dbPTM

AVEN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AVEN_HUMAN
UniProt AC	Q9NQS1
Protein Name	Cell death regulator Aven
Gene Name	AVEN
Organism	Homo sapiens (Human).
Sequence Length	362
Subcellular Localization	Endomembrane system Peripheral membrane protein. Associated with intracellular membranes.
Protein Description	Protects against apoptosis mediated by Apaf-1..
Protein Sequence	MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Dimethylation	GRGRRPGRGRPGGDR CCCCCCCCCCCCCCC	40.40	-
28	Dimethylation	GGDRHSERPGAAAAV CCCCCCCCCCCCCHH	37.66	-
28	Methylation	GGDRHSERPGAAAAV CCCCCCCCCCCCCHH	37.66	-
37	Dimethylation	GAAAAVARGGGGGGG CCCCHHHCCCCCCCC	37.38	-
37	Methylation	GAAAAVARGGGGGGG CCCCHHHCCCCCCCC	37.38	-
50	Methylation	GGGDGGGRRGRGRGR CCCCCCCCCCCCCCC	40.95	-
87	Phosphorylation	GGWGAGASAPVEDDS CCCCCCCCCCCCCCC	31.99	30206219
94	Phosphorylation	SAPVEDDSDAETYGE CCCCCCCCCHHHHCC	51.55	22167270
98	Phosphorylation	EDDSDAETYGEENDE CCCCCHHHHCCCCCC	38.25	22167270
99	Phosphorylation	DDSDAETYGEENDEQ CCCCHHHHCCCCCCC	17.66	22167270
109	Phosphorylation	ENDEQGNYSKRKIVS CCCCCCCCCCHHCCC	23.53	23403867
110	Phosphorylation	NDEQGNYSKRKIVSN CCCCCCCCCHHCCCC	29.95	23403867
116	Phosphorylation	YSKRKIVSNWDRYQD CCCHHCCCCHHHHHH	35.36	-
121	Phosphorylation	IVSNWDRYQDIEKEV CCCCHHHHHHHHHHH	14.20	28796482
129	Ubiquitination	QDIEKEVNNESGESQ HHHHHHHHCCCCCCC	47.87	22817900
131	Ubiquitination	IEKEVNNESGESQRG HHHHHHCCCCCCCCC	55.72	22817900
135	Phosphorylation	VNNESGESQRGTDFS HHCCCCCCCCCCCHH	28.80	18571408
140	Ubiquitination	GESQRGTDFSVLLSS CCCCCCCCHHHEECC	36.33	22817900
142	Ubiquitination	SQRGTDFSVLLSSAG CCCCCCHHHEECCCC	18.05	22817900
144	Ubiquitination	RGTDFSVLLSSAGDS CCCCHHHEECCCCCC	3.58	23000965
150	Ubiquitination	VLLSSAGDSFSQFRF HEECCCCCCHHHCCC	46.34	22817900
151	Phosphorylation	LLSSAGDSFSQFRFA EECCCCCCHHHCCCC	26.36	28348404
152	Ubiquitination	LSSAGDSFSQFRFAE ECCCCCCHHHCCCCH	8.72	22817900
155	Ubiquitination	AGDSFSQFRFAEEKE CCCCHHHCCCCHHHC	7.22	23000965
161	Ubiquitination	QFRFAEEKEWDSEAS HCCCCHHHCCCCCCC	56.46	29967540
165	Ubiquitination	AEEKEWDSEASCPKQ CHHHCCCCCCCCCCC	35.81	23000965
177	Phosphorylation	PKQNSAFYVDSELLV CCCCCCEEECHHHHH	11.76	27642862
215	Ubiquitination	PLEVPQVKPKRTDDG CCCCCCCCCCCCCCC	39.30	22817900
217	Ubiquitination	EVPQVKPKRTDDGKG CCCCCCCCCCCCCCC	63.31	22817900
230	Methylation	KGLGMQLKGPLGPGG CCCCCEEECCCCCCC	41.41	24129315
230	Ubiquitination	KGLGMQLKGPLGPGG CCCCCEEECCCCCCC	41.41	23000965
238	Methylation	GPLGPGGRGPIFELK CCCCCCCCCCCHHHH	54.34	-
245	Methylation	RGPIFELKSVAAGCP CCCCHHHHHHHCCCC	35.37	-
245	Ubiquitination	RGPIFELKSVAAGCP CCCCHHHHHHHCCCC	35.37	29967540
246	Phosphorylation	GPIFELKSVAAGCPV CCCHHHHHHHCCCCE	29.61	24732914
261	Phosphorylation	LLGKDNPSPGPSRDS EECCCCCCCCCCCCC	49.06	25159151
265	Phosphorylation	DNPSPGPSRDSQKPT CCCCCCCCCCCCCCC	55.42	23401153
268	Phosphorylation	SPGPSRDSQKPTSPL CCCCCCCCCCCCCCC	38.71	23663014
272	Phosphorylation	SRDSQKPTSPLQSAG CCCCCCCCCCCCCCC	50.43	25159151
273	Phosphorylation	RDSQKPTSPLQSAGD CCCCCCCCCCCCCCC	31.94	25159151
277	Phosphorylation	KPTSPLQSAGDHLEE CCCCCCCCCCCCHHH	41.73	23663014
307	Phosphorylation	DNILPDQTSQDLKSK CCCCCCCCCHHHHHC	35.42	20068231
308	Phosphorylation	NILPDQTSQDLKSKE CCCCCCCCHHHHHCC	18.96	18571408
328	Acetylation	QEEEVCAKPSVTEEK CHHHCCCCCCCCCCC	32.47	26051181
330	Phosphorylation	EEVCAKPSVTEEKNM HHCCCCCCCCCCCCC	40.75	23312004
332	Phosphorylation	VCAKPSVTEEKNMEP CCCCCCCCCCCCCCC	42.64	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
135	S	Phosphorylation	Kinase	ATM	Q13315	PSP
308	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AVEN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AVEN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2CL1_HUMAN	BCL2L1	physical	10949025
BCL2_HUMAN	BCL2	physical	10949025
APAF_HUMAN	APAF1	physical	10949025

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AVEN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.	18669648 [Abstract]