CLP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLP1_HUMAN
• UniProt AC: Q92989
• Protein Name: Polyribonucleotide 5'-hydroxyl-kinase Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}
• Gene Name: CLP1 {ECO:0000255|HAMAP-Rule:MF_03035}
• Organism: Homo sapiens (Human).
• Sequence Length: 425
• Subcellular Localization: Nucleus .
• Protein Description: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. [PubMed: 24766809]
• Protein Sequence: MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	GEEANDDKKPTTKFE CCCCCCCCCCCCCEE	64.61	24816145
12	Phosphorylation	ANDDKKPTTKFELER CCCCCCCCCCEEEEE	52.04	29759185
13	Phosphorylation	NDDKKPTTKFELERE CCCCCCCCCEEEEEE	42.11	29759185
30	Phosphorylation	LRFEVEASQSVQLEL EEEEEEECHHHHHHH	14.96	-
32	Phosphorylation	FEVEASQSVQLELLT EEEEECHHHHHHHHH	14.88	-
54	Ubiquitination	TELTRNKKFTFDAGA CCCCCCCCEEECCCC	53.86	29967540
79	Phosphorylation	SVQLSGRTEVAYVSK EEEECCCEEEEEEEC	38.03	21406692
83	Phosphorylation	SGRTEVAYVSKDTPM CCCEEEEEEECCCCE	15.49	21406692
85	Phosphorylation	RTEVAYVSKDTPMLL CEEEEEEECCCCEEE	16.49	21406692
88	Phosphorylation	VAYVSKDTPMLLYLN EEEEECCCCEEEEEE	17.84	24275569
93	Phosphorylation	KDTPMLLYLNTHTAL CCCCEEEEEEHHHHH	8.24	24275569
118	Sulfoxidation	EERGPRVMVVGPTDV HHHCCCEEEECCCCC	1.82	21406390
127	Ubiquitination	VGPTDVGKSTVCRLL ECCCCCCHHHHHHHH	42.68	21963094
202	Ubiquitination	TNIKLYNKITSRLAD CCHHHHHHHHHHHHH	33.53	29967540
203	Ubiquitination	NIKLYNKITSRLADV CHHHHHHHHHHHHHH	3.63	27667366
217	Ubiquitination	VFNQRCEVNRRASVS HHHHCCCCCCCCCCC	8.48	33845483
222	Phosphorylation	CEVNRRASVSGCVIN CCCCCCCCCCCEEEE	18.27	27251275
224	Phosphorylation	VNRRASVSGCVINTC CCCCCCCCCEEEECC	24.79	27251275
256	Ubiquitination	FEVDVVVVLDQERLY CCCEEEEEECHHHHH	3.09	33845483
261	Ubiquitination	VVVLDQERLYNELKR EEEECHHHHHHHHHH	36.52	33845483
263	Phosphorylation	VLDQERLYNELKRDL EECHHHHHHHHHHHC	16.89	28152594
264	Ubiquitination	LDQERLYNELKRDLP ECHHHHHHHHHHHCC	53.36	22817900
267	Acetylation	ERLYNELKRDLPHFV HHHHHHHHHHCCHHH	37.37	25953088
267	Ubiquitination	ERLYNELKRDLPHFV HHHHHHHHHHCCHHH	37.37	27667366
281	Ubiquitination	VRTVLLPKSGGVVER HEEEEECCCCCCEEC	62.80	21906983
282	Phosphorylation	RTVLLPKSGGVVERS EEEEECCCCCCEECC	38.55	30576142
287	Ubiquitination	PKSGGVVERSKDFRR CCCCCCEECCHHHHH	49.16	21963094
289	Phosphorylation	SGGVVERSKDFRREC CCCCEECCHHHHHHH	24.07	30576142
313	Phosphorylation	YGFRGCFYPHAFNVK HCCCCCCCCEEEEEE	9.74	-
320	Acetylation	YPHAFNVKFSDVKIY CCEEEEEECCCCEEE	40.01	26051181
320	Ubiquitination	YPHAFNVKFSDVKIY CCEEEEEECCCCEEE	40.01	33845483
325	Ubiquitination	NVKFSDVKIYKVGAP EEECCCCEEEEECCC	45.36	22817900
328	Ubiquitination	FSDVKIYKVGAPTIP CCCCEEEEECCCCCC	37.35	22817900
344	Phosphorylation	SCLPLGMSQEDNQLK CCCCCCCCCCCCCEE	28.72	25159151
351	Ubiquitination	SQEDNQLKLVPVTPG CCCCCCEEEEECCCC	37.36	21963094
356	Phosphorylation	QLKLVPVTPGRDMVH CEEEEECCCCHHHHH	17.60	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEN2_HUMAN	TSEN2	physical	15109492
SEN54_HUMAN	TSEN54	physical	15109492
SEN34_HUMAN	TSEN34	physical	15109492
CPSF5_HUMAN	NUDT21	physical	11060040
CPSF2_HUMAN	CPSF2	physical	11060040
CPSF6_HUMAN	CPSF6	physical	11060040
CPSF7_HUMAN	CPSF7	physical	11060040
CREB3_HUMAN	CREB3	physical	11384994
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615803: Pontocerebellar hypoplasia 10 (PCH10)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.