ZBT8A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT8A_HUMAN
• UniProt AC: Q96BR9
• Protein Name: Zinc finger and BTB domain-containing protein 8A
• Gene Name: ZBTB8A
• Organism: Homo sapiens (Human).
• Sequence Length: 441
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEISSHQSHLLQQLNEQRRQDVFCDCSILVEGKVFKAHRNVLFASSGYFKMLLSQNSKETSQPTTATFQAFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAASFLQMTDVISVCKTFIKSSLDISEKEKDRYFSLSDKDANSNGVERSSFYSGGWQEGSSSPRSHLSPEQGTGIISGKSWNKYNYHPASQKNTQQPLAKHEPRKESIKKTKHLRLSQPSEVTHYKSSKREVRTSDSSSHVSQSEEQAQIDAEMDSTPVGYQYGQGSDVTSKSFPDDLPRMRFKCPYCTHVVKRKADLKRHLRCHTGERPYPCQACGKRFSRLDHLSSHFRTIHQACKLICRKCKRHVTDLTGQVVQEGTRRYRLCNECLAEFGIDSLPIDLEAEQHLMSPSDGDKDSRWHLSEDENRSYVEIVEDGSGDLVIQQVDDSEEEEEKEIKPNIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	QDVFCDCSILVEGKV HHCCCCCEEEECCCE	13.00	-
84	Phosphorylation	TVILDFVYSGKLSLT EEEEEEHHHCCCCCC	16.23	-
89	Phosphorylation	FVYSGKLSLTGQNVI EHHHCCCCCCCCCHH	27.63	22210691
108	Phosphorylation	AASFLQMTDVISVCK HHHHHHHHHHHHHHH	17.72	22210691
112	Phosphorylation	LQMTDVISVCKTFIK HHHHHHHHHHHHHHH	22.70	22210691
119	Sumoylation	SVCKTFIKSSLDISE HHHHHHHHHCCCCCH	29.78	-
119	Sumoylation	SVCKTFIKSSLDISE HHHHHHHHHCCCCCH	29.78	-
138	Ubiquitination	RYFSLSDKDANSNGV CCEECCCCCCCCCCC	56.20	-
148	Phosphorylation	NSNGVERSSFYSGGW CCCCCCCCCCCCCCC	15.99	26074081
149	Phosphorylation	SNGVERSSFYSGGWQ CCCCCCCCCCCCCCC	34.13	26074081
151	Phosphorylation	GVERSSFYSGGWQEG CCCCCCCCCCCCCCC	14.35	26074081
152	Phosphorylation	VERSSFYSGGWQEGS CCCCCCCCCCCCCCC	28.90	26074081
159	Phosphorylation	SGGWQEGSSSPRSHL CCCCCCCCCCCCCCC	27.22	23401153
160	Phosphorylation	GGWQEGSSSPRSHLS CCCCCCCCCCCCCCC	56.04	23927012
161	Phosphorylation	GWQEGSSSPRSHLSP CCCCCCCCCCCCCCC	26.48	23927012
164	Phosphorylation	EGSSSPRSHLSPEQG CCCCCCCCCCCCCCC	31.97	30266825
167	Phosphorylation	SSPRSHLSPEQGTGI CCCCCCCCCCCCCCC	22.44	30266825
178	Sumoylation	GTGIISGKSWNKYNY CCCCCCCCCCCCCCC	45.57	28112733
178	Ubiquitination	GTGIISGKSWNKYNY CCCCCCCCCCCCCCC	45.57	-
178	Sumoylation	GTGIISGKSWNKYNY CCCCCCCCCCCCCCC	45.57	-
182	Sumoylation	ISGKSWNKYNYHPAS CCCCCCCCCCCCCCC	28.72	28112733
182	Sumoylation	ISGKSWNKYNYHPAS CCCCCCCCCCCCCCC	28.72	-
185	Phosphorylation	KSWNKYNYHPASQKN CCCCCCCCCCCCCCC	13.19	27642862
191	Sumoylation	NYHPASQKNTQQPLA CCCCCCCCCCCCCHH	60.51	28112733
191	Ubiquitination	NYHPASQKNTQQPLA CCCCCCCCCCCCCHH	60.51	-
199	Sumoylation	NTQQPLAKHEPRKES CCCCCHHHCCCCHHH	57.07	28112733
199	Sumoylation	NTQQPLAKHEPRKES CCCCCHHHCCCCHHH	57.07	-
216	Phosphorylation	KTKHLRLSQPSEVTH CCCCCCCCCCHHCCC	33.34	28555341
298	Methylation	VKRKADLKRHLRCHT HHCHHHHHHHHCCCC	38.02	-
298	Trimethylation	VKRKADLKRHLRCHT HHCHHHHHHHHCCCC	38.02	-
348	Phosphorylation	RKCKRHVTDLTGQVV HHHHHHHCCCCCCHH	21.11	-
351	Phosphorylation	KRHVTDLTGQVVQEG HHHHCCCCCCHHHCC	28.51	-
359	Phosphorylation	GQVVQEGTRRYRLCN CCHHHCCCHHHHHHH	15.95	-
389	Phosphorylation	EAEQHLMSPSDGDKD HHHHHHCCCCCCCCC	27.84	26074081
391	Phosphorylation	EQHLMSPSDGDKDSR HHHHCCCCCCCCCCC	47.09	18669648
397	Phosphorylation	PSDGDKDSRWHLSED CCCCCCCCCCCCCCC	42.90	26074081
402	Phosphorylation	KDSRWHLSEDENRSY CCCCCCCCCCCCCCC	30.07	30266825
437	Sumoylation	EEEEKEIKPNIR--- HHHHHHCCCCCC---	32.86	25218447
437	Sumoylation	EEEEKEIKPNIR--- HHHHHHCCCCCC---	32.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	LNX1	Q8TBB1	PMID:19668196

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT8A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT8A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT8A_HUMAN	ZBTB8A	physical	16189514
P53_HUMAN	TP53	physical	23329847
EP300_HUMAN	EP300	physical	23329847
ZBT8A_HUMAN	ZBTB8A	physical	25416956
RL9_HUMAN	RPL9	physical	21516116
PRPF3_HUMAN	PRPF3	physical	21516116
ZN276_HUMAN	ZNF276	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, AND MASSSPECTROMETRY.
PubMed: 18669648