ZFYV1_HUMAN - dbPTM
ZFYV1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZFYV1_HUMAN
UniProt AC Q9HBF4
Protein Name Zinc finger FYVE domain-containing protein 1
Gene Name ZFYVE1
Organism Homo sapiens (Human).
Sequence Length 777
Subcellular Localization Golgi apparatus, Golgi stack. Endoplasmic reticulum. Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum.
Protein Description
Protein Sequence MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHERIRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTVYNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
72UbiquitinationPGHVPYCDLCKGLSG
CCCCCHHHHCCCCCC		49.6229967540
124PhosphorylationPVTVYNVSNLQESLE
CEEEEEECCHHHHHH		28.3428122231
129PhosphorylationNVSNLQESLEAEEMD
EECCHHHHHHHHHCC		20.6729523821
139PhosphorylationAEEMDEETKRKKMTE
HHHCCHHHHHHHHHH		33.8228122231
171UbiquitinationNEEDFIRKLDCKPDQ
CHHHHHHHCCCCCCC		43.8129967540
213PhosphorylationEVFKTSPTQESCTVG
EEECCCCCCCCCEEE		44.74-
289UbiquitinationDASEAYLKHFTKELK
CHHHHHHHHHHHHHH		24.8129967540
296UbiquitinationKHFTKELKATTARCG
HHHHHHHHHHHHCCC		44.7929967540
355PhosphorylationGRFPEAFSSIHYKGT
CCCCHHHHCCCCCCC		35.1222210691
356PhosphorylationRFPEAFSSIHYKGTR
CCCHHHHCCCCCCCC		13.6122210691
359PhosphorylationEAFSSIHYKGTRTYN
HHHHCCCCCCCCCCC		14.9422210691
369PhosphorylationTRTYNPPTDFSGLRR
CCCCCCCCCHHHHHH		51.4321712546
386PhosphorylationEQLLENNTTRSPRHP
HHHHHCCCCCCCCCH		34.86-
487UbiquitinationEEVSVVPKTSASTDS
CEEEEECCCCCCCCC		43.4329967540
491PhosphorylationVVPKTSASTDSPWMG
EECCCCCCCCCCCCC		32.3027251275
492PhosphorylationVPKTSASTDSPWMGL
ECCCCCCCCCCCCCC		39.9727251275
494PhosphorylationKTSASTDSPWMGLAK
CCCCCCCCCCCCCCH		22.1322199227
599PhosphorylationPAYWRPNSQILSCNK
CCCCCCCCCEEECCC		22.6827282143
603PhosphorylationRPNSQILSCNKCATS
CCCCCEEECCCCCCC		19.7830631047
630PhosphorylationCGEGFCDSCSSKTRP
CCCCCCHHCCCCCCC		19.6527251275
632PhosphorylationEGFCDSCSSKTRPVP
CCCCHHCCCCCCCCC		38.53-
633PhosphorylationGFCDSCSSKTRPVPE
CCCHHCCCCCCCCCC		42.23-
729PhosphorylationHNCRKEFSIKLSKHH
CCCCCEEEEEECHHH		21.6524719451
733PhosphorylationKEFSIKLSKHHCRAC
CEEEEEECHHHHCCC		25.5829457462
753DimethylationDECSHDRRAVPSRGW
HHCCCCCCCCCCCCC		46.09-
753MethylationDECSHDRRAVPSRGW
HHCCCCCCCCCCCCC		46.0924380031
765DimethylationRGWDHPVRVCFNCNK
CCCCCCEEEEEECCC		24.76-
765MethylationRGWDHPVRVCFNCNK
CCCCCCEEEEEECCC		24.7624380039
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZFYV1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZFYV1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZFYV1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
TRI18_HUMANMID1physical
28514442
KCTD6_HUMANKCTD6physical
28514442
LIMD1_HUMANLIMD1physical
28514442
LONF2_HUMANLONRF2physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZFYV1_HUMAN

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Related Literatures of Post-Translational Modification

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