dbPTM

B2CL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	B2CL1_HUMAN
UniProt AC	Q07817
Protein Name	Bcl-2-like protein 1
Gene Name	BCL2L1
Organism	Homo sapiens (Human).
Sequence Length	233
Subcellular Localization	Isoform Bcl-X(L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Description	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. [PubMed: 17418785; Isoform Bcl-X(S) promotes apoptosis.]
Protein Sequence	MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQSNRELV ------CCCCCHHHH	42.17	22210691
4	Phosphorylation	----MSQSNRELVVD ----CCCCCHHHHHH	30.46	22210691
14	Phosphorylation	ELVVDFLSYKLSQKG HHHHHHHHHHHHHCC	21.88	30631047
16	Ubiquitination	VVDFLSYKLSQKGYS HHHHHHHHHHHCCCC	37.98	21890473
16 (in isoform 3)	Ubiquitination	-	37.98	21890473
16 (in isoform 1)	Ubiquitination	-	37.98	21890473
16 (in isoform 2)	Ubiquitination	-	37.98	21890473
18	Phosphorylation	DFLSYKLSQKGYSWS HHHHHHHHHCCCCHH	26.20	30631047
28	Phosphorylation	GYSWSQFSDVEENRT CCCHHHCCCCHHCCC	32.86	-
47	Phosphorylation	GTESEMETPSAINGN CCCCCCCCCCCCCCC	22.64	22617334
49	Phosphorylation	ESEMETPSAINGNPS CCCCCCCCCCCCCCC	49.56	21840391
62	Phosphorylation	PSWHLADSPAVNGAT CCCCCCCCCCCCCCC	14.78	7644501
87 (in isoform 3)	Ubiquitination	-	25.73	21890473
87 (in isoform 2)	Ubiquitination	-	25.73	21890473
87 (in isoform 1)	Ubiquitination	-	25.73	21890473
87	Ubiquitination	VIPMAAVKQALREAG HHHHHHHHHHHHHCC	25.73	21890473
115	Phosphorylation	LTSQLHITPGTAYQS HHHCCCCCCCHHHHC	12.62	22617334

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
47	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
47	T	Phosphorylation	Kinase	MAPK9	P45984	GPS
49	S	Phosphorylation	Kinase	PLK3	Q9H4B4	Uniprot
62	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
62	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
62	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
62	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
62	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
62	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
62	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
62	S	Phosphorylation	Kinase	PINK1	Q9BXM7	PSP
62	S	Phosphorylation	Kinase	PLK1	P53350	PSP
115	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
115	T	Phosphorylation	Kinase	MAPK9	P45984	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
49	S	Phosphorylation	21840391
Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.
62	S	Phosphorylation	19917720
Phosphorylated on Ser-62 by CDK1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of B2CL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AVEN_HUMAN	AVEN	physical	10949025
BNIP3_HUMAN	BNIP3	physical	10625696
RTN1_HUMAN	RTN1	physical	11126360
RTN4_HUMAN	RTN4	physical	11126360
BIK_HUMAN	BIK	physical	16189514
RAD9A_HUMAN	RAD9A	physical	16189514
BIK_HUMAN	BIK	physical	15694340
BID_HUMAN	BID	physical	15694340
APR_HUMAN	PMAIP1	physical	15694340
BAD_HUMAN	BAD	physical	15705582
BAK_HUMAN	BAK1	physical	12137781
BAX_HUMAN	BAX	physical	9824152
BAD_HUMAN	BAD	physical	12137781
BAX_HUMAN	BAX	physical	12137781
BCL2_HUMAN	BCL2	physical	12137781
BAK_HUMAN	BAK1	physical	14596824
B2L11_HUMAN	BCL2L11	physical	14596824
HRK_HUMAN	HRK	physical	14596824
VDAC1_HUMAN	VDAC1	physical	15637055
BAK_HUMAN	BAK1	physical	15901672
BIK_HUMAN	BIK	physical	12853473
VDAC1_HUMAN	VDAC1	physical	12767928
BAD_HUMAN	BAD	physical	12115603
PP1A_HUMAN	PPP1CA	physical	12115603
BECN1_HUMAN	BECN1	physical	9765397
RAD9A_HUMAN	RAD9A	physical	10620799
BIK_HUMAN	BIK	physical	11342619
CASP9_HUMAN	CASP9	physical	9539746
APAF_HUMAN	APAF1	physical	9539746
IKZF3_HUMAN	IKZF3	physical	11714801
FKBP8_HUMAN	FKBP8	physical	12510191
B2L11_MOUSE	Bcl2l11	physical	10198631
DYL1_HUMAN	DYNLL1	physical	10198631
BAD_HUMAN	BAD	physical	9389483
HRK_HUMAN	HRK	physical	10075695
BLID_HUMAN	BLID	physical	20400521
PARK7_HUMAN	PARK7	physical	21852238
BAX_HUMAN	BAX	physical	21852238
ZFYV1_HUMAN	ZFYVE1	physical	21900206
P53_HUMAN	TP53	physical	21900206
MET23_HUMAN	METTL23	physical	21900206
PPHLN_HUMAN	PPHLN1	physical	21900206
ZN219_HUMAN	ZNF219	physical	21900206
EDRF1_HUMAN	EDRF1	physical	21900206
PDIA4_HUMAN	PDIA4	physical	21900206
GLOD4_HUMAN	GLOD4	physical	21900206
RBM5_HUMAN	RBM5	physical	21900206
PLD3_HUMAN	PLD3	physical	21900206
DOCK7_HUMAN	DOCK7	physical	21900206
ZHX1_HUMAN	ZHX1	physical	21900206
UBR1_HUMAN	UBR1	physical	21900206
F16P1_HUMAN	FBP1	physical	21900206
TLE1_HUMAN	TLE1	physical	21900206
ACTB_HUMAN	ACTB	physical	21900206
ASPP2_HUMAN	TP53BP2	physical	21900206
LARP1_HUMAN	LARP1	physical	21900206
PTN_HUMAN	PTN	physical	21900206
CLUS_HUMAN	CLU	physical	21527247
B2L11_HUMAN	BCL2L11	physical	16260615
BMF_HUMAN	BMF	physical	16260615
CRYAA_HUMAN	CRYAA	physical	14752512
CRYAB_HUMAN	CRYAB	physical	14752512
BAD_HUMAN	BAD	physical	18628207
BECN1_HUMAN	BECN1	physical	18628207
ATX3_HUMAN	ATXN3	physical	23562578
BAK_HUMAN	BAK1	physical	10085290
PRKN_HUMAN	PARK2	physical	24999239
PINK1_HUMAN	PINK1	physical	24999239
B2L11_HUMAN	BCL2L11	physical	15721256
BID_HUMAN	BID	physical	15721256
BAD_HUMAN	BAD	physical	15721256
BIK_HUMAN	BIK	physical	15721256
BMF_HUMAN	BMF	physical	15721256
HRK_HUMAN	HRK	physical	15721256
APR_HUMAN	PMAIP1	physical	15721256
BBC3B_HUMAN	BBC3	physical	15721256
BBC3_HUMAN	BBC3	physical	15721256
ASPP2_HUMAN	TP53BP2	physical	18719108
TCTP_HUMAN	TPT1	physical	15870695
CDN2A_HUMAN	CDKN2A	physical	19049976
ARF_HUMAN	CDKN2A	physical	19049976
BECN1_HUMAN	BECN1	physical	19049976
BAX_HUMAN	BAX	physical	9027312
CASP1_HUMAN	CASP1	physical	9027312
C8AP2_HUMAN	CASP8AP2	physical	9027312
B2CL1_HUMAN	BCL2L1	physical	9111042
BAD_HUMAN	BAD	physical	9305851
BMF_HUMAN	BMF	physical	25416956
BAX_HUMAN	BAX	physical	19427863
B2L11_HUMAN	BCL2L11	physical	19427863
VDAC1_HUMAN	VDAC1	physical	20080789
MTOR_HUMAN	MTOR	physical	20080789
GIMA5_HUMAN	GIMAP5	physical	16509771
BID_HUMAN	BID	physical	16697956
B2L11_HUMAN	BCL2L11	physical	16697956
BAD_HUMAN	BAD	physical	16697956
BIK_HUMAN	BIK	physical	16697956
HRK_HUMAN	HRK	physical	16697956
BBC3B_HUMAN	BBC3	physical	16697956
BBC3_HUMAN	BBC3	physical	16697956
BMF_HUMAN	BMF	physical	16697956
BAD_HUMAN	BAD	physical	20603619
ATG5_HUMAN	ATG5	physical	16998475
PDS5A_HUMAN	PDS5A	physical	26186194
BCL2_HUMAN	BCL2	physical	26186194
BAX_HUMAN	BAX	physical	26186194
BAD_HUMAN	BAD	physical	26186194
B2L11_HUMAN	BCL2L11	physical	26186194
BNI3L_HUMAN	BNIP3L	physical	9973195
BAX_HUMAN	BAX	physical	25241761
CASP9_HUMAN	CASP9	physical	25241761
RAF1_HUMAN	RAF1	physical	25241761
B2L11_HUMAN	BCL2L11	physical	20836993
BAK_HUMAN	BAK1	physical	20836993
P53_HUMAN	TP53	physical	20837658
BAD_HUMAN	BAD	physical	20837658
PRKN_HUMAN	PARK2	physical	28038320
BBC3B_HUMAN	BBC3	physical	28202514
BBC3_HUMAN	BBC3	physical	28202514
BAX_HUMAN	BAX	physical	28202514
B2L11_HUMAN	BCL2L11	physical	28514442
BAD_HUMAN	BAD	physical	28514442
BCL2_HUMAN	BCL2	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
BAX_HUMAN	BAX	physical	28514442
CDK1_HUMAN	CDK1	physical	22617334
P53_HUMAN	TP53	physical	25115399
BAX_HUMAN	BAX	physical	25115399

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D09935	Navitoclax (USAN/INN)
D09936	Navitoclax dihydrochloride (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of B2CL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycleprogression and checkpoints."; Wang J., Beauchemin M., Bertrand R.; Cell. Signal. 23:2030-2038(2011). Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-49, ANDMUTAGENESIS OF SER-49.	21840391 [Abstract]
"Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation actsas a functional link coupling mitotic arrest and apoptosis."; Terrano D.T., Upreti M., Chambers T.C.; Mol. Cell. Biol. 30:640-656(2010). Cited for: FUNCTION IN APOPTOSIS, PHOSPHORYLATION AT SER-62 BY CDK1, ANDSUBCELLULAR LOCATION.	19917720 [Abstract]

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