dbPTM

RL9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL9_HUMAN
UniProt AC	P32969
Protein Name	60S ribosomal protein L9
Gene Name	RPL9
Organism	Homo sapiens (Human).
Sequence Length	192
Subcellular Localization
Protein Description
Protein Sequence	MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKTILSNQT ------CCEECCCCC	44.25	21906983
2	Sumoylation	------MKTILSNQT ------CCEECCCCC	44.25	-
3	Phosphorylation	-----MKTILSNQTV -----CCEECCCCCC	26.33	30622161
6	Phosphorylation	--MKTILSNQTVDIP --CCEECCCCCCCCC	24.04	21712546
9	Phosphorylation	KTILSNQTVDIPENV CEECCCCCCCCCCCE	25.13	21712546
21	Ubiquitination	ENVDITLKGRTVIVK CCEEEEECCCEEEEE	37.38	21890473
21	2-Hydroxyisobutyrylation	ENVDITLKGRTVIVK CCEEEEECCCEEEEE	37.38	-
21	Acetylation	ENVDITLKGRTVIVK CCEEEEECCCEEEEE	37.38	23236377
28	Ubiquitination	KGRTVIVKGPRGTLR CCCEEEEECCCCCCC	52.66	-
28	2-Hydroxyisobutyrylation	KGRTVIVKGPRGTLR CCCEEEEECCCCCCC	52.66	-
28	Acetylation	KGRTVIVKGPRGTLR CCCEEEEECCCCCCC	52.66	25953088
33	Phosphorylation	IVKGPRGTLRRDFNH EEECCCCCCCCCCCC	20.55	-
36	Methylation	GPRGTLRRDFNHINV CCCCCCCCCCCCEEE	56.86	115492331
50	Ubiquitination	VELSLLGKKKKRLRV EEEHHCCCCCCCEEE	62.48	21906983
50	Acetylation	VELSLLGKKKKRLRV EEEHHCCCCCCCEEE	62.48	25953088
51	Ubiquitination	ELSLLGKKKKRLRVD EEHHCCCCCCCEEEC	62.82	-
52	Ubiquitination	LSLLGKKKKRLRVDK EHHCCCCCCCEEECC	46.76	-
59	Ubiquitination	KKRLRVDKWWGNRKE CCCEEECCCCCCHHH	41.82	-
59	Acetylation	KKRLRVDKWWGNRKE CCCEEECCCCCCHHH	41.82	25825284
65	Acetylation	DKWWGNRKELATVRT CCCCCCHHHHHHHHH	62.17	26051181
65	2-Hydroxyisobutyrylation	DKWWGNRKELATVRT CCCCCCHHHHHHHHH	62.17	-
65	Ubiquitination	DKWWGNRKELATVRT CCCCCCHHHHHHHHH	62.17	21906983
74	Glutathionylation	LATVRTICSHVQNMI HHHHHHHHHHHHHHH	1.97	22555962
80	Sulfoxidation	ICSHVQNMIKGVTLG HHHHHHHHHHCCCEE	1.55	30846556
82	Ubiquitination	SHVQNMIKGVTLGFR HHHHHHHHCCCEECE	36.24	-
82	Acetylation	SHVQNMIKGVTLGFR HHHHHHHHCCCEECE	36.24	26051181
96	Phosphorylation	RYKMRSVYAHFPINV EEEEEEEEEECCEEE	8.80	-
121	Acetylation	IRNFLGEKYIRRVRM EEHHCCHHHHHHHCC	44.15	19608861
121	Ubiquitination	IRNFLGEKYIRRVRM EEHHCCHHHHHHHCC	44.15	21890473
121	Malonylation	IRNFLGEKYIRRVRM EEHHCCHHHHHHHCC	44.15	26320211
121	2-Hydroxyisobutyrylation	IRNFLGEKYIRRVRM EEHHCCHHHHHHHCC	44.15	-
122	Phosphorylation	RNFLGEKYIRRVRMR EHHCCHHHHHHHCCC	8.71	28152594
129	Methylation	YIRRVRMRPGVACSV HHHHHCCCCCCCCCC	17.79	115492323
135	Phosphorylation	MRPGVACSVSQAQKD CCCCCCCCCCHHHCC	18.31	26126808
168	Ubiquitination	IQQATTVKNKDIRKF HHHCHHCCCHHHHHH	57.07	21906983
168	2-Hydroxyisobutyrylation	IQQATTVKNKDIRKF HHHCHHCCCHHHHHH	57.07	-
170	Ubiquitination	QATTVKNKDIRKFLD HCHHCCCHHHHHHHC	49.14	-
174	2-Hydroxyisobutyrylation	VKNKDIRKFLDGIYV CCCHHHHHHHCEEEE	51.08	-
174	Sumoylation	VKNKDIRKFLDGIYV CCCHHHHHHHCEEEE	51.08	-
174	Ubiquitination	VKNKDIRKFLDGIYV CCCHHHHHHHCEEEE	51.08	21890473
174	Acetylation	VKNKDIRKFLDGIYV CCCHHHHHHHCEEEE	51.08	25953088
180	Phosphorylation	RKFLDGIYVSEKGTV HHHHCEEEECCCCCC	11.94	28152594
180	Nitration	RKFLDGIYVSEKGTV HHHHCEEEECCCCCC	11.94	-
182	Phosphorylation	FLDGIYVSEKGTVQQ HHCEEEECCCCCCEE	19.33	28152594
184	Acetylation	DGIYVSEKGTVQQAD CEEEECCCCCCEECC	52.99	26051181
184	Sumoylation	DGIYVSEKGTVQQAD CEEEECCCCCCEECC	52.99	-
184	Ubiquitination	DGIYVSEKGTVQQAD CEEEECCCCCCEECC	52.99	21906983
186	Phosphorylation	IYVSEKGTVQQADE- EEECCCCCCEECCC-	26.64	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RL9_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRBS2_HUMAN	SORBS2	physical	16169070
RS3_HUMAN	RPS3	physical	16169070
RS3_HUMAN	RPS3	physical	22939629
RS10_HUMAN	RPS10	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS14_HUMAN	RPS14	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
RT10_HUMAN	MRPS10	physical	22939629
VASN_HUMAN	VASN	physical	22939629
THIOM_HUMAN	TXN2	physical	22939629
RT11_HUMAN	MRPS11	physical	22939629
TERA_HUMAN	VCP	physical	25416956
ZBT14_HUMAN	ZBTB14	physical	25416956
CACO2_HUMAN	CALCOCO2	physical	25416956
PNMA2_HUMAN	PNMA2	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
ZBT7B_HUMAN	ZBTB7B	physical	25416956
HOMEZ_HUMAN	HOMEZ	physical	25416956
KXDL1_HUMAN	KXD1	physical	25416956
HMBX1_HUMAN	HMBOX1	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956
TIFA_HUMAN	TIFA	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
CC184_HUMAN	CCDC184	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
SELB_HUMAN	EEFSEC	physical	26344197
IF6_HUMAN	EIF6	physical	26344197
RM16_HUMAN	MRPL16	physical	26344197
RM22_HUMAN	MRPL22	physical	26344197
RBM34_HUMAN	RBM34	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL39_HUMAN	RPL39	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS16_HUMAN	RPS16	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197
RRP7A_HUMAN	RRP7A	physical	26344197
DHYS_HUMAN	DHPS	physical	28514442
CEP76_HUMAN	CEP76	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL9_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-121, AND MASS SPECTROMETRY.	19608861 [Abstract]