BBC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BBC3_HUMAN
• UniProt AC: Q9BXH1
• Protein Name: Bcl-2-binding component 3
• Gene Name: BBC3
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.
• Protein Description: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis..
• Protein Sequence: MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ARARQEGSSPEPVEG CCCCCCCCCCCCCCC	41.80	28450419
10	Phosphorylation	RARQEGSSPEPVEGL CCCCCCCCCCCCCCC	44.11	23911959
44 (in isoform 2)	Phosphorylation	-	4.25	-
58	Phosphorylation	PTLLPAAYLCAPTAP CCCCCHHHHHCCCCC	12.38	-
90 (in isoform 2)	Phosphorylation	-	54.78	-
96	Phosphorylation	RPDGPQPSLSLAEQH CCCCCCCCCHHHHHH	25.91	-
104 (in isoform 2)	Phosphorylation	-	7.52	-
106	Phosphorylation	LAEQHLESPVPSAPG HHHHHHCCCCCCCCC	37.24	-
110 (in isoform 2)	Phosphorylation	-	47.53	-
152	Phosphorylation	ADDLNAQYERRRQEE HHHHHHHHHHHHHHH	14.70	-
166	Phosphorylation	EQQRHRPSPWRVLYN HHHHHCCCHHHHHHH	36.73	-
172	Phosphorylation	PSPWRVLYNLIMGLL CCHHHHHHHHHHHHC	12.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	CHUK	O15111	GPS
10	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
58	Y	Phosphorylation	Kinase	ERBB2	P04626	GPS
96	S	Phosphorylation	Kinase	IKKB	O14920	PSP
106	S	Phosphorylation	Kinase	IKKB	O14920	PSP
152	Y	Phosphorylation	Kinase	ERBB2	P04626	GPS
172	Y	Phosphorylation	Kinase	ERBB2	P04626	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BBC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BBC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	15694340
B2CL1_HUMAN	BCL2L1	physical	15694340
MCL1_HUMAN	MCL1	physical	15694340
BCL2_HUMAN	BCL2	physical	11463392
MCL1_HUMAN	MCL1	physical	21730980
B2CL1_HUMAN	BCL2L1	physical	19074266

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.