GIMA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIMA5_HUMAN
• UniProt AC: Q96F15
• Protein Name: GTPase IMAP family member 5
• Gene Name: GIMAP5
• Organism: Homo sapiens (Human).
• Sequence Length: 307
• Subcellular Localization: Mitochondrion outer membrane; Single-pass type IV membrane protein. Lysosome .
• Protein Description: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity)..
• Protein Sequence: MGGFQRGKYGTMAEGRSEDNLSATPPALRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVRECERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQEDYRQYQAKVEWQVEKHKQELRENESNWAYKALLRVKHLMLLHYEIFVFLLLCSILFFIIFLFIFHYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MGGFQRGKYGTMAEG CCCCCCCCCCCCCCC	42.57	-
8	Acetylation	MGGFQRGKYGTMAEG CCCCCCCCCCCCCCC	42.57	25953088
9	Phosphorylation	GGFQRGKYGTMAEGR CCCCCCCCCCCCCCC	22.20	28464451
10 (in isoform 2)	Phosphorylation	-	16.70	24043423
11	Phosphorylation	FQRGKYGTMAEGRSE CCCCCCCCCCCCCCC	15.32	28464451
14 (in isoform 2)	Phosphorylation	-	44.30	24043423
17	Phosphorylation	GTMAEGRSEDNLSAT CCCCCCCCCCCCCCC	61.22	23401153
22	Phosphorylation	GRSEDNLSATPPALR CCCCCCCCCCCCEEE	36.03	23401153
24	Phosphorylation	SEDNLSATPPALRII CCCCCCCCCCEEEEE	26.82	23401153
35	Acetylation	LRIILVGKTGCGKSA EEEEEEECCCCCCCC	33.97	25953088
35	Ubiquitination	LRIILVGKTGCGKSA EEEEEEECCCCCCCC	33.97	-
36	Phosphorylation	RIILVGKTGCGKSAT EEEEEECCCCCCCCC	31.60	-
40	Ubiquitination	VGKTGCGKSATGNSI EECCCCCCCCCCCCC	40.78	-
41	Phosphorylation	GKTGCGKSATGNSIL ECCCCCCCCCCCCCC	19.15	28857561
43	Phosphorylation	TGCGKSATGNSILGQ CCCCCCCCCCCCCCC	43.94	28857561
46	Phosphorylation	GKSATGNSILGQPVF CCCCCCCCCCCCEEC	22.12	28857561
56	Ubiquitination	GQPVFESKLRAQSVT CCEECCHHHHHCEEE	34.49	-
69	Ubiquitination	VTRTCQVKTGTWNGR EECEEEEECCCCCCE	18.50	-
77	Ubiquitination	TGTWNGRKVLVVDTP CCCCCCEEEEEECCC	41.12	-
85	Phosphorylation	VLVVDTPSIFESQAD EEEECCCHHHCCCCC	41.84	25311616
89	Phosphorylation	DTPSIFESQADTQEL CCCHHHCCCCCHHHH	21.66	25311616
93	Phosphorylation	IFESQADTQELYKNI HHCCCCCHHHHHHHH	27.27	25311616
135	Ubiquitination	TVAIRKVKEVFGTGA HHHHHHHHHHHCCCC	51.72	-
174	Ubiquitination	NTDNCSLKDLVRECE CCCCCCHHHHHHHHH	32.49	-
217	Phosphorylation	LGREREGSFHSNDLF HHCCCCCCCCCCCHH	18.29	30108239
220	Phosphorylation	EREGSFHSNDLFLDA CCCCCCCCCCHHHCH	29.99	30108239
255	Ubiquitination	KVEWQVEKHKQELRE HHHHHHHHHHHHHHH	58.19	-
257	Ubiquitination	EWQVEKHKQELRENE HHHHHHHHHHHHHCC	57.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIMA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIMA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIMA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GRM2B_HUMAN	GRAMD3	physical	25416956
LSME2_HUMAN	LSMEM2	physical	25416956
LRAD1_HUMAN	LDLRAD1	physical	25416956
BCL2_HUMAN	BCL2	physical	16509771
B2CL1_HUMAN	BCL2L1	physical	16509771
BAX_HUMAN	BAX	physical	16509771
BAK_HUMAN	BAK1	physical	16509771
BAD_HUMAN	BAD	physical	16509771
B2L11_HUMAN	BCL2L11	physical	16509771

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.