ZN276_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN276_HUMAN
• UniProt AC: Q8N554
• Protein Name: Zinc finger protein 276
• Gene Name: ZNF276
• Organism: Homo sapiens (Human).
• Sequence Length: 614
• Subcellular Localization: Nucleus . Chromosome, centromere, kinetochore .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MKRDRLGRFLSPGSSRQCGASDGGGGVSRTRGRPSLSGGPRVDGATARRAWGPVGSCGDAGEDGADEAGAGRALAMGHCRLCHGKFSSRSLRSISERAPGASMERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNASPAGRRKPCAKVGAQPPTGAEEGACLVDLITSSPQCLHGLVGWVHGHAASCGALPHLQRTLSSEYCGVIQVVWGCDQGHDYTMDTSSSCKAFLLDSALAVKWPWDKETAPRLPQHRGWNPGDAPQTSQGRGTGTPVGAETKTLPSTDVAQPPSDSDAVGPRSGFPPQPSLPLCRAPGQLGEKQLPSSTSDDRVKDEFSDLSEGDVLSEDENDKKQNAQSSDESFEPYPERKVSGKKSESKEAKKSEEPRIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQDKALPLEAEPPPGPPSPSVTTEGQAVKPEPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	DRLGRFLSPGSSRQC CCCCCCCCCCCCCCC	25.22	23186163
21	Phosphorylation	SSRQCGASDGGGGVS CCCCCCCCCCCCCCC	23.28	-
28	Phosphorylation	SDGGGGVSRTRGRPS CCCCCCCCCCCCCCC	31.07	-
35	Phosphorylation	SRTRGRPSLSGGPRV CCCCCCCCCCCCCCC	33.53	24719451
90	Phosphorylation	HGKFSSRSLRSISER CCCCCCCHHHHHHHC	30.04	22210691
93	Phosphorylation	FSSRSLRSISERAPG CCCCHHHHHHHCCCC	35.44	22210691
148	Phosphorylation	AQFYQCHSLLKSFLQ HHHHHHHHHHHHHHH	42.92	24719451
160	Phosphorylation	FLQRVNASPAGRRKP HHHHHCCCCCCCCCC	15.30	28985074
219	Phosphorylation	ALPHLQRTLSSEYCG HHHHHHHHHCHHCCC	20.31	-
224	Phosphorylation	QRTLSSEYCGVIQVV HHHHCHHCCCEEEEE	9.10	-
291	Phosphorylation	QTSQGRGTGTPVGAE CCCCCCCCCCCCCCC	36.20	-
293	Phosphorylation	SQGRGTGTPVGAETK CCCCCCCCCCCCCCC	18.03	28985074
304	Phosphorylation	AETKTLPSTDVAQPP CCCCCCCCCCCCCCC	40.11	-
312	Phosphorylation	TDVAQPPSDSDAVGP CCCCCCCCCCCCCCC	57.33	28348404
341	Acetylation	APGQLGEKQLPSSTS CCCCCCCCCCCCCCC	56.17	23236377
341	Ubiquitination	APGQLGEKQLPSSTS CCCCCCCCCCCCCCC	56.17	-
357	Phosphorylation	DRVKDEFSDLSEGDV HHHHHHHCCCCCCCC	35.28	25850435
360	Phosphorylation	KDEFSDLSEGDVLSE HHHHCCCCCCCCCCC	44.52	25159151
366	Phosphorylation	LSEGDVLSEDENDKK CCCCCCCCCCCCHHH	42.73	25159151
378	Phosphorylation	DKKQNAQSSDESFEP HHHHHCCCCCCCCCC	37.03	25159151
379	Phosphorylation	KKQNAQSSDESFEPY HHHHCCCCCCCCCCC	33.06	25159151
382	Phosphorylation	NAQSSDESFEPYPER HCCCCCCCCCCCCCC	39.64	23663014
386	Phosphorylation	SDESFEPYPERKVSG CCCCCCCCCCCCCCC	15.55	28450419
519	Phosphorylation	LVHQMRHSGAKPLQC HHHHHCCCCCCCEEE	30.04	21712546
522	Acetylation	QMRHSGAKPLQCEVC HHCCCCCCCEEEEEC	50.19	26051181
541	Phosphorylation	RQRASLKYHMTKHKA HHHHHHHHHHHCCCC	11.34	29116813
550	Phosphorylation	MTKHKAETELDFACD HHCCCCHHHHHHHHH	46.86	-
599	Phosphorylation	EPPPGPPSPSVTTEG CCCCCCCCCCCCCCC	32.70	29255136
601	Phosphorylation	PPGPPSPSVTTEGQA CCCCCCCCCCCCCCC	36.11	29255136
603	Phosphorylation	GPPSPSVTTEGQAVK CCCCCCCCCCCCCCC	24.38	29255136
604	Phosphorylation	PPSPSVTTEGQAVKP CCCCCCCCCCCCCCC	35.64	29255136
614	Phosphorylation	QAVKPEPT------- CCCCCCCC-------	49.97	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN276_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN276_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN276_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT8A_HUMAN	ZBTB8A	physical	16189514
ZBT8A_HUMAN	ZBTB8A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90 AND SER-93, AND MASSSPECTROMETRY.
PubMed: 18187866