BAK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAK_HUMAN
• UniProt AC: Q16611
• Protein Name: Bcl-2 homologous antagonist/killer
• Gene Name: BAK1
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Mitochondrion membrane ; Single-pass membrane protein .
• Protein Description: Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases..
• Protein Sequence: MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGQGPGP ------CCCCCCCCC	23.51	19413330
3	Phosphorylation	-----MASGQGPGPP -----CCCCCCCCCC	30.28	28961369
108	Phosphorylation	QPTAENAYEYFTKIA CCCHHHHHHHHHHHH	23.81	22817900
110	Phosphorylation	TAENAYEYFTKIATS CHHHHHHHHHHHHHH	12.13	22817900
117	Phosphorylation	YFTKIATSLFESGIN HHHHHHHHHHHCCCC	23.26	-
148	Phosphorylation	HVYQHGLTGFLGQVT HHHHHCHHHHHHHHH	30.40	21406692
155	Phosphorylation	TGFLGQVTRFVVDFM HHHHHHHHHHHHHHH	15.53	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
108	Y	Phosphorylation	Kinase	BMX	P51813	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:18715924

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2CL1_HUMAN	BCL2L1	physical	16189514
FRYL_HUMAN	FRYL	physical	17353931
AKP13_HUMAN	AKAP13	physical	17353931
FBRL_HUMAN	FBL	physical	17353931
SRRM2_HUMAN	SRRM2	physical	17353931
K1H1_HUMAN	KRT31	physical	17353931
VDAC2_HUMAN	VDAC2	physical	17353931
DFFA_HUMAN	DFFA	physical	17353931
ARP2_HUMAN	ACTR2	physical	17353931
MYCB2_HUMAN	MYCBP2	physical	17353931
BAK_HUMAN	BAK1	physical	15077116
B2CL1_HUMAN	BCL2L1	physical	11175750
MCL1_HUMAN	MCL1	physical	10837489
BAX_HUMAN	BAX	physical	11571294
DREB_HUMAN	DBN1	physical	21900206
GDIR1_HUMAN	ARHGDIA	physical	21900206
TOM40_HUMAN	TOMM40	physical	22939629
TOM7_HUMAN	TOMM7	physical	22939629
IKBB_HUMAN	NFKBIB	physical	8887627
B2CL1_HUMAN	BCL2L1	physical	19060904
DHB4_HUMAN	HSD17B4	physical	21988832
B2CL1_HUMAN	BCL2L1	physical	10085290
B2LA1_HUMAN	BCL2A1	physical	25416956
B2CL2_HUMAN	BCL2L2	physical	25416956
P53_HUMAN	TP53	physical	25408501
HERC1_HUMAN	HERC1	physical	25408501
MCL1_HUMAN	MCL1	physical	17097560
MCL1_HUMAN	MCL1	physical	20836993
BCL2_HUMAN	BCL2	physical	20836993
B2CL1_HUMAN	BCL2L1	physical	20836993
NU5M_HUMAN	ND5	physical	25115399

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.