ZN639_HUMAN - dbPTM
ZN639_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN639_HUMAN
UniProt AC Q9UID6
Protein Name Zinc finger protein 639
Gene Name ZNF639
Organism Homo sapiens (Human).
Sequence Length 485
Subcellular Localization Nucleus .
Protein Description Binds DNA and may function as a transcriptional repressor..
Protein Sequence MNEYPKKRKRKTLHPSRYSDSSGISRIADGFNGIFSDHCYSVCSMRQPDLKYFDNKDDDSDTETSNDLPKFADGIKARNRNQNYLVPSPVLRILDHTAFSTEKSADIVICDEECDSPESVNQQTQEESPIEVHTAEDVPIAVEVHAISEDYDIETENNSSESLQDQTDEEPPAKLCKILDKSQALNVTAQQKWPLLRANSSGLYKCELCEFNSKYFSDLKQHMILKHKRTDSNVCRVCKESFSTNMLLIEHAKLHEEDPYICKYCDYKTVIFENLSQHIADTHFSDHLYWCEQCDVQFSSSSELYLHFQEHSCDEQYLCQFCEHETNDPEDLHSHVVNEHACKLIELSDKYNNGEHGQYSLLSKITFDKCKNFFVCQVCGFRSRLHTNVNRHVAIEHTKIFPHVCDDCGKGFSSMLEYCKHLNSHLSEGIYLCQYCEYSTGQIEDLKIHLDFKHSADLPHKCSDCLMRFGNERELISHLPVHETT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MNEYPKKRKRK
----CCCCCCCCCCC		18.4917287340
6Ubiquitination--MNEYPKKRKRKTL
--CCCCCCCCCCCCC		65.3924816145
16PhosphorylationKRKTLHPSRYSDSSG
CCCCCCHHHCCCCCC		32.8624719451
17MethylationRKTLHPSRYSDSSGI
CCCCCHHHCCCCCCC		39.15115920577
18PhosphorylationKTLHPSRYSDSSGIS
CCCCHHHCCCCCCCC		22.5929978859
19PhosphorylationTLHPSRYSDSSGISR
CCCHHHCCCCCCCCH		29.8821815630
21PhosphorylationHPSRYSDSSGISRIA
CHHHCCCCCCCCHHH		25.2323186163
22PhosphorylationPSRYSDSSGISRIAD
HHHCCCCCCCCHHHC		45.1723186163
25PhosphorylationYSDSSGISRIADGFN
CCCCCCCCHHHCCCC		22.5923186163
52PhosphorylationMRQPDLKYFDNKDDD
CCCCCCCCCCCCCCC		24.3823403867
60PhosphorylationFDNKDDDSDTETSND
CCCCCCCCCCCCCCC		54.1229255136
62PhosphorylationNKDDDSDTETSNDLP
CCCCCCCCCCCCCCH		45.1530266825
64PhosphorylationDDDSDTETSNDLPKF
CCCCCCCCCCCCHHH		34.6230266825
65PhosphorylationDDSDTETSNDLPKFA
CCCCCCCCCCCHHHH		23.3230266825
76SumoylationPKFADGIKARNRNQN
HHHHHHHHCCCCCCC		46.9928112733
76UbiquitinationPKFADGIKARNRNQN
HHHHHHHHCCCCCCC		46.9929967540
76SumoylationPKFADGIKARNRNQN
HHHHHHHHCCCCCCC		46.99-
84PhosphorylationARNRNQNYLVPSPVL
CCCCCCCCCCCCCHH		10.1826074081
88PhosphorylationNQNYLVPSPVLRILD
CCCCCCCCCHHHHCC		21.8419664994
100PhosphorylationILDHTAFSTEKSADI
HCCCCCCCCCCCCCE		32.9426846344
101PhosphorylationLDHTAFSTEKSADIV
CCCCCCCCCCCCCEE		40.7626846344
167PhosphorylationSESLQDQTDEEPPAK
CCCHHCCCCCCCCHH		54.3826074081
177SumoylationEPPAKLCKILDKSQA
CCCHHHHHHHCHHHH		57.6628112733
181SumoylationKLCKILDKSQALNVT
HHHHHHCHHHHCCCH		40.8128112733
181UbiquitinationKLCKILDKSQALNVT
HHHHHHCHHHHCCCH		40.8129967540
181SumoylationKLCKILDKSQALNVT
HHHHHHCHHHHCCCH		40.81-
182PhosphorylationLCKILDKSQALNVTA
HHHHHCHHHHCCCHH		21.9825159151
200PhosphorylationWPLLRANSSGLYKCE
CCCEECCCCCCEEEE		25.4625159151
201PhosphorylationPLLRANSSGLYKCEL
CCEECCCCCCEEEEE		32.4028450419
204PhosphorylationRANSSGLYKCELCEF
ECCCCCCEEEEECCC		19.6723312004
226SumoylationLKQHMILKHKRTDSN
HHHHHHHHCCCCCCC		35.8328112733
226SumoylationLKQHMILKHKRTDSN
HHHHHHHHCCCCCCC		35.83-
263UbiquitinationEEDPYICKYCDYKTV
CCCCCHHHHCCCEEE		39.0822817900
268UbiquitinationICKYCDYKTVIFENL
HHHHCCCEEEEEECH		24.0622817900
350UbiquitinationKLIELSDKYNNGEHG
HEEECHHHHCCCCCC		46.6429967540
360PhosphorylationNGEHGQYSLLSKITF
CCCCCCEEHHHEECH		18.2324719451
369UbiquitinationLSKITFDKCKNFFVC
HHEECHHHCCCEEEE		42.8129967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN639_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN639_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN639_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN639_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN639_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, AND MASSSPECTROMETRY.
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4, AND MASSSPECTROMETRY.

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