHHHCCCCCHHHH	35.70	21890473
880	Phosphorylation	KTEQNQGTRREAIRV HHHCCCCCHHHHHHH	19.45	24719451
898	Ubiquitination	LGALDPYKHKVNIGM HHHCCCCCCCCCEEC	42.19	21906983
898	Ubiquitination	LGALDPYKHKVNIGM HHHCCCCCCCCCEEC	42.19	21890473
900	Ubiquitination	ALDPYKHKVNIGMID HCCCCCCCCCEECCC	32.59	21906983
909	Phosphorylation	NIGMIDQSRDASAVS CEECCCCCCCCCCCC	28.51	20071362
913	Phosphorylation	IDQSRDASAVSLSES CCCCCCCCCCCCCCC	33.23	23312004
916	Phosphorylation	SRDASAVSLSESKSS CCCCCCCCCCCCCCC	26.37	20873877
918	Phosphorylation	DASAVSLSESKSSQD CCCCCCCCCCCCCCC	32.11	20071362
920	Phosphorylation	SAVSLSESKSSQDSS CCCCCCCCCCCCCCC	34.17	26437602
959	Ubiquitination	MVALMRIFRDQSLSH HHHHHHHHCCCCCCC	5.06	23503661
960	Ubiquitination	VALMRIFRDQSLSHH HHHHHHHCCCCCCCC	38.39	23503661
984	Ubiquitination	FIFKSLGLKCVQFLP HHHHHCCCHHHHHHH	4.75	23503661
990	Ubiquitination	GLKCVQFLPQVMPTF CCHHHHHHHHHHHHH	1.30	22817900
991	Ubiquitination	LKCVQFLPQVMPTFL CHHHHHHHHHHHHHH	26.47	22817900
1029	Ubiquitination	FVKSHIRPYMDEIVT HHHHCCHHHHHHHHH	28.35	22817900
1030	Ubiquitination	VKSHIRPYMDEIVTL HHHCCHHHHHHHHHH	13.83	22817900
1066	Ubiquitination	IVVALGGEFKLYLPQ HHHHHCCCHHHHHHH	37.50	21890473
1095	Ubiquitination	PGRIVSIKLLAAIQL CCCCHHHHHHHHHHH	29.91	23503661
1131	Phosphorylation	APEAPLPSRKAALET CCCCCCCCHHHHHHH	54.84	-
1133	Ubiquitination	EAPLPSRKAALETVD CCCCCCHHHHHHHHH	42.20	29967540
1143	Phosphorylation	LETVDRLTESLDFTD HHHHHHHHHCCCCCH	25.15	24114839
1145	Phosphorylation	TVDRLTESLDFTDYA HHHHHHHCCCCCHHH	28.18	24114839
1149	Phosphorylation	LTESLDFTDYASRII HHHCCCCCHHHHHHH	27.97	29759185
1151	Phosphorylation	ESLDFTDYASRIIHP HCCCCCHHHHHHHHH	11.92	29759185
1153	Phosphorylation	LDFTDYASRIIHPIV CCCCHHHHHHHHHHH	20.13	24114839
1162	Phosphorylation	IIHPIVRTLDQSPEL HHHHHHHCCCCCHHH	24.64	22167270
1166	Phosphorylation	IVRTLDQSPELRSTA HHHCCCCCHHHHHHH	21.73	22167270
1171	Phosphorylation	DQSPELRSTAMDTLS CCCHHHHHHHHHHHH	32.89	21406692
1172	Phosphorylation	QSPELRSTAMDTLSS CCHHHHHHHHHHHHH	21.40	21406692
1173	Ubiquitination	SPELRSTAMDTLSSL CHHHHHHHHHHHHHH	8.63	23503661
1176	Phosphorylation	LRSTAMDTLSSLVFQ HHHHHHHHHHHHHHH	18.56	21406692
1178	Phosphorylation	STAMDTLSSLVFQLG HHHHHHHHHHHHHHC	24.58	21406692
1179	Phosphorylation	TAMDTLSSLVFQLGK HHHHHHHHHHHHHCC	31.50	21406692
1179	Ubiquitination	TAMDTLSSLVFQLGK HHHHHHHHHHHHHCC	31.50	22817900
1186	Ubiquitination	SLVFQLGKKYQIFIP HHHHHHCCEEEEEEE	57.83	23503661
1187	Ubiquitination	LVFQLGKKYQIFIPM HHHHHCCEEEEEEEC	40.36	23503661
1188	Phosphorylation	VFQLGKKYQIFIPMV HHHHCCEEEEEEECH	15.44	-
1197	Ubiquitination	IFIPMVNKVLVRHRI EEEECHHHHHHHHCC	26.07	-
1218	Acetylation	VLICRIVKGYTLADE EEEEEEECCCCCCCC	43.77	19608861
1218	Malonylation	VLICRIVKGYTLADE EEEEEEECCCCCCCC	43.77	26320211
1218	Ubiquitination	VLICRIVKGYTLADE EEEEEEECCCCCCCC	43.77	21906983
1232	Phosphorylation	EEEDPLIYQHRMLRS CCCCCCHHHHCCHHC	13.12	21945579
1239	Phosphorylation	YQHRMLRSGQGDALA HHHCCHHCCCCCCCC	31.35	28555341
1239	Ubiquitination	YQHRMLRSGQGDALA HHHCCHHCCCCCCCC	31.35	21890473
1255	Sulfoxidation	GPVETGPMKKLHVST CCCCCCCCCEEEEEE	6.73	21406390
1256	Acetylation	PVETGPMKKLHVSTI CCCCCCCCEEEEEEE	56.15	26051181
1256	Ubiquitination	PVETGPMKKLHVSTI CCCCCCCCEEEEEEE	56.15	21906983
1257	Ubiquitination	VETGPMKKLHVSTIN CCCCCCCEEEEEEEE	37.26	22817900
1261	Phosphorylation	PMKKLHVSTINLQKA CCCEEEEEEEEHHHH	16.90	25159151
1262	Phosphorylation	MKKLHVSTINLQKAW CCEEEEEEEEHHHHH	16.88	30266825
1267	Ubiquitination	VSTINLQKAWGAARR EEEEEHHHHHHCCCC	49.63	-
1284	Ubiquitination	KDDWLEWLRRLSLEL HHHHHHHHHHHHHHH	1.34	23503661
1288	Phosphorylation	LEWLRRLSLELLKDS HHHHHHHHHHHHCCC	20.27	-
1293	Ubiquitination	RLSLELLKDSSSPSL HHHHHHHCCCCCHHH	69.09	21890473
1293	Ubiquitination	RLSLELLKDSSSPSL HHHHHHHCCCCCHHH	69.09	21890473
1296	Phosphorylation	LELLKDSSSPSLRSC HHHHCCCCCHHHHHH	57.30	20068231
1297	Phosphorylation	ELLKDSSSPSLRSCW HHHCCCCCHHHHHHH	23.59	20068231
1299	Phosphorylation	LKDSSSPSLRSCWAL HCCCCCHHHHHHHHH	38.06	20068231
1395	Ubiquitination	AKCRAYAKALHYKEL HHHHHHHHHHCHHHH	38.51	29967540
1400	Ubiquitination	YAKALHYKELEFQKG HHHHHCHHHHCCCCC	45.11	23503661
1406	Ubiquitination	YKELEFQKGPTPAIL HHHHCCCCCCCHHHH	72.65	21906983
1409	Phosphorylation	LEFQKGPTPAILESL HCCCCCCCHHHHHHH	33.74	27251275
1415	Phosphorylation	PTPAILESLISINNK CCHHHHHHHHHCCCC	27.79	25850435
1418	Phosphorylation	AILESLISINNKLQQ HHHHHHHHCCCCCCC	25.26	29507054
1428	Ubiquitination	NKLQQPEAAAGVLEY CCCCCHHHHHHHHHH	14.86	21890473
1465	Ubiquitination	DALVAYDKKMDTNKD HHHHHHHHCCCCCCC	37.00	29967540
1466	Ubiquitination	ALVAYDKKMDTNKDD HHHHHHHCCCCCCCC	38.83	29967540
1471	Ubiquitination	DKKMDTNKDDPELML HHCCCCCCCCHHHHH	66.65	29967540
1500	Ubiquitination	LHQQCCEKWTLVNDE HHHHHHHHCCCCCHH	31.40	29967540
1502	Phosphorylation	QQCCEKWTLVNDETQ HHHHHHCCCCCHHHH	31.71	-
1511	Ubiquitination	VNDETQAKMARMAAA CCHHHHHHHHHHHHH	24.23	23503661
1566	Ubiquitination	LAQQCIDKARDLLDA HHHHHHHHHHHHHHH	25.96	-
1635	Ubiquitination	RIVEDWQKILMVRSL HHHHHHHHHHHHHEE	33.29	-
1650	Ubiquitination	VVSPHEDMRTWLKYA CCCCCHHHHHHHHHH	3.61	27667366
1655	Ubiquitination	EDMRTWLKYASLCGK HHHHHHHHHHHHCCH	30.27	21890473
1655	Ubiquitination	EDMRTWLKYASLCGK HHHHHHHHHHHHCCH	30.27	21890473
1662	Ubiquitination	KYASLCGKSGRLALA HHHHHCCHHHHHHHH	49.06	29967540
1745	Ubiquitination	QHKQELHKLMARCFL HHHHHHHHHHHHHHH	53.21	29967540
1804	Phosphorylation	NFEAVLHYKHQNQAR CHHHHHHHHHHHCCH	13.15	20860994
1821	Phosphorylation	KKKLRHASGANITNA HHHHHHHCCCCCCCC	32.11	20873877
1826	Phosphorylation	HASGANITNATTAAT HHCCCCCCCCHHHHH	20.71	27080861
1829	Phosphorylation	GANITNATTAATTAA CCCCCCCHHHHHHCC	21.02	20873877
1830	Phosphorylation	ANITNATTAATTAAT CCCCCCHHHHHHCCC	16.34	27080861
1833	Phosphorylation	TNATTAATTAATATT CCCHHHHHHCCCCCC	17.95	20873877
1834	Phosphorylation	NATTAATTAATATTT CCHHHHHHCCCCCCC	15.01	27080861
1837	Phosphorylation	TAATTAATATTTAST HHHHHCCCCCCCCCC	23.28	27080861
1839	Phosphorylation	ATTAATATTTASTEG HHHCCCCCCCCCCCC	21.96	20873877
1839	Ubiquitination	ATTAATATTTASTEG HHHCCCCCCCCCCCC	21.96	22817900
1840	Phosphorylation	TTAATATTTASTEGS HHCCCCCCCCCCCCC	20.21	20873877
1841	Phosphorylation	TAATATTTASTEGSN HCCCCCCCCCCCCCC	17.79	20873877
1843	Phosphorylation	ATATTTASTEGSNSE CCCCCCCCCCCCCCH	25.54	20873877
1844	Phosphorylation	TATTTASTEGSNSES CCCCCCCCCCCCCHH	41.73	27080861
1847	Phosphorylation	TTASTEGSNSESEAE CCCCCCCCCCHHHHC	30.83	18691976
1849	Phosphorylation	ASTEGSNSESEAEST CCCCCCCCHHHHCCC	44.17	18691976
1851	Phosphorylation	TEGSNSESEAESTEN CCCCCCHHHHCCCCC	41.76	20873877
1855	Phosphorylation	NSESEAESTENSPTP CCHHHHCCCCCCCCC	48.33	27080861
1856	Phosphorylation	SESEAESTENSPTPS CHHHHCCCCCCCCCC	30.59	20873877
1859	Phosphorylation	EAESTENSPTPSPLQ HHCCCCCCCCCCHHH	24.74	20873877
1861	Phosphorylation	ESTENSPTPSPLQKK CCCCCCCCCCHHHHH	35.90	27080861
1863	Phosphorylation	TENSPTPSPLQKKVT CCCCCCCCHHHHHHC	40.49	20873877
1867	Ubiquitination	PTPSPLQKKVTEDLS CCCCHHHHHHCHHHH	57.82	23503661
1870	Phosphorylation	SPLQKKVTEDLSKTL CHHHHHHCHHHHHHH	32.44	19835603
1874	Phosphorylation	KKVTEDLSKTLLMYT HHHCHHHHHHHHHHH	35.60	19835603
1876	Phosphorylation	VTEDLSKTLLMYTVP HCHHHHHHHHHHHHH	23.03	19835603
1880	Phosphorylation	LSKTLLMYTVPAVQG HHHHHHHHHHHHHHH	12.45	19835603
1881	Phosphorylation	SKTLLMYTVPAVQGF HHHHHHHHHHHHHHH	13.17	20873877
1885	Ubiquitination	LMYTVPAVQGFFRSI HHHHHHHHHHHHHHH	4.72	23503661
1890	Ubiquitination	PAVQGFFRSISLSRG HHHHHHHHHHHCCCC	30.71	23503661
1893	Phosphorylation	QGFFRSISLSRGNNL HHHHHHHHCCCCCCH	22.87	24719451
1948	Phosphorylation	QLIARIDTPRPLVGR HHHHHCCCCCHHHHH	20.87	-
1958	Ubiquitination	PLVGRLIHQLLTDIG HHHHHHHHHHHHHHH	19.48	24816145
1982	Phosphorylation	PLTVASKSTTTARHN EEEECCCCCHHHHHH	28.61	20860994
1985	Phosphorylation	VASKSTTTARHNAAN ECCCCCHHHHHHHHH	23.06	20860994
1993	Ubiquitination	ARHNAANKILKNMCE HHHHHHHHHHHHHHH	44.69	29967540
2021	Ubiquitination	EELIRVAILWHEMWH HHHHHHHHHHHHHHH	3.81	24816145
2032	Phosphorylation	EMWHEGLEEASRLYF HHHHHCHHHHHHHHC	63.47	32645325
2045	Ubiquitination	YFGERNVKGMFEVLE HCCCCCCCHHHHHHH	48.48	-
2056	Ubiquitination	EVLEPLHAMMERGPQ HHHHHHHHHHHHCCC	13.50	23503661
2062	Phosphorylation	HAMMERGPQTLKETS HHHHHHCCCCHHHCC	30.15	33259812
2066	Malonylation	ERGPQTLKETSFNQA HHCCCCHHHCCHHHH	63.43	26320211
2066	Ubiquitination	ERGPQTLKETSFNQA HHCCCCHHHCCHHHH	63.43	27667366
2068	Phosphorylation	GPQTLKETSFNQAYG CCCCHHHCCHHHHHC	36.71	28857561
2069	Phosphorylation	PQTLKETSFNQAYGR CCCHHHCCHHHHHCH	24.24	28857561
2074	Ubiquitination	ETSFNQAYGRDLMEA HCCHHHHHCHHHHHH	11.70	23503661
2079	Ubiquitination	QAYGRDLMEAQEWCR HHHCHHHHHHHHHHH	4.74	23503661
2088	Phosphorylation	AQEWCRKYMKSGNVK HHHHHHHHHHHCCHH	7.16	23403867
2147	Ubiquitination	VPGTYDPNQPIIRIQ CCCCCCCCCCEEEEE	58.31	24816145
2155	Phosphorylation	QPIIRIQSIAPSLQV CCEEEEECCCCCCEE	20.53	-
2159	Phosphorylation	RIQSIAPSLQVITSK EEECCCCCCEEECCC	23.55	21576368
2164	Phosphorylation	APSLQVITSKQRPRK CCCCEEECCCCCCCE	30.89	21576368
2166	Ubiquitination	SLQVITSKQRPRKLT CCEEECCCCCCCEEE	41.50	-
2173	Phosphorylation	KQRPRKLTLMGSNGH CCCCCEEEEECCCCC	20.10	24247430
2207	Phosphorylation	QLFGLVNTLLANDPT HHHHHHHHHHHCCCC	18.70	24043423
2210	Ubiquitination	GLVNTLLANDPTSLR HHHHHHHHCCCCHHH	22.84	24816145
2214	Phosphorylation	TLLANDPTSLRKNLS HHHHCCCCHHHHCCC	43.17	24043423
2215	Phosphorylation	LLANDPTSLRKNLSI HHHCCCCHHHHCCCC	31.40	24043423
2218	Ubiquitination	NDPTSLRKNLSIQRY CCCCHHHHCCCCCEE	68.48	-
2221	Phosphorylation	TSLRKNLSIQRYAVI CHHHHCCCCCEEEEE	26.52	24719451
2283	Ubiquitination	DHLTLMQKVEVFEHA CCCHHHHHHHHHHHH	26.79	23503661
2301	Ubiquitination	TAGDDLAKLLWLKSP CCCCHHHHHHHHCCC	51.95	23503661
2306	Ubiquitination	LAKLLWLKSPSSEVW HHHHHHHCCCCCCCE	49.06	23503661
2370	Ubiquitination	EVAMTREKFPEKIPF HHHHCCCCCCCCCCH	64.03	-
2374	Ubiquitination	TREKFPEKIPFRLTR CCCCCCCCCCHHHHH	56.78	24816145
2380	Phosphorylation	EKIPFRLTRMLTNAM CCCCHHHHHHHCCCC	15.13	-
2434	Phosphorylation	LNWRLMDTNTKGNKR CCEEECCCCCCCCCC	30.72	-
2436	Phosphorylation	WRLMDTNTKGNKRSR EEECCCCCCCCCCCC	42.28	21955146
2437	Ubiquitination	RLMDTNTKGNKRSRT EECCCCCCCCCCCCC	63.66	24816145
2442	Phosphorylation	NTKGNKRSRTRTDSY CCCCCCCCCCCCCCC	39.34	22322096
2444	Phosphorylation	KGNKRSRTRTDSYSA CCCCCCCCCCCCCCC	38.88	22322096
2446	Phosphorylation	NKRSRTRTDSYSAGQ CCCCCCCCCCCCCCC	28.78	30266825
2448	Phosphorylation	RSRTRTDSYSAGQSV CCCCCCCCCCCCCCE	22.00	19664994
2449	Phosphorylation	SRTRTDSYSAGQSVE CCCCCCCCCCCCCEE	12.83	27273156
2450	Phosphorylation	RTRTDSYSAGQSVEI CCCCCCCCCCCCEEE	29.85	30266825
2454	Phosphorylation	DSYSAGQSVEILDGV CCCCCCCCEEEECCC	22.31	19664994
2471	Phosphorylation	GEPAHKKTGTTVPES CCCCHHCCCCCCCHH	44.56	22322096
2473	Phosphorylation	PAHKKTGTTVPESIH CCHHCCCCCCCHHHH	29.83	22322096
2474	Phosphorylation	AHKKTGTTVPESIHS CHHCCCCCCCHHHHH	35.09	22322096
2478	Phosphorylation	TGTTVPESIHSFIGD CCCCCCHHHHHHHCC	21.38	22322096
2481	Phosphorylation	TVPESIHSFIGDGLV CCCHHHHHHHCCCCC	19.52	22322096
2489	Ubiquitination	FIGDGLVKPEALNKK HHCCCCCCHHHCCHH	42.03	29967540
2496	Ubiquitination	KPEALNKKAIQIINR CHHHCCHHHHHHHHH	50.04	29967540
2509	Phosphorylation	NRVRDKLTGRDFSHD HHHHHHHCCCCCCCC	35.59	20068231
2514	Phosphorylation	KLTGRDFSHDDTLDV HHCCCCCCCCCCCCC	30.23	29759185
2518	Phosphorylation	RDFSHDDTLDVPTQV CCCCCCCCCCCCHHH	30.80	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1415	S	Phosphorylation	Kinase	CHUK	O15111	GPS
1418	S	Phosphorylation	Kinase	IKKA	O15111	PSP
2173	T	Phosphorylation	Kinase	AKT1	P31749	Uniprot
2446	T	Phosphorylation	Kinase	AKT1	P31749	PSP
2446	T	Phosphorylation	Kinase	KS6B1	P23443	PhosphoELM
2446	T	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
2446	T	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
2446	T	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
2448	S	Phosphorylation	Kinase	AKT1	P31749	PSP
2448	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
2448	S	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
2448	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
2448	S	Phosphorylation	Kinase	KS6B1	P23443	PhosphoELM
2454	S	Phosphorylation	Kinase	MTOR	P42345	PSP
2473	T	Phosphorylation	Kinase	MTOR	P42345	PSP
2474	T	Phosphorylation	Kinase	MTOR	P42345	PSP
2478	S	Phosphorylation	Kinase	MTOR	P42345	PSP
2481	S	Phosphorylation	Kinase	MTOR	P42345	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:23911927
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:18787170

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1261	S	Phosphorylation	Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation.	19487463
2159	S	Phosphorylation	Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation.	21576368
2164	T	Phosphorylation	Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation.	21576368
2173	T	Phosphorylation	Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.	24247430

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTOR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RICTR_HUMAN	RICTOR	physical	15467718
RPTOR_HUMAN	RPTOR	physical	15467718
RICTR_HUMAN	RICTOR	physical	15268862
RPTOR_HUMAN	RPTOR	physical	15268862
ABL1_HUMAN	ABL1	physical	10753870
4EBP1_HUMAN	EIF4EBP1	physical	12747827
4EBP1_HUMAN	EIF4EBP1	physical	12150925
4EBP1_HUMAN	EIF4EBP1	physical	15854902
4EBP1_HUMAN	EIF4EBP1	physical	12150926
4EBP1_HUMAN	EIF4EBP1	physical	10971657
4EBP1_HUMAN	EIF4EBP1	physical	9465032
FKB1A_HUMAN	FKBP1A	physical	15284440
FKB1A_HUMAN	FKBP1A	physical	15796538
MTOR_HUMAN	MTOR	physical	16870609
PA2G4_HUMAN	PA2G4	physical	15896331
PDK1_HUMAN	PDK1	genetic	10567431
PROP_HUMAN	CFP	physical	11733037
PLD2_HUMAN	PLD2	physical	16837165
2ABA_HUMAN	PPP2R2A	physical	10200280
KPCD_HUMAN	PRKCD	physical	10698949
RAP1A_HUMAN	RAP1A	physical	15854902
RHEB_HUMAN	RHEB	physical	15854902
KS6B1_HUMAN	RPS6KB1	physical	10567431
KS6B1_HUMAN	RPS6KB1	physical	15854902
KS6B1_HUMAN	RPS6KB1	physical	15896331
KS6B1_HUMAN	RPS6KB1	physical	15809305
KS6B1_HUMAN	RPS6KB1	physical	11914378
KS6B1_HUMAN	RPS6KB1	physical	12150925
KS6B1_HUMAN	RPS6KB1	physical	14679009
KS6B1_HUMAN	RPS6KB1	physical	16922504
KS6B1_HUMAN	RPS6KB1	physical	10971657
KS6B1_HUMAN	RPS6KB1	physical	9465032
KS6B1_HUMAN	RPS6KB1	physical	16183647
CLIP1_HUMAN	CLIP1	physical	12231510
STAT1_HUMAN	STAT1	physical	12807916
STAT3_HUMAN	STAT3	physical	10660304
STAT3_HUMAN	STAT3	physical	15522880
TERT_HUMAN	TERT	physical	15843522
EIF3F_HUMAN	EIF3F	physical	16541103
GEPH_HUMAN	GPHN	physical	10325225
RHEB_MOUSE	Rheb	physical	16631613
STAT3_RAT	Stat3	physical	12796477
UBQL1_HUMAN	UBQLN1	physical	11853878
RPTOR_HUMAN	RPTOR	physical	15459249
RPTOR_HUMAN	RPTOR	physical	15066126
RPTOR_HUMAN	RPTOR	physical	12719976
RPTOR_HUMAN	RPTOR	physical	12665511
RPTOR_HUMAN	RPTOR	physical	12150926
RPTOR_HUMAN	RPTOR	physical	12150925
RPTOR_HUMAN	RPTOR	physical	16847060
RPTOR_HUMAN	RPTOR	physical	16837165
RPTOR_HUMAN	RPTOR	physical	16798736
RPTOR_HUMAN	RPTOR	physical	16919458
RPTOR_HUMAN	RPTOR	physical	16631613
RPTOR_HUMAN	RPTOR	physical	16603397
RPTOR_HUMAN	RPTOR	physical	16354680
RPTOR_HUMAN	RPTOR	physical	16183647
RPTOR_HUMAN	RPTOR	physical	17043309
LST8_HUMAN	MLST8	physical	16183647
LST8_HUMAN	MLST8	physical	15066126
LST8_HUMAN	MLST8	physical	12719976
KS6B1_MOUSE	Rps6kb1	physical	16452250
RICTR_HUMAN	RICTOR	physical	16919458
RICTR_HUMAN	RICTOR	physical	16603397
RICTR_HUMAN	RICTOR	physical	16183647
RICTR_HUMAN	RICTOR	physical	17043309
MTOR_HUMAN	MTOR	physical	17360675
RPTOR_HUMAN	RPTOR	physical	20427287
TTI1_SCHPO	tti1	physical	20427287
TTI1_HUMAN	TTI1	physical	20427287
RICTR_HUMAN	RICTOR	physical	20427287
LST8_HUMAN	MLST8	physical	20427287
DPTOR_HUMAN	DEPTOR	physical	22017877
PRR5_HUMAN	PRR5	physical	17461779
RPTOR_HUMAN	RPTOR	physical	17461779
AKT1_HUMAN	AKT1	physical	21045808
RICTR_HUMAN	RICTOR	physical	21045808
KPCA_HUMAN	PRKCA	physical	21045808
RL23_HUMAN	RPL23	physical	21045808
RS6_HUMAN	RPS6	physical	21045808
RPTOR_HUMAN	RPTOR	physical	21045808
RL23A_HUMAN	RPL23A	physical	21045808
RL26_HUMAN	RPL26	physical	21045808
RL5_HUMAN	RPL5	physical	21045808
TELO2_HUMAN	TELO2	physical	18160036
KS6B1_HUMAN	RPS6KB1	physical	22544753
USP9X_HUMAN	USP9X	physical	22544753
RPTOR_HUMAN	RPTOR	physical	22544753
RICTR_HUMAN	RICTOR	physical	22544753
TTI1_HUMAN	TTI1	physical	22544753
RUVB2_HUMAN	RUVBL2	physical	22544753
RUVB1_HUMAN	RUVBL1	physical	22544753
AKT1_HUMAN	AKT1	physical	15718470
RPTOR_HUMAN	RPTOR	physical	22356909
KS6B1_HUMAN	RPS6KB1	physical	17386266
AKTS1_HUMAN	AKT1S1	physical	17386266
RPTOR_HUMAN	RPTOR	physical	17386266
SIN1_HUMAN	MAPKAP1	physical	17043309
IRS1_HUMAN	IRS1	physical	16354680
KS6B1_HUMAN	RPS6KB1	physical	15066126
4EBP1_HUMAN	EIF4EBP1	physical	15066126
4EBP1_HUMAN	EIF4EBP1	physical	16798736
4EBP2_HUMAN	EIF4EBP2	physical	16798736
LST8_HUMAN	MLST8	physical	16798736
LST8_HUMAN	MLST8	physical	15459249
4EBP1_HUMAN	EIF4EBP1	physical	15459249
RICTR_HUMAN	RICTOR	physical	16962653
RPTOR_HUMAN	RPTOR	physical	16962653
4EBP1_HUMAN	EIF4EBP1	physical	21460630
4EBP1_HUMAN	EIF4EBP1	physical	16824195
4EBP1_HUMAN	EIF4EBP1	physical	17693255
RPTOR_HUMAN	RPTOR	physical	12718876
LST8_HUMAN	MLST8	physical	12718876
KS6B1_HUMAN	RPS6KB1	physical	12718876
4EBP1_HUMAN	EIF4EBP1	physical	15767663
4EBP1_HUMAN	EIF4EBP1	physical	18722121
4EBP1_HUMAN	EIF4EBP1	physical	12665511
KS6B1_HUMAN	RPS6KB1	physical	12604610
4EBP1_HUMAN	EIF4EBP1	physical	12604610
DPTOR_HUMAN	DEPTOR	physical	22017875
RICTR_HUMAN	RICTOR	physical	18566587
AKT1_HUMAN	AKT1	physical	18566587
AKT1_HUMAN	AKT1	physical	21177249
RICTR_HUMAN	RICTOR	physical	21177249
RICTR_HUMAN	RICTOR	physical	19875983
SIN1_HUMAN	MAPKAP1	physical	19875983
STK38_HUMAN	STK38	physical	19875983
RPTOR_HUMAN	RPTOR	physical	19875983
RICTR_HUMAN	RICTOR	physical	23297343
RPTOR_HUMAN	RPTOR	physical	23297343
DDB1_HUMAN	DDB1	physical	23297343
4EBP1_HUMAN	EIF4EBP1	physical	18337751
DPTOR_HUMAN	DEPTOR	physical	19446321
AKTS1_HUMAN	AKT1S1	physical	19446321
LST8_HUMAN	MLST8	physical	19446321
RPTOR_HUMAN	RPTOR	physical	19446321
RICTR_HUMAN	RICTOR	physical	19446321
RICTR_HUMAN	RICTOR	physical	19619545
RPTOR_HUMAN	RPTOR	physical	19619545
P53_HUMAN	TP53	physical	19619545
PREX1_HUMAN	PREX1	physical	17565979
RPTOR_HUMAN	RPTOR	physical	22258093
LST8_HUMAN	MLST8	physical	22258093
PDIA3_HUMAN	PDIA3	physical	21321085
RPTOR_HUMAN	RPTOR	physical	21321085
RICTR_HUMAN	RICTOR	physical	21321085
LST8_HUMAN	MLST8	physical	21321085
HSP74_HUMAN	HSPA4	physical	18505677
RICTR_HUMAN	RICTOR	physical	18505677
SIN1_HUMAN	MAPKAP1	physical	18505677
PRR5_HUMAN	PRR5	physical	18505677
LST8_HUMAN	MLST8	physical	18505677
RPTOR_HUMAN	RPTOR	physical	18505677
AKT1_HUMAN	AKT1	physical	18505677
KS6B1_HUMAN	RPS6KB1	physical	18505677
STAT1_HUMAN	STAT1	physical	19553685
AMRA1_HUMAN	AMBRA1	physical	23524951
RPTOR_HUMAN	RPTOR	physical	23911927
MTA2_HUMAN	MTA2	physical	22863883
4EBP1_HUMAN	EIF4EBP1	physical	17991864
FKB1A_HUMAN	FKBP1A	physical	17991864
FKBP8_HUMAN	FKBP8	physical	17991864
GBB1_HUMAN	GNB1	physical	24462769
GBG2_HUMAN	GNG2	physical	24462769
GBB2_HUMAN	GNB2	physical	24462769
GBB3_HUMAN	GNB3	physical	24462769
GNB5_HUMAN	GNB5	physical	24462769
RICTR_HUMAN	RICTOR	physical	18030348
RPTOR_HUMAN	RPTOR	physical	18030348
SIN1_HUMAN	MAPKAP1	physical	18030348
PRR5L_HUMAN	PRR5L	physical	18030348
LST8_HUMAN	MLST8	physical	18030348
AKTS1_HUMAN	AKT1S1	physical	18030348
4EBP1_HUMAN	EIF4EBP1	physical	18030348
MTOR_HUMAN	MTOR	physical	18030348
ILK_HUMAN	ILK	physical	18339839
RICTR_HUMAN	RICTOR	physical	18339839
IKKA_HUMAN	CHUK	physical	18519641
IKKB_HUMAN	IKBKB	physical	18519641
NEMO_HUMAN	IKBKG	physical	18519641
RPTOR_HUMAN	RPTOR	physical	18519641
IKBA_HUMAN	NFKBIA	physical	18519641
SGK1_HUMAN	SGK1	physical	18570873
RPTOR_HUMAN	RPTOR	physical	18570873
AKTS1_HUMAN	AKT1S1	physical	18570873
RICTR_HUMAN	RICTOR	physical	18570873
SIN1_HUMAN	MAPKAP1	physical	18570873
AKT1_HUMAN	AKT1	physical	18566586
SIN1_HUMAN	MAPKAP1	physical	18566586
RICTR_HUMAN	RICTOR	physical	18566586
GA45A_HUMAN	GADD45A	physical	23329839
STAT3_HUMAN	STAT3	physical	23329839
RPTOR_HUMAN	RPTOR	physical	18955708
4EBP1_HUMAN	EIF4EBP1	physical	18955708
RHEB_HUMAN	RHEB	physical	16098514
REBL1_HUMAN	RHEBL1	physical	16098514
RICTR_HUMAN	RICTOR	physical	19114562
RPTOR_HUMAN	RPTOR	physical	19114562
AKTS1_HUMAN	AKT1S1	physical	19114562
MAF1_HUMAN	MAF1	physical	20543138
RICTR_HUMAN	RICTOR	physical	20978191
AKT1_HUMAN	AKT1	physical	21343617
RICTR_HUMAN	RICTOR	physical	21343617
AKT1_HUMAN	AKT1	physical	23872070
RICTR_HUMAN	RICTOR	physical	23872070
RPTOR_HUMAN	RPTOR	physical	23872070
NBN_HUMAN	NBN	physical	23762398
RPTOR_HUMAN	RPTOR	physical	20381137
AKT1_HUMAN	AKT1	physical	22084251
LST8_HUMAN	MLST8	physical	22084251
RICTR_HUMAN	RICTOR	physical	22084251
SIN1_HUMAN	MAPKAP1	physical	22084251
4EBP1_HUMAN	EIF4EBP1	physical	16354698
B2CL1_HUMAN	BCL2L1	physical	20080789
SUMO1_HUMAN	SUMO1	physical	20537536
4EBP1_HUMAN	EIF4EBP1	physical	20537536
TF3C1_HUMAN	GTF3C1	physical	20543138
KAP0_HUMAN	PRKAR1A	physical	16963469
RPTOR_HUMAN	RPTOR	physical	17277771
RICTR_HUMAN	RICTOR	physical	17277771
SIN1_HUMAN	MAPKAP1	physical	17277771
LST8_HUMAN	MLST8	physical	17277771
AKTS1_HUMAN	AKT1S1	physical	17277771
1433Z_HUMAN	YWHAZ	physical	17277771
4EBP1_HUMAN	EIF4EBP1	physical	17386266
RICTR_HUMAN	RICTOR	physical	25897075
MLXIP_HUMAN	MLXIP	physical	25332233
RPTOR_HUMAN	RPTOR	physical	25332233
MLXPL_HUMAN	MLXIPL	physical	25332233
RPTOR_HUMAN	RPTOR	physical	24516643
PDK1_HUMAN	PDK1	physical	24516643
FKB1A_HUMAN	FKBP1A	physical	26344197
TRM61_HUMAN	TRMT61A	physical	26344197
RAB1A_HUMAN	RAB1A	physical	25446900
RPTOR_HUMAN	RPTOR	physical	25446900
PRKN_HUMAN	PARK2	physical	25007995
RPTOR_HUMAN	RPTOR	physical	25007995
SQSTM_HUMAN	SQSTM1	physical	26279575
M3K3_HUMAN	MAP3K3	physical	26279575
ULK1_HUMAN	ULK1	physical	25686248
4EBP1_HUMAN	EIF4EBP1	physical	25686248
DCP2_HUMAN	DCP2	physical	26098573
KS6B1_HUMAN	RPS6KB1	physical	25738361
FKB1A_HUMAN	FKBP1A	physical	20851351
ZNRF2_HUMAN	ZNRF2	physical	27244671
FBX8_HUMAN	FBXO8	physical	27916606
PGFRA_HUMAN	PDGFRA	genetic	28319113
PRKDC_HUMAN	PRKDC	genetic	28319113
SMAD4_HUMAN	SMAD4	genetic	28319113
TOP1_HUMAN	TOP1	genetic	28319113
PTEN_HUMAN	PTEN	genetic	28319113
AKT1_HUMAN	AKT1	physical	22337773
P53_HUMAN	TP53	genetic	27438146
THADA_HUMAN	THADA	physical	27173435
LST8_HUMAN	MLST8	physical	27173435
CHK1_HUMAN	CHEK1	genetic	27453043
1433Z_HUMAN	YWHAZ	genetic	27453043
RPTOR_HUMAN	RPTOR	physical	26522726
ESR1_HUMAN	ESR1	physical	26522726
SKP2_HUMAN	SKP2	physical	28446188
FKBP8_HUMAN	FKBP8	physical	24205284
EP300_HUMAN	EP300	physical	29033323

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00753: Sirolimus (USAN/INN); Rapamune (TN); Rapamycin (TN)
• D02714: Everolimus (JAN/USAN/INN); Afinitor (TN); Votubia (TN); Zortress (TN)
• D06068: Temsirolimus (JAN/USAN/INN); Torisel (TN)
• D08900: Ridaforolimus (JAN/USAN); Deforolimus
• D10076: Olcorolimus (USAN)
• DrugBank
• DB01590: Everolimus
• DB00337: Pimecrolimus
• DB00877: Sirolimus
• DB06287: Temsirolimus

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1218, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"mTOR kinase domain phosphorylation promotes mTORC1 signaling, cellgrowth, and cell cycle progression.";
Ekim B., Magnuson B., Acosta-Jaquez H.A., Keller J.A., Feener E.P.,Fingar D.C.;
Mol. Cell. Biol. 31:2787-2801(2011).
Cited for: AUTOPHOSPHORYLATION AT SER-2159.
PubMed: 21576368

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567; SER-916; SER-1261;THR-1829; THR-1839; THR-1840; THR-1841; SER-1843; SER-1847; SER-1849;SER-1851; THR-1856; SER-1859; SER-1863; SER-2448; TYR-2449 ANDTHR-2471, AND MASS SPECTROMETRY.
PubMed: 19369195

"Site-specific mTOR phosphorylation promotes mTORC1-mediated signalingand cell growth.";
Acosta-Jaquez H.A., Keller J.A., Foster K.G., Ekim B., Soliman G.A.,Feener E.P., Ballif B.A., Fingar D.C.;
Mol. Cell. Biol. 29:4308-4324(2009).
Cited for: PHOSPHORYLATION AT SER-1261.
PubMed: 19487463

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2478 AND SER-2481, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567 AND SER-1261, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1162, AND MASSSPECTROMETRY.
PubMed: 18187866

"Identification of S6 kinase 1 as a novel mammalian target ofrapamycin (mTOR)-phosphorylating kinase.";
Holz M.K., Blenis J.;
J. Biol. Chem. 280:26089-26093(2005).
Cited for: AUTOPHOSPHORYLATION AT THR-2446.
PubMed: 15905173