dbPTM

RFA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFA2_HUMAN
UniProt AC	P15927
Protein Name	Replication protein A 32 kDa subunit
Gene Name	RPA2
Organism	Homo sapiens (Human).
Sequence Length	270
Subcellular Localization	Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Protein Description	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance..
Protein Sequence	MWNSGFESYGSSSYGGAGGYTQSPGGFGSPAPSQAEKKSRARAQHIVPCTISQLLSATLVDEVFRIGNVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMDVRQWVDTDDTSSENTVVPPETYVKVAGHLRSFQNKKSLVAFKIMPLEDMNEFTTHILEVINAHMVLSKANSQPSAGRAPISNPGMSEAGNFGGNSFMPANGLTVAQNQVLNLIKACPRPEGLNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKSTDAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MWNSGFES -------CCCCCCCC	7.44	9139719
4	Phosphorylation	----MWNSGFESYGS ----CCCCCCCCCCC	29.37	21731742
8	Phosphorylation	MWNSGFESYGSSSYG CCCCCCCCCCCCCCC	32.31	21731742
9	Phosphorylation	WNSGFESYGSSSYGG CCCCCCCCCCCCCCC	17.52	30206219
11	Phosphorylation	SGFESYGSSSYGGAG CCCCCCCCCCCCCCC	14.10	9295339
12	Phosphorylation	GFESYGSSSYGGAGG CCCCCCCCCCCCCCC	24.18	9295339
13	Phosphorylation	FESYGSSSYGGAGGY CCCCCCCCCCCCCCC	29.51	9295339
14	Phosphorylation	ESYGSSSYGGAGGYT CCCCCCCCCCCCCCC	22.87	30206219
20	Phosphorylation	SYGGAGGYTQSPGGF CCCCCCCCCCCCCCC	10.73	28450419
21	Phosphorylation	YGGAGGYTQSPGGFG CCCCCCCCCCCCCCC	26.33	19704001
23	Phosphorylation	GAGGYTQSPGGFGSP CCCCCCCCCCCCCCC	20.08	25159151
29	Phosphorylation	QSPGGFGSPAPSQAE CCCCCCCCCCCCHHH	18.67	19671522
33	Phosphorylation	GFGSPAPSQAEKKSR CCCCCCCCHHHHHHH	44.09	21731742
37	Ubiquitination	PAPSQAEKKSRARAQ CCCCHHHHHHHHHHH	60.09	PubMed
38	Ubiquitination	APSQAEKKSRARAQH CCCHHHHHHHHHHHH	36.36	26474068
39	Phosphorylation	PSQAEKKSRARAQHI CCHHHHHHHHHHHHC	42.09	18669648
52	Phosphorylation	HIVPCTISQLLSATL HCCHHHHHHHHHHHH	9.16	17035231
72	Phosphorylation	RIGNVEISQVTIVGI CCCCEEEEEEEEEEE	12.70	17035231
75	Phosphorylation	NVEISQVTIVGIIRH CEEEEEEEEEEEEEC	11.43	20068231
85	Ubiquitination	GIIRHAEKAPTNIVY EEEECCHHCCCCEEE	61.52	-
88	Phosphorylation	RHAEKAPTNIVYKID ECCHHCCCCEEEEEC	42.30	21406692
92	Phosphorylation	KAPTNIVYKIDDMTA HCCCCEEEEECCCCC	9.83	21406692
93	Ubiquitination	APTNIVYKIDDMTAA CCCCEEEEECCCCCC	28.85	21906983
93 (in isoform 1)	Ubiquitination	-	28.85	21890473
93	Acetylation	APTNIVYKIDDMTAA CCCCEEEEECCCCCC	28.85	25953088
97	Sulfoxidation	IVYKIDDMTAAPMDV EEEEECCCCCCCCCH	2.14	21406390
101 (in isoform 2)	Ubiquitination	-	19.62	21890473
101 (in isoform 3)	Phosphorylation	-	19.62	22210691
105	Methylation	TAAPMDVRQWVDTDD CCCCCCHHHHCCCCC	22.00	115491159
109 (in isoform 3)	Phosphorylation	-	41.27	22210691
110	Phosphorylation	DVRQWVDTDDTSSEN CHHHHCCCCCCCCCC	26.59	20873877
113	Phosphorylation	QWVDTDDTSSENTVV HHCCCCCCCCCCCCC	36.64	20873877
114	Phosphorylation	WVDTDDTSSENTVVP HCCCCCCCCCCCCCC	42.52	27251275
115	Phosphorylation	VDTDDTSSENTVVPP CCCCCCCCCCCCCCC	36.64	20873877
118	Phosphorylation	DDTSSENTVVPPETY CCCCCCCCCCCCHHH	20.87	27251275
124	Phosphorylation	NTVVPPETYVKVAGH CCCCCCHHHHHHHHC	39.11	20873877
125	Phosphorylation	TVVPPETYVKVAGHL CCCCCHHHHHHHHCH	9.16	20873877
127 (in isoform 1)	Ubiquitination	-	18.89	21890473
127	Ubiquitination	VPPETYVKVAGHLRS CCCHHHHHHHHCHHH	18.89	21890473
133	Methylation	VKVAGHLRSFQNKKS HHHHHCHHHHCCCCC	29.74	115491165
135 (in isoform 2)	Ubiquitination	-	8.19	21890473
139	Acetylation	LRSFQNKKSLVAFKI HHHHCCCCCEEEEEE	57.48	26051181
139	Ubiquitination	LRSFQNKKSLVAFKI HHHHCCCCCEEEEEE	57.48	-
139	2-Hydroxyisobutyrylation	LRSFQNKKSLVAFKI HHHHCCCCCEEEEEE	57.48	-
171	Ubiquitination	NAHMVLSKANSQPSA HHHHHHHCCCCCCCC	47.64	2190698
173 (in isoform 3)	Ubiquitination	-	44.93	-
174	Phosphorylation	MVLSKANSQPSAGRA HHHHCCCCCCCCCCC	48.61	25849741
181 (in isoform 3)	Ubiquitination	-	12.59	21890473
198	Phosphorylation	AGNFGGNSFMPANGL CCCCCCCCCCCCCCC	26.62	24532841
215 (in isoform 3)	Ubiquitination	-	3.57	21890473
231	Ubiquitination	GLNFQDLKNQLKHMS CCCHHHHHHHHHHCC	51.44	-
231	Acetylation	GLNFQDLKNQLKHMS CCCHHHHHHHHHHCC	51.44	23749302
235	Ubiquitination	QDLKNQLKHMSVSSI HHHHHHHHHCCHHHH	27.74	-
238	Phosphorylation	KNQLKHMSVSSIKQA HHHHHHCCHHHHHHH	20.68	25159151
240	Phosphorylation	QLKHMSVSSIKQAVD HHHHCCHHHHHHHHH	21.02	25159151
241	Phosphorylation	LKHMSVSSIKQAVDF HHHCCHHHHHHHHHH	31.48	25159151
243	Ubiquitination	HMSVSSIKQAVDFLS HCCHHHHHHHHHHHH	33.87	-
323 (in isoform 3)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	S	Phosphorylation	Kinase	DNAPK	P78527	PSP
8	S	Phosphorylation	Kinase	DNAPK	P78527	PSP
21	T	Phosphorylation	Kinase	ATM	Q13315	PSP
21	T	Phosphorylation	Kinase	DNAPK	P78527	PSP
21	T	Phosphorylation	Kinase	ATR	Q13535	PSP
23	S	Phosphorylation	Kinase	ATM	Q13315	PSP
23	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
23	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
23	S	Phosphorylation	Kinase	CDK2	P24941	Uniprot
23	S	Phosphorylation	Kinase	CDK1	P06493	PSP
29	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
29	S	Phosphorylation	Kinase	CDK2	P24941	PSP
29	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
29	S	Phosphorylation	Kinase	ATM	Q13315	PSP
29	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
33	S	Phosphorylation	Kinase	CDK1	P06493	PSP
33	S	Phosphorylation	Kinase	CDK2	P24941	PSP
33	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
33	S	Phosphorylation	Kinase	ATR	Q13535	PSP
33	S	Phosphorylation	Kinase	DNAPK	P78527	PSP
52	S	Phosphorylation	Kinase	ATR	Q13535	PSP
72	S	Phosphorylation	Kinase	ATR	Q13535	PSP
174	S	Phosphorylation	Kinase	ATR	Q13535	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	PRPF19	Q9UMS4	PMID:24332808

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
4	S	Phosphorylation	21731742
Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage.
8	S	Phosphorylation	20154705
Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage.
21	T	Phosphorylation	9139719
Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage.
21	T	Phosphorylation	9139719
Phosphorylation at Thr-21 depends upon RFWD3 presence.
23	S	Phosphorylation	1318195
Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis.
23	S	Phosphorylation	1318195
Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation.
29	S	Phosphorylation	1318195
Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis.
29	S	Phosphorylation	1318195
Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation.
33	S	Phosphorylation	9139719
Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	10875894
MCM2_HUMAN	MCM2	physical	12614612
ORC2_HUMAN	ORC2	physical	12614612
ORC1_HUMAN	ORC1	physical	12614612
ORC4_HUMAN	ORC4	physical	12614612
ORC5_HUMAN	ORC5	physical	12614612
MCM3_HUMAN	MCM3	physical	12614612
MCM4_HUMAN	MCM4	physical	12614612
MCM5_HUMAN	MCM5	physical	12614612
PPA5_HUMAN	ACP5	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
RLA1_HUMAN	RPLP1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
MED31_HUMAN	MED31	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
G3P_HUMAN	GAPDH	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
TBB2A_HUMAN	TUBB2A	physical	16169070
PRKDC_HUMAN	PRKDC	physical	10064605
XRCC6_HUMAN	XRCC6	physical	10064605
UNG_HUMAN	UNG	physical	9045683
SRTD3_HUMAN	SERTAD3	physical	10982866
RAD52_HUMAN	RAD52	physical	12139939
RFA3_HUMAN	RPA3	physical	11927569
MEN1_HUMAN	MEN1	physical	12509449
PRI1_HUMAN	PRIM1	physical	17035231
A4_HUMAN	APP	physical	21832049
RFA3_HUMAN	RPA3	physical	22939629
UBXN1_HUMAN	UBXN1	physical	22939629
VATA_HUMAN	ATP6V1A	physical	22939629
RFA3_HUMAN	RPA3	physical	19338310
CAB45_HUMAN	SDF4	physical	21988832
S17A9_HUMAN	SLC17A9	physical	21988832
MARCS_HUMAN	MARCKS	physical	22863883
PFD2_HUMAN	PFDN2	physical	22863883
KAPCA_HUMAN	PRKACA	physical	22863883
RFA1_HUMAN	RPA1	physical	22863883
SHLB1_HUMAN	SH3GLB1	physical	22863883
TPD54_HUMAN	TPD52L2	physical	22863883
TPRKB_HUMAN	TPRKB	physical	22863883
UBQL2_HUMAN	UBQLN2	physical	22863883
PARP1_HUMAN	PARP1	physical	24332808
HNRPM_HUMAN	HNRNPM	physical	24332808
SMAL1_HUMAN	SMARCAL1	physical	24332808
MYH9_HUMAN	MYH9	physical	24332808
PAR14_HUMAN	PARP14	physical	24332808
DNLI3_HUMAN	LIG3	physical	24332808
TOP3A_HUMAN	TOP3A	physical	24332808
ATR_HUMAN	ATR	physical	24332808
FBH1_HUMAN	FBXO18	physical	24332808
DHX36_HUMAN	DHX36	physical	24332808
PRKDC_HUMAN	PRKDC	physical	24332808
DNA2_HUMAN	DNA2	physical	24332808
XRCC1_HUMAN	XRCC1	physical	24332808
HNRL1_HUMAN	HNRNPUL1	physical	24332808
HLTF_HUMAN	HLTF	physical	24332808
XRN2_HUMAN	XRN2	physical	24332808
HNRPD_HUMAN	HNRNPD	physical	24332808
XRCC6_HUMAN	XRCC6	physical	24332808
GTF2I_HUMAN	GTF2I	physical	24332808
MYH10_HUMAN	MYH10	physical	24332808
IQGA1_HUMAN	IQGAP1	physical	24332808
CARF_HUMAN	CDKN2AIP	physical	24332808
SFPQ_HUMAN	SFPQ	physical	24332808
RMI1_HUMAN	RMI1	physical	24332808
MSI2H_HUMAN	MSI2	physical	24332808
RTEL1_HUMAN	RTEL1	physical	24332808
XRCC5_HUMAN	XRCC5	physical	24332808
TIAR_HUMAN	TIAL1	physical	24332808
WRN_HUMAN	WRN	physical	24332808
FUS_HUMAN	FUS	physical	24332808
3MG_HUMAN	MPG	physical	24332808
TADBP_HUMAN	TARDBP	physical	24332808
ROA0_HUMAN	HNRNPA0	physical	24332808
UNG_HUMAN	UNG	physical	24332808
PARP9_HUMAN	PARP9	physical	24332808
ROA2_HUMAN	HNRNPA2B1	physical	24332808
PURB_HUMAN	PURB	physical	24332808
G3P_HUMAN	GAPDH	physical	24332808
PNKP_HUMAN	PNKP	physical	24332808
MSH2_HUMAN	MSH2	physical	24332808
RFC5_HUMAN	RFC5	physical	24332808
RBM4_HUMAN	RBM4	physical	24332808
NPM_HUMAN	NPM1	physical	24332808
RFOX2_HUMAN	RBFOX2	physical	24332808
MSH3_HUMAN	MSH3	physical	24332808
FLNA_HUMAN	FLNA	physical	24332808
IF2A_HUMAN	EIF2S1	physical	24332808
ACTB_HUMAN	ACTB	physical	24332808
ROA1_HUMAN	HNRNPA1	physical	24332808
CPSF5_HUMAN	NUDT21	physical	24332808
ROAA_HUMAN	HNRNPAB	physical	24332808
KCAB2_HUMAN	KCNAB2	physical	24332808
YTHD1_HUMAN	YTHDF1	physical	24332808
XRN1_HUMAN	XRN1	physical	24332808
YTHD3_HUMAN	YTHDF3	physical	24332808
U520_HUMAN	SNRNP200	physical	24332808
NONO_HUMAN	NONO	physical	24332808
INT6_HUMAN	INTS6	physical	24332808
CN166_HUMAN	C14orf166	physical	24332808
ELAV1_HUMAN	ELAVL1	physical	24332808
KC1A_HUMAN	CSNK1A1	physical	24332808
CUL1_HUMAN	CUL1	physical	24332808
RBM14_HUMAN	RBM14	physical	24332808
DTX3L_HUMAN	DTX3L	physical	24332808
FUBP3_HUMAN	FUBP3	physical	24332808
RFC4_HUMAN	RFC4	physical	24332808
HNRPU_HUMAN	HNRNPU	physical	24332808
RLA0_HUMAN	RPLP0	physical	24332808
RAVR1_HUMAN	RAVER1	physical	24332808
ACTA_HUMAN	ACTA2	physical	24332808
PTBP1_HUMAN	PTBP1	physical	24332808
EWS_HUMAN	EWSR1	physical	24332808
PRDX1_HUMAN	PRDX1	physical	24332808
IMDH2_HUMAN	IMPDH2	physical	24332808
PAR12_HUMAN	PARP12	physical	24332808
RNH1_HUMAN	RNASEH1	physical	24332808
SLN11_HUMAN	SLFN11	physical	24332808
BLM_HUMAN	BLM	physical	24332808
RB11B_HUMAN	RAB11B	physical	24332808
RL7_HUMAN	RPL7	physical	24332808
EF1A2_HUMAN	EEF1A2	physical	24332808
RAB13_HUMAN	RAB13	physical	24332808
SPB12_HUMAN	SERPINB12	physical	24332808
ANXA2_HUMAN	ANXA2	physical	24332808
NTH_HUMAN	NTHL1	physical	24332808
RBP56_HUMAN	TAF15	physical	24332808
NTPCR_HUMAN	NTPCR	physical	24332808
DAZP1_HUMAN	DAZAP1	physical	24332808
EF1A1_HUMAN	EEF1A1	physical	24332808
YTHD2_HUMAN	YTHDF2	physical	24332808
CELF1_HUMAN	CELF1	physical	24332808
ESRP2_HUMAN	ESRP2	physical	24332808
HNRDL_HUMAN	HNRNPDL	physical	24332808
MATR3_HUMAN	MATR3	physical	24332808
SF3B1_HUMAN	SF3B1	physical	24332808
TBB4B_HUMAN	TUBB4B	physical	24332808
DHX15_HUMAN	DHX15	physical	24332808
TBA4A_HUMAN	TUBA4A	physical	24332808
ATRIP_HUMAN	ATRIP	physical	24332808
ACTBL_HUMAN	ACTBL2	physical	24332808
ROA3_HUMAN	HNRNPA3	physical	24332808
KHDR1_HUMAN	KHDRBS1	physical	24332808
RAB5C_HUMAN	RAB5C	physical	24332808
RFWD3_HUMAN	RFWD3	physical	24332808
HSPB1_HUMAN	HSPB1	physical	24332808
RSMB_HUMAN	SNRPB	physical	24332808
TBA1C_HUMAN	TUBA1C	physical	24332808
APEX1_HUMAN	APEX1	physical	24332808
MYH11_HUMAN	MYH11	physical	24332808
DDX5_HUMAN	DDX5	physical	24332808
PRP6_HUMAN	PRPF6	physical	24332808
DDX17_HUMAN	DDX17	physical	24332808
RS9_HUMAN	RPS9	physical	24332808
RAB7A_HUMAN	RAB7A	physical	24332808
SC22B_HUMAN	SEC22B	physical	24332808
RAB1A_HUMAN	RAB1A	physical	24332808
TBB5_HUMAN	TUBB	physical	24332808
RS7_HUMAN	RPS7	physical	24332808
CAZA1_HUMAN	CAPZA1	physical	24332808
NEP1_HUMAN	EMG1	physical	24332808
RAB8A_HUMAN	RAB8A	physical	24332808
RAI14_HUMAN	RAI14	physical	24332808
HNRPK_HUMAN	HNRNPK	physical	24332808
PDS5A_HUMAN	PDS5A	physical	24332808
LMO7_HUMAN	LMO7	physical	24332808
RBM27_HUMAN	RBM27	physical	24332808
SF3B2_HUMAN	SF3B2	physical	24332808
NUCL_HUMAN	NCL	physical	24332808
RL13A_HUMAN	RPL13A	physical	24332808
RS5_HUMAN	RPS5	physical	24332808
LDHA_HUMAN	LDHA	physical	24332808
PP1G_HUMAN	PPP1CC	physical	24332808
RFC2_HUMAN	RFC2	physical	24332808
U5S1_HUMAN	EFTUD2	physical	24332808
SF3A1_HUMAN	SF3A1	physical	24332808
MPRIP_HUMAN	MPRIP	physical	24332808
CTF18_HUMAN	CHTF18	physical	24332808
RBM25_HUMAN	RBM25	physical	24332808
ILF3_HUMAN	ILF3	physical	24332808
SF3B3_HUMAN	SF3B3	physical	24332808
RBM26_HUMAN	RBM26	physical	24332808
SPTN1_HUMAN	SPTAN1	physical	24332808
BAP31_HUMAN	BCAP31	physical	24332808
MAT1_HUMAN	MNAT1	physical	24332808
DDX3X_HUMAN	DDX3X	physical	24332808
SPF27_HUMAN	BCAS2	physical	24332808
MDC1_HUMAN	MDC1	physical	24332808
RAB35_HUMAN	RAB35	physical	24332808
RBM39_HUMAN	RBM39	physical	24332808
RL19_HUMAN	RPL19	physical	24332808
RL9_HUMAN	RPL9	physical	24332808
BUB3_HUMAN	BUB3	physical	24332808
RS8_HUMAN	RPS8	physical	24332808
KC1AL_HUMAN	CSNK1A1L	physical	24332808
RAB10_HUMAN	RAB10	physical	24332808
TMM33_HUMAN	TMEM33	physical	24332808
MYO1C_HUMAN	MYO1C	physical	24332808
DESP_HUMAN	DSP	physical	24332808
PRP8_HUMAN	PRPF8	physical	24332808
TOP2B_HUMAN	TOP2B	physical	24332808
PABP1_HUMAN	PABPC1	physical	24332808
TCOF_HUMAN	TCOF1	physical	24332808
TFR1_HUMAN	TFRC	physical	24332808
MYO1E_HUMAN	MYO1E	physical	24332808
RBM15_HUMAN	RBM15	physical	24332808
PR40A_HUMAN	PRPF40A	physical	24332808
SK2L2_HUMAN	SKIV2L2	physical	24332808
MYOF_HUMAN	MYOF	physical	24332808
PP1RA_HUMAN	PPP1R10	physical	24332808
SMC3_HUMAN	SMC3	physical	24332808
INT3_HUMAN	INTS3	physical	24332808
THOC2_HUMAN	THOC2	physical	24332808
RAD50_HUMAN	RAD50	physical	24332808
SYMPK_HUMAN	SYMPK	physical	24332808
CLH1_HUMAN	CLTC	physical	24332808
WASC5_HUMAN	KIAA0196	physical	24332808
TIF1B_HUMAN	TRIM28	physical	24332808
ARHG2_HUMAN	ARHGEF2	physical	24332808
HNRPR_HUMAN	HNRNPR	physical	24332808
LIMC1_HUMAN	LIMCH1	physical	24332808
PPB1_HUMAN	ALPP	physical	24332808
CDC5L_HUMAN	CDC5L	physical	24332808
CKAP5_HUMAN	CKAP5	physical	24332808
RL6_HUMAN	RPL6	physical	24332808
SMC1A_HUMAN	SMC1A	physical	24332808
SMC2_HUMAN	SMC2	physical	24332808
HSP7C_HUMAN	HSPA8	physical	24332808
CCAR2_HUMAN	CCAR2	physical	24332808
LIMA1_HUMAN	LIMA1	physical	24332808
LMAN2_HUMAN	LMAN2	physical	24332808
MYO1B_HUMAN	MYO1B	physical	24332808
WDR82_HUMAN	WDR82	physical	24332808
DSRAD_HUMAN	ADAR	physical	24332808
FKB15_HUMAN	FKBP15	physical	24332808
HNRPL_HUMAN	HNRNPL	physical	24332808
ILF2_HUMAN	ILF2	physical	24332808
MOV10_HUMAN	MOV10	physical	24332808
RFC1_HUMAN	RFC1	physical	24332808
SPTB2_HUMAN	SPTBN1	physical	24332808
THOC6_HUMAN	THOC6	physical	24332808
AHNK_HUMAN	AHNAK	physical	24332808
PRC2A_HUMAN	PRRC2A	physical	24332808
CHD4_HUMAN	CHD4	physical	24332808
DHX9_HUMAN	DHX9	physical	24332808
GRP78_HUMAN	HSPA5	physical	24332808
KDM1A_HUMAN	KDM1A	physical	24332808
MRE11_HUMAN	MRE11A	physical	24332808
C1TC_HUMAN	MTHFD1	physical	24332808
SNAA_HUMAN	NAPA	physical	24332808
RPR1B_HUMAN	RPRD1B	physical	24332808
HNRPQ_HUMAN	SYNCRIP	physical	24332808
TOP2A_HUMAN	TOP2A	physical	24332808
DDX23_HUMAN	DDX23	physical	24332808
TDIF1_HUMAN	DNTTIP1	physical	24332808
SCAM3_HUMAN	SCAMP3	physical	24332808
SR140_HUMAN	U2SURP	physical	24332808
TSR1_HUMAN	TSR1	physical	24332808
WDR3_HUMAN	WDR3	physical	24332808
ADDA_HUMAN	ADD1	physical	24332808
CAPR1_HUMAN	CAPRIN1	physical	24332808
CCNH_HUMAN	CCNH	physical	24332808
CPSF7_HUMAN	CPSF7	physical	24332808
EXOSX_HUMAN	EXOSC10	physical	24332808
TF2H3_HUMAN	GTF2H3	physical	24332808
MAP4_HUMAN	MAP4	physical	24332808
NBN_HUMAN	NBN	physical	24332808
DPOLA_HUMAN	POLA1	physical	24332808
PSIP1_HUMAN	PSIP1	physical	24332808
RAB2A_HUMAN	RAB2A	physical	24332808
RFC3_HUMAN	RFC3	physical	24332808
RL18A_HUMAN	RPL18A	physical	24332808
SNR40_HUMAN	SNRNP40	physical	24332808
SRBD1_HUMAN	SRBD1	physical	24332808
TAGL2_HUMAN	TAGLN2	physical	24332808
LAP2A_HUMAN	TMPO	physical	24332808
LAP2B_HUMAN	TMPO	physical	24332808
TPX2_HUMAN	TPX2	physical	24332808
AP1B1_HUMAN	AP1B1	physical	24332808
BAG2_HUMAN	BAG2	physical	24332808
BBX_HUMAN	BBX	physical	24332808
EMSA1_HUMAN	ELMSAN1	physical	24332808
CALD1_HUMAN	CALD1	physical	24332808
CALX_HUMAN	CANX	physical	24332808
CDK7_HUMAN	CDK7	physical	24332808
COPA_HUMAN	COPA	physical	24332808
CSK22_HUMAN	CSNK2A2	physical	24332808
DDX46_HUMAN	DDX46	physical	24332808
EGFR_HUMAN	EGFR	physical	24332808
ERGI1_HUMAN	ERGIC1	physical	24332808
GEMI5_HUMAN	GEMIN5	physical	24332808
TF3C2_HUMAN	GTF3C2	physical	24332808
PKP3_HUMAN	PKP3	physical	24332808
RPA2_HUMAN	POLR1B	physical	24332808
RPAB1_HUMAN	POLR2E	physical	24332808
RALY_HUMAN	RALY	physical	24332808
SMC4_HUMAN	SMC4	physical	24332808
STRBP_HUMAN	STRBP	physical	24332808
THOC7_HUMAN	THOC7	physical	24332808
TRIPC_HUMAN	TRIP12	physical	24332808
WDR33_HUMAN	WDR33	physical	24332808
VA0D1_HUMAN	ATP6V0D1	physical	24332808
CG050_HUMAN	C7orf50	physical	24332808
CAV1_HUMAN	CAV1	physical	24332808
EPN4_HUMAN	CLINT1	physical	24332808
COBL_HUMAN	COBL	physical	24332808
CPSF1_HUMAN	CPSF1	physical	24332808
SRC8_HUMAN	CTTN	physical	24332808
DDB1_HUMAN	DDB1	physical	24332808
DDX1_HUMAN	DDX1	physical	24332808
DIDO1_HUMAN	DIDO1	physical	24332808
DNJC9_HUMAN	DNAJC9	physical	24332808
EDC4_HUMAN	EDC4	physical	24332808
IF2B_HUMAN	EIF2S2	physical	24332808
ESYT1_HUMAN	ESYT1	physical	24332808
HCFC1_HUMAN	HCFC1	physical	24332808
INT1_HUMAN	INTS1	physical	24332808
MO4L2_HUMAN	MORF4L2	physical	24332808
PCF11_HUMAN	PCF11	physical	24332808
PP2AA_HUMAN	PPP2CA	physical	24332808
RAB14_HUMAN	RAB14	physical	24332808
RAB6B_HUMAN	RAB6B	physical	24332808
RL15_HUMAN	RPL15	physical	24332808
SMCA5_HUMAN	SMARCA5	physical	24332808
THOC1_HUMAN	THOC1	physical	24332808
TPM2_HUMAN	TPM2	physical	24332808
UBC_HUMAN	UBC	physical	24332808
ZN638_HUMAN	ZNF638	physical	24332808
AKAP8_HUMAN	AKAP8	physical	24332808
AP2A1_HUMAN	AP2A1	physical	24332808
AP2A2_HUMAN	AP2A2	physical	24332808
AP2B1_HUMAN	AP2B1	physical	24332808
ARGI1_HUMAN	ARG1	physical	24332808
CHERP_HUMAN	CHERP	physical	24332808
SYEP_HUMAN	EPRS	physical	24332808
EXOS7_HUMAN	EXOSC7	physical	24332808
EXOS8_HUMAN	EXOSC8	physical	24332808
FBRL_HUMAN	FBL	physical	24332808
GEMI4_HUMAN	GEMIN4	physical	24332808
HNRC1_HUMAN	HNRNPCL1	physical	24332808
HNRPF_HUMAN	HNRNPF	physical	24332808
HNRH1_HUMAN	HNRNPH1	physical	24332808
ITB1_HUMAN	ITGB1	physical	24332808
WASC4_HUMAN	KIAA1033	physical	24332808
MED4_HUMAN	MED4	physical	24332808
MYO1F_HUMAN	MYO1F	physical	24332808
NIPBL_HUMAN	NIPBL	physical	24332808
NUMA1_HUMAN	NUMA1	physical	24332808
PABP4_HUMAN	PABPC4	physical	24332808
PELP1_HUMAN	PELP1	physical	24332808
PGRC1_HUMAN	PGRMC1	physical	24332808
MYPT1_HUMAN	PPP1R12A	physical	24332808
PRP19_HUMAN	PRPF19	physical	24332808
RAB6A_HUMAN	RAB6A	physical	24332808
RAD21_HUMAN	RAD21	physical	24332808
RBM10_HUMAN	RBM10	physical	24332808
RL10L_HUMAN	RPL10L	physical	24332808
RL18_HUMAN	RPL18	physical	24332808
RPRD2_HUMAN	RPRD2	physical	24332808
RS3A_HUMAN	RPS3A	physical	24332808
RTN4_HUMAN	RTN4	physical	24332808
RUVB2_HUMAN	RUVBL2	physical	24332808
SEH1_HUMAN	SEH1L	physical	24332808
SFR15_HUMAN	SCAF4	physical	24332808
SMRC2_HUMAN	SMARCC2	physical	24332808
TCRG1_HUMAN	TCERG1	physical	24332808
TERF2_HUMAN	TERF2	physical	24332808
TEX10_HUMAN	TEX10	physical	24332808
UBP7_HUMAN	USP7	physical	24332808
WAPL_HUMAN	WAPAL	physical	24332808
WDHD1_HUMAN	WDHD1	physical	24332808
ZCHC8_HUMAN	ZCCHC8	physical	24332808
ZFR_HUMAN	ZFR	physical	24332808
ZN598_HUMAN	ZNF598	physical	24332808
RFA3_HUMAN	RPA3	physical	26186194
RFA1_HUMAN	RPA1	physical	26186194
XPC_HUMAN	XPC	physical	26186194
SP16H_HUMAN	SUPT16H	physical	26186194
DNLI3_HUMAN	LIG3	physical	26186194
PARP2_HUMAN	PARP2	physical	26186194
PARP1_HUMAN	PARP1	physical	26186194
HLTF_HUMAN	HLTF	physical	26186194
SSRP1_HUMAN	SSRP1	physical	26186194
CETN2_HUMAN	CETN2	physical	26186194
HMCES_HUMAN	HMCES	physical	26186194
H2A2B_HUMAN	HIST2H2AB	physical	26186194
CDK7_HUMAN	CDK7	physical	26344197
HNRPF_HUMAN	HNRNPF	physical	26344197
HYPK_HUMAN	HYPK	physical	26344197
TXND5_HUMAN	TXNDC5	physical	26344197
XRCC6_HUMAN	XRCC6	physical	26344197
UNG_HUMAN	UNG	physical	10393198
RFA1_HUMAN	RPA1	physical	26474068
RFWD3_HUMAN	RFWD3	physical	26474068
XPC_HUMAN	XPC	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
HMCES_HUMAN	HMCES	physical	28514442
RFA3_HUMAN	RPA3	physical	28514442
RFA1_HUMAN	RPA1	physical	28514442
DNLI3_HUMAN	LIG3	physical	28514442
SP16H_HUMAN	SUPT16H	physical	28514442
PARP1_HUMAN	PARP1	physical	28514442
SSRP1_HUMAN	SSRP1	physical	28514442
CETN2_HUMAN	CETN2	physical	28514442
XRCC1_HUMAN	XRCC1	physical	28514442
ATRIP_HUMAN	ATRIP	physical	23723247
RFWD3_HUMAN	RFWD3	physical	28575657
RFA1_HUMAN	RPA1	physical	28575657
TERA_HUMAN	VCP	physical	28575658

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFA2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent proteinkinase and Cdc2 kinase in vitro."; Niu H., Erdjument-Bromage H., Pan Z.-Q., Lee S.-H., Tempst P.,Hurwitz J.; J. Biol. Chem. 272:12634-12641(1997). Cited for: ACETYLATION AT MET-1, PHOSPHORYLATION AT THR-21; SER-29 AND SER-33,MASS SPECTROMETRY, AND MUTAGENESIS OF SER-29.	9139719 [Abstract]
Phosphorylation
Reference	PubMed
"Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent proteinkinase and Cdc2 kinase in vitro."; Niu H., Erdjument-Bromage H., Pan Z.-Q., Lee S.-H., Tempst P.,Hurwitz J.; J. Biol. Chem. 272:12634-12641(1997). Cited for: ACETYLATION AT MET-1, PHOSPHORYLATION AT THR-21; SER-29 AND SER-33,MASS SPECTROMETRY, AND MUTAGENESIS OF SER-29.	9139719 [Abstract]
"RING finger and WD repeat domain 3 (RFWD3) associates withreplication protein A (RPA) and facilitates RPA-mediated DNA damageresponse."; Liu S., Chu J., Yucer N., Leng M., Wang S.Y., Chen B.P.,Hittelman W.N., Wang Y.; J. Biol. Chem. 286:22314-22322(2011). Cited for: INTERACTION WITH RFWD3, SUBCELLULAR LOCATION, AND PHOSPHORYLATION ATTHR-21.	21558276 [Abstract]

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