WDR33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR33_HUMAN
• UniProt AC: Q9C0J8
• Protein Name: pre-mRNA 3' end processing protein WDR33
• Gene Name: WDR33
• Organism: Homo sapiens (Human).
• Sequence Length: 1336
• Subcellular Localization: Nucleus .
• Protein Description: Essential for both cleavage and polyadenylation of pre-mRNA 3' ends..
• Protein Sequence: MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGRRPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATEIGSPP ------CCCCCCCCC	25.83	21406692
3	Phosphorylation	-----MATEIGSPPR -----CCCCCCCCCC	39.74	28464451
7	Phosphorylation	-MATEIGSPPRFFHM -CCCCCCCCCCCCCC	37.07	29255136
10	Dimethylation	TEIGSPPRFFHMPRF CCCCCCCCCCCCCCC	50.69	-
10	Methylation	TEIGSPPRFFHMPRF CCCCCCCCCCCCCCC	50.69	30763443
16	Dimethylation	PRFFHMPRFQHQAPR CCCCCCCCCCCCCCH	35.96	-
16	Methylation	PRFFHMPRFQHQAPR CCCCCCCCCCCCCCH	35.96	30763437
23	Dimethylation	RFQHQAPRQLFYKRP CCCCCCCHHHHHCCC	49.18	-
23	Methylation	RFQHQAPRQLFYKRP CCCCCCCHHHHHCCC	49.18	30763449
28	Ubiquitination	APRQLFYKRPDFAQQ CCHHHHHCCCCHHHH	50.55	21906983
28	Ubiquitination	APRQLFYKRPDFAQQ CCHHHHHCCCCHHHH	50.55	21890473
28	Ubiquitination	APRQLFYKRPDFAQQ CCHHHHHCCCCHHHH	50.55	21890473
28	Ubiquitination	APRQLFYKRPDFAQQ CCHHHHHCCCCHHHH	50.55	21890473
28	Ubiquitination	APRQLFYKRPDFAQQ CCHHHHHCCCCHHHH	50.55	21890473
28	Ubiquitination	APRQLFYKRPDFAQQ CCHHHHHCCCCHHHH	50.55	21890473
29	Methylation	PRQLFYKRPDFAQQQ CHHHHHCCCCHHHHH	25.33	115919969
38	Sulfoxidation	DFAQQQAMQQLTFDG CHHHHHHHHHHHCCH	1.96	21406390
42	Phosphorylation	QQAMQQLTFDGKRMR HHHHHHHHCCHHHHH	18.49	24173317
46	Acetylation	QQLTFDGKRMRKAVN HHHHCCHHHHHHHHH	44.88	19608861
46	Ubiquitination	QQLTFDGKRMRKAVN HHHHCCHHHHHHHHH	44.88	22817900
50	Ubiquitination	FDGKRMRKAVNRKTI CCHHHHHHHHHCCCC	47.55	22817900
55	Ubiquitination	MRKAVNRKTIDYNPS HHHHHHCCCCCCCHH	44.63	22505724
55	Malonylation	MRKAVNRKTIDYNPS HHHHHHCCCCCCCHH	44.63	32601280
65	Ubiquitination	DYNPSVIKYLENRIW CCCHHHHHHHHHHHH	41.44	22817900
65 (in isoform 2)	Ubiquitination	-	41.44	-
65	Ubiquitination	DYNPSVIKYLENRIW CCCHHHHHHHHHHHH	41.44	21890473
65	Ubiquitination	DYNPSVIKYLENRIW CCCHHHHHHHHHHHH	41.44	21890473
65	Ubiquitination	DYNPSVIKYLENRIW CCCHHHHHHHHHHHH	41.44	21890473
65	Ubiquitination	DYNPSVIKYLENRIW CCCHHHHHHHHHHHH	41.44	21890473
65	Ubiquitination	DYNPSVIKYLENRIW CCCHHHHHHHHHHHH	41.44	21890473
88	Phosphorylation	AIQPDAGYYNDLVPP HHCCCCCCCCCCCCC	10.79	23401153
89	Phosphorylation	IQPDAGYYNDLVPPI HCCCCCCCCCCCCCC	10.98	29116813
107	Phosphorylation	NNPMNAVTTKFVRTS CCCCHHHHHHHHEEC	23.12	23401153
108	Phosphorylation	NPMNAVTTKFVRTST CCCHHHHHHHHEECC	18.84	23401153
109	Ubiquitination	PMNAVTTKFVRTSTN CCHHHHHHHHEECCC	32.28	21963094
109 (in isoform 2)	Ubiquitination	-	32.28	-
119	Ubiquitination	RTSTNKVKCPVFVVR EECCCCEECCEEEEE	34.14	-
187	Phosphorylation	DHGGYVKYWQSNMNN CCCCHHHEHHHCCCC	9.91	25332170
190	Phosphorylation	GYVKYWQSNMNNVKM CHHHEHHHCCCCHHH	24.73	25332170
196	Ubiquitination	QSNMNNVKMFQAHKE HHCCCCHHHHHHHHH	35.80	-
196	Acetylation	QSNMNNVKMFQAHKE HHCCCCHHHHHHHHH	35.80	25953088
202	Ubiquitination	VKMFQAHKEAIREAS HHHHHHHHHHHHHHC	52.43	21906983
209	Phosphorylation	KEAIREASFSPTDNK HHHHHHHCCCCCCCC	22.85	21406692
211	Phosphorylation	AIREASFSPTDNKFA HHHHHCCCCCCCCCE	25.13	21406692
213	Phosphorylation	REASFSPTDNKFATC HHHCCCCCCCCCEEC	51.51	21406692
216	Ubiquitination	SFSPTDNKFATCSDD CCCCCCCCCEECCCC	38.90	21963094
216	Acetylation	SFSPTDNKFATCSDD CCCCCCCCCEECCCC	38.90	26051181
217 (in isoform 2)	Phosphorylation	-	9.49	-
221	Phosphorylation	DNKFATCSDDGTVRI CCCCEECCCCCCEEH	34.09	22468782
225	Phosphorylation	ATCSDDGTVRIWDFL EECCCCCCEEHHHHH	17.38	22468782
228 (in isoform 2)	Phosphorylation	-	3.44	-
248	Ubiquitination	RGHGADVKCVDWHPT CCCCCCCEEECCCCC	29.14	29967540
248	Acetylation	RGHGADVKCVDWHPT CCCCCCCEEECCCCC	29.14	25953088
264	Acetylation	GLVVSGSKDSQQPIK CEEEECCCCCCCCCC	65.99	26051181
264	Ubiquitination	GLVVSGSKDSQQPIK CEEEECCCCCCCCCC	65.99	27667366
264	Malonylation	GLVVSGSKDSQQPIK CEEEECCCCCCCCCC	65.99	32601280
266	Phosphorylation	VVSGSKDSQQPIKFW EEECCCCCCCCCCEE	34.16	25159151
271	Ubiquitination	KDSQQPIKFWDPKTG CCCCCCCCEECCCCC	47.27	29967540
277	Phosphorylation	IKFWDPKTGQSLATL CCEECCCCCCCHHEE	45.93	20068231
280	Phosphorylation	WDPKTGQSLATLHAH ECCCCCCCHHEEECC	22.70	20068231
283	Phosphorylation	KTGQSLATLHAHKNT CCCCCHHEEECCCCC	25.11	20068231
288	Ubiquitination	LATLHAHKNTVMEVK HHEEECCCCCEEEEE	55.91	29967540
290	Phosphorylation	TLHAHKNTVMEVKLN EEECCCCCEEEEEEE	26.49	21712546
321	Sumoylation	LFDIRNLKEELQVFR HHHHCCHHHHHHHHH	53.33	-
321	Ubiquitination	LFDIRNLKEELQVFR HHHHCCHHHHHHHHH	53.33	29967540
464	Phosphorylation	EQMGKDESNEIEMTI HHHCCCCCCCEEEEC	50.31	23403867
470	Phosphorylation	ESNEIEMTIPGLDWG CCCCEEEECCCCCCC	15.95	23403867
493	Acetylation	QKKVPQKKVPYAKPI HHCCCCCCCCCCCCC	43.10	23954790
496	Phosphorylation	VPQKKVPYAKPIPAQ CCCCCCCCCCCCCHH	30.19	-
498	Acetylation	QKKVPYAKPIPAQFQ CCCCCCCCCCCHHHH	37.32	25953088
526	Sumoylation	NEVLNDRKEDIKLEE HHHHCCHHHHCCHHH	63.70	28112733
530	Sumoylation	NDRKEDIKLEEKKKT CCHHHHCCHHHHHHH	63.27	-
530	Sumoylation	NDRKEDIKLEEKKKT CCHHHHCCHHHHHHH	63.27	28112733
550	Phosphorylation	QEMATLQYTNPQLLE HHHHHHHCCCHHHHH	16.17	27642862
560	Sumoylation	PQLLEQLKIERLAQK HHHHHHHHHHHHHHH	42.06	-
560	Ubiquitination	PQLLEQLKIERLAQK HHHHHHHHHHHHHHH	42.06	29967540
560	Sumoylation	PQLLEQLKIERLAQK HHHHHHHHHHHHHHH	42.06	28112733
764	Phosphorylation	GIQGGPGSQGIQGPV CCCCCCCCCCCCCCC	28.50	-
772	Phosphorylation	QGIQGPVSQGPLMGL CCCCCCCCCCCCCCC	32.33	25332170
782	Methylation	PLMGLNPRGMQGPPG CCCCCCCCCCCCCCC	52.74	24129315
791	Methylation	MQGPPGPRENQGPAP CCCCCCCCCCCCCCC	62.50	115919973
811	Methylation	GHPPQEMRGPHPPGG CCCCHHHCCCCCCCC	55.53	115919977
828	Methylation	GHGPQEMRGPQEIRG CCCCCHHCCCHHHCC	53.54	115919981
834	Methylation	MRGPQEIRGMQGPPP HCCCHHHCCCCCCCC	33.50	115919985
907	Phosphorylation	IPFQQQKTPLLGDGP CCCCCCCCCCCCCCC	18.16	21406692
915	Asymmetric dimethylarginine	PLLGDGPRAPFNQEG CCCCCCCCCCCCCCC	61.49	-
915	Methylation	PLLGDGPRAPFNQEG CCCCCCCCCCCCCCC	61.49	24129315
942	Methylation	GQQGAQGRIPPLNPG CCCCCCCCCCCCCCC	26.59	115919989
971	Phosphorylation	NHHMGPMSERRHEQS CCCCCCCHHCHHHHC	30.96	27080861
987	Methylation	GPEHGPERGPFRGGQ CCCCCCCCCCCCCCC	62.31	-
991	Methylation	GPERGPFRGGQDCRG CCCCCCCCCCCCCCC	52.01	115388571
1030	Methylation	KRFGHRLREFEGRGG CHHHHHHHHCCCCCC	46.65	30989889
1035	Dimethylation	RLREFEGRGGPLPQE HHHHCCCCCCCCCHH	39.43	-
1035	Methylation	RLREFEGRGGPLPQE HHHHCCCCCCCCCHH	39.43	12020187
1047	Methylation	PQEEKWRRGGPGPPF CHHHHHHCCCCCCCC	53.99	54560557
1067	Methylation	EFSEGDGRGAARGPP CCCCCCCCCCCCCCC	36.00	59080629
1071	Methylation	GDGRGAARGPPGAWE CCCCCCCCCCCCCCC	58.58	80702207
1106	Methylation	RREESFRRGAPPRHE CCHHHHHCCCCCCCC	43.55	115919933
1111	Methylation	FRRGAPPRHEGRAPP HHCCCCCCCCCCCCC	39.16	115919937
1121	Methylation	GRAPPRGRDGFPGPE CCCCCCCCCCCCCCH	42.00	115919941
1139	Phosphorylation	PEENFDASEEAARGR CHHCCCHHHHHHHCC	37.50	20068231
1144	Dimethylation	DASEEAARGRDLRGR CHHHHHHHCCCCCCC	47.96	-
1144	Methylation	DASEEAARGRDLRGR CHHHHHHHCCCCCCC	47.96	16289359
1146	Methylation	SEEAARGRDLRGRGR HHHHHHCCCCCCCCC	33.95	18959317
1166	Phosphorylation	GRKGLLPTPDEFPRF CCCCCCCCCCCCCCC	43.26	30266825
1181	Phosphorylation	EGGRKPDSWDGNREP CCCCCCCCCCCCCCC	35.28	28985074
1198	Phosphorylation	GHEHFRDTPRPDHPP CCCCCCCCCCCCCCC	19.55	23927012
1210	Phosphorylation	HPPHDGHSPASRERS CCCCCCCCHHHHHHH	27.91	29255136
1213	Phosphorylation	HDGHSPASRERSSSL CCCCCHHHHHHHHHC	37.75	23927012
1217	Phosphorylation	SPASRERSSSLQGMD CHHHHHHHHHCCCCC	21.37	30631047
1218	Phosphorylation	PASRERSSSLQGMDM HHHHHHHHHCCCCCH	41.09	30631047
1219	Phosphorylation	ASRERSSSLQGMDMA HHHHHHHHCCCCCHH	26.42	25159151
1227	Phosphorylation	LQGMDMASLPPRKRP CCCCCHHHCCCCCCC	34.47	20068231
1233	Methylation	ASLPPRKRPWHDGPG HHCCCCCCCCCCCCC	40.60	115388563
1241	Phosphorylation	PWHDGPGTSEHREME CCCCCCCCHHCCCCC	33.79	29449344
1242	Phosphorylation	WHDGPGTSEHREMEA CCCCCCCHHCCCCCC	37.00	29449344
1247	Sulfoxidation	GTSEHREMEAPGGPS CCHHCCCCCCCCCCC	5.55	21406390
1254	Phosphorylation	MEAPGGPSEDRGGKG CCCCCCCCCCCCCCC	56.24	-
1257	Methylation	PGGPSEDRGGKGRGG CCCCCCCCCCCCCCC	52.27	54560549
1262	Methylation	EDRGGKGRGGPGPAQ CCCCCCCCCCCCCCC	50.83	18583783
1270	Methylation	GGPGPAQRVPKSGRS CCCCCCCCCCCCCCC	49.14	115919945
1276	Methylation	QRVPKSGRSSSLDGE CCCCCCCCCCCCCCC	40.22	115919949
1277	Phosphorylation	RVPKSGRSSSLDGEH CCCCCCCCCCCCCCC	28.01	23663014
1278	Phosphorylation	VPKSGRSSSLDGEHH CCCCCCCCCCCCCCC	33.29	30266825
1279	Phosphorylation	PKSGRSSSLDGEHHD CCCCCCCCCCCCCCC	31.55	23401153
1288	Phosphorylation	DGEHHDGYHRDEPFG CCCCCCCCCCCCCCC	10.35	22167270
1290	Methylation	EHHDGYHRDEPFGGP CCCCCCCCCCCCCCC	41.31	115919953
1302	Phosphorylation	GGPPGSGTPSRGGRS CCCCCCCCCCCCCCC	21.56	-
1304	Phosphorylation	PPGSGTPSRGGRSGS CCCCCCCCCCCCCCC	43.31	-
1305	Methylation	PGSGTPSRGGRSGSN CCCCCCCCCCCCCCC	53.43	115919957
1308	Methylation	GTPSRGGRSGSNWGR CCCCCCCCCCCCCCC	40.44	115919961
1315	Asymmetric dimethylarginine	RSGSNWGRGSNMNSG CCCCCCCCCCCCCCC	36.66	-
1315	Methylation	RSGSNWGRGSNMNSG CCCCCCCCCCCCCCC	36.66	24129315
1325	Methylation	NMNSGPPRRGASRGG CCCCCCCCCCCCCCC	53.45	115368641

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT7_HUMAN	KAT7	physical	16169070
PROF2_HUMAN	PFN2	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
SH3G3_HUMAN	SH3GL3	physical	16169070
ZHX1_HUMAN	ZHX1	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
ANM1_HUMAN	PRMT1	physical	16169070
P53_HUMAN	TP53	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
ZN622_HUMAN	ZNF622	physical	22939629
CPSF2_HUMAN	CPSF2	physical	26344197
PAPOA_HUMAN	PAPOLA	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-7, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-7, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1210, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.
PubMed: 17081983