dbPTM

PCF11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PCF11_HUMAN
UniProt AC	O94913
Protein Name	Pre-mRNA cleavage complex 2 protein Pcf11
Gene Name	PCF11
Organism	Homo sapiens (Human).
Sequence Length	1555
Subcellular Localization	Nucleus.
Protein Description	Component of pre-mRNA cleavage complex II..
Protein Sequence	MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGTNRDPRLNRISQHSHGKDQSHRKEFLMNTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPTSTPKAGKIRQSGAKQSHMEEFTPPSREDRNAKRSTKQDIRDPRRMKKTEEERPQETTNQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPGVGIRFEGPLVQQGGGMRFEGPSVPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRFERTPGQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLESVSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFDEKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQTDSATTQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCDSPKVKEERIDTPPACTEESIATPSEIKTENDTVESV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEQTPAEA ------CCCCCHHHH	50.11	22814378
22	Phosphorylation	REDACRDYQSSLEDL HHHHHHHHHHHHHHC	7.31	20068231
24	Phosphorylation	DACRDYQSSLEDLTF HHHHHHHHHHHHCCC	30.57	20068231
25	Phosphorylation	ACRDYQSSLEDLTFN HHHHHHHHHHHCCCC	21.91	20068231
30	Phosphorylation	QSSLEDLTFNSKPHI HHHHHHCCCCCCCCC	32.85	20068231
33	Phosphorylation	LEDLTFNSKPHINML HHHCCCCCCCCCCHH	43.29	20068231
56	Phosphorylation	PFAKEIVSLIEAQTA HHHHHHHHHHHHHCC	29.32	24144214
62	Phosphorylation	VSLIEAQTAKAPSSE HHHHHHHCCCCCCCC	36.85	24144214
64	Ubiquitination	LIEAQTAKAPSSEKL HHHHHCCCCCCCCCC	65.30	29967540
67	Phosphorylation	AQTAKAPSSEKLPVM HHCCCCCCCCCCCHH	56.86	26552605
68	Phosphorylation	QTAKAPSSEKLPVMY HCCCCCCCCCCCHHH	37.38	26552605
75	Phosphorylation	SEKLPVMYLMDSIVK CCCCCHHHHHHHHHH	10.10	26552605
79	Phosphorylation	PVMYLMDSIVKNVGR CHHHHHHHHHHHHCH	18.47	24719451
114	Phosphorylation	VDENTRKSLFKLRST CCCCHHHHHHHHHHC	35.43	24719451
120	Phosphorylation	KSLFKLRSTWDEIFP HHHHHHHHCHHHHCC	44.26	-
121	Phosphorylation	SLFKLRSTWDEIFPL HHHHHHHCHHHHCCH	30.42	-
129	Ubiquitination	WDEIFPLKKLYALDV HHHHCCHHHEEEEEC	40.76	29967540
130	Ubiquitination	DEIFPLKKLYALDVR HHHCCHHHEEEEECC	55.18	-
140	Phosphorylation	ALDVRVNSLDPAWPI EEECCCCCCCCCCCC	31.15	-
164	Acetylation	SSIHVNPKFLNKSPE CCEECCHHHCCCCCC	58.23	25953088
169	Phosphorylation	NPKFLNKSPEEPSTP CHHHCCCCCCCCCCC	36.15	23401153
174	Phosphorylation	NKSPEEPSTPGTVVS CCCCCCCCCCCCEEC	50.98	25159151
175	Phosphorylation	KSPEEPSTPGTVVSS CCCCCCCCCCCEECC	36.13	25159151
178	O-linked_Glycosylation	EEPSTPGTVVSSPSI CCCCCCCCEECCCCC	20.95	30379171
178	Phosphorylation	EEPSTPGTVVSSPSI CCCCCCCCEECCCCC	20.95	25159151
181	O-linked_Glycosylation	STPGTVVSSPSISTP CCCCCEECCCCCCCC	31.99	30379171
181	Phosphorylation	STPGTVVSSPSISTP CCCCCEECCCCCCCC	31.99	25159151
182	Phosphorylation	TPGTVVSSPSISTPP CCCCEECCCCCCCCC	15.85	25159151
184	Phosphorylation	GTVVSSPSISTPPIV CCEECCCCCCCCCCC	30.99	25159151
186	Phosphorylation	VVSSPSISTPPIVPD EECCCCCCCCCCCCC	38.92	25159151
187	Phosphorylation	VSSPSISTPPIVPDI ECCCCCCCCCCCCCH	31.26	25159151
196	Ubiquitination	PIVPDIQKNLTQEQL CCCCCHHHCCCHHHH	55.01	29967540
211	Ubiquitination	IRQQLLAKQKQLLEL HHHHHHHHHHHHHHH	58.98	29967540
237	Phosphorylation	AKAQLAVSLSVQQET HHHHHHHEEECCCCC	14.87	22210691
239	Phosphorylation	AQLAVSLSVQQETSN HHHHHEEECCCCCCC	15.46	22210691
251	Phosphorylation	TSNLGPGSAPSKLHV CCCCCCCCCCCCEEC	39.89	22210691
259	Phosphorylation	APSKLHVSQIPPMAV CCCCEECCCCCCCCC	16.19	22210691
267	Acetylation	QIPPMAVKAPHQVPV CCCCCCCCCCCCCCC	46.81	25953088
268	Phosphorylation	IPPMAVKAPHQVPVQ CCCCCCCCCCCCCCC	10.54	18669648
277	Phosphorylation	HQVPVQSEKSRPGPS CCCCCCCCCCCCCCC	37.65	18669648
279	Phosphorylation	VPVQSEKSRPGPSLQ CCCCCCCCCCCCCCC	39.39	28555341
280	Phosphorylation	PVQSEKSRPGPSLQI CCCCCCCCCCCCCCE	51.79	18669648
281	Phosphorylation	VQSEKSRPGPSLQIQ CCCCCCCCCCCCCEE	67.16	18669648
283	Phosphorylation	SEKSRPGPSLQIQDL CCCCCCCCCCCEECC	34.25	18669648
285	Phosphorylation	KSRPGPSLQIQDLKG CCCCCCCCCEECCCC	6.14	18669648
286	Phosphorylation	SRPGPSLQIQDLKGT CCCCCCCCEECCCCC	35.32	18669648
291	Sumoylation	SLQIQDLKGTNRDPR CCCEECCCCCCCCHH	72.48	28112733
303	Phosphorylation	DPRLNRISQHSHGKD CHHHHHHHHCCCCCC	20.71	29449344
306	Phosphorylation	LNRISQHSHGKDQSH HHHHHHCCCCCCHHH	26.71	29449344
312	Phosphorylation	HSHGKDQSHRKEFLM CCCCCCHHHHHHHHH	35.08	-
319	Sulfoxidation	SHRKEFLMNTLNQSD HHHHHHHHHHCCCCC	4.35	21406390
321	Phosphorylation	RKEFLMNTLNQSDTK HHHHHHHHCCCCCCC	17.08	-
325	Phosphorylation	LMNTLNQSDTKTSKT HHHHCCCCCCCCCCC	46.29	25159151
327	Phosphorylation	NTLNQSDTKTSKTIP HHCCCCCCCCCCCCC	41.28	-
328	Sumoylation	TLNQSDTKTSKTIPS HCCCCCCCCCCCCCH	56.65	28112733
337	Acetylation	SKTIPSEKLNSSKQE CCCCCHHHHCCCHHH	58.25	23749302
355	Acetylation	SGEKITKKELDQLDS CCCCCCHHHHHHHHH	55.66	26051181
362	Phosphorylation	KELDQLDSKSKSKSK HHHHHHHHHCCCCCC	47.63	26074081
364	Phosphorylation	LDQLDSKSKSKSKSP HHHHHHHCCCCCCCC	46.22	26074081
366	Phosphorylation	QLDSKSKSKSKSPSP HHHHHCCCCCCCCCH	49.61	26074081
368	Phosphorylation	DSKSKSKSKSPSPLK HHHCCCCCCCCCHHH	45.52	26055452
370	Phosphorylation	KSKSKSKSPSPLKNK HCCCCCCCCCHHHHH	37.39	25159151
372	Phosphorylation	KSKSKSPSPLKNKLS CCCCCCCCHHHHHHH	50.37	25159151
379	Phosphorylation	SPLKNKLSHTKDLKN CHHHHHHHCCHHHCC	30.62	26074081
381	Phosphorylation	LKNKLSHTKDLKNQE HHHHHHCCHHHCCCC	23.91	26074081
382	Ubiquitination	KNKLSHTKDLKNQES HHHHHCCHHHCCCCC	56.49	29967540
389	Phosphorylation	KDLKNQESESMRLSD HHHCCCCCHHHHHHH	25.80	26074081
391	Phosphorylation	LKNQESESMRLSDMN HCCCCCHHHHHHHHH	20.62	28555341
395	Phosphorylation	ESESMRLSDMNKRDP CCHHHHHHHHHHCCH	25.17	25159151
420	Ubiquitination	DGKDDDVKEKRKTAE CCCCCCHHHHHHHHH	65.59	24816145
456	Sumoylation	IINGIVQKQDTITEE HHHHHHHHCCCCCHH	38.97	-
456	Sumoylation	IINGIVQKQDTITEE HHHHHHHHCCCCCHH	38.97	28112733
459	Phosphorylation	GIVQKQDTITEESEK HHHHHCCCCCHHHHH	27.57	23917254
461	Phosphorylation	VQKQDTITEESEKQG HHHCCCCCHHHHHCC	35.47	23186163
480	Phosphorylation	RSSTRKRSRSRSPKS CCCCCHHCCCCCCCC	37.33	29743597
482	Phosphorylation	STRKRSRSRSPKSRS CCCHHCCCCCCCCCC	38.05	29743597
484	Phosphorylation	RKRSRSRSPKSRSPI CHHCCCCCCCCCCCC	37.62	22468782
487	Phosphorylation	SRSRSPKSRSPIIHS CCCCCCCCCCCCCCC	41.18	25159151
489	Phosphorylation	SRSPKSRSPIIHSPK CCCCCCCCCCCCCCC	27.78	22167270
494	Phosphorylation	SRSPIIHSPKRRDRR CCCCCCCCCCCCCCC	23.00	22167270
502	Phosphorylation	PKRRDRRSPKRRQRS CCCCCCCCHHHHHHC	35.35	-
509	O-linked_Glycosylation	SPKRRQRSMSPTSTP CHHHHHHCCCCCCCC	18.44	30379171
509	Phosphorylation	SPKRRQRSMSPTSTP CHHHHHHCCCCCCCC	18.44	30266825
511	O-linked_Glycosylation	KRRQRSMSPTSTPKA HHHHHCCCCCCCCCC	26.69	30379171
511	Phosphorylation	KRRQRSMSPTSTPKA HHHHHCCCCCCCCCC	26.69	29255136
513	Phosphorylation	RQRSMSPTSTPKAGK HHHCCCCCCCCCCCC	37.62	30266825
514	Phosphorylation	QRSMSPTSTPKAGKI HHCCCCCCCCCCCCC	46.20	30266825
515	Phosphorylation	RSMSPTSTPKAGKIR HCCCCCCCCCCCCCC	31.14	30266825
529	Phosphorylation	RQSGAKQSHMEEFTP CCCCCCHHCHHHCCC	24.89	23312004
535	Phosphorylation	QSHMEEFTPPSREDR HHCHHHCCCCCHHHH	37.25	25159151
538	Phosphorylation	MEEFTPPSREDRNAK HHHCCCCCHHHHHCC	49.89	28985074
547	Phosphorylation	EDRNAKRSTKQDIRD HHHHCCCCCHHHHHC	38.97	24719451
561	Phosphorylation	DPRRMKKTEEERPQE CHHHHHCCHHHCCCC	43.01	-
569	Phosphorylation	EEERPQETTNQHSTK HHHCCCCCCCCCCCC	26.29	-
570	Phosphorylation	EERPQETTNQHSTKS HHCCCCCCCCCCCCC	31.93	-
588	Phosphorylation	PKENVENWQSSKSAK CCHHHHHHHHCHHHH	5.97	17081983
593	Phosphorylation	ENWQSSKSAKRWKSG HHHHHCHHHHHHHHH	40.76	17081983
606	Phosphorylation	SGWEENKSLQQVDEH HHHHHHHCHHHHCCC	42.88	28555341
624	Phosphorylation	PHLRHRESWSSTKGI CCCCCCHHHHCCCCC	32.01	30576142
626	Phosphorylation	LRHRESWSSTKGILS CCCCHHHHCCCCCCC	37.09	26055452
627	Phosphorylation	RHRESWSSTKGILSP CCCHHHHCCCCCCCC	28.07	27251275
628	Phosphorylation	HRESWSSTKGILSPR CCHHHHCCCCCCCCC	27.98	27251275
633	Phosphorylation	SSTKGILSPRAPKQQ HCCCCCCCCCCCCHH	15.49	25159151
645	Phosphorylation	KQQQHRLSVDANLQI CHHCCCCCCCCCCCC	20.22	25159151
654	Sumoylation	DANLQIPKELTLASK CCCCCCCHHHHHHHH	67.97	28112733
661	Acetylation	KELTLASKRELLQKT HHHHHHHHHHHHHHH	44.26	25953088
661	Ubiquitination	KELTLASKRELLQKT HHHHHHHHHHHHHHH	44.26	29967540
667	Ubiquitination	SKRELLQKTSERLAS HHHHHHHHHHHHHHC	54.72	-
705	Phosphorylation	GVREEQRSPFNDRFP CCCHHHCCCCCCCCC	33.27	29255136
721	Phosphorylation	KRPRYEDSDKPFVDS CCCCCCCCCCCCCCC	35.28	24732914
723	Acetylation	PRYEDSDKPFVDSPA CCCCCCCCCCCCCHH	44.28	23236377
723	Sumoylation	PRYEDSDKPFVDSPA CCCCCCCCCCCCCHH	44.28	28112733
723	Ubiquitination	PRYEDSDKPFVDSPA CCCCCCCCCCCCCHH	44.28	29967540
728	Phosphorylation	SDKPFVDSPASRFAG CCCCCCCCHHHHHCC	19.64	25159151
731	Phosphorylation	PFVDSPASRFAGLDT CCCCCHHHHHCCCCH	31.17	24732914
738	Phosphorylation	SRFAGLDTNQRLTAL HHHCCCCHHHHHHHH	37.99	28555341
756	Phosphorylation	RPLFDGPSRPSVARD CCCCCCCCCCCCCCC	63.45	24719451
759	Phosphorylation	FDGPSRPSVARDGPT CCCCCCCCCCCCCCC	27.57	28555341
766	Phosphorylation	SVARDGPTKMIFEGP CCCCCCCCEEEEECC	38.48	-
775	Acetylation	MIFEGPNKLSPRIDG EEEECCCCCCCCCCC	54.17	25953088
775	Ubiquitination	MIFEGPNKLSPRIDG EEEECCCCCCCCCCC	54.17	24816145
777	Phosphorylation	FEGPNKLSPRIDGPP EECCCCCCCCCCCCC	17.47	29255136
779	Methylation	GPNKLSPRIDGPPTP CCCCCCCCCCCCCCC	35.93	115486619
785	Phosphorylation	PRIDGPPTPASLRFD CCCCCCCCCCCEEEC	34.32	30266825
788	Phosphorylation	DGPPTPASLRFDGSP CCCCCCCCEEECCCC	22.68	30266825
790	Methylation	PPTPASLRFDGSPGQ CCCCCCEEECCCCCC	25.72	81452609
794	Phosphorylation	ASLRFDGSPGQMGGG CCEEECCCCCCCCCC	27.92	29255136
804	Phosphorylation	QMGGGGPLRFEGPQG CCCCCCCCEEECCCC	12.70	18220336
805	Asymmetric dimethylarginine	MGGGGPLRFEGPQGQ CCCCCCCEEECCCCC	30.61	-
805	Methylation	MGGGGPLRFEGPQGQ CCCCCCCEEECCCCC	30.61	24129315
820	Asymmetric dimethylarginine	LGGGCPLRFEGPPGP CCCCCCCEECCCCCC	16.83	-
820	Methylation	LGGGCPLRFEGPPGP CCCCCCCEECCCCCC	16.83	24129315
827	Phosphorylation	RFEGPPGPVGTPLRF EECCCCCCCCCCEEE	27.43	18669648
830	Phosphorylation	GPPGPVGTPLRFEGP CCCCCCCCCEEEECC	21.27	21815630
833	Asymmetric dimethylarginine	GPVGTPLRFEGPIGQ CCCCCCEEEECCCCC	28.86	-
833	Methylation	GPVGTPLRFEGPIGQ CCCCCCEEEECCCCC	28.86	24129315
847	Dimethylation	QAGGGGFRFEGSPGL CCCCCCCEECCCCCC	31.79	-
847	Methylation	QAGGGGFRFEGSPGL CCCCCCCEECCCCCC	31.79	115383869
851	Phosphorylation	GGFRFEGSPGLRFEG CCCEECCCCCCEECC	14.48	30266825
854	Ubiquitination	RFEGSPGLRFEGSPG EECCCCCCEECCCCC	6.86	29967540
855	Dimethylation	FEGSPGLRFEGSPGG ECCCCCCEECCCCCC	33.22	-
855	Methylation	FEGSPGLRFEGSPGG ECCCCCCEECCCCCC	33.22	80702721
859	Phosphorylation	PGLRFEGSPGGLRFE CCCEECCCCCCEEEE	17.11	21815630
864	Dimethylation	EGSPGGLRFEGPGGQ CCCCCCEEEECCCCC	30.74	-
864	Methylation	EGSPGGLRFEGPGGQ CCCCCCEEEECCCCC	30.74	18968905
876	Phosphorylation	GGQPVGGLRFEGHRG CCCCCCCEEEECCCC	4.69	18669648
877	Dimethylation	GQPVGGLRFEGHRGQ CCCCCCEEEECCCCC	30.74	-
877	Methylation	GQPVGGLRFEGHRGQ CCCCCCEEEECCCCC	30.74	80702729
882	Dimethylation	GLRFEGHRGQPVGGL CEEEECCCCCEECCE	57.19	-
882	Methylation	GLRFEGHRGQPVGGL CEEEECCCCCEECCE	57.19	82797519
884	Phosphorylation	RFEGHRGQPVGGLRF EEECCCCCEECCEEE	29.48	18220336
890	Dimethylation	GQPVGGLRFEGPHGQ CCEECCEEEECCCCC	30.74	-
890	Methylation	GQPVGGLRFEGPHGQ CCEECCEEEECCCCC	30.74	115383877
903	Dimethylation	GQPVGGLRFDNPRGQ CCCCCCEEEECCCCC	39.90	-
903	Methylation	GQPVGGLRFDNPRGQ CCCCCCEEEECCCCC	39.90	54549441
906	Ubiquitination	VGGLRFDNPRGQPVG CCCEEEECCCCCEEC	26.00	24816145
908	Methylation	GLRFDNPRGQPVGGL CEEEECCCCCEECCE	63.73	115383885
929	Asymmetric dimethylarginine	GPSGAAIRFDGPHGQ CCCCCEEEECCCCCC	20.90	-
929	Methylation	GPSGAAIRFDGPHGQ CCCCCEEEECCCCCC	20.90	24129315
942	Asymmetric dimethylarginine	GQPGGGIRFEGPLLQ CCCCCCEEEECCCHH	27.17	-
942	Methylation	GQPGGGIRFEGPLLQ CCCCCCEEEECCCHH	27.17	24129315
950	Phosphorylation	FEGPLLQQGVGMRFE EECCCHHCCCCEEEE	48.81	18669648
955	Asymmetric dimethylarginine	LQQGVGMRFEGPHGQ HHCCCCEEEECCCCC	22.12	-
955	Methylation	LQQGVGMRFEGPHGQ HHCCCCEEEECCCCC	22.12	24129315
963	Phosphorylation	FEGPHGQSVAGLRFE EECCCCCCEEEEEEE	20.66	24719451
968	Methylation	GQSVAGLRFEGQHNQ CCCEEEEEEECCCCC	27.01	115383893
981	Asymmetric dimethylarginine	NQLGGNLRFEGPHGQ CCCCCEEEEECCCCC	31.41	-
981	Methylation	NQLGGNLRFEGPHGQ CCCCCEEEEECCCCC	31.41	24129315
994	Asymmetric dimethylarginine	GQPGVGIRFEGPLVQ CCCCCEEEEECCEEE	20.03	-
994	Methylation	GQPGVGIRFEGPLVQ CCCCCEEEEECCEEE	20.03	24129315
1007	Asymmetric dimethylarginine	VQQGGGMRFEGPSVP EEECCCCCCCCCCCC	29.73	-
1007	Methylation	VQQGGGMRFEGPSVP EEECCCCCCCCCCCC	29.73	24129315
1019	Methylation	SVPGGGLRIEGPLGQ CCCCCCEEEECCCCC	28.34	115383829
1030	Dimethylation	PLGQGGPRFEGCHAL CCCCCCCCCCCCEEE	45.59	-
1030	Methylation	PLGQGGPRFEGCHAL CCCCCCCCCCCCEEE	45.59	52717377
1038	Methylation	FEGCHALRFDGQPGQ CCCCEEEEECCCCCC	28.52	115383845
1047	Phosphorylation	DGQPGQPSLLPRFDG CCCCCCCCCCCCCCC	34.35	24719451
1051	Dimethylation	GQPSLLPRFDGLHGQ CCCCCCCCCCCCCCC	42.11	-
1051	Methylation	GQPSLLPRFDGLHGQ CCCCCCCCCCCCCCC	42.11	54548651
1062	Dimethylation	LHGQPGPRFERTPGQ CCCCCCCCCCCCCCC	52.56	-
1062	Methylation	LHGQPGPRFERTPGQ CCCCCCCCCCCCCCC	52.56	54549763
1065	Dimethylation	QPGPRFERTPGQPGP CCCCCCCCCCCCCCC	43.43	-
1065	Methylation	QPGPRFERTPGQPGP CCCCCCCCCCCCCCC	43.43	115382791
1074	Dimethylation	PGQPGPQRFDGPPGQ CCCCCCCCCCCCCCC	34.45	-
1074	Methylation	PGQPGPQRFDGPPGQ CCCCCCCCCCCCCCC	34.45	18600801
1086	Dimethylation	PGQQVQPRFDGVPQR CCCCCCCCCCCCCCC	25.79	-
1086	Methylation	PGQQVQPRFDGVPQR CCCCCCCCCCCCCCC	25.79	115382771
1093	Asymmetric dimethylarginine	RFDGVPQRFDGPQHQ CCCCCCCCCCCCCCC	26.08	-
1093	Methylation	RFDGVPQRFDGPQHQ CCCCCCCCCCCCCCC	26.08	24129315
1104	Asymmetric dimethylarginine	PQHQQASRFDIPLGL CCCCCCCCCCCCCCC	35.95	-
1104	Methylation	PQHQQASRFDIPLGL CCCCCCCCCCCCCCC	35.95	24129315
1114	Phosphorylation	IPLGLQGTRFDNHPS CCCCCCCCCCCCCHH	18.40	21406692
1115	Methylation	PLGLQGTRFDNHPSQ CCCCCCCCCCCCHHH	43.69	115486603
1135	Phosphorylation	SFNQTGPYNDPPGNA ECCCCCCCCCCCCCC	33.28	28555341
1161	Phosphorylation	RHEQIFDSPQGPNFN EHHHHCCCCCCCCCC	14.36	25159151
1177	Phosphorylation	PHGPGNQSFSNPLNR CCCCCCCCCCCHHHH	34.34	26055452
1179	Phosphorylation	GPGNQSFSNPLNRAS CCCCCCCCCHHHHHC	42.67	27174698
1186	Phosphorylation	SNPLNRASGHYFDEK CCHHHHHCCCCCCHH	23.90	25159151
1189	Phosphorylation	LNRASGHYFDEKNLQ HHHHCCCCCCHHCCC	19.09	26074081
1211	Phosphorylation	GNIPAPMTVGNIQAS CCCCCCEECCHHHHH	24.97	-
1218	Phosphorylation	TVGNIQASQQVLSGV ECCHHHHHHHHHHCC	12.55	-
1274	Phosphorylation	VDVNELFSKLLKTGI CCHHHHHHHHHHHCC	34.71	24719451
1275	Acetylation	DVNELFSKLLKTGIL CHHHHHHHHHHHCCH	50.97	23954790
1275	Ubiquitination	DVNELFSKLLKTGIL CHHHHHHHHHHHCCH	50.97	29967540
1278	Sumoylation	ELFSKLLKTGILKLS HHHHHHHHHCCHHHH	55.96	-
1278	Sumoylation	ELFSKLLKTGILKLS HHHHHHHHHCCHHHH	55.96	28112733
1278	Ubiquitination	ELFSKLLKTGILKLS HHHHHHHHHCCHHHH	55.96	29967540
1376	Phosphorylation	NRTEKDVSRKVTHRR CCCCCHHHHHHHCHH	36.20	24719451
1406	Phosphorylation	DLEERAKSQFFEKVH CHHHHHHHHHHHHHH	31.10	28555341
1406	Ubiquitination	DLEERAKSQFFEKVH CHHHHHHHHHHHHHH	31.10	29967540
1409	Ubiquitination	ERAKSQFFEKVHEEV HHHHHHHHHHHHHHH	7.43	29967540
1418	Ubiquitination	KVHEEVVLKTQEAAK HHHHHHHHHHHHHHH	6.33	29967540
1419	Sumoylation	VHEEVVLKTQEAAKE HHHHHHHHHHHHHHH	36.23	28112733
1419	Ubiquitination	VHEEVVLKTQEAAKE HHHHHHHHHHHHHHH	36.23	29967540
1420	Phosphorylation	HEEVVLKTQEAAKEK HHHHHHHHHHHHHHH	27.73	-
1474	Phosphorylation	IRVDGKIYHPSCYED EEECCEEECHHHHCC	15.91	27732954
1477	Phosphorylation	DGKIYHPSCYEDYQN CCEEECHHHHCCCCC	18.93	27732954
1479	Phosphorylation	KIYHPSCYEDYQNTS EEECHHHHCCCCCCC	19.03	27732954
1482	Phosphorylation	HPSCYEDYQNTSSFD CHHHHCCCCCCCCCC	7.54	20873877
1485	Phosphorylation	CYEDYQNTSSFDCTP HHCCCCCCCCCCCCC	15.38	23663014
1486	Phosphorylation	YEDYQNTSSFDCTPS HCCCCCCCCCCCCCC	36.24	22617229
1487	Phosphorylation	EDYQNTSSFDCTPSP CCCCCCCCCCCCCCC	24.06	22617229
1491	Phosphorylation	NTSSFDCTPSPSKTP CCCCCCCCCCCCCCC	28.75	22617229
1493	Phosphorylation	SSFDCTPSPSKTPVE CCCCCCCCCCCCCCC	24.53	23401153
1495	Phosphorylation	FDCTPSPSKTPVENP CCCCCCCCCCCCCCH	54.20	25159151
1497	Phosphorylation	CTPSPSKTPVENPLN CCCCCCCCCCCCHHH	36.58	28464451
1511	Sumoylation	NIMLNIVKNELQEPC HHHHHHHHHHCCCCC	40.69	-
1511	Sumoylation	NIMLNIVKNELQEPC HHHHHHHHHHCCCCC	40.69	28112733
1520	Phosphorylation	ELQEPCDSPKVKEER HCCCCCCCCCCCHHH	33.08	29255136
1524	Sumoylation	PCDSPKVKEERIDTP CCCCCCCCHHHCCCC	61.04	-
1524	Sumoylation	PCDSPKVKEERIDTP CCCCCCCCHHHCCCC	61.04	28112733
1529	Phosphorylation	KVKEERIDTPPACTE CCCHHHCCCCCCCCC	60.42	32142685
1530	Phosphorylation	VKEERIDTPPACTEE CCHHHCCCCCCCCCC	28.88	29255136
1535	Phosphorylation	IDTPPACTEESIATP CCCCCCCCCCCCCCH	44.91	23663014
1538	Phosphorylation	PPACTEESIATPSEI CCCCCCCCCCCHHHC	15.99	23663014
1541	Phosphorylation	CTEESIATPSEIKTE CCCCCCCCHHHCCCC	26.19	25159151
1543	Phosphorylation	EESIATPSEIKTEND CCCCCCHHHCCCCCC	47.82	29396449
1546	Sumoylation	IATPSEIKTENDTVE CCCHHHCCCCCCCCC	45.81	28112733
1547	Phosphorylation	ATPSEIKTENDTVES CCHHHCCCCCCCCCC	45.76	26552605
1549	Ubiquitination	PSEIKTENDTVESV- HHHCCCCCCCCCCC-	56.32	29967540
1550	Ubiquitination	SEIKTENDTVESV-- HHCCCCCCCCCCC--	45.99	29967540
1551	Phosphorylation	EIKTENDTVESV--- HCCCCCCCCCCC---	37.44	26552605
1554	Phosphorylation	TENDTVESV------ CCCCCCCCC------	28.88	28985074
1619	Phosphorylation	----------------------------------------------------------------------- -----------------------------------------------------------------------		18669648
1629	Phosphorylation	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		15302935
1660	Phosphorylation	---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------		32142685
1661	Phosphorylation	----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------		32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
120	S	Phosphorylation	Kinase	WNK1	Q9H4A3	PSP
121	T	Phosphorylation	Kinase	WNK1	Q9H4A3	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PCF11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PCF11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THOC4_HUMAN	ALYREF	physical	19110458
PLCB1_HUMAN	PLCB1	physical	22939629
TXND9_HUMAN	TXNDC9	physical	22939629
ATF7_HUMAN	ATF7	physical	26344197
SPF27_HUMAN	BCAS2	physical	26344197
CLP1_HUMAN	CLP1	physical	26344197
CPSF2_HUMAN	CPSF2	physical	26344197
SELB_HUMAN	EEFSEC	physical	26344197
PLRG1_HUMAN	PLRG1	physical	26344197
SAE2_HUMAN	UBA2	physical	26344197
WDR33_HUMAN	WDR33	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PCF11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-182; SER-186;SER-728; SER-777; SER-851 AND SER-1520, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489 AND SER-494, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-785, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1530, AND MASSSPECTROMETRY.	15302935 [Abstract]