NTAQ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTAQ1_HUMAN
• UniProt AC: Q96HA8
• Protein Name: Protein N-terminal glutamine amidohydrolase
• Gene Name: WDYHV1
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm, cytosol . Nucleus .
• Protein Description: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine..
• Protein Sequence: MEGNGPAAVHYQPASPPRDACVYSSCYCEENIWKLCEYIKNHDQYPLEECYAVFISNERKMIPIWKQQARPGDGPVIWDYHVVLLHVSSGGQNFIYDLDTVLPFPCLFDTYVEDAFKSDDDIHPQFRRKFRVIRADSYLKNFASDRSHMKDSSGNWREPPPPYPCIETGDSKMNLNDFISMDPKVGWGAVYTLSEFTHRFGSKNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	NGPAAVHYQPASPPR CCCCCCCCCCCCCCC	15.03	27642862
15	Phosphorylation	AVHYQPASPPRDACV CCCCCCCCCCCCEEE	41.96	25159151
60	Ubiquitination	VFISNERKMIPIWKQ EEECCCCCEEEEEHH	34.70	21890473
80	Ubiquitination	DGPVIWDYHVVLLHV CCCEECEEEEEEEEE	4.98	-
140	Ubiquitination	IRADSYLKNFASDRS EECHHHHHHHHHCCC	41.61	-
150	Ubiquitination	ASDRSHMKDSSGNWR HHCCCCCCCCCCCCC	49.38	-
168	Phosphorylation	PPYPCIETGDSKMNL CCCCCCCCCCCCCCH	26.78	-
171	Phosphorylation	PCIETGDSKMNLNDF CCCCCCCCCCCHHHH	34.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTAQ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTAQ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTAQ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCTP1_HUMAN	DCTPP1	physical	16189514
PCH2_HUMAN	TRIP13	physical	19060904
PLAK_HUMAN	JUP	physical	19060904
DHB14_HUMAN	HSD17B14	physical	19060904
NDKA_HUMAN	NME1	physical	19060904
PRAF1_HUMAN	RABAC1	physical	19060904
HPRT_HUMAN	HPRT1	physical	19060904
PTPS_HUMAN	PTS	physical	19060904
THAP1_HUMAN	THAP1	physical	25416956
VAC14_HUMAN	VAC14	physical	25416956
SEPT3_HUMAN	SEPT3	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
NCOA5_HUMAN	NCOA5	physical	25416956
KLH12_HUMAN	KLHL12	physical	25416956
COAC_HUMAN	PPCDC	physical	25416956
CA050_HUMAN	C1orf50	physical	25416956
C102B_HUMAN	CCDC102B	physical	25416956
NPL_HUMAN	NPL	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
5NT1A_HUMAN	NT5C1A	physical	25416956
ZN341_HUMAN	ZNF341	physical	25416956
KRA94_HUMAN	KRTAP9-4	physical	25416956
KRA42_HUMAN	KRTAP4-2	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
PNMA5_HUMAN	PNMA5	physical	25416956
EDAD_HUMAN	EDARADD	physical	25416956
AMOT_HUMAN	AMOT	physical	25416956
MARHA_HUMAN	MARCH10	physical	25416956
NUD14_HUMAN	NUDT14	physical	25416956
KCTD1_HUMAN	KCTD1	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
CC184_HUMAN	CCDC184	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
TM239_HUMAN	TMEM239	physical	25416956
THAP1_HUMAN	THAP1	physical	21516116
RAD54_HUMAN	RAD54L	physical	28514442
ARFG3_HUMAN	ARFGAP3	physical	28514442
SBNO1_HUMAN	SBNO1	physical	28514442
TRI33_HUMAN	TRIM33	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
ERN1_HUMAN	ERN1	physical	28514442
SHB_HUMAN	SHB	physical	28514442
NF2IP_HUMAN	NFATC2IP	physical	28514442
INP4A_HUMAN	INPP4A	physical	28514442
MTG2_HUMAN	MTG2	physical	28514442
ZN639_HUMAN	ZNF639	physical	28514442
KS6A3_HUMAN	RPS6KA3	physical	28514442
PADC1_HUMAN	PRADC1	physical	28514442
TIF1A_HUMAN	TRIM24	physical	28514442
ZHX3_HUMAN	ZHX3	physical	28514442
LPP_HUMAN	LPP	physical	28514442
TRAF2_HUMAN	TRAF2	physical	28514442
ZBTB2_HUMAN	ZBTB2	physical	28514442
ARHG8_HUMAN	NET1	physical	28514442
TRM1_HUMAN	TRMT1	physical	28514442
SIX4_HUMAN	SIX4	physical	28514442
IF4G3_HUMAN	EIF4G3	physical	28514442
ASPH_HUMAN	ASPH	physical	28514442
NDC80_HUMAN	NDC80	physical	28514442
CEP85_HUMAN	CEP85	physical	28514442
CRTC2_HUMAN	CRTC2	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
HMGCL_HUMAN	HMGCL	physical	28514442
HTRA2_HUMAN	HTRA2	physical	28514442
KIF2C_HUMAN	KIF2C	physical	28514442
R3HD1_HUMAN	R3HDM1	physical	28514442
GNPTG_HUMAN	GNPTG	physical	28514442
DMXL2_HUMAN	DMXL2	physical	28514442
F122B_HUMAN	FAM122B	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
NUP53_HUMAN	NUP35	physical	28514442
MTMR4_HUMAN	MTMR4	physical	28514442
ALR_HUMAN	GFER	physical	28514442
QRIC1_HUMAN	QRICH1	physical	28514442
PINX1_HUMAN	PINX1	physical	28514442
RIOK1_HUMAN	RIOK1	physical	28514442
INP5K_HUMAN	INPP5K	physical	28514442
NUF2_HUMAN	NUF2	physical	28514442
PCCA_HUMAN	PCCA	physical	28514442
AXIN1_HUMAN	AXIN1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.