dbPTM

ANM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANM1_HUMAN
UniProt AC	Q99873
Protein Name	Protein arginine N-methyltransferase 1 {ECO:0000305}
Gene Name	PRMT1 {ECO:0000312\|HGNC:HGNC:5187}
Organism	Homo sapiens (Human).
Sequence Length	371
Subcellular Localization	Nucleus . Nucleus, nucleoplasm. Cytoplasm . Cytoplasm, cytosol. Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity)..
Protein Description	Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1. [PubMed: 16879614]
Protein Sequence	MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 2)	Phosphorylation	-	2.22	20068231
14	Phosphorylation	ANCIMENFVATLANG HHHHHHHHHHHHHCC	7.04	25849741
14	Phosphorylation	ANCIMENFVATLANG HHHHHHHHHHHHHCC	7.04	25627689
14 (in isoform 2)	Phosphorylation	-	7.04	20068231
14 (in isoform 4)	Phosphorylation	-	7.04	25849741
15 (in isoform 2)	Phosphorylation	-	30.20	20068231
22	Phosphorylation	VATLANGMSLQPPLE HHHHHCCCCCCCCHH	18.79	25159151
24 (in isoform 2)	Phosphorylation	-	23.40	20068231
25 (in isoform 2)	Phosphorylation	-	46.41	20068231
32	Phosphorylation	QPPLEEVSCGQAESS CCCHHCCCCCCCCCC	41.01	-
32	Ubiquitination	QPPLEEVSCGQAESS CCCHHCCCCCCCCCC	41.01	33845483
38	Phosphorylation	VSCGQAESSEKPNAE CCCCCCCCCCCCCHH	44.97	25072903
39	Phosphorylation	SCGQAESSEKPNAED CCCCCCCCCCCCHHH	19.52	25072903
42	Phosphorylation	QAESSEKPNAEDMTS CCCCCCCCCHHHCCC	15.12	25884760
43	Phosphorylation	AESSEKPNAEDMTSK CCCCCCCCHHHCCCC	15.84	25884760
46	Phosphorylation	SEKPNAEDMTSKDYY CCCCCHHHCCCCCHH	17.83	25072903
47	Phosphorylation	EKPNAEDMTSKDYYF CCCCHHHCCCCCHHH	13.12	25072903
49	Phosphorylation	PNAEDMTSKDYYFDS CCHHHCCCCCHHHHH	17.15	20068231
50	Ubiquitination	NAEDMTSKDYYFDSY CHHHCCCCCHHHHHH	8.17	33845483
52	Phosphorylation	EDMTSKDYYFDSYAH HHCCCCCHHHHHHHC	3.45	-
53	Phosphorylation	DMTSKDYYFDSYAHF HCCCCCHHHHHHHCC	25.91	-
59	Ubiquitination	YYFDSYAHFGIHEEM HHHHHHHCCCCCHHH	56.51	27667366
64	Ubiquitination	YAHFGIHEEMLKDEV HHCCCCCHHHHHHHH	2.51	27667366
69	Phosphorylation	IHEEMLKDEVRTLTY CCHHHHHHHHHHHHH	17.52	28857561
70	Ubiquitination	HEEMLKDEVRTLTYR CHHHHHHHHHHHHHC	4.53	27667366
84	Ubiquitination	RNSMFHNRHLFKDKV CCCCCCCCCCCCCEE	30.99	22053931
88	Ubiquitination	FHNRHLFKDKVVLDV CCCCCCCCCEEEEEE	23.25	27667366
89	Ubiquitination	HNRHLFKDKVVLDVG CCCCCCCCEEEEEEC	23.81	22053931
90	Ubiquitination	NRHLFKDKVVLDVGS CCCCCCCEEEEEECC	17.88	32015554
95	Ubiquitination	KDKVVLDVGSGTGIL CCEEEEEECCCCCHH	6.12	22053931
99	Ubiquitination	VLDVGSGTGILCMFA EEEECCCCCHHHHHH	16.49	23000965
102	Ubiquitination	VGSGTGILCMFAAKA ECCCCCHHHHHHHHC	32.62	23000965
103	Ubiquitination	GSGTGILCMFAAKAG CCCCCHHHHHHHHCC	37.36	-
103 (in isoform 3)	Ubiquitination	-	37.36	21890473
104	Ubiquitination	SGTGILCMFAAKAGA CCCCHHHHHHHHCCC	3.95	23000965
105	Ubiquitination	GTGILCMFAAKAGAR CCCHHHHHHHHCCCC	5.29	21890473
106 (in isoform 3)	Ubiquitination	-	16.78	21890473
107	Ubiquitination	GILCMFAAKAGARKV CHHHHHHHHCCCCEE	3.11	23000965
107 (in isoform 2)	Ubiquitination	-	3.11	21890473
108	Ubiquitination	ILCMFAAKAGARKVI HHHHHHHHCCCCEEE	24.12	32015554
110	Phosphorylation	CMFAAKAGARKVIGI HHHHHHCCCCEEEEE	20.23	28152594
110	Ubiquitination	CMFAAKAGARKVIGI HHHHHHCCCCEEEEE	20.23	21890473
110 (in isoform 2)	Ubiquitination	-	20.23	21890473
111	Phosphorylation	MFAAKAGARKVIGIE HHHHHCCCCEEEEEE	37.46	25159151
113	Ubiquitination	AAKAGARKVIGIECS HHHCCCCEEEEEECC	26.90	-
113	Phosphorylation	AAKAGARKVIGIECS HHHCCCCEEEEEECC	26.90	28152594
113	Ubiquitination	AAKAGARKVIGIECS HHHCCCCEEEEEECC	26.90	23000965
114	Ubiquitination	AKAGARKVIGIECSS HHCCCCEEEEEECCC	33.47	22817900
115	Phosphorylation	KAGARKVIGIECSSI HCCCCEEEEEECCCC	13.40	28152594
115 (in isoform 3)	Ubiquitination	-	13.40	21890473
116	Ubiquitination	AGARKVIGIECSSIS CCCCEEEEEECCCCC	10.91	21890473
116	Ubiquitination	AGARKVIGIECSSIS CCCCEEEEEECCCCC	10.91	21890473
116	Ubiquitination	AGARKVIGIECSSIS CCCCEEEEEECCCCC	10.91	23000965
117 (in isoform 3)	Ubiquitination	-	3.37	21890473
118	Acetylation	ARKVIGIECSSISDY CCEEEEEECCCCCHH	33.34	25953088
119	Ubiquitination	RKVIGIECSSISDYA CEEEEEECCCCCHHH	2.86	22817900
119 (in isoform 2)	Ubiquitination	-	2.86	21890473
121	Phosphorylation	VIGIECSSISDYAVK EEEEECCCCCHHHHH	50.11	-
121	Ubiquitination	VIGIECSSISDYAVK EEEEECCCCCHHHHH	50.11	21906983
121 (in isoform 2)	Ubiquitination	-	50.11	21890473
124	Acetylation	IECSSISDYAVKIVK EECCCCCHHHHHHHH	61.22	23749302
124	Succinylation	IECSSISDYAVKIVK EECCCCCHHHHHHHH	61.22	-
124	Succinylation	IECSSISDYAVKIVK EECCCCCHHHHHHHH	61.22	21890473
124	Ubiquitination	IECSSISDYAVKIVK EECCCCCHHHHHHHH	61.22	21890473
125	Ubiquitination	ECSSISDYAVKIVKA ECCCCCHHHHHHHHH	5.74	33845483
126	Ubiquitination	CSSISDYAVKIVKAN CCCCCHHHHHHHHHC	33.86	16196087
127	Ubiquitination	SSISDYAVKIVKANK CCCCHHHHHHHHHCC	26.78	27667366
128	2-Hydroxyisobutyrylation	SISDYAVKIVKANKL CCCHHHHHHHHHCCC	3.97	-
128	Ubiquitination	SISDYAVKIVKANKL CCCHHHHHHHHHCCC	3.97	23000965
131	Ubiquitination	DYAVKIVKANKLDHV HHHHHHHHHCCCCEE	1.75	-
131	Ubiquitination	DYAVKIVKANKLDHV HHHHHHHHHCCCCEE	1.75	16196087
131 (in isoform 1)	Ubiquitination	-	1.75	21890473
133	Ubiquitination	AVKIVKANKLDHVVT HHHHHHHCCCCEEEE	49.15	21906983
134	Ubiquitination	VKIVKANKLDHVVTI HHHHHHCCCCEEEEE	28.91	-
134	2-Hydroxyisobutyrylation	VKIVKANKLDHVVTI HHHHHHCCCCEEEEE	28.91	-
134	Acetylation	VKIVKANKLDHVVTI HHHHHHCCCCEEEEE	28.91	-
134	Succinylation	VKIVKANKLDHVVTI HHHHHHCCCCEEEEE	28.91	-
134	Ubiquitination	VKIVKANKLDHVVTI HHHHHHCCCCEEEEE	28.91	23000965
134 (in isoform 1)	Ubiquitination	-	28.91	21890473
135	Acetylation	KIVKANKLDHVVTII HHHHHCCCCEEEEEE	41.28	23954790
135	Ubiquitination	KIVKANKLDHVVTII HHHHHCCCCEEEEEE	41.28	-
137	Ubiquitination	VKANKLDHVVTIIKG HHHCCCCEEEEEEEC	60.87	16196087
143	Ubiquitination	DHVVTIIKGKVEEVE CEEEEEEECCCEEEE	20.35	-
143	2-Hydroxyisobutyrylation	DHVVTIIKGKVEEVE CEEEEEEECCCEEEE	20.35	-
143	Ubiquitination	DHVVTIIKGKVEEVE CEEEEEEECCCEEEE	20.35	33845483
143 (in isoform 1)	Ubiquitination	-	20.35	21890473
145	Ubiquitination	VVTIIKGKVEEVELP EEEEEECCCEEEECC	45.50	-
145	2-Hydroxyisobutyrylation	VVTIIKGKVEEVELP EEEEEECCCEEEECC	45.50	-
145	Acetylation	VVTIIKGKVEEVELP EEEEEECCCEEEECC	45.50	21339330
145	Ubiquitination	VVTIIKGKVEEVELP EEEEEECCCEEEECC	45.50	27667366
145 (in isoform 1)	Ubiquitination	-	45.50	21890473
154	Ubiquitination	EEVELPVEKVDIIIS EEEECCHHHHHEEHH	2.11	22505724
155	Ubiquitination	EVELPVEKVDIIISE EEECCHHHHHEEHHH	15.86	16196087
155 (in isoform 3)	Ubiquitination	-	15.86	21890473
156	Phosphorylation	VELPVEKVDIIISEW EECCHHHHHEEHHHH	3.07	-
159	Ubiquitination	PVEKVDIIISEWMGY CHHHHHEEHHHHHHH	5.93	22505724
159 (in isoform 2)	Ubiquitination	-	5.93	21890473
160	Phosphorylation	VEKVDIIISEWMGYC HHHHHEEHHHHHHHH	8.31	-
165	Ubiquitination	IIISEWMGYCLFYES EEHHHHHHHHHHHHH	21.35	22505724
173	Acetylation	YCLFYESMLNTVLYA HHHHHHHHHHHHHHH	38.26	26822725
173	Ubiquitination	YCLFYESMLNTVLYA HHHHHHHHHHHHHHH	38.26	21906983
183	Ubiquitination	TVLYARDKWLAPDGL HHHHHCCCCCCCCCC	24.16	-
183	2-Hydroxyisobutyrylation	TVLYARDKWLAPDGL HHHHHCCCCCCCCCC	24.16	-
183	Ubiquitination	TVLYARDKWLAPDGL HHHHHCCCCCCCCCC	24.16	22505724
183 (in isoform 1)	Ubiquitination	-	24.16	21890473
185	Methylation	LYARDKWLAPDGLIF HHHCCCCCCCCCCCC	29.70	-
187	Phosphorylation	ARDKWLAPDGLIFPD HCCCCCCCCCCCCCC	21.37	28442448
189	Phosphorylation	DKWLAPDGLIFPDRA CCCCCCCCCCCCCCC	7.44	28152594
190	Ubiquitination	KWLAPDGLIFPDRAT CCCCCCCCCCCCCCE	3.07	21963094
191	Phosphorylation	WLAPDGLIFPDRATL CCCCCCCCCCCCCEE	14.36	28442448
195	Methylation	DGLIFPDRATLYVTA CCCCCCCCCEEEEEE	36.55	-
196	Methylation	GLIFPDRATLYVTAI CCCCCCCCEEEEEEE	29.01	-
198	Phosphorylation	IFPDRATLYVTAIED CCCCCCEEEEEEEEC	13.51	29759185
199	Phosphorylation	FPDRATLYVTAIEDR CCCCCEEEEEEEECC	46.36	-
199	Ubiquitination	FPDRATLYVTAIEDR CCCCCEEEEEEEECC	46.36	23000965
201	Phosphorylation	DRATLYVTAIEDRQY CCCEEEEEEEECCCC	14.00	-
204	Ubiquitination	TLYVTAIEDRQYKDY EEEEEEEECCCCCCC	21.31	23000965
205 (in isoform 3)	Ubiquitination	-	13.93	21890473
206	Methylation	YVTAIEDRQYKDYKI EEEEEECCCCCCCEE	3.52	-
209	Ubiquitination	AIEDRQYKDYKIHWW EEECCCCCCCEEEEE	3.16	23000965
209 (in isoform 2)	Ubiquitination	-	3.16	21890473
210	Ubiquitination	IEDRQYKDYKIHWWE EECCCCCCCEEEEEE	24.53	23000965
214	Ubiquitination	QYKDYKIHWWENVYG CCCCCEEEEEECCCC	3.08	21890473
215	Ubiquitination	YKDYKIHWWENVYGF CCCCEEEEEECCCCC	17.97	21890473
215	Ubiquitination	YKDYKIHWWENVYGF CCCCEEEEEECCCCC	17.97	21890473
215	Ubiquitination	YKDYKIHWWENVYGF CCCCEEEEEECCCCC	17.97	23000965
215 (in isoform 3)	Ubiquitination	-	17.97	21890473
219	Ubiquitination	KIHWWENVYGFDMSC EEEEEECCCCCCHHH	18.37	21890473
219 (in isoform 2)	Ubiquitination	-	18.37	21890473
223	Acetylation	WENVYGFDMSCIKDV EECCCCCCHHHHCCC	43.47	26822725
223	Ubiquitination	WENVYGFDMSCIKDV EECCCCCCHHHHCCC	43.47	21890473
225	Ubiquitination	NVYGFDMSCIKDVAI CCCCCCHHHHCCCEE	32.45	21890473
225	Ubiquitination	NVYGFDMSCIKDVAI CCCCCCHHHHCCCEE	32.45	21890473
225	Ubiquitination	NVYGFDMSCIKDVAI CCCCCCHHHHCCCEE	32.45	21890473
227	Ubiquitination	YGFDMSCIKDVAIKE CCCCHHHHCCCEECC	8.42	21963094
228	Acetylation	GFDMSCIKDVAIKEP CCCHHHHCCCEECCC	42.26	-
228	Ubiquitination	GFDMSCIKDVAIKEP CCCHHHHCCCEECCC	42.26	23000965
233	Ubiquitination	CIKDVAIKEPLVDVV HHCCCEECCCCCCCC	52.37	-
233	Acetylation	CIKDVAIKEPLVDVV HHCCCEECCCCCCCC	52.37	26051181
233	Ubiquitination	CIKDVAIKEPLVDVV HHCCCEECCCCCCCC	52.37	23000965
233 (in isoform 1)	Ubiquitination	-	52.37	21890473
240	S-palmitoylation	KEPLVDVVDPKQLVT CCCCCCCCCHHHHHH	4.35	26865113
243	Ubiquitination	LVDVVDPKQLVTNAC CCCCCCHHHHHHCEE	38.44	-
243	2-Hydroxyisobutyrylation	LVDVVDPKQLVTNAC CCCCCCHHHHHHCEE	38.44	-
243	Ubiquitination	LVDVVDPKQLVTNAC CCCCCCHHHHHHCEE	38.44	21890473
243 (in isoform 1)	Ubiquitination	-	38.44	21890473
247	Ubiquitination	VDPKQLVTNACLIKE CCHHHHHHCEEEEEE	3.62	21963094
248	Phosphorylation	DPKQLVTNACLIKEV CHHHHHHCEEEEEEE	10.87	-
252	Ubiquitination	LVTNACLIKEVDIYT HHHCEEEEEEEEEEE	6.34	21963094
253	Ubiquitination	VTNACLIKEVDIYTV HHCEEEEEEEEEEEE	41.40	-
253	Ubiquitination	VTNACLIKEVDIYTV HHCEEEEEEEEEEEE	41.40	-
256	Ubiquitination	ACLIKEVDIYTVKVE EEEEEEEEEEEEEEE	36.87	23000965
258	Phosphorylation	LIKEVDIYTVKVEDL EEEEEEEEEEEEEEC	30.19	-
258	Ubiquitination	LIKEVDIYTVKVEDL EEEEEEEEEEEEEEC	30.19	21963094
262	S-nitrosocysteine	VDIYTVKVEDLTFTS EEEEEEEEEECEECC	2.70	-
262	Glutathionylation	VDIYTVKVEDLTFTS EEEEEEEEEECEECC	2.70	22555962
262	S-nitrosylation	VDIYTVKVEDLTFTS EEEEEEEEEECEECC	2.70	19483679
266	Acetylation	TVKVEDLTFTSPFCL EEEEEECEECCCEEE	32.30	25953088
266	Succinylation	TVKVEDLTFTSPFCL EEEEEECEECCCEEE	32.30	23954790
270	Ubiquitination	EDLTFTSPFCLQVKR EECEECCCEEEEEEC	9.55	33845483
276	Ubiquitination	SPFCLQVKRNDYVHA CCEEEEEECCCHHEE	12.21	-
276	Ubiquitination	SPFCLQVKRNDYVHA CCEEEEEECCCHHEE	12.21	21963094
284	Ubiquitination	RNDYVHALVAYFNIE CCCHHEEEEEEEEEE	26.34	21963094
285 (in isoform 2)	Phosphorylation	-	3.94	-
285 (in isoform 3)	Ubiquitination	-	3.94	21890473
287 (in isoform 3)	Phosphorylation	-	56.11	21406692
289	Phosphorylation	HALVAYFNIEFTRCH EEEEEEEEEEEEECC	47.59	26356563
289	Ubiquitination	HALVAYFNIEFTRCH EEEEEEEEEEEEECC	47.59	21963094
289 (in isoform 2)	Ubiquitination	-	47.59	21890473
292	Phosphorylation	VAYFNIEFTRCHKRT EEEEEEEEEECCCCC	29.35	26356563
293	Phosphorylation	AYFNIEFTRCHKRTG EEEEEEEEECCCCCC	46.14	26356563
294	Phosphorylation	YFNIEFTRCHKRTGF EEEEEEEECCCCCCC	26.02	25159151
295	Ubiquitination	FNIEFTRCHKRTGFS EEEEEEECCCCCCCC	46.29	21963094
297	Phosphorylation	IEFTRCHKRTGFSTS EEEEECCCCCCCCCC	26.96	25159151
299	Phosphorylation	FTRCHKRTGFSTSPE EEECCCCCCCCCCCC	22.10	27155012
299 (in isoform 3)	Phosphorylation	-	22.10	21406692
300	Phosphorylation	TRCHKRTGFSTSPES EECCCCCCCCCCCCC	25.33	27273156
303	Acetylation	HKRTGFSTSPESPYT CCCCCCCCCCCCCCC	28.61	-
303	Ubiquitination	HKRTGFSTSPESPYT CCCCCCCCCCCCCCC	28.61	21906983
304	Phosphorylation	KRTGFSTSPESPYTH CCCCCCCCCCCCCCC	37.39	23186163
305	Phosphorylation	RTGFSTSPESPYTHW CCCCCCCCCCCCCCC	14.62	21406692
306 (in isoform 3)	Phosphorylation	-	2.76	21406692
307	Phosphorylation	GFSTSPESPYTHWKQ CCCCCCCCCCCCCCC	5.66	23186163
308	Phosphorylation	FSTSPESPYTHWKQT CCCCCCCCCCCCCCE	8.68	21406692
309	Phosphorylation	STSPESPYTHWKQTV CCCCCCCCCCCCCEE	1.83	18083107
310	Phosphorylation	TSPESPYTHWKQTVF CCCCCCCCCCCCEEE	31.93	-
312	Phosphorylation	PESPYTHWKQTVFYM CCCCCCCCCCEEEEE	7.32	21406692
313	Ubiquitination	ESPYTHWKQTVFYME CCCCCCCCCEEEEEE	7.40	23000965
313 (in isoform 1)	Ubiquitination	-	7.40	21890473
314	Phosphorylation	SPYTHWKQTVFYMED CCCCCCCCEEEEEEC	17.46	21406692
314 (in isoform 3)	Ubiquitination	-	17.46	21890473
317	Phosphorylation	THWKQTVFYMEDYLT CCCCCEEEEEECEEE	45.55	21406692
318	Ubiquitination	HWKQTVFYMEDYLTV CCCCEEEEEECEEEE	25.48	23000965
318 (in isoform 2)	Ubiquitination	-	25.48	21890473
324	Ubiquitination	FYMEDYLTVKTGEEI EEEECEEEEECCCCE	12.01	21890473
324	Ubiquitination	FYMEDYLTVKTGEEI EEEECEEEEECCCCE	12.01	21890473
324	Phosphorylation	FYMEDYLTVKTGEEI EEEECEEEEECCCCE	12.01	21406692
324	Ubiquitination	FYMEDYLTVKTGEEI EEEECEEEEECCCCE	12.01	23000965
332	Ubiquitination	VKTGEEIFGTIGMRP EECCCCEECCCCCCC	62.49	21890473
338	Ubiquitination	IFGTIGMRPNAKNNR EECCCCCCCCCCCCC	42.82	33845483
342	Ubiquitination	IGMRPNAKNNRDLDF CCCCCCCCCCCCCEE	36.81	-
342	Ubiquitination	IGMRPNAKNNRDLDF CCCCCCCCCCCCCEE	36.81	23000965
342 (in isoform 1)	Ubiquitination	-	36.81	21890473
353	Phosphorylation	DLDFTIDLDFKGQLC CCEEEEEEECCCCEE	5.46	28555341
356	Phosphorylation	FTIDLDFKGQLCELS EEEEEECCCCEEEEE	41.18	21815630
356	Ubiquitination	FTIDLDFKGQLCELS EEEEEECCCCEEEEE	41.18	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANM1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
145	K	ubiquitylation	-
Polyubiquitinated at Lys-145 by the SCF(FBXL17) complex, leading to its subsequent degradation.
228	K	Acetylation	-
Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex.
228	K	Acetylation	-
Deacetylated at Lys-228 and Lys-233 by SIRT1.
228	K	Acetylation	-
Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.
228	K	ubiquitylation	-
Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex.
228	K	ubiquitylation	-
Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.
233	K	Acetylation	-
Acetylated at Lys-233 by p300/EP300.
233	K	Acetylation	-
Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex.
233	K	Acetylation	-
Deacetylated at Lys-228 and Lys-233 by SIRT1.
233	K	Acetylation	-
Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.
233	K	ubiquitylation	-
Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex.
233	K	ubiquitylation	-
Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHX9_HUMAN	DHX9	physical	15084609
ANM1_HUMAN	PRMT1	physical	12737817
SPT5H_HUMAN	SUPT5H	physical	12718890
ILF3_HUMAN	ILF3	physical	10749851
KHDR1_HUMAN	KHDRBS1	physical	12529443
BTG1_HUMAN	BTG1	physical	8663146
BTG2_HUMAN	BTG2	physical	8663146
ROA1_HUMAN	HNRNPA1	physical	8663146
NCOA3_HUMAN	NCOA3	physical	11050077
NCOA2_HUMAN	NCOA2	physical	11050077
NCOA1_HUMAN	NCOA1	physical	11050077
ESR1_HUMAN	ESR1	physical	11050077
THB_HUMAN	THRB	physical	11050077
ANDR_HUMAN	AR	physical	11050077
CARM1_HUMAN	CARM1	genetic	11050077
HNRPR_HUMAN	HNRNPR	physical	12183049
HNRPK_HUMAN	HNRNPK	physical	12183049
ZBT14_HUMAN	ZBTB14	physical	12183049
HNRPQ_HUMAN	SYNCRIP	physical	12183049
CAPR1_HUMAN	CAPRIN1	physical	12183049
RBP56_HUMAN	TAF15	physical	12183049
FUS_HUMAN	FUS	physical	12183049
HNRPU_HUMAN	HNRNPU	physical	11850402
CIRBP_HUMAN	CIRBP	physical	11850402
ILF3_HUMAN	ILF3	physical	11850402
FUS_HUMAN	FUS	physical	11850402
IGS21_HUMAN	IGSF21	physical	16169070
MED31_HUMAN	MED31	physical	16169070
ANM1_HUMAN	PRMT1	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
HNRL1_HUMAN	HNRNPUL1	physical	11513728
TERF1_HUMAN	TERF1	physical	19596784
TERF2_HUMAN	TERF2	physical	19596784
KHDR1_HUMAN	KHDRBS1	physical	19596784
NRIP1_HUMAN	NRIP1	physical	17053781
HNF4A_HUMAN	HNF4A	physical	17052457
BTG2_HUMAN	BTG2	physical	16782888
IF4A1_HUMAN	EIF4A1	physical	18700728
TYY1_HUMAN	YY1	physical	12704081
FBRL_HUMAN	FBL	physical	16157300
STA5A_HUMAN	STAT5A	physical	18413343
TF65_HUMAN	RELA	physical	18280497
PARP1_HUMAN	PARP1	physical	18280497
ANM1_HUMAN	PRMT1	physical	17426288
GRIP1_HUMAN	GRIP1	physical	17426288
KHDR1_HUMAN	KHDRBS1	physical	17891136
SH3G1_HUMAN	SH3GL1	physical	17891136
KHDR1_HUMAN	KHDRBS1	physical	17264152
ROA1_HUMAN	HNRNPA1	physical	17264152
BRCA1_HUMAN	BRCA1	physical	20614009
ASH2L_HUMAN	ASH2L	physical	21285357
AXIN1_HUMAN	AXIN1	physical	21242974
RUNX1_HUMAN	RUNX1	physical	22498736
H31_HUMAN	HIST1H3A	physical	22451921
ORF73_HHV8P	HHV8GK18_gp81	physical	22179613
STAT1_HUMAN	STAT1	physical	11257227
NOP53_HUMAN	GLTSCR2	physical	22939629
ROA1_HUMAN	HNRNPA1	physical	19101556
FGF2_HUMAN	FGF2	physical	10652299
RN187_HUMAN	RNF187	physical	23624934
ANM1_HUMAN	PRMT1	physical	23455924
ANM8_HUMAN	PRMT8	physical	23455924
ACLY_HUMAN	ACLY	physical	22863883
CSN7B_HUMAN	COPS7B	physical	22863883
NUCL_HUMAN	NCL	physical	22863883
DGCR8_HUMAN	DGCR8	physical	24778252
ANM1_HUMAN	PRMT1	physical	25416956
HNRPR_HUMAN	HNRNPR	physical	25416956
SPEG_HUMAN	SPEG	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
ANM8_HUMAN	PRMT8	physical	25416956
GAR1_HUMAN	GAR1	physical	26344197
NSUN5_HUMAN	NSUN5	physical	26344197
CHTOP_HUMAN	CHTOP	physical	25284789
UBP2L_HUMAN	UBAP2L	physical	26381755
RBM15_HUMAN	RBM15	physical	26575292
SMUF2_HUMAN	SMURF2	physical	26126536
VIME_HUMAN	VIM	physical	27173435

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANM1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-299, AND MASSSPECTROMETRY.	18083107 [Abstract]

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