P53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P53_HUMAN
• UniProt AC: P04637
• Protein Name: Cellular tumor antigen p53
• Gene Name: TP53
• Organism: Homo sapiens (Human).
• Sequence Length: 393
• Subcellular Localization: Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates t
• Protein Description: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2. [PubMed: 24051492]
• Protein Sequence: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEEPQSDPSVEPP --CCCCCCCCCCCCC	63.30	15792956
7 (in isoform 4)	Phosphorylation	-	33.96	-
7 (in isoform 5)	Phosphorylation	-	33.96	-
7 (in isoform 6)	Phosphorylation	-	33.96	-
9	Phosphorylation	EEPQSDPSVEPPLSQ CCCCCCCCCCCCCCH	44.07	9765199
15	Phosphorylation	PSVEPPLSQETFSDL CCCCCCCCHHHHHHH	31.57	20123963
18	Phosphorylation	EPPLSQETFSDLWKL CCCCCHHHHHHHHHH	22.32	10606744
20	Phosphorylation	PLSQETFSDLWKLLP CCCHHHHHHHHHHCC	38.93	11258706
24	Ubiquitination	ETFSDLWKLLPENNV HHHHHHHHHCCCCCC	47.66	-
32	Ubiquitination	LLPENNVLSPLPSQA HCCCCCCCCCCCHHH	4.79	21890473
32	Ubiquitination	LLPENNVLSPLPSQA HCCCCCCCCCCCHHH	4.79	21890473
33	Phosphorylation	LPENNVLSPLPSQAM CCCCCCCCCCCHHHH	21.80	17906639
37	Phosphorylation	NVLSPLPSQAMDDLM CCCCCCCHHHHHHHC	37.95
46	Phosphorylation	AMDDLMLSPDDIEQW HHHHHCCCHHHHHHH	16.59	16793543
55	Phosphorylation	DDIEQWFTEDPGPDE HHHHHHHHCCCCCCC	36.20	16793543
81	Phosphorylation	APAPAAPTPAAPAPA CCCCCCCCCCCCCCC	22.34	12531896
99	Phosphorylation	PLSSSVPSQKTYQGS CCCCCCCCCCEEECC	42.00	17525332
101	Ubiquitination	SSSVPSQKTYQGSYG CCCCCCCCEEECCCE	54.24	21890473
101 (in isoform 1)	Ubiquitination	-	54.24	21890473
101 (in isoform 2)	Ubiquitination	-	54.24	21890473
101	Ubiquitination	SSSVPSQKTYQGSYG CCCCCCCCEEECCCE	54.24	21890473
101	Ubiquitination	SSSVPSQKTYQGSYG CCCCCCCCEEECCCE	54.24	21890473
101	Ubiquitination	SSSVPSQKTYQGSYG CCCCCCCCEEECCCE	54.24	21890473
103	Nitration	SVPSQKTYQGSYGFR CCCCCCEEECCCEEE	20.22	-
103	Phosphorylation	SVPSQKTYQGSYGFR CCCCCCEEECCCEEE	20.22	29496907
106	Phosphorylation	SQKTYQGSYGFRLGF CCCEEECCCEEEEEE	13.42	-
107	Nitration	QKTYQGSYGFRLGFL CCEEECCCEEEEEEE	27.40	-
110	Methylation	YQGSYGFRLGFLHSG EECCCEEEEEEECCC	29.55	5168515
115	Methylation	GFRLGFLHSGTAKSV EEEEEEECCCCCCEE	23.17	5168519
120	Acetylation	FLHSGTAKSVTCTYS EECCCCCCEEEEECC	45.34	23431171
120	Ubiquitination	FLHSGTAKSVTCTYS EECCCCCCEEEEECC	45.34	19536131
120 (in isoform 1)	Ubiquitination	-	45.34	21890473
120 (in isoform 2)	Ubiquitination	-	45.34	21890473
122	Ubiquitination	HSGTAKSVTCTYSPA CCCCCCEEEEECCHH	5.13	21890473
124	Glutathionylation	GTAKSVTCTYSPALN CCCCEEEEECCHHHH	2.93	22833525
124	S-nitrosylation	GTAKSVTCTYSPALN CCCCEEEEECCHHHH	2.93	23796488
125	Phosphorylation	TAKSVTCTYSPALNK CCCEEEEECCHHHHH	20.05	26471730
126	Nitration	AKSVTCTYSPALNKM CCEEEEECCHHHHHH	18.14	-
126	Phosphorylation	AKSVTCTYSPALNKM CCEEEEECCHHHHHH	18.14	30377224
127	Phosphorylation	KSVTCTYSPALNKMF CEEEEECCHHHHHHH	5.88	30377224
132	Ubiquitination	TYSPALNKMFCQLAK ECCHHHHHHHHHHHC	33.92	21890473
132 (in isoform 1)	Ubiquitination	-	33.92	21890473
132 (in isoform 2)	Ubiquitination	-	33.92	21890473
132	Ubiquitination	TYSPALNKMFCQLAK ECCHHHHHHHHHHHC	33.92	21890473
132	Ubiquitination	TYSPALNKMFCQLAK ECCHHHHHHHHHHHC	33.92	21890473
132	Ubiquitination	TYSPALNKMFCQLAK ECCHHHHHHHHHHHC	33.92	21890473
139	Ubiquitination	KMFCQLAKTCPVQLW HHHHHHHCCCCEEEE	60.29	17371868
141	Glutathionylation	FCQLAKTCPVQLWVD HHHHHCCCCEEEEEC	2.83	22833525
141	S-nitrosylation	FCQLAKTCPVQLWVD HHHHHCCCCEEEEEC	2.83	23796488
149	O-linked_Glycosylation	PVQLWVDSTPPPGTR CEEEEECCCCCCCCE	32.94	25619971
149	Phosphorylation	PVQLWVDSTPPPGTR CEEEEECCCCCCCCE	32.94	28450419
150	Phosphorylation	VQLWVDSTPPPGTRV EEEEECCCCCCCCEE	35.04	17906639
154	Ubiquitination	VDSTPPPGTRVRAMA ECCCCCCCCEEEEEE	31.74	21890473
155	Phosphorylation	DSTPPPGTRVRAMAI CCCCCCCCEEEEEEE	31.59	28450419
160	Acetylation	PGTRVRAMAIYKQSQ CCCEEEEEEEEEHHH	1.31	19608861
160	Ubiquitination	PGTRVRAMAIYKQSQ CCCEEEEEEEEEHHH	1.31	19608861
160	Ubiquitination	PGTRVRAMAIYKQSQ CCCEEEEEEEEEHHH	1.31	21890473
160	Ubiquitination	PGTRVRAMAIYKQSQ CCCEEEEEEEEEHHH	1.31	21890473
163	Nitration	RVRAMAIYKQSQHMT EEEEEEEEEHHHHHH	8.08	-
164	Acetylation	VRAMAIYKQSQHMTE EEEEEEEEHHHHHHH	37.04	18485870
164	Ubiquitination	VRAMAIYKQSQHMTE EEEEEEEEHHHHHHH	37.04	21890473
164 (in isoform 1)	Ubiquitination	-	37.04	21890473
164 (in isoform 2)	Ubiquitination	-	37.04	21890473
164	Ubiquitination	VRAMAIYKQSQHMTE EEEEEEEEHHHHHHH	37.04	21890473
164	Ubiquitination	VRAMAIYKQSQHMTE EEEEEEEEHHHHHHH	37.04	21890473
164	Ubiquitination	VRAMAIYKQSQHMTE EEEEEEEEHHHHHHH	37.04	21890473
173	Acetylation	SQHMTEVVRRCPHHE HHHHHHHHHHCCCCC	2.32	19608861
173	Ubiquitination	SQHMTEVVRRCPHHE HHHHHHHHHHCCCCC	2.32	19608861
173	Ubiquitination	SQHMTEVVRRCPHHE HHHHHHHHHHCCCCC	2.32	21890473
173	Ubiquitination	SQHMTEVVRRCPHHE HHHHHHHHHHCCCCC	2.32	21890473
182	Glutathionylation	RCPHHERCSDSDGLA HCCCCCCCCCCCCCC	4.89	22833525
182	S-nitrosylation	RCPHHERCSDSDGLA HCCCCCCCCCCCCCC	4.89	23796488
183	Phosphorylation	CPHHERCSDSDGLAP CCCCCCCCCCCCCCC	46.50	22611192
187	Acetylation	ERCSDSDGLAPPQHL CCCCCCCCCCCCHHE	27.91	17110336
187	Ubiquitination	ERCSDSDGLAPPQHL CCCCCCCCCCCCHHE	27.91	17110336
188	Acetylation	RCSDSDGLAPPQHLI CCCCCCCCCCCHHEE	8.52	9891054
188	Ubiquitination	RCSDSDGLAPPQHLI CCCCCCCCCCCHHEE	8.52	9891054
189	Acetylation	CSDSDGLAPPQHLIR CCCCCCCCCCHHEEE	21.18	17110336
189	Ubiquitination	CSDSDGLAPPQHLIR CCCCCCCCCCHHEEE	21.18	17110336
205	Nitration	EGNLRVEYLDDRNTF ECCEEEEEECCCCCE	16.75	-
205	Phosphorylation	EGNLRVEYLDDRNTF ECCEEEEEECCCCCE	16.75	25690035
209	Methylation	RVEYLDDRNTFRHSV EEEEECCCCCEEEEE	43.70	5168513
211	Phosphorylation	EYLDDRNTFRHSVVV EEECCCCCEEEEEEE	23.96	22611192
213	Methylation	LDDRNTFRHSVVVPY ECCCCCEEEEEEECC	21.09	5168517
215	Phosphorylation	DRNTFRHSVVVPYEP CCCCEEEEEEECCCC	16.61	22611192
219	Ubiquitination	FRHSVVVPYEPPEVG EEEEEEECCCCCCCC	19.03	11046142
220	Nitration	RHSVVVPYEPPEVGS EEEEEECCCCCCCCC	29.47	-
220	Phosphorylation	RHSVVVPYEPPEVGS EEEEEECCCCCCCCC	29.47	-
225	Ubiquitination	VPYEPPEVGSDCTTI ECCCCCCCCCCCEEE	12.56	11046142
234	Nitration	SDCTTIHYNYMCNSS CCCEEEECEECCCCC	12.25	-
236	Nitration	CTTIHYNYMCNSSCM CEEEECEECCCCCCC	8.90	-
238	Acetylation	TIHYNYMCNSSCMGG EEECEECCCCCCCCC	2.93	17110336
238	Methylation	TIHYNYMCNSSCMGG EEECEECCCCCCCCC	2.93	17110336
238	Ubiquitination	TIHYNYMCNSSCMGG EEECEECCCCCCCCC	2.93	17110336
240	Acetylation	HYNYMCNSSCMGGMN ECEECCCCCCCCCCC	21.71	9288740
240	Methylation	HYNYMCNSSCMGGMN ECEECCCCCCCCCCC	21.71	9288740
240	Ubiquitination	HYNYMCNSSCMGGMN ECEECCCCCCCCCCC	21.71	9288740
241	Acetylation	YNYMCNSSCMGGMNR CEECCCCCCCCCCCC	8.30	17110336
241	Methylation	YNYMCNSSCMGGMNR CEECCCCCCCCCCCC	8.30	17110336
241	Ubiquitination	YNYMCNSSCMGGMNR CEECCCCCCCCCCCC	8.30	17110336
249	Acetylation	CMGGMNRRPILTIIT CCCCCCCCCEEEEEE	20.01	17110336
249	Phosphorylation	CMGGMNRRPILTIIT CCCCCCCCCEEEEEE	20.01	-
249	Ubiquitination	CMGGMNRRPILTIIT CCCCCCCCCEEEEEE	20.01	17110336
250	Acetylation	MGGMNRRPILTIITL CCCCCCCCEEEEEEE	23.78	19608861
250	Methylation	MGGMNRRPILTIITL CCCCCCCCEEEEEEE	23.78	19608861
250	Ubiquitination	MGGMNRRPILTIITL CCCCCCCCEEEEEEE	23.78	19608861
253	Acetylation	MNRRPILTIITLEDS CCCCCEEEEEEEECC	15.85	19608861
253	Ubiquitination	MNRRPILTIITLEDS CCCCCEEEEEEEECC	15.85	19608861
254	Acetylation	NRRPILTIITLEDSS CCCCEEEEEEEECCC	1.71	17110336
254	Methylation	NRRPILTIITLEDSS CCCCEEEEEEEECCC	1.71	17110336
254	Ubiquitination	NRRPILTIITLEDSS CCCCEEEEEEEECCC	1.71	17110336
266	Acetylation	DSSGNLLGRNSFEVR CCCCCCCCCCCEEEE	29.86	19608861
266	Ubiquitination	DSSGNLLGRNSFEVR CCCCCCCCCCCEEEE	29.86	19608861
269	Phosphorylation	GNLLGRNSFEVRVCA CCCCCCCCEEEEEEE	22.79	22817900
280	Acetylation	RVCACPGRDRRTEEE EEEECCCCCCCCHHH	21.29	17110336
280	Ubiquitination	RVCACPGRDRRTEEE EEEECCCCCCCCHHH	21.29	17110336
281	Acetylation	VCACPGRDRRTEEEN EEECCCCCCCCHHHH	50.78	9891054
281	Ubiquitination	VCACPGRDRRTEEEN EEECCCCCCCCHHHH	50.78	9891054
282	Acetylation	CACPGRDRRTEEENL EECCCCCCCCHHHHH	46.16	17110336
282	Ubiquitination	CACPGRDRRTEEENL EECCCCCCCCHHHHH	46.16	17110336
282	Ubiquitination	CACPGRDRRTEEENL EECCCCCCCCHHHHH	46.16	21890473
284	Phosphorylation	CPGRDRRTEEENLRK CCCCCCCCHHHHHHH	48.95	20959462
290	Methylation	RTEEENLRKKGEPHH CCHHHHHHHCCCCCC	50.66	115486213
291	Ubiquitination	TEEENLRKKGEPHHE CHHHHHHHCCCCCCC	69.19	19536131
292	Acetylation	EEENLRKKGEPHHEL HHHHHHHCCCCCCCC	63.17	19608861
292	Propionylation	EEENLRKKGEPHHEL HHHHHHHCCCCCCCC	63.17	-
292	Ubiquitination	EEENLRKKGEPHHEL HHHHHHHCCCCCCCC	63.17	19536131
292 (in isoform 1)	Ubiquitination	-	63.17	21890473
292 (in isoform 2)	Ubiquitination	-	63.17	21890473
292	Ubiquitination	EEENLRKKGEPHHEL HHHHHHHCCCCCCCC	63.17	21890473
292	Ubiquitination	EEENLRKKGEPHHEL HHHHHHHCCCCCCCC	63.17	21890473
292	Ubiquitination	EEENLRKKGEPHHEL HHHHHHHCCCCCCCC	63.17	21890473
295	Ubiquitination	NLRKKGEPHHELPPG HHHHCCCCCCCCCCC	42.68	21890473
304	Phosphorylation	HELPPGSTKRALPNN CCCCCCCCCCCCCCC	30.39	-
305	Acetylation	ELPPGSTKRALPNNT CCCCCCCCCCCCCCC	37.05	19608861
305	Ubiquitination	ELPPGSTKRALPNNT CCCCCCCCCCCCCCC	37.05	19608861
305 (in isoform 1)	Ubiquitination	-	37.05	21890473
305 (in isoform 2)	Ubiquitination	-	37.05	21890473
305	Ubiquitination	ELPPGSTKRALPNNT CCCCCCCCCCCCCCC	37.05	21890473
305	Ubiquitination	ELPPGSTKRALPNNT CCCCCCCCCCCCCCC	37.05	21890473
305	Ubiquitination	ELPPGSTKRALPNNT CCCCCCCCCCCCCCC	37.05	21890473
310	Ubiquitination	STKRALPNNTSSSPQ CCCCCCCCCCCCCCC	66.32	21890473
311	Ubiquitination	TKRALPNNTSSSPQP CCCCCCCCCCCCCCC	39.12	21890473
312	Phosphorylation	KRALPNNTSSSPQPK CCCCCCCCCCCCCCC	36.30	30266825
313	Phosphorylation	RALPNNTSSSPQPKK CCCCCCCCCCCCCCC	30.83	30266825
314	Phosphorylation	ALPNNTSSSPQPKKK CCCCCCCCCCCCCCC	43.96	29255136
315	Phosphorylation	LPNNTSSSPQPKKKP CCCCCCCCCCCCCCC	27.59	29255136
318 (in isoform 4)	Ubiquitination	-	54.54	-
319	Acetylation	TSSSPQPKKKPLDGE CCCCCCCCCCCCCCC	69.08	17267393
319	Butyrylation	TSSSPQPKKKPLDGE CCCCCCCCCCCCCCC	69.08	-
319	Propionylation	TSSSPQPKKKPLDGE CCCCCCCCCCCCCCC	69.08	-
319	Ubiquitination	TSSSPQPKKKPLDGE CCCCCCCCCCCCCCC	69.08	19927155
320	Acetylation	SSSPQPKKKPLDGEY CCCCCCCCCCCCCCC	67.32	9891054
320	Butyrylation	SSSPQPKKKPLDGEY CCCCCCCCCCCCCCC	67.32	-
320	Neddylation	SSSPQPKKKPLDGEY CCCCCCCCCCCCCCC	67.32	-
320	Propionylation	SSSPQPKKKPLDGEY CCCCCCCCCCCCCCC	67.32	-
320	Ubiquitination	SSSPQPKKKPLDGEY CCCCCCCCCCCCCCC	67.32	9891054
320 (in isoform 1)	Ubiquitination	-	67.32	21890473
320	Ubiquitination	SSSPQPKKKPLDGEY CCCCCCCCCCCCCCC	67.32	21890473
321	Acetylation	SSPQPKKKPLDGEYF CCCCCCCCCCCCCCE	57.87	19608861
321	Neddylation	SSPQPKKKPLDGEYF CCCCCCCCCCCCCCE	57.87	-
321	Ubiquitination	SSPQPKKKPLDGEYF CCCCCCCCCCCCCCE	57.87	19608861
321 (in isoform 1)	Ubiquitination	-	57.87	21890473
321	Ubiquitination	SSPQPKKKPLDGEYF CCCCCCCCCCCCCCE	57.87	21890473
327	Nitration	KKPLDGEYFTLQIRG CCCCCCCCEEEEEEC	13.85	-
327	Phosphorylation	KKPLDGEYFTLQIRG CCCCCCCCEEEEEEC	13.85	27642862
333	Methylation	EYFTLQIRGRERFEM CCEEEEEECHHHHHH	25.75	19011621
334 (in isoform 4)	Acetylation	-	37.11	-
335	Dimethylation	FTLQIRGRERFEMFR EEEEEECHHHHHHHH	23.28	-
335	Methylation	FTLQIRGRERFEMFR EEEEEECHHHHHHHH	23.28	19011621
337	Dimethylation	LQIRGRERFEMFREL EEEECHHHHHHHHHH	31.31	-
337	Methylation	LQIRGRERFEMFREL EEEECHHHHHHHHHH	31.31	19011621
340	Sulfoxidation	RGRERFEMFRELNEA ECHHHHHHHHHHHHH	3.36	18781628
343 (in isoform 4)	Acetylation	-	44.69	-
347 (in isoform 4)	Ubiquitination	-	12.79	-
351	Ubiquitination	LNEALELKDAQAGKE HHHHHHHHHHHCCCC	41.46	11046142
357	Acetylation	LKDAQAGKEPGGSRA HHHHHCCCCCCCCCC	64.85	19155208
357	Ubiquitination	LKDAQAGKEPGGSRA HHHHHCCCCCCCCCC	64.85	19536131
357 (in isoform 1)	Ubiquitination	-	64.85	21890473
362	Phosphorylation	AGKEPGGSRAHSSHL CCCCCCCCCCCHHHH	32.01	29954749
366	Phosphorylation	PGGSRAHSSHLKSKK CCCCCCCHHHHCCCC	20.61	19933256
367	Phosphorylation	GGSRAHSSHLKSKKG CCCCCCHHHHCCCCC	23.99	30387612
370	"N6,N6-dimethyllysine"	RAHSSHLKSKKGQST CCCHHHHCCCCCCCC	55.60	-
370	Acetylation	RAHSSHLKSKKGQST CCCHHHHCCCCCCCC	55.60	21057544
370	Methylation	RAHSSHLKSKKGQST CCCHHHHCCCCCCCC	55.60	9288740
370	Neddylation	RAHSSHLKSKKGQST CCCHHHHCCCCCCCC	55.60	-
370	Ubiquitination	RAHSSHLKSKKGQST CCCHHHHCCCCCCCC	55.60	19536131
370 (in isoform 1)	Ubiquitination	-	55.60	21890473
371	Phosphorylation	AHSSHLKSKKGQSTS CCHHHHCCCCCCCCC	46.06	30387612
372	Acetylation	HSSHLKSKKGQSTSR CHHHHCCCCCCCCCH	60.37	18485870
372	Butyrylation	HSSHLKSKKGQSTSR CHHHHCCCCCCCCCH	60.37	-
372	Methylation	HSSHLKSKKGQSTSR CHHHHCCCCCCCCCH	60.37	9288740
372	Neddylation	HSSHLKSKKGQSTSR CHHHHCCCCCCCCCH	60.37	-
372	Ubiquitination	HSSHLKSKKGQSTSR CHHHHCCCCCCCCCH	60.37	9288740
373	"N6,N6-dimethyllysine"	SSHLKSKKGQSTSRH HHHHCCCCCCCCCHH	70.08	-
373	Acetylation	SSHLKSKKGQSTSRH HHHHCCCCCCCCCHH	70.08	9288740
373	Butyrylation	SSHLKSKKGQSTSRH HHHHCCCCCCCCCHH	70.08	-
373	Methylation	SSHLKSKKGQSTSRH HHHHCCCCCCCCCHH	70.08	20118233
373	Neddylation	SSHLKSKKGQSTSRH HHHHCCCCCCCCCHH	70.08	-
373	Ubiquitination	SSHLKSKKGQSTSRH HHHHCCCCCCCCCHH	70.08	9288740
376	Phosphorylation	LKSKKGQSTSRHKKL HCCCCCCCCCHHHEE	36.70	9571186
377	Phosphorylation	KSKKGQSTSRHKKLM CCCCCCCCCHHHEEE	23.15	22817900
378	Phosphorylation	SKKGQSTSRHKKLMF CCCCCCCCHHHEEEE	37.32	1454855
381	Acetylation	GQSTSRHKKLMFKTE CCCCCHHHEEEEECC	46.63	19608861
381	Ubiquitination	GQSTSRHKKLMFKTE CCCCCHHHEEEEECC	46.63	19608861
382	"N6,N6-dimethyllysine"	QSTSRHKKLMFKTEG CCCCHHHEEEEECCC	38.77	-
382	Acetylation	QSTSRHKKLMFKTEG CCCCHHHEEEEECCC	38.77	17707234
382	Butyrylation	QSTSRHKKLMFKTEG CCCCHHHEEEEECCC	38.77	-
382	Methylation	QSTSRHKKLMFKTEG CCCCHHHEEEEECCC	38.77	17707234
382	Ubiquitination	QSTSRHKKLMFKTEG CCCCHHHEEEEECCC	38.77	17707234
386	"N6,N6-dimethyllysine"	RHKKLMFKTEGPDSD HHHEEEEECCCCCCC	31.53	-
386	Acetylation	RHKKLMFKTEGPDSD HHHEEEEECCCCCCC	31.53	18485870
386	Methylation	RHKKLMFKTEGPDSD HHHEEEEECCCCCCC	31.53	-
386	Sumoylation	RHKKLMFKTEGPDSD HHHEEEEECCCCCCC	31.53	22214662
386	Ubiquitination	RHKKLMFKTEGPDSD HHHEEEEECCCCCCC	31.53	10562557
387	Phosphorylation	HKKLMFKTEGPDSD- HHEEEEECCCCCCC-	34.60	23927012
392	Phosphorylation	FKTEGPDSD------ EECCCCCCC------	48.64	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
9	S	Phosphorylation	Kinase	HIPK4	Q8NE63	Uniprot
9	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
9	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
15	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
15	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
15	S	Phosphorylation	Kinase	ATM	Q62388	PSP
15	S	Phosphorylation	Kinase	ATR	Q13535	PSP
15	S	Phosphorylation	Kinase	BTK	Q06187	PSP
15	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
15	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
15	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
15	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
15	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
15	S	Phosphorylation	Kinase	ERK2	P63085	PSP
15	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
15	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
15	S	Phosphorylation	Kinase	NUAK1	O60285	Uniprot
15	S	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
15	S	Phosphorylation	Kinase	TP53RK	Q96S44	GPS
15	S	Phosphorylation	Kinase	SMG1	Q96Q15	PSP
15	S	Phosphorylation	Kinase	STK11	Q15831	GPS
15	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
18	T	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
18	T	Phosphorylation	Kinase	CHEK1	O14757	GPS
18	T	Phosphorylation	Kinase	CHEK2	O96017	GPS
18	T	Phosphorylation	Kinase	DAPK1	P53355	PSP
18	T	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
18	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
18	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
18	T	Phosphorylation	Kinase	TTK	P33981	PhosphoELM
18	T	Phosphorylation	Kinase	VRK1	Q99986	Uniprot
18	T	Phosphorylation	Kinase	VRK2	Q86Y07	Uniprot
18	T	Phosphorylation	Kinase	CK1-FAMILY	-	GPS
18	T	Phosphorylation	Kinase	CK1	-	Uniprot
18	T	Phosphorylation	Kinase	CK1_GROUP	-	PhosphoELM
20	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
20	S	Phosphorylation	Kinase	ATM	Q13315	PSP
20	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
20	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
20	S	Phosphorylation	Kinase	CHK2	O96017	PSP
20	S	Phosphorylation	Kinase	DAPK1	P53355	PSP
20	S	Phosphorylation	Kinase	DAPK3	O43293	PSP
20	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
20	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
20	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
20	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
20	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
20	S	Phosphorylation	Kinase	PLK3	Q9H4B4	Uniprot
20	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
20	S	Phosphorylation	Kinase	STK17A	Q9UEE5	GPS
20	S	Phosphorylation	Kinase	CK1	-	Uniprot
33	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
33	S	Phosphorylation	Kinase	CDK7	P50613	Uniprot
33	S	Phosphorylation	Kinase	CDK9	P50750	PSP
33	S	Phosphorylation	Kinase	P38G	P53778	PSP
33	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
33	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
33	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
33	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
33	S	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
37	S	Phosphorylation	Kinase	ATR	Q13535	PSP
37	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
37	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
37	S	Phosphorylation	Kinase	CK1A	P48729	PSP
37	S	Phosphorylation	Kinase	MAPK5	Q8IW41	PhosphoELM
37	S	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
46	S	Phosphorylation	Kinase	ATM	Q13315	PSP
46	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
46	S	Phosphorylation	Kinase	DYRK2	Q92630	Uniprot
46	S	Phosphorylation	Kinase	HIPK2	Q9H2X6	Uniprot
46	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
46	S	Phosphorylation	Kinase	PRKCG	P05129	Uniprot
46	S	Phosphorylation	Kinase	JNK2	P45984	PSP
46	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
46	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
55	T	Phosphorylation	Kinase	GRK5	P34947	Uniprot
55	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
55	T	Phosphorylation	Kinase	TAF1	P21675	Uniprot
55	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
55	T	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
81	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
106	S	Phosphorylation	Kinase	AURKA	O14965	GPS
126	Y	Phosphorylation	Kinase	SRC	P12931	PSP
149	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
150	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
155	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
183	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
211	T	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
215	S	Phosphorylation	Kinase	AURKA	O14965	PhosphoELM
215	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
215	S	Phosphorylation	Kinase	PAK4	O96013	PSP
220	Y	Phosphorylation	Kinase	SRC	P12931	PSP
269	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
269	S	Phosphorylation	Kinase	DAPK1	P53355	PSP
284	T	Phosphorylation	Kinase	AURB	Q96GD4	PSP
304	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
315	S	Phosphorylation	Kinase	AURA	O14965	PSP
315	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
315	S	Phosphorylation	Kinase	CDK2	P24941	Uniprot
315	S	Phosphorylation	Kinase	CDK9	P50750	PSP
315	S	Phosphorylation	Kinase	NEK2	P51955	PSP
366	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
371	S	Phosphorylation	Kinase	CDK7	P50613	PSP
371	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
376	S	Phosphorylation	Kinase	CDK7	P50613	PSP
376	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
376	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
377	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
377	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
378	S	Phosphorylation	Kinase	CDK7	P50613	PSP
378	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
378	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
378	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
378	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
387	T	Phosphorylation	Kinase	CHEK1	O14757	GPS
392	S	Phosphorylation	Kinase	CDK2	P24941	Uniprot
392	S	Phosphorylation	Kinase	CDK7	P50613	PSP
392	S	Phosphorylation	Kinase	CDK9	P50750	PSP
392	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
392	S	Phosphorylation	Kinase	CK2B	P67870	PSP
392	S	Phosphorylation	Kinase	EIF2AK2	P19525	GPS
392	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
392	S	Phosphorylation	Kinase	NUAK1	O60285	Uniprot
392	S	Phosphorylation	Kinase	STK11	Q15831	GPS
392	S	Phosphorylation	Kinase	CK2	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:10207051
-	K	Ubiquitination	E3 ubiquitin ligase	MDM4	O15151	PMID:12393902
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO42	Q6P3S6	PMID:19509332
-	K	Ubiquitination	E3 ubiquitin ligase	MUL1	Q969V5	PMID:31235254
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM39	Q9HCM9	PMID:23213260
-	K	Ubiquitination	E3 ubiquitin ligase	RNF38	Q9H0F5	PMID:23973461
-	K	Ubiquitination	E3 ubiquitin ligase	UHRF1	Q96T88	PMID:26102039
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	C10orf90	Q96M02	PMID:24240685
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:20618441
-	K	Ubiquitination	E3 ubiquitin ligase	HUWE1	Q7Z6Z7	PMID:17580310
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM28	Q13263	PMID:20864041
-	K	Ubiquitination	E3 ubiquitin ligase	DTL	Q9NZJ0	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RCHY1	Q96PM5	PMID:17721809
-	K	Ubiquitination	E3 ubiquitin ligase	TOPORS	Q9NS56	PMID:19895323
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:10726657
-	K	Ubiquitination	E3 ubiquitin ligase	SYVN1	Q86TM6	PMID:17828301
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO11	Q86XK2	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	MSL2	Q9HCI7	PMID:19033443
-	K	Ubiquitination	E3 ubiquitin ligase	DET1	Q7L5Y6	PMID:17968316
-	K	Ubiquitination	E3 ubiquitin ligase	E4F1	Q66K89	PMID:17110336
-	K	Ubiquitination	E3 ubiquitin ligase	RFWD3	Q6PCD5	PMID:20173098
-	K	Ubiquitination	E3 ubiquitin ligase	RNF34	Q969K3	PMID:17121812
-	K	Ubiquitination	E3 ubiquitin ligase	RFFL	Q8WZ73	PMID:32296023
-	K	Ubiquitination	E3 ubiquitin ligase	WWP1	Q9H0M0	PMID:16924229
-	K	Ubiquitination	E3 ubiquitin ligase	MKRN1	Q9UHC7	PMID:19536131
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM24	O15164	PMID:19844164
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RNF125	Q96EQ8	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	EP300	Q09472	PMID:12690203
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:21127074
-	K	Ubiquitination	E3 ubiquitin ligase	UBE4B	O95155	PMID:21317885
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF7	Q6Q0C0	PMID:23128672
-	K	Ubiquitination	E3 ubiquitin ligase	DET1#COP1	Q7L5Y6#Q8NHY2	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:25860929:31346036
-	K	Ubiquitination	E3 ubiquitin ligase	CCAR1	Q8IX12	PMID:32296023
-	K	Ubiquitination	E3 ubiquitin ligase	CUL1	Q13616	PMID:32296023
-	K	Ubiquitination	E3 ubiquitin ligase	CUL5	Q93034	PMID:32296023
-	K	Ubiquitination	E3 ubiquitin ligase	CUL7	Q14999	PMID:32296023
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	Q8NHY2	PMID:15103385
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO22	Q8NEZ5	PMID:26868148
-	K	Ubiquitination	E3 ubiquitin ligase	E6	P03126	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	N/A#E4	P03243#Q6VGT3	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	ASAP1#TP53BP1	Q9ULH1#Q12888	PMID:32296023

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
9	S	Phosphorylation	Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter.	20959462
15	S	Oxidation	Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes.	20959462
15	S	Phosphorylation	Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes.	20959462
15	S	Phosphorylation	Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin.	28842590
15	S	Phosphorylation	Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with BANP.	20959462
15	S	Phosphorylation	Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1.	21317932
15	S	Phosphorylation	It is unclear whether AMP directly mediates phosphorylation at Ser-15.	20959462
18	T	ubiquitylation	Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300.	20959462
18	T	Phosphorylation	Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300.	20959462
18	T	Phosphorylation	Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2.	20959462
18	T	Phosphorylation	Phosphorylated on Thr-18 by VRK1.	20959462
18	T	Acetylation	Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300.	20959462
20	S	Phosphorylation	Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis.	20959462
20	S	ubiquitylation	Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.	20959462
20	S	Phosphorylation	Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.	20959462
24	K	ubiquitylation	Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation.	21597459
33	S	Phosphorylation	Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes.	20959462
33	S	Phosphorylation	Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage.	20959462
33	S	Oxidation	Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes.	20959462
46	S	Oxidation	Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes.	20959462
46	S	Acetylation	Phosphorylation on Ser-46 is required for acetylation by CREBBP.	20959462
46	S	Phosphorylation	Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress.	20959462
46	S	Phosphorylation	Phosphorylated on Ser-46 by HIPK2 upon UV irradiation.	20959462
46	S	Phosphorylation	Phosphorylation on Ser-46 is required for acetylation by CREBBP.	20959462
46	S	Phosphorylation	Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes.	20959462
55	T	Phosphorylation	Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation.	20959462
55	T	Phosphorylation	Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55.	-
291	K	ubiquitylation	Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation.	19536131
292	K	ubiquitylation	Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation.	19536131
315	S	Phosphorylation	Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage.	20959462
333	R	Methylation	Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity.	19011621
335	R	Methylation	Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity.	19011621
337	R	Methylation	Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity.	19011621
370	K	Methylation	Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation.	17805299
370	K	Methylation	Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20.	22864287
370	K	Methylation	Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370.	17108971
370	K	Methylation	Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity.	17108971
370	K	ubiquitylation	Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20.	22864287
372	K	Methylation	Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation.	15525938
372	K	Methylation	Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370.	17108971
373	K	Methylation	Dimethylated at Lys-373 by EHMT1 and EHMT2.	20118233
382	K	Acetylation	Acetylation of Lys-382 by CREBBP enhances transcriptional activity.	20228809
382	K	Acetylation	Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence.	20228809
382	K	Methylation	Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20.	22864287
382	K	Methylation	Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity.	17707234
382	K	ubiquitylation	Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20.	22864287
386	K	Sumoylation	Sumoylated at Lys-386 by UBC9.	22214662
392	S	Phosphorylation	Phosphorylated on Ser-392 following UV but not gamma irradiation.	20959462
392	S	Phosphorylation	Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1.	21317932
392	S	Phosphorylation	Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage.	20959462

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWOX_HUMAN	WWOX	physical	11058590
CC14A_HUMAN	CDC14A	physical	10644693
MAGBI_HUMAN	MAGEB18	physical	16189514
TP53B_HUMAN	TP53BP1	physical	12110597
BAK_HUMAN	BAK1	physical	15077116
BLM_HUMAN	BLM	physical	15364958
BLM_HUMAN	BLM	physical	11399766
TP53B_HUMAN	TP53BP1	physical	14978302
P53_HUMAN	TP53	physical	14580323
RFA1_HUMAN	RPA1	physical	15489903
CHK1_HUMAN	CHEK1	physical	15364958
TP53B_HUMAN	TP53BP1	physical	11877378
1433S_HUMAN	SFN	physical	11896572
TP53B_HUMAN	TP53BP1	physical	12351827
AP2A_HUMAN	TFAP2A	physical	12226108
AP2C_HUMAN	TFAP2C	physical	12226108
CDN1A_HUMAN	CDKN1A	physical	11896572
CHK1_HUMAN	CHEK1	physical	11896572
S100B_HUMAN	S100B	physical	15178678
EP300_HUMAN	EP300	physical	15186775
ANM1_HUMAN	PRMT1	physical	15186775
CARM1_HUMAN	CARM1	physical	15186775
ANKR2_HUMAN	ANKRD2	physical	15136035
CABL2_HUMAN	CABLES2	physical	14637168
CABL1_HUMAN	CABLES1	physical	14637168
CDN2A_HUMAN	CDKN2A	physical	14612427
ARF_HUMAN	CDKN2A	physical	14612427
RL11_HUMAN	RPL11	physical	14612427
MDM2_HUMAN	MDM2	physical	14612427
PHB_HUMAN	PHB	physical	14500729
MTA1_HUMAN	MTA1	physical	12920132
MTA2_HUMAN	MTA2	physical	12920132
PML_HUMAN	PML	physical	12915590
MDM2_HUMAN	MDM2	physical	12915590
EF2_HUMAN	EEF2	physical	12891704
T53I1_HUMAN	TP53INP1	physical	12851404
ING4_HUMAN	ING4	physical	12750254
ING5_HUMAN	ING5	physical	12750254
HIPK1_HUMAN	HIPK1	physical	12702766
PTEN_HUMAN	PTEN	physical	12620407
MDM2_HUMAN	MDM2	physical	12620407
MDM2_HUMAN	MDM2	physical	12426395
HDAC1_HUMAN	HDAC1	physical	12426395
SNF5_HUMAN	SMARCB1	physical	11950834
SMCA4_HUMAN	SMARCA4	physical	11950834
SMRC1_HUMAN	SMARCC1	physical	11950834
EP300_HUMAN	EP300	genetic	10942770
CBP_HUMAN	CREBBP	genetic	11782467
CREB1_HUMAN	CREB1	physical	10848610
HIPK2_HUMAN	HIPK2	physical	11740489
EP300_HUMAN	EP300	physical	9809062
PLAL1_HUMAN	PLAGL1	genetic	11360197
ELL_HUMAN	ELL	physical	10358050
CDN2A_HUMAN	CDKN2A	physical	12446718
ARF_HUMAN	CDKN2A	physical	12446718
E4F1_HUMAN	E4F1	physical	12446718
HS90A_HUMAN	HSP90AA1	physical	12427754
TOP1_HUMAN	TOP1	physical	10468612
TF3B_HUMAN	BRF1	physical	8943363
ESR1_HUMAN	ESR1	physical	10766163
MDM2_HUMAN	MDM2	physical	10766163
E2AK2_HUMAN	EIF2AK2	physical	10348343
RAD51_HUMAN	RAD51	physical	8617246
HMGB1_HUMAN	HMGB1	physical	11106654
APEX1_HUMAN	APEX1	physical	9119221
NECD_HUMAN	NDN	physical	10347180
PLK3_HUMAN	PLK3	physical	11551930
HD_HUMAN	HTT	physical	10823891
PGH2_HUMAN	PTGS2	physical	11687965
AURKA_HUMAN	AURKA	physical	12198151
PIN1_HUMAN	PIN1	physical	12388558
RFA1_HUMAN	RPA1	physical	11751427
CDN2A_HUMAN	CDKN2A	physical	9529249
ARF_HUMAN	CDKN2A	physical	9529249
MDM2_HUMAN	MDM2	physical	9529249
CCNG1_HUMAN	CCNG1	physical	12556559
RAD51_HUMAN	RAD51	physical	9380510
TFDP1_HUMAN	TFDP1	physical	8816502
IKBA_HUMAN	NFKBIA	physical	11799106
E4F1_HUMAN	E4F1	physical	10644996
ZN148_HUMAN	ZNF148	physical	11416144
BRCA2_HUMAN	BRCA2	physical	9811893
IASPP_HUMAN	PPP1R13L	physical	12524540
MED1_HUMAN	MED1	physical	11118038
CC14B_HUMAN	CDC14B	physical	10644693
STK11_HUMAN	STK11	physical	11430832
IF16_HUMAN	IFI16	physical	11146555
TF2H1_HUMAN	GTF2H1	physical	7935417
UBC9_HUMAN	UBE2I	physical	10380882
PIAS1_HUMAN	PIAS1	physical	10380882
FBLN4_HUMAN	EFEMP2	physical	10380882
TOP1_HUMAN	TOP1	physical	11805286
ATF3_HUMAN	ATF3	physical	11792711
ERCC3_HUMAN	ERCC3	physical	7663514
ERCC2_HUMAN	ERCC2	physical	7663514
ERCC6_HUMAN	ERCC6	physical	7663514
MK09_HUMAN	MAPK9	physical	9393873
MK10_HUMAN	MAPK10	physical	9393873
WRN_HUMAN	WRN	physical	11427532
HMGB1_HUMAN	HMGB1	physical	11748221
PP4C_HUMAN	PPP4C	physical	9837938
NUCL_HUMAN	NCL	physical	12138209
TS101_HUMAN	TSG101	physical	11172000
MDM2_HUMAN	MDM2	physical	9271120
HIF1A_HUMAN	HIF1A	physical	10640274
PARP1_HUMAN	PARP1	physical	9565608
BAG1_HUMAN	BAG1	genetic	9582267
UBC9_HUMAN	UBE2I	physical	8921390
PML_HUMAN	PML	physical	11025664
TOP2A_HUMAN	TOP2A	physical	10666337
TOP2B_HUMAN	TOP2B	physical	10666337
CDK9_HUMAN	CDK9	genetic	10656684
EGR1_HUMAN	EGR1	physical	11251186
HIPK2_HUMAN	HIPK2	physical	11925430
PIAS1_HUMAN	PIAS1	physical	11583632
ERCC6_HUMAN	ERCC6	physical	10882116
MDM4_HUMAN	MDM4	physical	9226370
MAT1_HUMAN	MNAT1	physical	9372954
GNL3_HUMAN	GNL3	physical	12464630
TAF1B_HUMAN	TAF1B	physical	10913176
TAF1A_HUMAN	TAF1A	physical	10913176
TAF1C_HUMAN	TAF1C	physical	10913176
UBP7_HUMAN	USP7	physical	11923872
GRP75_HUMAN	HSPA9	physical	11900485
SMN_HUMAN	SMN1	physical	11704667
CCNH_HUMAN	CCNH	physical	9840937
HIF1A_HUMAN	HIF1A	physical	9537326
TP53B_HUMAN	TP53BP1	physical	8016121
ASPP2_HUMAN	TP53BP2	physical	8016121
IMB1_HUMAN	KPNB1	physical	11297531
HS90A_HUMAN	HSP90AA1	physical	11297531
HSP7C_HUMAN	HSPA8	physical	11297531
ING1_HUMAN	ING1	physical	9440695
T53I1_HUMAN	TP53INP1	physical	11511362
PTTG1_HUMAN	PTTG1	physical	12355087
TAF9_HUMAN	TAF9	physical	7761466
CUL9_HUMAN	CUL9	physical	12526791
YBOX1_HUMAN	YBX1	physical	11175333
HS90A_HUMAN	HSP90AA1	physical	11507088
ASPP2_HUMAN	TP53BP2	physical	8668206
MDM2_HUMAN	MDM2	physical	19188367
MDM2_HUMAN	MDM2	physical	19166840
FKBP3_HUMAN	FKBP3	physical	19166840
MDM2_HUMAN	MDM2	physical	19071110
AIMP2_HUMAN	AIMP2	physical	18695251
ITCH_HUMAN	ITCH	physical	18559494
CFLAR_HUMAN	CFLAR	physical	18559494
MDM2_HUMAN	MDM2	physical	18332869
PSME3_HUMAN	PSME3	physical	18309296
MDM2_HUMAN	MDM2	physical	18223694
HSP74_HUMAN	HSPA4	physical	18223694
CHIP_HUMAN	STUB1	physical	18223694
MDM2_HUMAN	MDM2	physical	18172499
NUMB_HUMAN	NUMB	physical	18172499
MDM2_HUMAN	MDM2	physical	18485870
MDM2_HUMAN	MDM2	physical	17936559
MDM2_HUMAN	MDM2	physical	17908790
CSN5_HUMAN	COPS5	physical	17879958
RAD51_HUMAN	RAD51	physical	16983346
CDK5_HUMAN	CDK5	physical	17591690
MDM2_HUMAN	MDM2	physical	17591690
KAT7_HUMAN	KAT7	physical	17954561
ING4_HUMAN	ING4	physical	17954561
ING5_HUMAN	ING5	physical	17954561
MDM2_HUMAN	MDM2	physical	17369817
MDM2_HUMAN	MDM2	physical	17363365
ETHE1_HUMAN	ETHE1	physical	17353187
DAPK1_HUMAN	DAPK1	physical	17339337
MDM2_HUMAN	MDM2	physical	17470788
PADI4_HUMAN	PADI4	physical	18505818
CUL9_HUMAN	CUL9	physical	17380154
ING4_HUMAN	ING4	physical	15882981
NR4A1_HUMAN	NR4A1	physical	17139261
FBX11_HUMAN	FBXO11	physical	17098746
MDM2_HUMAN	MDM2	physical	17098746
UBE2N_HUMAN	UBE2N	physical	17000756
HDAC2_HUMAN	HDAC2	physical	20190809
MDM2_HUMAN	MDM2	physical	16964247
SP1_HUMAN	SP1	physical	8463313
STAT6_HUMAN	STAT6	physical	20121258
TAF6_HUMAN	TAF6	physical	20096117
MTA1_HUMAN	MTA1	physical	20071335
ADHX_HUMAN	ADH5	physical	20308539
CBPC2_HUMAN	AGBL2	physical	20308539
ASF1A_HUMAN	ASF1A	physical	20308539
ASPM_HUMAN	ASPM	physical	20308539
BRD8_HUMAN	BRD8	physical	20308539
NPRL3_HUMAN	NPRL3	physical	20308539
TPC11_HUMAN	TRAPPC11	physical	20308539
DAB2P_HUMAN	DAB2IP	physical	20308539
DNJB6_HUMAN	DNAJB6	physical	20308539
DPH1_HUMAN	DPH1	physical	20308539
AGO1_HUMAN	AGO1	physical	20308539
AGO2_HUMAN	AGO2	physical	20308539
NOG1_HUMAN	GTPBP4	physical	20308539
IF2B1_HUMAN	IGF2BP1	physical	20308539
LPPRC_HUMAN	LRPPRC	physical	20308539
MTHSD_HUMAN	MTHFSD	physical	20308539
MYL9_HUMAN	MYL9	physical	20308539
PIWL1_HUMAN	PIWIL1	physical	20308539
RNF38_HUMAN	RNF38	physical	20308539
SMRD2_HUMAN	SMARCD2	physical	20308539
SPSB1_HUMAN	SPSB1	physical	20308539
TRM11_HUMAN	TRMT11	physical	20308539
TTLL5_HUMAN	TTLL5	physical	20308539
CUL7_HUMAN	CUL7	physical	16547496
BRE1A_HUMAN	RNF20	physical	16337599
MDM2_HUMAN	MDM2	physical	19223463
CBP_HUMAN	CREBBP	physical	19166313
MDM4_HUMAN	MDM4	physical	16227609
HDAC1_HUMAN	HDAC1	physical	16107876
PSD10_HUMAN	PSMD10	physical	16023600
MDM2_HUMAN	MDM2	physical	16023600
ATF3_HUMAN	ATF3	physical	15933712
SMYD2_HUMAN	SMYD2	physical	17108971
BACH1_HUMAN	BACH1	physical	19011633
MAFK_HUMAN	MAFK	physical	19011633
P53_HUMAN	TP53	physical	19011633
HDAC1_HUMAN	HDAC1	physical	19011633
NCOR1_HUMAN	NCOR1	physical	19011633
XRCC6_HUMAN	XRCC6	physical	15782130
VRK1_HUMAN	VRK1	physical	15542844
MDM2_HUMAN	MDM2	physical	15542844
MK08_HUMAN	MAPK8	physical	15538975
HDAC1_HUMAN	HDAC1	physical	18765668
SP1_HUMAN	SP1	physical	18765668
CTBP1_HUMAN	CTBP1	physical	18765668
MAGA2_HUMAN	MAGEA2	physical	16847267
SP1_HUMAN	SP1	physical	16740634
NPM_HUMAN	NPM1	physical	16740634
KAT5_HUMAN	KAT5	physical	15310756
RL23_HUMAN	RPL23	physical	15308643
RL11_HUMAN	RPL11	physical	15308643
MDM2_HUMAN	MDM2	physical	15308643
RL5_HUMAN	RPL5	physical	15308643
TYY1_HUMAN	YY1	physical	15295102
MDM2_HUMAN	MDM2	physical	15295102
KAT5_HUMAN	KAT5	physical	16601686
TYY1_HUMAN	YY1	physical	15210108
MDM2_HUMAN	MDM2	physical	15210108
SETD2_HUMAN	SETD2	physical	18585004
VHL_HUMAN	VHL	physical	16678111
KAT2B_HUMAN	KAT2B	physical	16678111
MDM2_HUMAN	MDM2	physical	15122315
HABP4_HUMAN	HABP4	physical	16455055
ZN420_HUMAN	ZNF420	physical	19377469
H2AX_HUMAN	H2AFX	physical	16322227
SP1_HUMAN	SP1	physical	12665570
MSH2_HUMAN	MSH2	physical	12101417
AURKA_HUMAN	AURKA	physical	14702041
MDM2_HUMAN	MDM2	physical	14702041
ING2_HUMAN	ING2	physical	16024799
KAT8_HUMAN	KAT8	physical	15960975
KMT2A_HUMAN	KMT2A	physical	15960975
RBBP5_HUMAN	RBBP5	physical	15960975
MEN1_HUMAN	MEN1	physical	15960975
WDR5_HUMAN	WDR5	physical	15960975
1433S_HUMAN	SFN	physical	14517281
NFYA_HUMAN	NFYA	physical	15831478
NFYB_HUMAN	NFYB	physical	15831478
HECW2_HUMAN	HECW2	physical	12890487
SP1_HUMAN	SP1	physical	15674334
MDM2_HUMAN	MDM2	physical	12612087
CBP_HUMAN	CREBBP	physical	15632413
MDM2_HUMAN	MDM2	physical	12167711
KAT5_HUMAN	KAT5	physical	18280244
TRRAP_HUMAN	TRRAP	physical	18250150
KAT2A_HUMAN	KAT2A	physical	18250150
TAF5L_HUMAN	TAF5L	physical	18250150
SUPT3_HUMAN	SUPT3H	physical	18250150
TAF9_HUMAN	TAF9	physical	18250150
ST65G_HUMAN	SUPT7L	physical	18250150
TADA1_HUMAN	TADA1	physical	18250150
TAD2A_HUMAN	TADA2A	physical	18250150
TADA3_HUMAN	TADA3	physical	18250150
TAF10_HUMAN	TAF10	physical	18250150
HDAC1_HUMAN	HDAC1	physical	11313951
TBP_HUMAN	TBP	physical	11313951
SIN3A_MOUSE	Sin3a	physical	11313951
HDAC1_HUMAN	HDAC1	physical	11099047
MTA2_HUMAN	MTA2	physical	11099047
HDAC1_HUMAN	HDAC1	physical	10777477
SIN3A_HUMAN	SIN3A	physical	10521394
HDAC1_HUMAN	HDAC1	physical	10521394
MDM2_HUMAN	MDM2	physical	15154850
HDAC1_HUMAN	HDAC1	physical	14976551
HDAC2_HUMAN	HDAC2	physical	14976551
PRAM_HUMAN	PRAM1	physical	14976551
PML_HUMAN	PML	physical	14976551
PIAS2_HUMAN	PIAS2	physical	11867732
DNMT1_HUMAN	DNMT1	physical	17991895
MDM2_HUMAN	MDM2	physical	11744695
CBP_HUMAN	CREBBP	physical	9288775
CBP_HUMAN	CREBBP	physical	9194564
MTA1_HUMAN	MTA1	physical	17914590
HDAC1_HUMAN	HDAC1	physical	17827154
HDAC2_HUMAN	HDAC2	physical	17827154
KDM1A_HUMAN	KDM1A	physical	17805299
GCR_HUMAN	NR3C1	physical	11562347
MDM2_HUMAN	MDM2	physical	11562347
MDM2_HUMAN	MDM2	physical	21454483
MDM2_HUMAN	MDM2	physical	11384992
TAF9_HUMAN	TAF9	physical	11278372
HDAC2_HUMAN	HDAC2	physical	21344396
MDM2_HUMAN	MDM2	physical	11094089
MDM2_HUMAN	MDM2	physical	11046142
MDM2_HUMAN	MDM2	physical	10980696
MDM2_HUMAN	MDM2	physical	10347217
HDAC1_HUMAN	HDAC1	physical	20633551
HMGA1_HUMAN	HMGA1	physical	20335021
MDM2_HUMAN	MDM2	physical	20570896
SP1_HUMAN	SP1	physical	20570896
TP53B_HUMAN	TP53BP1	physical	20307547
VDR_HUMAN	VDR	physical	20227041
UBE3A_HUMAN	UBE3A	physical	9688277
MDM2_HUMAN	MDM2	physical	9724739
UBE3A_HUMAN	UBE3A	physical	8380895
MDM2_HUMAN	MDM2	physical	9824166
HDAC1_HUMAN	HDAC1	physical	20075864
BANP_HUMAN	BANP	physical	20075864
MDM2_HUMAN	MDM2	physical	11572869
AURKB_HUMAN	AURKB	physical	20959462
NOC2L_HUMAN	NOC2L	physical	20959462
MDM2_HUMAN	MDM2	physical	20959462
SIVA_HUMAN	SIVA1	physical	19590512
MDM2_HUMAN	MDM2	physical	19590512
MTA1_HUMAN	MTA1	physical	19837670
UBP7_HUMAN	USP7	physical	20713061
CFLAR_HUMAN	CFLAR	physical	21474069
ITCH_HUMAN	ITCH	physical	21474069
UBE3A_HUMAN	UBE3A	physical	17131388
MDHC_HUMAN	MDH1	physical	19229245
MDM2_HUMAN	MDM2	physical	21465263
MDM4_HUMAN	MDM4	physical	19432880
MDM2_HUMAN	MDM2	physical	21726810
G3BP1_HUMAN	G3BP1	physical	17297477
G3BP2_HUMAN	G3BP2	physical	17297477
MDM2_HUMAN	MDM2	physical	17297477
MDM2_HUMAN	MDM2	physical	17268548
UBP7_HUMAN	USP7	physical	17268548
TIF1A_HUMAN	TRIM24	physical	19556538
MDM2_HUMAN	MDM2	physical	19411846
MDM2_HUMAN	MDM2	physical	21750659
ZN668_HUMAN	ZNF668	physical	21852383
ZN363_HUMAN	RCHY1	physical	17568776
UBP10_HUMAN	USP10	physical	20096447
UBR5_HUMAN	UBR5	physical	21383020
HSP82_YEAST	HSP82	physical	21892170
HSC82_YEAST	HSC82	physical	21892170
GNL3L_HUMAN	GNL3L	physical	21132010
MDM2_HUMAN	MDM2	physical	21132010
MDM2_HUMAN	MDM2	physical	18061646
UBP7_HUMAN	USP7	physical	21170034
MSL2_HUMAN	MSL2	physical	19033443
MDM2_HUMAN	MDM2	physical	20174603
MDM4_HUMAN	MDM4	physical	20174603
UIMC1_HUMAN	UIMC1	physical	19433585
NUB1_HUMAN	NUB1	physical	20101219
MDM2_HUMAN	MDM2	physical	21149449
SIR1_HUMAN	SIRT1	physical	21149449
SOX4_HUMAN	SOX4	physical	19234109
CDK8_HUMAN	CDK8	physical	10024883
MED21_HUMAN	MED21	physical	10024883
MDM2_HUMAN	MDM2	physical	20847049
HSP74_HUMAN	HSPA4	physical	20847049
UBE4B_HUMAN	UBE4B	physical	21317885
MDM2_HUMAN	MDM2	physical	21317885
BI2L1_HUMAN	BAIAP2L1	physical	21887275
MDM2_HUMAN	MDM2	physical	21887275
VIF_HV1B1	vif	physical	21071676
VIF_HV1BR	vif	physical	21071676
VIF_HV1H2	vif	physical	21071676
MDM2_HUMAN	MDM2	physical	21071676
MDM2_HUMAN	MDM2	physical	19332559
RFWD3_HUMAN	RFWD3	physical	20173098
MDM2_HUMAN	MDM2	physical	20173098
HUWE1_HUMAN	HUWE1	physical	15989956
MDM2_HUMAN	MDM2	physical	20479273
PSMD4_HUMAN	PSMD4	physical	20479273
PRS8_HUMAN	PSMC5	physical	20479273
UHRF2_HUMAN	UHRF2	physical	21952639
FBX42_HUMAN	FBXO42	physical	19509332
UCHL1_HUMAN	UCHL1	physical	20395212
MDM2_HUMAN	MDM2	physical	20395212
CDN2A_HUMAN	CDKN2A	physical	20395212
ARF_HUMAN	CDKN2A	physical	20395212
UBP7_HUMAN	USP7	physical	20816748
NOTC4_HUMAN	NOTCH4	physical	21402876
UT14A_HUMAN	UTP14A	physical	21078665
KC1A_HUMAN	CSNK1A1	physical	19759023
HSPB1_HUMAN	HSPB1	physical	17184779
HSP74_HUMAN	HSPA4	physical	17184779
GRP75_HUMAN	HSPA9	physical	17184779
GRP78_HUMAN	HSPA5	physical	17184779
ZNHI1_HUMAN	ZNHIT1	physical	17380123
SYVN1_HUMAN	SYVN1	physical	21903092
OTUB1_HUMAN	OTUB1	physical	22124327
MDM2_HUMAN	MDM2	physical	21060154
PDLI7_HUMAN	PDLIM7	physical	21060154
APOH_HUMAN	APOH	physical	18624398
UBC9_HUMAN	UBE2I	physical	18624398
BMP1_HUMAN	BMP1	physical	18624398
PIAS2_HUMAN	PIAS2	physical	18624398
MDM4_HUMAN	MDM4	physical	21925390
MDM2_HUMAN	MDM2	physical	21925390
USO1_HUMAN	USO1	physical	21147777
MK03_HUMAN	MAPK3	physical	21147777
MK01_HUMAN	MAPK1	physical	21147777
SMAD2_HUMAN	SMAD2	physical	12732139
SMAD3_HUMAN	SMAD3	physical	12732139
UBC9_HUMAN	UBE2I	physical	21829513
PSME3_HUMAN	PSME3	physical	21084564
P53_HUMAN	TP53	physical	21084564
MDM2_HUMAN	MDM2	physical	21084564
BCL2_HUMAN	BCL2	physical	21624955
MDM2_HUMAN	MDM2	physical	21098709
TRIA1_HUMAN	TRIAP1	physical	15735003
PML_HUMAN	PML	physical	21057547
AXIN1_HUMAN	AXIN1	physical	21057547
HIPK2_HUMAN	HIPK2	physical	21057547
MDM2_HUMAN	MDM2	physical	20659896
MDM2_HUMAN	MDM2	physical	22227409
SIN3B_HUMAN	SIN3B	physical	22028823
ANGT_HUMAN	AGT	physical	22416758
EGR1_HUMAN	EGR1	physical	21325822
SP1_HUMAN	SP1	physical	21325822
MSH2_HUMAN	MSH2	physical	15064730
MSH6_HUMAN	MSH6	physical	15064730
ARI1A_HUMAN	ARID1A	physical	21900401
SMCA4_HUMAN	SMARCA4	physical	21900401
TYY1_HUMAN	YY1	physical	22440256
ETS1_HUMAN	ETS1	physical	18374905
ETS2_HUMAN	ETS2	physical	18374905
ACL6A_HUMAN	ACTL6A	physical	17878219
KAT5_HUMAN	KAT5	physical	17704809
MDM2_HUMAN	MDM2	physical	22411991
KAT5_HUMAN	KAT5	physical	17189186
CSK2B_HUMAN	CSNK2B	physical	21675959
MK14_HUMAN	MAPK14	physical	21675959
MK01_HUMAN	MAPK1	physical	21675959
NR0B2_HUMAN	NR0B2	physical	22575647
MDM2_HUMAN	MDM2	physical	22575647
NCOA1_HUMAN	NCOA1	physical	10551785
CBP_HUMAN	CREBBP	physical	10551785
NCOA3_HUMAN	NCOA3	physical	10551785
EP300_HUMAN	EP300	physical	22013068
KDM4D_HUMAN	KDM4D	physical	22514644
HDAC2_HUMAN	HDAC2	physical	22493095
SMCA4_HUMAN	SMARCA4	physical	18303029
SMRC1_HUMAN	SMARCC1	physical	18303029
EWS_HUMAN	EWSR1	physical	22266186
EP300_HUMAN	EP300	physical	22266186
HDAC1_HUMAN	HDAC1	physical	22266186
CHIP_HUMAN	STUB1	physical	17666403
MDM2_HUMAN	MDM2	physical	17666403
MDM2_HUMAN	MDM2	physical	22084066
TP53B_HUMAN	TP53BP1	physical	22084066
CBP_HUMAN	CREBBP	physical	22084066
CCDC8_HUMAN	CCDC8	physical	22084066
UBP7_HUMAN	USP7	physical	22084066
UBE2A_HUMAN	UBE2A	physical	22083959
UBE2B_HUMAN	UBE2B	physical	22083959
MDM2_HUMAN	MDM2	physical	22083959
RS10_HUMAN	RPS10	physical	15536084
MDM2_HUMAN	MDM2	physical	12897156
CDN1A_HUMAN	CDKN1A	physical	12897156
MDM2_HUMAN	MDM2	physical	22444248
LYN_HUMAN	LYN	physical	12642697
MDM2_HUMAN	MDM2	physical	22391559
MDM2_HUMAN	MDM2	physical	22266850
MDM4_HUMAN	MDM4	physical	22266850
PRGC1_HUMAN	PPARGC1A	physical	22099309
CUL9_HUMAN	CUL9	physical	17229476
CUL7_HUMAN	CUL7	physical	17229476
MDM2_HUMAN	MDM2	physical	19357310
CBP_HUMAN	CREBBP	physical	19357310
G3P_HUMAN	GAPDH	physical	18552833
MDM2_HUMAN	MDM2	physical	17159902
CRYAB_HUMAN	CRYAB	physical	19343786
FBX4_HUMAN	FBXO4	physical	19343786
MDM2_HUMAN	MDM2	physical	10827196
MDM4_HUMAN	MDM4	physical	10827196
MDM2_HUMAN	MDM2	physical	16861890
PCNA_HUMAN	PCNA	physical	16861890
MDM4_HUMAN	MDM4	physical	21075307
MDM2_HUMAN	MDM2	physical	21075307
SIR1_HUMAN	SIRT1	physical	22389628
UBP7_HUMAN	USP7	physical	16474402
NR0B2_HUMAN	NR0B2	physical	22737255
MDM2_HUMAN	MDM2	physical	16215989
MDM2_HUMAN	MDM2	physical	16055726
RNF43_HUMAN	RNF43	physical	21108931
MDM2_HUMAN	MDM2	physical	22366412
GRP75_HUMAN	HSPA9	physical	22366412
MK09_HUMAN	MAPK9	physical	22366412
P63_HUMAN	TP63	genetic	21511729
RFWD2_HUMAN	RFWD2	physical	15103385
P53_HUMAN	TP53	physical	18414054
CUL9_HUMAN	CUL9	physical	17332328
P53_HUMAN	TP53	physical	17332328
CUL7_HUMAN	CUL7	physical	17332328
MDM2_HUMAN	MDM2	physical	15094782
MDM2_HUMAN	MDM2	physical	19941302
NQO1_HUMAN	NQO1	physical	14634213
HUWE1_HUMAN	HUWE1	physical	22552282
MDM2_HUMAN	MDM2	physical	16152627
MDM2_HUMAN	MDM2	physical	21268072
CHIP_HUMAN	STUB1	physical	21268072
HSP74_HUMAN	HSPA4	physical	21268072
HS90A_HUMAN	HSP90AA1	physical	21268072
PIAS4_HUMAN	PIAS4	physical	15383276
P53_HUMAN	TP53	physical	15383276
ZHX1_HUMAN	ZHX1	physical	15383276
MDM2_HUMAN	MDM2	physical	20639885
NPM_HUMAN	NPM1	physical	15144954
MDM2_HUMAN	MDM2	physical	22819825
ARI2_HUMAN	ARIH2	physical	22819825
P53_HUMAN	TP53	physical	22819825
DMTF1_HUMAN	DMTF1	physical	22331460
MDM2_HUMAN	MDM2	physical	22331460
HEXI1_HUMAN	HEXIM1	physical	22948151
MDM2_HUMAN	MDM2	physical	22948151
MDM2_HUMAN	MDM2	physical	15604276
MUL1_HUMAN	MUL1	physical	21597459
BCL2_HUMAN	BCL2	physical	21597459
MDM2_HUMAN	MDM2	physical	10435614
T22D1_HUMAN	TSC22D1	physical	22870275
UBD_HUMAN	UBD	physical	21396347
ANGI_HUMAN	ANG	physical	22266868
MDM2_HUMAN	MDM2	physical	22266868
MDM2_HUMAN	MDM2	physical	22318540
PDCD5_HUMAN	PDCD5	physical	22914926
MDM2_HUMAN	MDM2	physical	22914926
MDM2_HUMAN	MDM2	physical	22474335
CUL7_HUMAN	CUL7	physical	17942889
MDM2_HUMAN	MDM2	physical	9223638
HIF1A_MOUSE	Hif1a	physical	11707426
MDM2_HUMAN	MDM2	physical	1614537
MDM2_HUMAN	MDM2	physical	17616658
MDM2_HUMAN	MDM2	physical	14499615
MDM4_HUMAN	MDM4	physical	20724842
WWOX_HUMAN	WWOX	physical	16219768
DAXX_HUMAN	DAXX	physical	12954772
M3K1_HUMAN	MAP3K1	physical	20923779
MDM2_HUMAN	MDM2	physical	14741215
MDM2_HUMAN	MDM2	physical	15848166
MED1_HUMAN	MED1	physical	15848166
ERCC8_HUMAN	ERCC8	physical	22032989
ERCC6_HUMAN	ERCC6	physical	22032989
MDM2_HUMAN	MDM2	physical	22032989
DAXX_HUMAN	DAXX	physical	12482984
MDM2_HUMAN	MDM2	physical	12552135
MDM2_HUMAN	MDM2	physical	9363941
MDM4_HUMAN	MDM4	physical	19075013
MDM2_HUMAN	MDM2	physical	11351297
MDM2_HUMAN	MDM2	physical	16905769
DAXX_HUMAN	DAXX	physical	21482821
HIPK2_HUMAN	HIPK2	physical	16212962
MDM2_HUMAN	MDM2	physical	12842086
MDM2_HUMAN	MDM2	physical	11839577
MDM4_HUMAN	MDM4	physical	19153082
MDM2_HUMAN	MDM2	physical	19153082
MDM2_HUMAN	MDM2	physical	16870621
MDM4_HUMAN	MDM4	physical	19305137
MDM2_HUMAN	MDM2	physical	19305137
DAXX_HUMAN	DAXX	physical	15364927
DCAF1_HUMAN	VPRBP	physical	22184063
MDM2_HUMAN	MDM2	physical	16432196
MDM2_HUMAN	MDM2	physical	11178989
MDM2_HUMAN	MDM2	physical	9278461
BAK_HUMAN	BAK1	physical	21712378
BRCA1_HUMAN	BRCA1	physical	9582019
MDM2_HUMAN	MDM2	physical	15558054
EP300_HUMAN	EP300	physical	15558054
CUL7_HUMAN	CUL7	physical	16875676
MDM2_HUMAN	MDM2	physical	18604177
MDM2_HUMAN	MDM2	physical	17302414
TAF1_HUMAN	TAF1	physical	15053879
TAF5_HUMAN	TAF5	physical	15053879
MDM2_HUMAN	MDM2	physical	15053879
MDM2_HUMAN	MDM2	physical	19411066
MDM2_HUMAN	MDM2	physical	19033382
GNL3_HUMAN	GNL3	physical	19033382
BRCA1_HUMAN	BRCA1	physical	19509300
CREB1_HUMAN	CREB1	physical	21295542
TIF1B_HUMAN	TRIM28	physical	17056014
MDM2_HUMAN	MDM2	physical	17056014
MDM2_MOUSE	Mdm2	physical	11983168
MDM4_HUMAN	MDM4	physical	12370303
CDN1A_HUMAN	CDKN1A	physical	17371838
CASP8_HUMAN	CASP8	physical	17290218
TOPRS_HUMAN	TOPORS	physical	17290218
SIR1_HUMAN	SIRT1	physical	12006491
DVL2_HUMAN	DVL2	physical	16713569
MAGBI_HUMAN	MAGEB18	physical	16713569
SCAM1_HUMAN	SCAMP1	physical	16713569
DAXX_HUMAN	DAXX	physical	15339933
MDM2_HUMAN	MDM2	physical	14559824
PTEN_HUMAN	PTEN	physical	14559824
WT1_HUMAN	WT1	physical	9556563
BRCA1_HUMAN	BRCA1	physical	21742769
BARD1_HUMAN	BARD1	physical	21742769
SOCS1_HUMAN	SOCS1	physical	20005840
KAT2B_HUMAN	KAT2B	physical	14614455
EP300_HUMAN	EP300	physical	19218448
PARK7_HUMAN	PARK7	physical	18042550
MDM2_HUMAN	MDM2	physical	21471462
SMAD1_HUMAN	SMAD1	physical	22588298
MDM2_HUMAN	MDM2	physical	22588298
MDM2_HUMAN	MDM2	physical	20235143
P53_HUMAN	TP53	physical	20235143
KC1D_HUMAN	CSNK1D	physical	18246126
MDM2_HUMAN	MDM2	physical	7689721
MDM2_HUMAN	MDM2	physical	8058315
PARP1_HUMAN	PARP1	physical	9312059
ERCC3_HUMAN	ERCC3	physical	12379483
TBP_HUMAN	TBP	physical	12379483
MUC1_HUMAN	MUC1	physical	15710329
RING2_HUMAN	RNF2	physical	23318437
MDM2_HUMAN	MDM2	physical	23318437
PHF1_HUMAN	PHF1	physical	23150668
MDM2_HUMAN	MDM2	physical	23150668
TRI39_HUMAN	TRIM39	physical	23213260
HNRPK_HUMAN	HNRNPK	physical	23092970
SOSB1_HUMAN	NABP2	physical	23184057
TWST1_HUMAN	TWIST1	physical	18504427
PHF20_HUMAN	PHF20	physical	22864287
NPM_HUMAN	NPM1	physical	12080348
EP400_HUMAN	EP400	physical	9194565
EP300_HUMAN	EP300	physical	9194565
SP1_HUMAN	SP1	physical	15710382
TF2H1_HUMAN	GTF2H1	physical	18160537
SNAI1_HUMAN	SNAI1	physical	20385133
ZN420_HUMAN	ZNF420	physical	20713054
SYVN1_HUMAN	SYVN1	physical	17170702
MDM2_HUMAN	MDM2	physical	17347673
TWST1_HUMAN	TWIST1	physical	22975381
MDM2_HUMAN	MDM2	physical	22975381
TNAP3_HUMAN	TNFAIP3	physical	23471665
MKRN1_HUMAN	MKRN1	physical	19536131
MDM4_HUMAN	MDM4	physical	19521340
BCL2_HUMAN	BCL2	physical	19521340
RNF39_HUMAN	RNF39	physical	17719541
MDM2_HUMAN	MDM2	physical	22807444
MDM4_HUMAN	MDM4	physical	22807444
MDM4_HUMAN	MDM4	physical	23028042
TRIM8_HUMAN	TRIM8	physical	22262183
P53_HUMAN	TP53	physical	16009130
NFYA_HUMAN	NFYA	physical	16959611
NFYB_HUMAN	NFYB	physical	16959611
EP300_HUMAN	EP300	physical	16959611
HDAC1_HUMAN	HDAC1	physical	16959611
TF2H1_HUMAN	GTF2H1	physical	18354501
EP300_HUMAN	EP300	physical	18391200
RABL6_HUMAN	RABL6	physical	23572512
CDK7_HUMAN	CDK7	physical	9315650
ANXA2_HUMAN	ANXA2	physical	9315650
MBB1A_HUMAN	MYBBP1A	physical	21471221
EP300_HUMAN	EP300	physical	16611888
TF2H1_HUMAN	GTF2H1	physical	8612585
ERCC2_HUMAN	ERCC2	physical	8612585
TF2H4_HUMAN	GTF2H4	physical	8612585
ERCC3_HUMAN	ERCC3	physical	8612585
RFWD2_HUMAN	RFWD2	physical	23736031
NECD_HUMAN	NDN	physical	23785149
MDM2_HUMAN	MDM2	physical	23826318
AXIN1_HUMAN	AXIN1	physical	23826318
ECD_HUMAN	ECD	physical	23880345
TXNIP_HUMAN	TXNIP	physical	23880345
MDM2_HUMAN	MDM2	physical	23609977
BTBD2_HUMAN	BTBD2	physical	16169070
UBE2K_HUMAN	UBE2K	physical	23933584
P53_HUMAN	TP53	physical	21988832
RNF38_HUMAN	RNF38	physical	23973461
TF2H1_HUMAN	GTF2H1	physical	16793543
SQSTM_HUMAN	SQSTM1	physical	16793543
SMAD2_HUMAN	SMAD2	physical	23687300
SMAD3_HUMAN	SMAD3	physical	23687300
PGH2_HUMAN	PTGS2	physical	19465063
P53_HUMAN	TP53	physical	20080206
MDM2_HUMAN	MDM2	physical	20080206
ANK2_HUMAN	ANK2	physical	20195357
NCOA2_HUMAN	NCOA2	physical	20195357
PGH2_HUMAN	PTGS2	physical	16928824
EP300_HUMAN	EP300	physical	16928824
MDM2_HUMAN	MDM2	physical	23483203
PGH2_HUMAN	PTGS2	physical	21187340
EP300_HUMAN	EP300	physical	21187340
MK03_HUMAN	MAPK3	physical	21187340
ZHANG_HUMAN	CREBZF	physical	24200963
MDM2_HUMAN	MDM2	physical	24200963
MDM2_HUMAN	MDM2	physical	24240685
OTUD5_HUMAN	OTUD5	physical	24143256
TNAP3_HUMAN	TNFAIP3	physical	24099634
MDM2_HUMAN	MDM2	physical	21561866
UBE4B_HUMAN	UBE4B	physical	24587254
XPC_HUMAN	XPC	physical	24258024
PSMD6_HUMAN	PSMD6	physical	24258024
PTTG_HUMAN	PTTG1IP	physical	24506068
UBE2A_HUMAN	UBE2A	physical	24506068
MDM2_HUMAN	MDM2	physical	24643130
HERC2_HUMAN	HERC2	physical	24722987
P53_HUMAN	TP53	physical	24722987
ZBT16_HUMAN	ZBTB16	physical	24821727
NLK_HUMAN	NLK	physical	24926618
MDM2_HUMAN	MDM2	physical	24926618
NLK_HUMAN	NLK	genetic	24926618
MDM2_HUMAN	MDM2	physical	10681559
RUNX2_HUMAN	RUNX2	physical	23618908
RN128_HUMAN	RNF128	physical	23370271
MDM2_HUMAN	MDM2	physical	23370271
EP300_HUMAN	EP300	physical	23402884
ACK1_HUMAN	TNK2	physical	23402884
MDM2_HUMAN	MDM2	physical	23402884
DNJC7_HUMAN	DNAJC7	physical	23261415
DNJC7_HUMAN	DNAJC7	genetic	23261415
MDM2_HUMAN	MDM2	physical	23261415
ZBT8A_HUMAN	ZBTB8A	physical	23329847
DAXX_HUMAN	DAXX	physical	23038753
DNMT1_HUMAN	DNMT1	physical	23038753
MDM2_HUMAN	MDM2	physical	23201157
PATZ1_HUMAN	PATZ1	physical	24336083
EP300_HUMAN	EP300	physical	24157709
SMAD3_HUMAN	SMAD3	physical	24157709
NCOR1_HUMAN	NCOR1	physical	24157709
PML_HUMAN	PML	physical	22869143
MK07_HUMAN	MAPK7	physical	22869143
SP1_HUMAN	SP1	physical	23650532
ABR_HUMAN	ABR	physical	23443559
ACSL4_HUMAN	ACSL4	physical	23443559
ACTA_HUMAN	ACTA2	physical	23443559
ACTB_HUMAN	ACTB	physical	23443559
AIFM2_HUMAN	AIFM2	physical	23443559
AKA12_HUMAN	AKAP12	physical	23443559
ATPA_HUMAN	ATP5A1	physical	23443559
BAG2_HUMAN	BAG2	physical	23443559
PRC2A_HUMAN	PRRC2A	physical	23443559
PRC2C_HUMAN	PRRC2C	physical	23443559
PYR1_HUMAN	CAD	physical	23443559
CAN1_HUMAN	CAPN1	physical	23443559
CCDC8_HUMAN	CCDC8	physical	23443559
TCPB_HUMAN	CCT2	physical	23443559
TCPG_HUMAN	CCT3	physical	23443559
TCPD_HUMAN	CCT4	physical	23443559
TCPE_HUMAN	CCT5	physical	23443559
TCPZ_HUMAN	CCT6A	physical	23443559
TCPH_HUMAN	CCT7	physical	23443559
TCPQ_HUMAN	CCT8	physical	23443559
CEP55_HUMAN	CEP55	physical	23443559
CPNE7_HUMAN	CPNE7	physical	23443559
CRTC2_HUMAN	CRTC2	physical	23443559
CUL7_HUMAN	CUL7	physical	23443559
CUL9_HUMAN	CUL9	physical	23443559
TBB5_HUMAN	TUBB	physical	23443559
DDB1_HUMAN	DDB1	physical	23443559
DDX5_HUMAN	DDX5	physical	23443559
DGC14_HUMAN	DGCR14	physical	23443559
DNJA1_HUMAN	DNAJA1	physical	23443559
DNJA2_HUMAN	DNAJA2	physical	23443559
DOCK7_HUMAN	DOCK7	physical	23443559
EBP2_HUMAN	EBNA1BP2	physical	23443559
EF1A1_HUMAN	EEF1A1	physical	23443559
IF4E2_HUMAN	EIF4E2	physical	23443559
ENAH_HUMAN	ENAH	physical	23443559
CSK21_HUMAN	CSNK2A1	physical	23443559
RT18B_HUMAN	MRPS18B	physical	23443559
RCN2_HUMAN	RCN2	physical	23443559
RL24_HUMAN	RPL24	physical	23443559
RL23_HUMAN	RPL23	physical	23443559
EXOS7_HUMAN	EXOSC7	physical	23443559
EXOS8_HUMAN	EXOSC8	physical	23443559
MZT2B_HUMAN	MZT2B	physical	23443559
UBIM_HUMAN	FAU	physical	23443559
FBRL_HUMAN	FBL	physical	23443559
FBX21_HUMAN	FBXO21	physical	23443559
FRIH_HUMAN	FTH1	physical	23443559
MOGS_HUMAN	MOGS	physical	23443559
GGYF2_HUMAN	GIGYF2	physical	23443559
GPTC8_HUMAN	GPATCH8	physical	23443559
GRWD1_HUMAN	GRWD1	physical	23443559
TF3C3_HUMAN	GTF3C3	physical	23443559
TF3C4_HUMAN	GTF3C4	physical	23443559
HECD1_HUMAN	HECTD1	physical	23443559
ROA1_HUMAN	HNRNPA1	physical	23443559
ROA2_HUMAN	HNRNPA2B1	physical	23443559
HNRPF_HUMAN	HNRNPF	physical	23443559
HNRH1_HUMAN	HNRNPH1	physical	23443559
HNRPM_HUMAN	HNRNPM	physical	23443559
HNRPU_HUMAN	HNRNPU	physical	23443559
HPCA_HUMAN	HPCA	physical	23443559
HS90A_HUMAN	HSP90AA1	physical	23443559
HS90B_HUMAN	HSP90AB1	physical	23443559
HS71L_HUMAN	HSPA1L	physical	23443559
GRP78_HUMAN	HSPA5	physical	23443559
HSP7C_HUMAN	HSPA8	physical	23443559
GRP75_HUMAN	HSPA9	physical	23443559
IDH3B_HUMAN	IDH3B	physical	23443559
IF2B1_HUMAN	IGF2BP1	physical	23443559
IF2B3_HUMAN	IGF2BP3	physical	23443559
ARHGH_HUMAN	ARHGEF17	physical	23443559
IQGA1_HUMAN	IQGAP1	physical	23443559
IRS4_HUMAN	IRS4	physical	23443559
IP3KC_HUMAN	ITPKC	physical	23443559
LPPRC_HUMAN	LRPPRC	physical	23443559
LY65B_HUMAN	LY6G5B	physical	23443559
MAGD2_HUMAN	MAGED2	physical	23443559
MK01_HUMAN	MAPK1	physical	23443559
MDM2_HUMAN	MDM2	physical	23443559
MFAP4_HUMAN	MFAP4	physical	23443559
KMT2A_HUMAN	KMT2A	physical	23443559
RM24_HUMAN	MRPL24	physical	23443559
RM38_HUMAN	MRPL38	physical	23443559
RM39_HUMAN	MRPL39	physical	23443559
RM41_HUMAN	MRPL41	physical	23443559
RT14_HUMAN	MRPS14	physical	23443559
RT02_HUMAN	MRPS2	physical	23443559
RT22_HUMAN	MRPS22	physical	23443559
RT23_HUMAN	MRPS23	physical	23443559
RT25_HUMAN	MRPS25	physical	23443559
RT27_HUMAN	MRPS27	physical	23443559
RT28_HUMAN	MRPS28	physical	23443559
RT05_HUMAN	MRPS5	physical	23443559
RT09_HUMAN	MRPS9	physical	23443559
NPM_HUMAN	NPM1	physical	23443559
OBSL1_HUMAN	OBSL1	physical	23443559
RL13_HUMAN	RPL13	physical	23443559
PABP1_HUMAN	PABPC1	physical	23443559
PCBP1_HUMAN	PCBP1	physical	23443559
PIMT_HUMAN	PCMT1	physical	23443559
PDCD6_HUMAN	PDCD6	physical	23443559
KPB2_HUMAN	PHKA2	physical	23443559
KPBB_HUMAN	PHKB	physical	23443559
PHKG2_HUMAN	PHKG2	physical	23443559
PDIP2_HUMAN	POLDIP2	physical	23443559
LIPB1_HUMAN	PPFIBP1	physical	23443559
IASPP_HUMAN	PPP1R13L	physical	23443559
PP2BA_HUMAN	PPP3CA	physical	23443559
CANB1_HUMAN	PPP3R1	physical	23443559
PTCD3_HUMAN	PTCD3	physical	23443559
RAE1L_HUMAN	RAE1	physical	23443559
RAVR1_HUMAN	RAVER1	physical	23443559
RBBP4_HUMAN	RBBP4	physical	23443559
RBBP7_HUMAN	RBBP7	physical	23443559
RBX1_HUMAN	RBX1	physical	23443559
RDH13_HUMAN	RDH13	physical	23443559
RFC3_HUMAN	RFC3	physical	23443559
RFC4_HUMAN	RFC4	physical	23443559
MRRP1_HUMAN	TRMT10C	physical	23443559
RL7A_HUMAN	RPL7A	physical	23443559
RL10A_HUMAN	RPL10A	physical	23443559
RL10L_HUMAN	RPL10L	physical	23443559
RL11_HUMAN	RPL11	physical	23443559
RL12_HUMAN	RPL12	physical	23443559
RL14_HUMAN	RPL14	physical	23443559
RL15_HUMAN	RPL15	physical	23443559
RL18_HUMAN	RPL18	physical	23443559
RL18A_HUMAN	RPL18A	physical	23443559
RL19_HUMAN	RPL19	physical	23443559
RL21_HUMAN	RPL21	physical	23443559
RL23A_HUMAN	RPL23A	physical	23443559
RL26_HUMAN	RPL26	physical	23443559
RL26L_HUMAN	RPL26L1	physical	23443559
RL27_HUMAN	RPL27	physical	23443559
RL3_HUMAN	RPL3	physical	23443559
RL30_HUMAN	RPL30	physical	23443559
RL31_HUMAN	RPL31	physical	23443559
RL37A_HUMAN	RPL37A	physical	23443559
RL4_HUMAN	RPL4	physical	23443559
RL5_HUMAN	RPL5	physical	23443559
RL6_HUMAN	RPL6	physical	23443559
RL7_HUMAN	RPL7	physical	23443559
RL8_HUMAN	RPL8	physical	23443559
RLA0_HUMAN	RPLP0	physical	23443559
RLA2_HUMAN	RPLP2	physical	23443559
RPR1A_HUMAN	RPRD1A	physical	23443559
RS10_HUMAN	RPS10	physical	23443559
RS14_HUMAN	RPS14	physical	23443559
RS15_HUMAN	RPS15	physical	23443559
RS17_HUMAN	RPS17	physical	23443559
RS2_HUMAN	RPS2	physical	23443559
RS24_HUMAN	RPS24	physical	23443559
RS25_HUMAN	RPS25	physical	23443559
RS26_HUMAN	RPS26	physical	23443559
RS27_HUMAN	RPS27	physical	23443559
RS3A_HUMAN	RPS3A	physical	23443559
RS6_HUMAN	RPS6	physical	23443559
RS7_HUMAN	RPS7	physical	23443559
RS8_HUMAN	RPS8	physical	23443559
RS9_HUMAN	RPS9	physical	23443559
RRP1B_HUMAN	RRP1B	physical	23443559
SNUT1_HUMAN	SART1	physical	23443559
SCO2_HUMAN	SCO2	physical	23443559
SF3B2_HUMAN	SF3B2	physical	23443559
SKP1_HUMAN	SKP1	physical	23443559
GTR12_HUMAN	SLC2A12	physical	23443559
SMD3_HUMAN	SNRPD3	physical	23443559
SNW1_HUMAN	SNW1	physical	23443559
SPT6H_HUMAN	SUPT6H	physical	23443559
TADA3_HUMAN	TADA3	physical	23443559
TBCD4_HUMAN	TBC1D4	physical	23443559
TCAL4_HUMAN	TCEAL4	physical	23443559
TCPA_HUMAN	TCP1	physical	23443559
TFR1_HUMAN	TFRC	physical	23443559
TIM50_HUMAN	TIMM50	physical	23443559
TOIP2_HUMAN	TOR1AIP2	physical	23443559
IFG15_HUMAN	TOR1AIP2	physical	23443559
TBA1A_HUMAN	TUBA1A	physical	23443559
TBA1C_HUMAN	TUBA1C	physical	23443559
TBA4A_HUMAN	TUBA4A	physical	23443559
TBB2A_HUMAN	TUBB2A	physical	23443559
TBB4B_HUMAN	TUBB4B	physical	23443559
TBG1_HUMAN	TUBG1	physical	23443559
UBB_HUMAN	UBB	physical	23443559
UBR4_HUMAN	UBR4	physical	23443559
UBR5_HUMAN	UBR5	physical	23443559
VASP_HUMAN	VASP	physical	23443559
VAT1_HUMAN	VAT1	physical	23443559
TERA_HUMAN	VCP	physical	23443559
DCAF7_HUMAN	DCAF7	physical	23443559
YBOX1_HUMAN	YBX1	physical	23443559
YTHD1_HUMAN	YTHDF1	physical	23443559
1433E_HUMAN	YWHAE	physical	23443559
ZWINT_HUMAN	ZWINT	physical	23443559
MDM2_HUMAN	MDM2	physical	23946421
MDM4_HUMAN	MDM4	physical	23946421
PER2_HUMAN	PER2	physical	25103245
MDM2_HUMAN	MDM2	physical	25103245
UBP10_HUMAN	USP10	physical	24998844
ZN363_HUMAN	RCHY1	physical	19483087
MDM2_HUMAN	MDM2	physical	19483087
T22D3_HUMAN	TSC22D3	physical	25168242
MDM2_HUMAN	MDM2	physical	25168242
UBC_HUMAN	UBC	physical	25168242
TRI32_HUMAN	TRIM32	physical	25146927
HSP72_HUMAN	HSPA2	physical	25144556
HSP76_HUMAN	HSPA6	physical	25144556
HSP7C_HUMAN	HSPA8	physical	25144556
GRP75_HUMAN	HSPA9	physical	25144556
CHIP_HUMAN	STUB1	physical	25144556
BAG2_HUMAN	BAG2	physical	25144556
BAG5_HUMAN	BAG5	physical	25144556
TCPA_HUMAN	TCP1	physical	25144556
TCPB_HUMAN	CCT2	physical	25144556
TCPG_HUMAN	CCT3	physical	25144556
TCPD_HUMAN	CCT4	physical	25144556
TCPE_HUMAN	CCT5	physical	25144556
TCPZ_HUMAN	CCT6A	physical	25144556
TCPH_HUMAN	CCT7	physical	25144556
TCPQ_HUMAN	CCT8	physical	25144556
RBM3_HUMAN	RBM3	physical	25144556
RBM39_HUMAN	RBM39	physical	25144556
PABP1_HUMAN	PABPC1	physical	25144556
SRSF6_HUMAN	SRSF6	physical	25144556
DDX3X_HUMAN	DDX3X	physical	25144556
DDX5_HUMAN	DDX5	physical	25144556
ACTB_HUMAN	ACTB	physical	25144556
ACTBL_HUMAN	ACTBL2	physical	25144556
TBA1C_HUMAN	TUBA1C	physical	25144556
TBB5_HUMAN	TUBB	physical	25144556
TBB2A_HUMAN	TUBB2A	physical	25144556
MYH9_HUMAN	MYH9	physical	25144556
MYLK_HUMAN	MYLK	physical	25144556
MYO1C_HUMAN	MYO1C	physical	25144556
MYO6_HUMAN	MYO6	physical	25144556
TPM1_HUMAN	TPM1	physical	25144556
TPM3_HUMAN	TPM3	physical	25144556
TPM4_HUMAN	TPM4	physical	25144556
CAPZB_HUMAN	CAPZB	physical	25144556
GELS_HUMAN	GSN	physical	25144556
VIME_HUMAN	VIM	physical	25144556
CKAP4_HUMAN	CKAP4	physical	25144556
COR1C_HUMAN	CORO1C	physical	25144556
DREB_HUMAN	DBN1	physical	25144556
FLNA_HUMAN	FLNA	physical	25144556
LIMA1_HUMAN	LIMA1	physical	25144556
LMNA_HUMAN	LMNA	physical	25144556
RL7A_HUMAN	RPL7A	physical	25144556
RL8_HUMAN	RPL8	physical	25144556
RL27_HUMAN	RPL27	physical	25144556
RL28_HUMAN	RPL28	physical	25144556
RLA0_HUMAN	RPLP0	physical	25144556
RS2_HUMAN	RPS2	physical	25144556
RS3A_HUMAN	RPS3A	physical	25144556
RS4X_HUMAN	RPS4X	physical	25144556
RS13_HUMAN	RPS13	physical	25144556
RS16_HUMAN	RPS16	physical	25144556
RS17_HUMAN	RPS17	physical	25144556
RS18_HUMAN	RPS18	physical	25144556
RS19_HUMAN	RPS19	physical	25144556
ROA1_HUMAN	HNRNPA1	physical	25144556
HNRPK_HUMAN	HNRNPK	physical	25144556
HNRPL_HUMAN	HNRNPL	physical	25144556
HNRPM_HUMAN	HNRNPM	physical	25144556
THOC4_HUMAN	ALYREF	physical	25144556
CALD1_HUMAN	CALD1	physical	25144556
CHM4B_HUMAN	CHMP4B	physical	25144556
CLCA_HUMAN	CLTA	physical	25144556
CLCB_HUMAN	CLTB	physical	25144556
CLH1_HUMAN	CLTC	physical	25144556
DHRS4_HUMAN	DHRS4	physical	25144556
DNJA1_HUMAN	DNAJA1	physical	25144556
IF2P_HUMAN	EIF5B	physical	25144556
GBB2_HUMAN	GNB2	physical	25144556
GTF2I_HUMAN	GTF2I	physical	25144556
ECHB_HUMAN	HADHB	physical	25144556
KCD17_HUMAN	KCTD17	physical	25144556
LS14A_HUMAN	LSM14A	physical	25144556
LYSC_HUMAN	LYZ	physical	25144556
NDKM_HUMAN	NME4	physical	25144556
MYPT1_HUMAN	PPP1R12A	physical	25144556
ANM5_HUMAN	PRMT5	physical	25144556
ADT2_HUMAN	SLC25A5	physical	25144556
TR150_HUMAN	THRAP3	physical	25144556
MEP50_HUMAN	WDR77	physical	25144556
YBOX1_HUMAN	YBX1	physical	25144556
HSP74_HUMAN	HSPA4	physical	25144556
SQSTM_HUMAN	SQSTM1	physical	25144556
EP300_HUMAN	EP300	physical	25156994
MDM2_HUMAN	MDM2	physical	25156994
ABRX2_HUMAN	FAM175B	physical	25283148
MDM2_HUMAN	MDM2	physical	25283148
UBP7_HUMAN	USP7	physical	25283148
MDM2_HUMAN	MDM2	physical	25313037
XAF1_HUMAN	XAF1	physical	25313037
XAF1_HUMAN	XAF1	genetic	25313037
IASPP_HUMAN	PPP1R13L	physical	20840860
UBE3A_HUMAN	UBE3A	physical	1661671
CJ090_HUMAN	C10orf90	physical	24240685
EP300_HUMAN	EP300	physical	22074660
P53_HUMAN	TP53	physical	19339993
TADA3_HUMAN	TADA3	physical	17272277
EP300_HUMAN	EP300	physical	23307557
SENP1_HUMAN	SENP1	physical	19339993
PTTG_HUMAN	PTTG1IP	physical	25408419
ING4_HUMAN	ING4	physical	23967213
KAT2B_HUMAN	KAT2B	physical	9891054
TAT_HV1H2	tat	physical	12501250
MDM2_HUMAN	MDM2	physical	25384516
CBP_HUMAN	CREBBP	physical	17434128
TF65_HUMAN	RELA	physical	17434128
IKKA_HUMAN	CHUK	physical	17434128
EP300_HUMAN	EP300	physical	14612423
CBP_HUMAN	CREBBP	physical	14759370
ASH2L_HUMAN	ASH2L	physical	23870121
SET1A_HUMAN	SETD1A	physical	23870121
RBBP5_HUMAN	RBBP5	physical	23870121
CXXC1_HUMAN	CXXC1	physical	23870121
WDR82_HUMAN	WDR82	physical	23870121
WDR5_HUMAN	WDR5	physical	23870121
P53_HUMAN	TP53	physical	21231916
UBC9_HUMAN	UBE2I	physical	12565873
UBP7_HUMAN	USP7	physical	23382381
ZN302_HUMAN	ZNF302	physical	18307271
IRF7_HUMAN	IRF7	physical	18307271
RANB9_HUMAN	RANBP9	physical	18307271
CAPG_HUMAN	CAPG	physical	18307271
B2CL1_HUMAN	BCL2L1	physical	24474649
FBW1A_HUMAN	BTRC	physical	21521785
BCL6_HUMAN	BCL6	physical	25402006
SOSB2_HUMAN	NABP1	physical	25402006
NEIL3_HUMAN	NEIL3	physical	25402006
PADI1_HUMAN	PADI1	physical	25402006
TOP1M_HUMAN	TOP1MT	physical	25402006
TYY1_HUMAN	YY1	physical	25402006
TYY2_HUMAN	YY2	physical	25402006
ZIC3_HUMAN	ZIC3	physical	25402006
ITF2_HUMAN	TCF4	physical	25402006
TRI59_HUMAN	TRIM59	physical	25046164
MK14_HUMAN	MAPK14	physical	21050851
SRPK1_HUMAN	SRPK1	physical	21130767
SAFB1_HUMAN	SAFB	physical	21130767
KDM6A_HUMAN	KDM6A	physical	24078252
HDAC1_HUMAN	HDAC1	physical	19303885
MDM2_HUMAN	MDM2	physical	19303885
BANP_HUMAN	BANP	physical	19303885
MDM2_HUMAN	MDM2	physical	24659749
MDM4_HUMAN	MDM4	physical	24659749
UBC_HUMAN	UBC	physical	25471832
MDM2_HUMAN	MDM2	physical	26186194
MDM4_HUMAN	MDM4	physical	26186194
ABRX2_HUMAN	FAM175B	physical	26186194
CUL9_HUMAN	CUL9	physical	26186194
CUL7_HUMAN	CUL7	physical	26186194
TCAL1_HUMAN	TCEAL1	physical	26186194
BRD7_HUMAN	BRD7	physical	20228809
P63_HUMAN	TP63	physical	22575646
KAISO_HUMAN	ZBTB33	physical	25288747
EP300_HUMAN	EP300	physical	25288747
MDM2_HUMAN	MDM2	physical	25362358
ZN363_HUMAN	RCHY1	physical	25116336
CSN4_HUMAN	COPS4	physical	24725084
GCYA3_HUMAN	GUCY1A3	physical	24725084
CSN5_HUMAN	COPS5	physical	24725084
BIRC6_HUMAN	BIRC6	physical	25196217
MDM2_HUMAN	MDM2	physical	25464845
MDM4_HUMAN	MDM4	physical	25464845
CC106_HUMAN	CCDC106	physical	20159018
AP2B_HUMAN	TFAP2B	physical	20159018
OTUD5_HUMAN	OTUD5	physical	25499082
KLF5_HUMAN	KLF5	physical	16595680
MDM2_HUMAN	MDM2	physical	16595680
AAGAB_HUMAN	AAGAB	genetic	23284306
ACV1C_HUMAN	ACVR1C	genetic	23284306
ADA28_HUMAN	ADAM28	genetic	23284306
ARL3_HUMAN	ARL3	genetic	23284306
ARMX5_HUMAN	ARMCX5	genetic	23284306
ARP21_HUMAN	ARPP21	genetic	23284306
ATR_HUMAN	ATR	genetic	23284306
CENPA_HUMAN	CENPA	genetic	23284306
CBPA5_HUMAN	CPA5	genetic	23284306
CP20A_HUMAN	CYP20A1	genetic	23284306
CL049_HUMAN	C12orf49	genetic	23284306
DCR1C_HUMAN	DCLRE1C	genetic	23284306
DDX50_HUMAN	DDX50	genetic	23284306
DKK2_HUMAN	DKK2	genetic	23284306
DOT1L_HUMAN	DOT1L	genetic	23284306
DPP6_HUMAN	DPP6	genetic	23284306
DZIP1_HUMAN	DZIP1	genetic	23284306
EGFR_HUMAN	EGFR	genetic	23284306
ELL3_HUMAN	ELL3	genetic	23284306
EPG5_HUMAN	EPG5	genetic	23284306
ETV1_HUMAN	ETV1	genetic	23284306
EXOS4_HUMAN	EXOSC4	genetic	23284306
RMD1_HUMAN	RMDN1	genetic	23284306
FHIT_HUMAN	FHIT	genetic	23284306
GBRG3_HUMAN	GABRG3	genetic	23284306
GFPT2_HUMAN	GFPT2	genetic	23284306
GLPK2_HUMAN	GK2	genetic	23284306
GPSM3_HUMAN	GPSM3	genetic	23284306
NMDE2_HUMAN	GRIN2B	genetic	23284306
HAUS1_HUMAN	HAUS1	genetic	23284306
HAUS4_HUMAN	HAUS4	genetic	23284306
HINT3_HUMAN	HINT3	genetic	23284306
HXA9_HUMAN	HOXA9	genetic	23284306
HYAL4_HUMAN	HYAL4	genetic	23284306
IL1A_HUMAN	IL1A	genetic	23284306
IL8_HUMAN	CXCL8	genetic	23284306
IMP3_HUMAN	IMP3	genetic	23284306
INSI1_HUMAN	INSIG1	genetic	23284306
IRX1_HUMAN	IRX1	genetic	23284306
JMJD8_HUMAN	JMJD8	genetic	23284306
KLH40_HUMAN	KLHL40	genetic	23284306
KLRF1_HUMAN	KLRF1	genetic	23284306
LAPM5_HUMAN	LAPTM5	genetic	23284306
AMPL_HUMAN	LAP3	genetic	23284306
LGI4_HUMAN	LGI4	genetic	23284306
MCM8_HUMAN	MCM8	genetic	23284306
MED8_HUMAN	MED8	genetic	23284306
MED22_HUMAN	MED22	genetic	23284306
MFS12_HUMAN	MFSD12	genetic	23284306
MIA2_HUMAN	MIA2	genetic	23284306
MORN2_HUMAN	MORN2	genetic	23284306
MYPC1_HUMAN	MYBPC1	genetic	23284306
MYOTI_HUMAN	MYOT	genetic	23284306
NGN2_HUMAN	NEUROG2	genetic	23284306
5NT3A_HUMAN	NT5C3A	genetic	23284306
PACRG_HUMAN	PACRG	genetic	23284306
PDIA5_HUMAN	PDIA5	genetic	23284306
PAHX_HUMAN	PHYH	genetic	23284306
IPKA_HUMAN	PKIA	genetic	23284306
PLAC8_HUMAN	PLAC8	genetic	23284306
ASPP1_HUMAN	PPP1R13B	genetic	23284306
DPOD3_HUMAN	POLD3	genetic	23284306
PRP6_HUMAN	PRPF6	genetic	23284306
PSD3_HUMAN	PSD3	genetic	23284306
PTTG_HUMAN	PTTG1IP	genetic	23284306
PTX3_HUMAN	PTX3	genetic	23284306
PURG_HUMAN	PURG	genetic	23284306
RBBP5_HUMAN	RBBP5	genetic	23284306
RECQ5_HUMAN	RECQL5	genetic	23284306
RETNB_HUMAN	RETNLB	genetic	23284306
RNAS4_HUMAN	RNASE4	genetic	23284306
RUSD4_HUMAN	RPUSD4	genetic	23284306
SACS_HUMAN	SACS	genetic	23284306
SAMD7_HUMAN	SAMD7	genetic	23284306
MTMRD_HUMAN	SBF2	genetic	23284306
SEC63_HUMAN	SEC63	genetic	23284306
SLAF1_HUMAN	SLAMF1	genetic	23284306
CTR2_HUMAN	SLC7A2	genetic	23284306
SNX12_HUMAN	SNX12	genetic	23284306
SPESP_HUMAN	SPESP1	genetic	23284306
STAM2_HUMAN	STAM2	genetic	23284306
STT3B_HUMAN	STT3B	genetic	23284306
STXB4_HUMAN	STXBP4	genetic	23284306
STX2_HUMAN	STX2	genetic	23284306
SUPT3_HUMAN	SUPT3H	genetic	23284306
TBC24_HUMAN	TBC1D24	genetic	23284306
THAP1_HUMAN	THAP1	genetic	23284306
NELFD_HUMAN	NELFCD	genetic	23284306
T200A_HUMAN	TMEM200A	genetic	23284306
TM1L1_HUMAN	TOM1L1	genetic	23284306
TOP2A_HUMAN	TOP2A	genetic	23284306
TTC28_HUMAN	TTC28	genetic	23284306
UBQL2_HUMAN	UBQLN2	genetic	23284306
UMPS_HUMAN	UMPS	genetic	23284306
USH2A_HUMAN	USH2A	genetic	23284306
UBP1_HUMAN	USP1	genetic	23284306
ZN300_HUMAN	ZNF300	genetic	23284306
ZN619_HUMAN	ZNF619	genetic	23284306
ZN763_HUMAN	ZNF763	genetic	23284306
TERT_HUMAN	TERT	genetic	23284306
PARK7_HUMAN	PARK7	physical	22683601
ZBT17_HUMAN	ZBTB17	physical	19901969
UB2Q1_HUMAN	UBE2Q1	physical	25987028
MDM2_HUMAN	MDM2	physical	26578655
RN125_HUMAN	RNF125	physical	25591766
CBP_HUMAN	CREBBP	physical	25451029
HDAC1_HUMAN	HDAC1	physical	25241761
SMAD2_HUMAN	SMAD2	physical	25241761
PML_HUMAN	PML	physical	25241761
MDM2_HUMAN	MDM2	physical	25241761
FOXO3_HUMAN	FOXO3	physical	25241761
PIAS1_HUMAN	PIAS1	physical	25241761
DAXX_HUMAN	DAXX	physical	25241761
LAMA4_HUMAN	LAMA4	physical	25241761
BCR_HUMAN	BCR	physical	25241761
PIAS2_HUMAN	PIAS2	physical	25241761
CSK21_HUMAN	CSNK2A1	physical	25241761
2A5G_HUMAN	PPP2R5C	physical	25241761
BAX_HUMAN	BAX	physical	25241761
2AAA_HUMAN	PPP2R1A	physical	25241761
STK4_HUMAN	STK4	physical	25241761
MK01_HUMAN	MAPK1	physical	25241761
KC1E_HUMAN	CSNK1E	physical	25241761
KC1D_HUMAN	CSNK1D	physical	25241761
CREB1_HUMAN	CREB1	physical	25241761
CDN1A_HUMAN	CDKN1A	physical	25241761
P63_HUMAN	TP63	physical	25417702
P73_HUMAN	TP73	physical	25417702
MDM2_HUMAN	MDM2	physical	25417702
M3K1_HUMAN	MAP3K1	physical	26018553
MDM2_HUMAN	MDM2	physical	25277184
SMCA5_HUMAN	SMARCA5	physical	25609649
CUL9_HUMAN	CUL9	physical	25609649
CUL7_HUMAN	CUL7	physical	25609649
FBXW8_HUMAN	FBXW8	physical	25609649
OBSL1_HUMAN	OBSL1	physical	25609649
MDM2_HUMAN	MDM2	physical	25609649
MDM4_HUMAN	MDM4	physical	25609649
MOV10_HUMAN	MOV10	physical	25609649
NPAS3_HUMAN	NPAS3	physical	25609649
PESC_HUMAN	PES1	physical	25609649
RPOM_HUMAN	POLRMT	physical	25609649
RN5A_HUMAN	RNASEL	physical	25609649
RFA2_HUMAN	RPA2	physical	25609649
SMG5_HUMAN	SMG5	physical	25609649
MDM4_HUMAN	MDM4	physical	26148237
MDM2_HUMAN	MDM2	physical	26556313
B2CL1_HUMAN	BCL2L1	physical	26556313
ESR1_HUMAN	ESR1	physical	26556313
MDM2_HUMAN	MDM2	physical	24621507
UBE4B_HUMAN	UBE4B	physical	26673821
MDM2_HUMAN	MDM2	physical	26673821
KAISO_HUMAN	ZBTB33	physical	26183023
ENPL_HUMAN	HSP90B1	physical	25637791
MDM2_HUMAN	MDM2	physical	25739118
PATZ1_HUMAN	PATZ1	physical	25755280
MDM2_HUMAN	MDM2	physical	26350565
TFP11_HUMAN	TFIP11	physical	26460617
SYVN1_HUMAN	SYVN1	physical	26254280
ERN1_HUMAN	ERN1	physical	26254280
MDM2_HUMAN	MDM2	physical	24980433
UHRF1_HUMAN	UHRF1	physical	26102039
ELL3_HUMAN	ELL3	physical	26540344
MDM2_HUMAN	MDM2	physical	26540344
UBE3A_HUMAN	UBE3A	physical	26789255
NUCL_HUMAN	NCL	physical	26238070
UBP7_HUMAN	USP7	physical	26238070
MDM2_HUMAN	MDM2	physical	26238070
MDM4_HUMAN	MDM4	physical	25825738
LTOR5_HUMAN	LAMTOR5	physical	26229107
EP300_HUMAN	EP300	physical	26229107
TGM2_HUMAN	TGM2	physical	27031960
SQSTM_HUMAN	SQSTM1	physical	27031960
MDM2_HUMAN	MDM2	physical	27031960
BARD1_HUMAN	BARD1	physical	26022179
TP53B_HUMAN	TP53BP1	physical	26022179
NAT10_HUMAN	NAT10	physical	26882543
MDM4_HUMAN	MDM4	physical	27114532
KC1A_HUMAN	CSNK1A1	physical	27114532
CCND1_HUMAN	CCND1	physical	27129163
MDM2_HUMAN	MDM2	physical	27129163
NQO1_HUMAN	NQO1	physical	26078718
MDM2_HUMAN	MDM2	physical	27106262
NUMB_HUMAN	NUMB	physical	27106262
MDM2_HUMAN	MDM2	physical	26203195
UBP7_HUMAN	USP7	physical	24462112
GUAA_HUMAN	GMPS	physical	24462112
MDM2_HUMAN	MDM2	physical	24462112
SIR1_HUMAN	SIRT1	physical	22689577
CBP_HUMAN	CREBBP	physical	26976603
TRI65_HUMAN	TRIM65	physical	27012201
MDM2_HUMAN	MDM2	physical	26883110
P53_HUMAN	TP53	physical	8035799
PGH2_HUMAN	PTGS2	physical	15707991
DGKZ_HUMAN	DGKZ	physical	23606744
TSNAX_HUMAN	TSNAX	genetic	20506231
KIF2A_HUMAN	KIF2A	genetic	20506231
HSP7C_HUMAN	HSPA8	physical	7954368
SP1_HUMAN	SP1	physical	19846904
CDK9_HUMAN	CDK9	physical	16741955
CDN1C_HUMAN	CDKN1C	physical	12665691
HBB_HUMAN	HBB	physical	12665691
2AAA_HUMAN	PPP2R1A	physical	12665691
EEA1_HUMAN	EEA1	physical	12665691
HDAC1_HUMAN	HDAC1	physical	26539911
NOP53_HUMAN	GLTSCR2	physical	22522597
P53_HUMAN	TP53	physical	22522597
E2AK2_HUMAN	EIF2AK2	physical	19631745
CSK21_HUMAN	CSNK2A1	physical	15358769
LRRK2_HUMAN	LRRK2	physical	26384650
PER2_HUMAN	PER2	physical	27834218
PCNA_HUMAN	PCNA	physical	27407148
POLI_HUMAN	POLI	physical	27407148
ATX3_HUMAN	ATXN3	physical	27851749
UBP15_HUMAN	USP15	physical	27893708
CYLD_HUMAN	CYLD	physical	27561390
BAG5_HUMAN	BAG5	physical	27807478
MDM2_HUMAN	MDM2	physical	27807478
CHIP_HUMAN	STUB1	physical	27807478
BAG2_HUMAN	BAG2	physical	27807478
MDM2_HUMAN	MDM2	physical	25312347
TP53B_HUMAN	TP53BP1	physical	27546791
MDM2_HUMAN	MDM2	physical	27336364
TNR16_HUMAN	NGFR	physical	27282385
MDM2_HUMAN	MDM2	physical	27282385
MDM2_HUMAN	MDM2	physical	26876197
MDM4_HUMAN	MDM4	physical	26876197
MDM2_HUMAN	MDM2	physical	26475964
BAK_HUMAN	BAK1	physical	27818144
MCL1_HUMAN	MCL1	physical	27818144
EP300_HUMAN	EP300	physical	27818144
P53_HUMAN	TP53	physical	27462439
SMG7_HUMAN	SMG7	physical	27462439
MDM2_HUMAN	MDM2	physical	27462439
DNJA1_HUMAN	DNAJA1	physical	27775703
CHIP_HUMAN	STUB1	physical	27775703
HIF1A_HUMAN	HIF1A	physical	27345397
TBP_HUMAN	TBP	physical	8083962
RB_HUMAN	RB1	physical	8083962
MDM2_HUMAN	MDM2	physical	28082682
TBPL1_HUMAN	TBPL1	physical	28082682
MDM2_HUMAN	MDM2	physical	28223335
MSI2H_HUMAN	MSI2	physical	28223335
NUMB_HUMAN	NUMB	physical	28223335
P53_HUMAN	TP53	physical	24037342
MDM2_HUMAN	MDM2	physical	20660730
PTEN_HUMAN	PTEN	physical	18339852
OTUD1_HUMAN	OTUD1	physical	28216291
SIR1_HUMAN	SIRT1	physical	18753379
NECD_HUMAN	NDN	physical	18753379
CUL9_HUMAN	CUL9	physical	28514442
CUL7_HUMAN	CUL7	physical	28514442
MDM2_HUMAN	MDM2	physical	28514442
ABRX2_HUMAN	FAM175B	physical	28514442
HAIR_HUMAN	HR	physical	27355563
LT_SV40	SV40gp6	physical	10570441
CBP_HUMAN	CREBBP	physical	23908595
NFYA_HUMAN	NFYA	physical	23908595
OLIG2_HUMAN	OLIG2	genetic	21397859
AIPL1_HUMAN	AIPL1	physical	27173435
MDM2_HUMAN	MDM2	physical	27308622
DACH1_HUMAN	DACH1	physical	23798621
P53_HUMAN	TP53	physical	25603536
SUH_HUMAN	RBPJ	physical	26302407
P73_HUMAN	TP73	physical	9891077
MDM4_HUMAN	MDM4	physical	28487147
CETP_HUMAN	CETP	physical	27229929
ACKR3_HUMAN	ACKR3	physical	27229929
RAB7A_HUMAN	RAB7A	physical	27229929
SL9A9_HUMAN	SLC9A9	physical	27229929
STA10_HUMAN	STARD10	physical	27229929
UB2V2_HUMAN	UBE2V2	physical	27229929
ZN679_HUMAN	ZNF679	physical	27229929
ZN839_HUMAN	ZNF839	physical	27229929
MDM2_HUMAN	MDM2	physical	10561590
TRI45_HUMAN	TRIM45	physical	28542145
MDM2_HUMAN	MDM2	physical	28542145
MDM2_HUMAN	MDM2	physical	10202144
MDM2_MOUSE	Mdm2	physical	10202144
MDM2_HUMAN	MDM2	physical	28549433
TRX2_YEAST	TRX2	genetic	26264138
FBX42_HUMAN	FBXO42	physical	21127074
ATF3_HUMAN	ATF3	physical	24554706
RFA1_HUMAN	RPA1	physical	23267009
MDM2_HUMAN	MDM2	physical	28394340
UCHL1_HUMAN	UCHL1	physical	29126443
BRCA1_HUMAN	BRCA1	physical	26140185
RAD51_HUMAN	RAD51	physical	26140185
MDM2_HUMAN	MDM2	physical	11284721
PIAS1_HUMAN	PIAS1	physical	15133049
DMTF1_HUMAN	DMTF1	physical	28406729
MDM2_HUMAN	MDM2	physical	28362432
MDM2_HUMAN	MDM2	physical	18316739
FOXO3_HUMAN	FOXO3	physical	27886165
MDM2_HUMAN	MDM2	physical	27886165
UBP3_HUMAN	USP3	physical	28807825

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma.
• 133239:
• 151623: Li-Fraumeni syndrome (LFS)
• 275355: Squamous cell carcinoma of the head and neck (HNSCC)
• 211980: Lung cancer (LNCR)
• 260500: Papilloma of choroid plexus (CPP)
• 202300: Adrenocortical carcinoma (ADCC)
• 614740: Basal cell carcinoma 7 (BCC7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00945: Acetylsalicylic acid

Related Literatures of Post-Translational Modification

Acetylation

"BRD7 is a candidate tumour suppressor gene required for p53function.";
Drost J., Mantovani F., Tocco F., Elkon R., Comel A., Holstege H.,Kerkhoven R., Jonkers J., Voorhoeve P.M., Agami R., Del Sal G.;
Nat. Cell Biol. 12:380-389(2010).
Cited for: INTERACTION WITH BRD7, AND ACETYLATION AT LYS-382.
PubMed: 20228809

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-292; LYS-305; LYS-381 ANDLYS-382, AND MASS SPECTROMETRY.
PubMed: 19608861

"Identification and characterization of a novel p300-mediated p53acetylation site, lysine 305.";
Wang Y.H., Tsay Y.G., Tan B.C., Lo W.Y., Lee S.C.;
J. Biol. Chem. 278:25568-25576(2003).
Cited for: ACETYLATION AT LYS-305.
PubMed: 12724314

"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.";
Vaziri H., Dessain S.K., Ng Eaton E., Imai S., Frye R.A.,Pandita T.K., Guarente L., Weinberg R.A.;
Cell 107:149-159(2001).
Cited for: DEACETYLATION AT LYS-382 BY SIRT1.
PubMed: 11672523

"Post-translational modification of p53 protein in response toionizing radiation analyzed by mass spectrometry.";
Abraham J., Kelly J., Thibault P., Benchimol S.;
J. Mol. Biol. 295:853-864(2000).
Cited for: ACETYLATION AT LYS-373 AND LYS-382.
PubMed: 10656795

Methylation

"G9a and Glp methylate lysine 373 in the tumor suppressor p53.";
Huang J., Dorsey J., Chuikov S., Perez-Burgos L., Zhang X.,Jenuwein T., Reinberg D., Berger S.L.;
J. Biol. Chem. 285:9636-9641(2010).
Cited for: METHYLATION AT LYS-373, AND MUTAGENESIS OF LYS-373.
PubMed: 20118233

"Repression of p53 activity by Smyd2-mediated methylation.";
Huang J., Perez-Burgos L., Placek B.J., Sengupta R., Richter M.,Dorsey J.A., Kubicek S., Opravil S., Jenuwein T., Berger S.L.;
Nature 444:629-632(2006).
Cited for: METHYLATION AT LYS-370, AND MUTAGENESIS OF LYS-370.
PubMed: 17108971

"The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation atlysine 382 to target gene repression.";
West L.E., Roy S., Lachmi-Weiner K., Hayashi R., Shi X., Appella E.,Kutateladze T.G., Gozani O.;
J. Biol. Chem. 285:37725-37732(2010).
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 377-386, METHYLATION ATLYS-382, MUTAGENESIS OF LYS-382, AND INTERACTION WITH L3MBTL1.
PubMed: 20870725

"Modulation of p53 function by SET8-mediated methylation at lysine382.";
Shi X., Kachirskaia I., Yamaguchi H., West L.E., Wen H., Wang E.W.,Dutta S., Appella E., Gozani O.;
Mol. Cell 27:636-646(2007).
Cited for: METHYLATION AT LYS-382, AND MUTAGENESIS OF LYS-382.
PubMed: 17707234

"Structural basis for the methylation site specificity of SET7/9.";
Couture J.-F., Collazo E., Hauk G., Trievel R.C.;
Nat. Struct. Mol. Biol. 13:140-146(2006).
Cited for: MOTIF, AND METHYLATION AT LYS-372.
PubMed: 16415881

"Regulation of p53 activity through lysine methylation.";
Chuikov S., Kurash J.K., Wilson J.R., Xiao B., Justin N., Ivanov G.S.,McKinney K., Tempst P., Prives C., Gamblin S.J., Barlev N.A.,Reinberg D.;
Nature 432:353-360(2004).
Cited for: METHYLATION AT LYS-372, AND MUTAGENESIS OF LYS-372.
PubMed: 15525938

Phosphorylation

"A new role of NUAK1: directly phosphorylating p53 and regulating cellproliferation.";
Hou X., Liu J.E., Liu W., Liu C.Y., Liu Z.Y., Sun Z.Y.;
Oncogene 30:2933-2942(2011).
Cited for: INTERACTION WITH NUAK1, AND PHOSPHORYLATION AT SER-15 AND SER-392.
PubMed: 21317932

"Aurora B interacts with NIR-p53, leading to p53 phosphorylation inits DNA-binding domain and subsequent functional suppression.";
Wu L., Ma C.A., Zhao Y., Jain A.;
J. Biol. Chem. 286:2236-2244(2011).
Cited for: FUNCTION, INTERACTION WITH AURKB AND NOC2L, PHOSPHORYLATION ATSER-183; SER-269 AND THR-284, CHARACTERIZATION OF VARIANT ALA-284,MUTAGENESIS OF SER-183 AND SER-269, AND MASS SPECTROMETRY.
PubMed: 20959462

"Isoform specific phosphorylation of p53 by protein kinase CK1.";
Venerando A., Marin O., Cozza G., Bustos V.H., Sarno S., Pinna L.A.;
Cell. Mol. Life Sci. 67:1105-1118(2010).
Cited for: PHOSPHORYLATION AT SER-20 BY CSNK1D/CK1.
PubMed: 20041275

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313; SER-314 ANDSER-392, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314; SER-315 ANDSER-392, AND MASS SPECTROMETRY.
PubMed: 19413330

"Serine 15 phosphorylation of p53 directs its interaction withB56gamma and the tumor suppressor activity of B56gamma-specificprotein phosphatase 2A.";
Shouse G.P., Cai X., Liu X.;
Mol. Cell. Biol. 28:448-456(2008).
Cited for: INTERACTION WITH PPP2CA; PPP2R1A AND PPP2R5C, PHOSPHORYLATION ATSER-15 BY ATM, AND MUTAGENESIS OF SER-15.
PubMed: 17967874

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.
PubMed: 17525332

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND MASSSPECTROMETRY.
PubMed: 17287340

"Stabilization and activation of p53 induced by Cdk5 contributes toneuronal cell death.";
Lee J.-H., Kim H.-S., Lee S.-J., Kim K.-T.;
J. Cell Sci. 120:2259-2271(2007).
Cited for: PHOSPHORYLATION AT SER-15; SER-33 AND SER-46, INTERACTION WITH CDK5,AND SUBCELLULAR LOCATION.
PubMed: 17591690

"Novel homeodomain-interacting protein kinase family member, HIPK4,phosphorylates human p53 at serine 9.";
Arai S., Matsushita A., Du K., Yagi K., Okazaki Y., Kurokawa R.;
FEBS Lett. 581:5649-5657(2007).
Cited for: PHOSPHORYLATION AT SER-9.
PubMed: 18022393

"PRAK is essential for ras-induced senescence and tumor suppression.";
Sun P., Yoshizuka N., New L., Moser B.A., Li Y., Liao R., Xie C.,Chen J., Deng Q., Yamout M., Dong M.Q., Frangou C.G., Yates J.R. III,Wright P.E., Han J.;
Cell 128:295-308(2007).
Cited for: PHOSPHORYLATION AT SER-37, AND MUTAGENESIS OF SER-37.
PubMed: 17254968

"Protein kinase C delta regulates Ser46 phosphorylation of p53 tumorsuppressor in the apoptotic response to DNA damage.";
Yoshida K., Liu H., Miki Y.;
J. Biol. Chem. 281:5734-5740(2006).
Cited for: PHOSPHORYLATION AT SER-46, AND INTERACTION WITH PRKCG.
PubMed: 16377624

"LKB1 is recruited to the p21/WAF1 promoter by p53 to mediatetranscriptional activation.";
Zeng P.Y., Berger S.L.;
Cancer Res. 66:10701-10708(2006).
Cited for: INTERACTION WITH STK11/LKB1, AND PHOSPHORYLATION AT SER-15 ANDSER-392.
PubMed: 17108107

"AMP-activated protein kinase induces a p53-dependent metaboliccheckpoint.";
Jones R.G., Plas D.R., Kubek S., Buzzai M., Mu J., Xu Y.,Birnbaum M.J., Thompson C.B.;
Mol. Cell 18:283-293(2005).
Cited for: PHOSPHORYLATION AT SER-15.
PubMed: 15866171

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392, AND MASSSPECTROMETRY.
PubMed: 16083285

"Tumor suppressor SMAR1 activates and stabilizes p53 through itsarginine-serine-rich motif.";
Jalota-Badhwar A., Singh K., Pavithra L., Kaul-Ghanekar R., Jameel S.,Chattopadhyay S.;
J. Biol. Chem. 280:16019-16029(2005).
Cited for: INTERACTION WITH BANP, SUBCELLULAR LOCATION, AND PHOSPHORYLATION ATSER-15.
PubMed: 15701641

"Phosphorylation by aurora kinase A induces Mdm2-mediateddestabilization and inhibition of p53.";
Katayama H., Sasai K., Kawai H., Yuan Z.M., Bondaruk J., Suzuki F.,Fujii S., Arlinghaus R.B., Czerniak B.A., Sen S.;
Nat. Genet. 36:55-62(2004).
Cited for: INTERACTION WITH AURKA, AND PHOSPHORYLATION AT SER-315.
PubMed: 14702041

"The promyelocytic leukemia protein protects p53 from Mdm2-mediatedinhibition and degradation.";
Louria-Hayon I., Grossman T., Sionov R.V., Alsheich O., Pandolfi P.P.,Haupt Y.;
J. Biol. Chem. 278:33134-33141(2003).
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CHEK2 AND PML,UBIQUITINATION BY MDM2, AND PHOSPHORYLATION AT SER-20.
PubMed: 12810724

"Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46and mediates apoptosis.";
D'Orazi G., Cecchinelli B., Bruno T., Manni I., Higashimoto Y.,Saito S., Gostissa M., Coen S., Marchetti A., Del Sal G., Piaggio G.,Fanciulli M., Appella E., Soddu S.;
Nat. Cell Biol. 4:11-19(2002).
Cited for: INTERACTION WITH HIPK2, AND PHOSPHORYLATION AT SER-46.
PubMed: 11780126

"Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.";
Hofmann T.G., Moeller A., Sirma H., Zentgraf H., Taya Y., Droege W.,Will H., Schmitz M.L.;
Nat. Cell Biol. 4:1-10(2002).
Cited for: INTERACTION WITH HIPK2, PHOSPHORYLATION AT SER-46, AND MUTAGENESIS OFSER-46 AND LYS-382.
PubMed: 11740489

"A DNA damage-induced p53 serine 392 kinase complex contains CK2,hSpt16, and SSRP1.";
Keller D.M., Zeng X., Wang Y., Zhang Q.H., Kapoor M., Shu H.,Goodman R., Lozano G., Zhao Y., Lu H.;
Mol. Cell 7:283-292(2001).
Cited for: PHOSPHORYLATION AT SER-392.
PubMed: 11239457

"Plk3 functionally links DNA damage to cell cycle arrest and apoptosisat least in part via the p53 pathway.";
Xie S., Wu H., Wang Q., Cogswell J.P., Husain I., Conn C.,Stambrook P., Jhanwar-Uniyal M., Dai W.;
J. Biol. Chem. 276:43305-43312(2001).
Cited for: PHOSPHORYLATION AT SER-20 BY PLK3.
PubMed: 11551930

"Reactive oxygen species-induced phosphorylation of p53 on serine 20is mediated in part by polo-like kinase-3.";
Xie S., Wang Q., Wu H., Cogswell J., Lu L., Jhanwar-Uniyal M., Dai W.;
J. Biol. Chem. 276:36194-36199(2001).
Cited for: PHOSPHORYLATION AT SER-20 BY PLK3.
PubMed: 11447225

"Cell cycle regulation via p53 phosphorylation by a 5'-AMP activatedprotein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.";
Imamura K., Ogura T., Kishimoto A., Kaminishi M., Esumi H.;
Biochem. Biophys. Res. Commun. 287:562-567(2001).
Cited for: PHOSPHORYLATION AT SER-15.
PubMed: 11554766

"The C-terminal regulatory domain of p53 contains a functional dockingsite for cyclin A.";
Luciani M.G., Hutchins J.R.A., Zheleva D., Hupp T.R.;
J. Mol. Biol. 300:503-518(2000).
Cited for: PHOSPHORYLATION AT SER-315 AND SER-392 BY CDK2, AND MUTAGENESIS OFLYS-382; LEU-383 AND PHE-385.
PubMed: 10884347

"Phosphorylation of Ser-20 mediates stabilization of human p53 inresponse to DNA damage.";
Chehab N.H., Malikzay A., Stavridi E.S., Halazonetis T.D.;
Proc. Natl. Acad. Sci. U.S.A. 96:13777-13782(1999).
Cited for: PHOSPHORYLATION AT SER-15 AND SER-20, INDUCTION BY DNA DAMAGE,CHARACTERIZATION OF LFS VARIANT HIS-273, MUTAGENESIS OF THR-18; SER-20AND 22-LEU-TRP-23, SUBCELLULAR LOCATION, AND INTERACTION WITH PML ANDMDM2.
PubMed: 10570149

"p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependentmanner.";
Ko L.J., Shieh S.-Y., Chen X., Jayaraman L., Tamai K., Taya Y.,Prives C., Pan Z.-Q.;
Mol. Cell. Biol. 17:7220-7229(1997).
Cited for: PHOSPHORYLATION AT SER-33.
PubMed: 9372954

"G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibitsDNA damage-induced apoptosis.";
Chen X., Zhu H., Yuan M., Fu J., Zhou Y., Ma L.;
J. Biol. Chem. 285:12823-12830(2010).
Cited for: PHOSPHORYLATION AT THR-55, AND INTERACTION WITH GRK5.
PubMed: 20124405

"The subcellular localization of vaccinia-related kinase-2 (VRK2)isoforms determines their different effect on p53 stability in tumourcell lines.";
Blanco S., Klimcakova L., Vega F.M., Lazo P.A.;
FEBS J. 273:2487-2504(2006).
Cited for: PHOSPHORYLATION AT THR-18.
PubMed: 16704422

"Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a rolefor TAF1 in cell G1 progression.";
Li H.-H., Li A.G., Sheppard H.M., Liu X.;
Mol. Cell 13:867-878(2004).
Cited for: PHOSPHORYLATION AT THR-55, MUTAGENESIS OF THR-55, AND INTERACTION WITHTAF1.
PubMed: 15053879

"The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressorprotein.";
Lopez-Borges S., Lazo P.A.;
Oncogene 19:3656-3664(2000).
Cited for: PHOSPHORYLATION AT THR-18.
PubMed: 10951572

"Protein kinase CK1 is a p53-threonine 18 kinase which requires priorphosphorylation of serine 15.";
Dumaz N., Milne D.M., Meek D.W.;
FEBS Lett. 463:312-316(1999).
Cited for: PHOSPHORYLATION AT THR-18 BY CSNK1D/CK1.
PubMed: 10606744

Sumoylation

"SUMO-1 conjugation in vivo requires both a consensus modificationmotif and nuclear targeting.";
Rodriguez M.S., Dargemont C., Hay R.T.;
J. Biol. Chem. 276:12654-12659(2001).
Cited for: SUMOYLATION AT LYS-386, SUBCELLULAR LOCATION, AND MUTAGENESIS OFPHE-385; LYS-386; THR-387 AND GLU-388.
PubMed: 11124955

Ubiquitylation

"Differential regulation of p53 and p21 by MKRN1 E3 ligase controlscell cycle arrest and apoptosis.";
Lee E.-W., Lee M.-S., Camus S., Ghim J., Yang M.-R., Oh W., Ha N.-C.,Lane D.P., Song J.;
EMBO J. 28:2100-2113(2009).
Cited for: INTERACTION WITH MKRN1, MUTAGENESIS OF 291-LYS-LYS-292, ANDUBIQUITINATION AT LYS-291 AND LYS-292 BY MKRN1.
PubMed: 19536131