| UniProt ID | IGS21_HUMAN | |
|---|---|---|
| UniProt AC | Q96ID5 | |
| Protein Name | Immunoglobulin superfamily member 21 {ECO:0000305} | |
| Gene Name | IGSF21 {ECO:0000244|HGNC:HGNC:28246} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 467 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Lipid-anchor, GPI-anchor . |
|
| Protein Description | Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.. | |
| Protein Sequence | MRTAPSLRRCVCLLLAAILDLARGYLTVNIEPLPPVVAGDAVTLKCNFKTDGRMREIVWYRVTDGGTIKQKIFTFDAMFSTNYSHMENYRKREDLVYQSTVRLPEVRISDNGPYECHVGIYDRATREKVVLASGNIFLNVMAPPTSIEVVAADTPAPFSRYQAQNFTLVCIVSGGKPAPMVYFKRDGEPIDAVPLSEPPAASSGPLQDSRPFRSLLHRDLDDTKMQKSLSLLDAENRGGRPYTERPSRGLTPDPNILLQPTTENIPETVVSREFPRWVHSAEPTYFLRHSRTPSSDGTVEVRALLTWTLNPQIDNEALFSCEVKHPALSMPMQAEVTLVAPKGPKIVMTPSRARVGDTVRILVHGFQNEVFPEPMFTWTRVGSRLLDGSAEFDGKELVLERVPAELNGSMYRCTAQNPLGSTDTHTRLIVFENPNIPRGTEDSNGSIGPTGARLTLVLALTVILELT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MRTAPSLRRC -----CCCCHHHHHH | 41.44 | 23532336 | |
| 6 | Phosphorylation | --MRTAPSLRRCVCL --CCCCHHHHHHHHH | 31.85 | 20873877 | |
| 82 | N-linked_Glycosylation | FDAMFSTNYSHMENY EEHHHCCCCHHHHHH | 34.80 | UniProtKB CARBOHYD | |
| 165 | N-linked_Glycosylation | FSRYQAQNFTLVCIV CHHHCCCCEEEEEEE | 34.58 | UniProtKB CARBOHYD | |
| 209 | Phosphorylation | SSGPLQDSRPFRSLL CCCCCCCCCCHHHHH | 28.97 | 24719451 | |
| 280 | Phosphorylation | EFPRWVHSAEPTYFL CCCCCCCCCCCEEEE | 25.38 | 24719451 | |
| 389 | Phosphorylation | GSRLLDGSAEFDGKE CCEECCCCCEECCEE | 25.05 | 25159151 | |
| 407 | N-linked_Glycosylation | ERVPAELNGSMYRCT EECCHHHCCCEEEEE | 31.81 | UniProtKB CARBOHYD | |
| 443 | Phosphorylation | IPRGTEDSNGSIGPT CCCCCCCCCCCCCCH | 36.54 | 28787133 | |
| 444 | N-linked_Glycosylation | PRGTEDSNGSIGPTG CCCCCCCCCCCCCHH | 61.63 | UniProtKB CARBOHYD | |
| 446 | Phosphorylation | GTEDSNGSIGPTGAR CCCCCCCCCCCHHHH | 28.73 | 28787133 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IGS21_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IGS21_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IGS21_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IGS21_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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