SRBS2_HUMAN - dbPTM
SRBS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRBS2_HUMAN
UniProt AC O94875
Protein Name Sorbin and SH3 domain-containing protein 2
Gene Name SORBS2
Organism Homo sapiens (Human).
Sequence Length 1100
Subcellular Localization Cytoplasm, perinuclear region . Apical cell membrane . Cell junction, focal adhesion . Cell projection, lamellipodium . Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferential
Protein Description Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. [PubMed: 18559503 Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.]
Protein Sequence MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 10)Phosphorylation-43.8023663014
2 (in isoform 12)Phosphorylation-43.8028348404
2 (in isoform 9)Phosphorylation-43.8028348404
3 (in isoform 10)Phosphorylation-18.5723663014
3 (in isoform 11)Phosphorylation-18.5725627689
3 (in isoform 2)Phosphorylation-18.5722199227
3 (in isoform 4)Phosphorylation-18.5722199227
3 (in isoform 5)Phosphorylation-18.5722199227
4 (in isoform 6)Phosphorylation-13.8224043423
4 (in isoform 7)Phosphorylation-13.8224043423
5 (in isoform 11)Phosphorylation-38.0325159151
5 (in isoform 6)Phosphorylation-38.0326657352
5 (in isoform 7)Phosphorylation-38.0326657352
7 (in isoform 10)Phosphorylation-20.6723663014
7 (in isoform 2)Phosphorylation-20.6722199227
7 (in isoform 4)Phosphorylation-20.6722199227
7 (in isoform 5)Phosphorylation-20.6722199227
7 (in isoform 8)Phosphorylation-20.6723663014
9PhosphorylationSYYQRPFSPSAYSLP
CCCCCCCCCCHHCCC		22.1928348404
9 (in isoform 2)Phosphorylation-22.1922199227
9 (in isoform 4)Phosphorylation-22.1922199227
9 (in isoform 5)Phosphorylation-22.1922199227
9 (in isoform 6)Phosphorylation-22.1924043423
9 (in isoform 7)Phosphorylation-22.1924043423
9 (in isoform 8)Phosphorylation-22.1928355574
12 (in isoform 2)Phosphorylation-11.0026055452
12 (in isoform 4)Phosphorylation-11.0026055452
12 (in isoform 5)Phosphorylation-11.0026055452
12 (in isoform 8)Phosphorylation-11.0027732954
13PhosphorylationRPFSPSAYSLPASLN
CCCCCCHHCCCCHHC		18.31-
13 (in isoform 12)Phosphorylation-18.3126846344
13 (in isoform 9)Phosphorylation-18.3126846344
14 (in isoform 12)Phosphorylation-27.8225159151
14 (in isoform 9)Phosphorylation-27.8225159151
16 (in isoform 11)Phosphorylation-17.5428348404
16 (in isoform 8)Phosphorylation-17.5425159151
18 (in isoform 2)Phosphorylation-26.5827174698
18 (in isoform 4)Phosphorylation-26.5827174698
18 (in isoform 5)Phosphorylation-26.5827174698
20 (in isoform 11)Phosphorylation-31.0824275569
24 (in isoform 12)Phosphorylation-3.0523663014
24 (in isoform 9)Phosphorylation-3.0523663014
26 (in isoform 12)Phosphorylation-22.4428355574
26 (in isoform 9)Phosphorylation-22.4428355574
27 (in isoform 11)Phosphorylation-24.3326846344
28 (in isoform 11)Phosphorylation-10.5025159151
28 (in isoform 2)Phosphorylation-10.5028387310
28 (in isoform 4)Phosphorylation-10.5028387310
28 (in isoform 5)Phosphorylation-10.5028387310
29 (in isoform 12)Phosphorylation-24.8027174698
29 (in isoform 9)Phosphorylation-24.8027174698
30PhosphorylationIVMQHGTSLDSTDTY
CHHHCCCCCCCCCCC		34.47-
30 (in isoform 2)Phosphorylation-34.4727174698
30 (in isoform 4)Phosphorylation-34.4727174698
30 (in isoform 5)Phosphorylation-34.4727174698
31 (in isoform 8)Phosphorylation-6.3925159151
32 (in isoform 2)Phosphorylation-49.6227174698
32 (in isoform 4)Phosphorylation-49.6227174698
32 (in isoform 5)Phosphorylation-49.6227174698
33 (in isoform 12)Phosphorylation-33.2125159151
33 (in isoform 9)Phosphorylation-33.2125159151
35 (in isoform 2)Phosphorylation-48.4727174698
35 (in isoform 4)Phosphorylation-48.4727174698
35 (in isoform 5)Phosphorylation-48.4727174698
38 (in isoform 11)Phosphorylation-22.9023663014
40 (in isoform 11)Phosphorylation-22.6428355574
40 (in isoform 2)Phosphorylation-22.6427174698
40 (in isoform 4)Phosphorylation-22.6427174698
40 (in isoform 5)Phosphorylation-22.6427174698
41 (in isoform 8)Phosphorylation-8.7327174698
43PhosphorylationTYPQHAQSLDGTTSS
CCCCHHHHCCCCCCC		29.25-
43 (in isoform 11)Phosphorylation-29.2527174698
45 (in isoform 2)Phosphorylation-58.6027174698
45 (in isoform 4)Phosphorylation-58.6027174698
45 (in isoform 5)Phosphorylation-58.6027174698
47 (in isoform 11)Phosphorylation-24.1525159151
48 (in isoform 12)Phosphorylation-31.9425159151
48 (in isoform 2)Phosphorylation-31.9427174698
48 (in isoform 4)Phosphorylation-31.9427174698
48 (in isoform 5)Phosphorylation-31.9427174698
48 (in isoform 9)Phosphorylation-31.9425159151
49 (in isoform 2)Phosphorylation-23.1727174698
49 (in isoform 4)Phosphorylation-23.1727174698
49 (in isoform 5)Phosphorylation-23.1727174698
50 (in isoform 2)Phosphorylation-30.1427174698
50 (in isoform 4)Phosphorylation-30.1427174698
50 (in isoform 5)Phosphorylation-30.1427174698
51 (in isoform 8)Phosphorylation-28.1728387310
53 (in isoform 8)Phosphorylation-25.8627174698
55 (in isoform 8)Phosphorylation-11.7727174698
58 (in isoform 12)Phosphorylation-39.7727174698
58 (in isoform 8)Phosphorylation-39.7727174698
58 (in isoform 9)Phosphorylation-39.7727174698
59 (in isoform 2)Phosphorylation-72.00-
62 (in isoform 11)Phosphorylation-56.2925159151
63 (in isoform 8)Phosphorylation-32.3927174698
68AcetylationEKRVTVIKAPHYPGI
CCCEEEEECCCCCCC		52.0826051181
68 (in isoform 12)Phosphorylation-52.0828387310
68 (in isoform 8)Phosphorylation-52.0827174698
68 (in isoform 9)Phosphorylation-52.0828387310
69 (in isoform 10)Phosphorylation-5.74-
70 (in isoform 12)Phosphorylation-23.6527174698
70 (in isoform 9)Phosphorylation-23.6527174698
71 (in isoform 8)Phosphorylation-46.4027174698
72PhosphorylationTVIKAPHYPGIGPVD
EEEECCCCCCCCCCC		11.3329116813
72 (in isoform 11)Phosphorylation-11.3327174698
72 (in isoform 12)Phosphorylation-11.3327174698
72 (in isoform 8)Phosphorylation-11.3327174698
72 (in isoform 9)Phosphorylation-11.3327174698
73 (in isoform 8)Phosphorylation-25.5427174698
75 (in isoform 12)Phosphorylation-4.9427174698
75 (in isoform 9)Phosphorylation-4.9427174698
80 (in isoform 12)Phosphorylation-51.6127174698
80 (in isoform 9)Phosphorylation-51.6127174698
82 (in isoform 11)Phosphorylation-28.0428387310
84 (in isoform 11)Phosphorylation-21.2127174698
85PhosphorylationVDESGIPTAIRTTVD
CCCCCCCCEEEECCC		32.5629116813
85 (in isoform 12)Phosphorylation-32.5627174698
85 (in isoform 9)Phosphorylation-32.5627174698
86 (in isoform 10)Phosphorylation-5.50-
86 (in isoform 11)Phosphorylation-5.5027174698
88 (in isoform 10)Phosphorylation-23.1422985185
88 (in isoform 12)Phosphorylation-23.1427174698
88 (in isoform 9)Phosphorylation-23.1427174698
89 (in isoform 11)Phosphorylation-25.6727174698
89 (in isoform 12)Phosphorylation-25.6727174698
89 (in isoform 9)Phosphorylation-25.6727174698
90 (in isoform 12)Phosphorylation-15.5727174698
90 (in isoform 9)Phosphorylation-15.5727174698
94 (in isoform 11)Phosphorylation-34.2027174698
99 (in isoform 11)Phosphorylation-29.2927174698
102 (in isoform 11)Phosphorylation-6.7927174698
103 (in isoform 11)Phosphorylation-37.2027174698
104 (in isoform 11)Phosphorylation-21.3927174698
115PhosphorylationVHKPDDDTDMYNTPY
CCCCCCCCCCCCCCC		29.66-
118PhosphorylationPDDDTDMYNTPYTYN
CCCCCCCCCCCCCCC		20.77-
120PhosphorylationDDTDMYNTPYTYNAG
CCCCCCCCCCCCCCC		10.53-
122PhosphorylationTDMYNTPYTYNAGLY
CCCCCCCCCCCCCCC		21.59-
129PhosphorylationYTYNAGLYNPPYSAQ
CCCCCCCCCCCCCCC		25.38-
136 (in isoform 10)Phosphorylation-36.0124173317
143PhosphorylationQSHPAAKTQTYRPLS
CCCCCCCCCCCCCCC		22.7826437602
145PhosphorylationHPAAKTQTYRPLSKS
CCCCCCCCCCCCCCC		27.0828857561
146PhosphorylationPAAKTQTYRPLSKSH
CCCCCCCCCCCCCCC		10.6223312004
150PhosphorylationTQTYRPLSKSHSDNS
CCCCCCCCCCCCCCC		34.4928387310
151 (in isoform 10)Phosphorylation-60.93-
152PhosphorylationTYRPLSKSHSDNSPN
CCCCCCCCCCCCCCC		25.5025159151
153 (in isoform 6)Amidation-42.8011786189
154PhosphorylationRPLSKSHSDNSPNAF
CCCCCCCCCCCCCCC		45.6528355574
157PhosphorylationSKSHSDNSPNAFKDA
CCCCCCCCCCCCCCC		25.2323927012
157 (in isoform 10)Phosphorylation-25.23-
159 (in isoform 10)Phosphorylation-58.80-
160 (in isoform 10)Phosphorylation-19.0922210691
164 (in isoform 2)Phosphorylation-16.70-
165PhosphorylationPNAFKDASSPVPPPH
CCCCCCCCCCCCCCC		45.3625159151
166PhosphorylationNAFKDASSPVPPPHV
CCCCCCCCCCCCCCC		31.4725159151
175 (in isoform 2)Phosphorylation-41.24-
183 (in isoform 10)Phosphorylation-45.61-
186PhosphorylationPLRPRDRSSTEKHDW
CCCCCCCCCCCCCCC		45.9926657352
187PhosphorylationLRPRDRSSTEKHDWD
CCCCCCCCCCCCCCC		41.2928857561
188PhosphorylationRPRDRSSTEKHDWDP
CCCCCCCCCCCCCCC		50.7528857561
207PhosphorylationVDTRKFRSEPRSIFE
CCHHHCCCCCCCCEE		55.9021857030
211PhosphorylationKFRSEPRSIFEYEPG
HCCCCCCCCEECCCC		42.2020068231
215PhosphorylationEPRSIFEYEPGKSSI
CCCCCEECCCCCCCH		19.3725159151
215 (in isoform 3)Phosphorylation-19.3725159151
220PhosphorylationFEYEPGKSSILQHER
EECCCCCCCHHCCCC		28.6423403867
220 (in isoform 3)Phosphorylation-28.6426437602
221PhosphorylationEYEPGKSSILQHERP
ECCCCCCCHHCCCCC		30.7023403867
230PhosphorylationLQHERPASLYQSSID
HCCCCCHHHHHHHHH		30.2328176443
232PhosphorylationHERPASLYQSSIDRS
CCCCHHHHHHHHHHH		12.1224732914
233 (in isoform 3)Phosphorylation-35.6826657352
234PhosphorylationRPASLYQSSIDRSLE
CCHHHHHHHHHHHCC		18.7228176443
234 (in isoform 3)Phosphorylation-18.7225159151
235PhosphorylationPASLYQSSIDRSLER
CHHHHHHHHHHHCCC		17.0025159151
236 (in isoform 3)Phosphorylation-6.5427251275
239PhosphorylationYQSSIDRSLERPMSS
HHHHHHHHCCCCCCH		30.7325159151
245PhosphorylationRSLERPMSSASMASD
HHCCCCCCHHHHHHH		25.9926657352
246PhosphorylationSLERPMSSASMASDF
HCCCCCCHHHHHHHH		20.3628555341
248PhosphorylationERPMSSASMASDFRK
CCCCCHHHHHHHHHH		19.4828857561
248 (in isoform 3)Phosphorylation-19.4824275569
250 (in isoform 11)Phosphorylation-11.9427251275
250 (in isoform 3)Phosphorylation-11.9424275569
251PhosphorylationMSSASMASDFRKRRK
CCHHHHHHHHHHHHC		28.7428857561
252 (in isoform 12)Phosphorylation-37.5224719451
254 (in isoform 11)Phosphorylation-36.2427251275
256 (in isoform 3)Phosphorylation-47.1822167270
257 (in isoform 11)Phosphorylation-50.3027251275
258 (in isoform 3)Phosphorylation-64.3028355574
259PhosphorylationDFRKRRKSEPAVGPP
HHHHHHCCCCCCCCC		47.1825463755
260 (in isoform 3)Phosphorylation-40.0728355574
261 (in isoform 4)Phosphorylation-39.0625159151
261 (in isoform 5)Phosphorylation-39.0625159151
265 (in isoform 11)Phosphorylation-14.6027251275
265 (in isoform 3)Phosphorylation-14.6022199227
266 (in isoform 4)Phosphorylation-36.7226437602
266 (in isoform 5)Phosphorylation-36.7226437602
269 (in isoform 3)Phosphorylation-7.8322199227
271 (in isoform 3)Phosphorylation-44.2822199227
272 (in isoform 3)Phosphorylation-38.8122199227
273PhosphorylationPRGLGDQSASRTSPG
CCCCCCCCCCCCCCC		32.7125159151
275PhosphorylationGLGDQSASRTSPGRV
CCCCCCCCCCCCCCE		41.1424732914
277PhosphorylationGDQSASRTSPGRVDL
CCCCCCCCCCCCEEC		36.4625159151
278PhosphorylationDQSASRTSPGRVDLP
CCCCCCCCCCCEECC		25.0125463755
278 (in isoform 3)Phosphorylation-25.0125159151
279 (in isoform 4)Phosphorylation-33.7126657352
279 (in isoform 5)Phosphorylation-33.7126657352
280 (in isoform 3)Phosphorylation-41.8523927012
280 (in isoform 4)Phosphorylation-41.8525159151
280 (in isoform 5)Phosphorylation-41.8525159151
280 (in isoform 8)Phosphorylation-41.8528348404
282 (in isoform 4)Phosphorylation-12.5827251275
282 (in isoform 5)Phosphorylation-12.5827251275
284 (in isoform 8)Phosphorylation-4.7828348404
287PhosphorylationGRVDLPGSSTTLTKS
CCEECCCCCCEEEEE		23.6722617229
288O-linked_GlycosylationRVDLPGSSTTLTKSF
CEECCCCCCEEEEEE		31.1830379171
288PhosphorylationRVDLPGSSTTLTKSF
CEECCCCCCEEEEEE		31.1823403867
288 (in isoform 11)Phosphorylation-31.1827251275
289PhosphorylationVDLPGSSTTLTKSFT
EECCCCCCEEEEEEC		27.7624732914
289 (in isoform 3)Phosphorylation-27.7627174698
289 (in isoform 8)Phosphorylation-27.7628348404
290O-linked_GlycosylationDLPGSSTTLTKSFTS
ECCCCCCEEEEEECC		34.0830379171
290PhosphorylationDLPGSSTTLTKSFTS
ECCCCCCEEEEEECC		34.0823403867
290 (in isoform 8)Phosphorylation-34.0828348404
291 (in isoform 2)Phosphorylation-6.0227642862
292PhosphorylationPGSSTTLTKSFTSSS
CCCCCEEEEEECCCC		23.6624732914
294PhosphorylationSSTTLTKSFTSSSPS
CCCEEEEEECCCCCC		28.6422167270
294 (in isoform 3)Phosphorylation-28.6427251275
294 (in isoform 4)Phosphorylation-28.6424275569
294 (in isoform 5)Phosphorylation-28.6424275569
295 (in isoform 3)Phosphorylation-9.0627251275
296PhosphorylationTTLTKSFTSSSPSSP
CEEEEEECCCCCCCH		34.4922167270
296 (in isoform 4)Phosphorylation-34.4924275569
296 (in isoform 5)Phosphorylation-34.4924275569
297PhosphorylationTLTKSFTSSSPSSPS
EEEEEECCCCCCCHH		27.1522167270
298PhosphorylationLTKSFTSSSPSSPSR
EEEEECCCCCCCHHH		43.1225463755
299PhosphorylationTKSFTSSSPSSPSRA
EEEECCCCCCCHHHC		28.6825463755
301PhosphorylationSFTSSSPSSPSRAKG
EECCCCCCCHHHCCC		57.7525463755
301 (in isoform 12)Phosphorylation-57.7525159151
301 (in isoform 9)Phosphorylation-57.7524719451
302PhosphorylationFTSSSPSSPSRAKGG
ECCCCCCCHHHCCCC		30.2222167270
302 (in isoform 3)Phosphorylation-30.22-
302 (in isoform 4)Phosphorylation-30.2222167270
302 (in isoform 5)Phosphorylation-30.2222167270
304PhosphorylationSSSPSSPSRAKGGDD
CCCCCCHHHCCCCCC		46.9825463755
304 (in isoform 3)Phosphorylation-46.98-
304 (in isoform 4)Phosphorylation-46.9828355574
304 (in isoform 5)Phosphorylation-46.9828355574
306 (in isoform 12)Phosphorylation-21.1226437602
306 (in isoform 3)Phosphorylation-21.1224275569
306 (in isoform 4)Phosphorylation-21.1228355574
306 (in isoform 5)Phosphorylation-21.1228355574
306 (in isoform 9)Phosphorylation-21.1224719451
307 (in isoform 3)Phosphorylation-63.4224275569
310 (in isoform 2)Phosphorylation-66.7227642862
310 (in isoform 8)Phosphorylation-66.7227251275
311 (in isoform 3)Phosphorylation-55.9225159151
311 (in isoform 4)Phosphorylation-55.9222199227
311 (in isoform 5)Phosphorylation-55.9222199227
311 (in isoform 8)Phosphorylation-55.9227251275
315 (in isoform 2)Phosphorylation-1.8427251275
315 (in isoform 4)Phosphorylation-1.8422199227
315 (in isoform 5)Phosphorylation-1.8422199227
316 (in isoform 2)Phosphorylation-33.5327251275
317 (in isoform 4)Phosphorylation-37.2822199227
317 (in isoform 5)Phosphorylation-37.2822199227
318 (in isoform 4)Phosphorylation-1.0422199227
318 (in isoform 5)Phosphorylation-1.0422199227
318 (in isoform 8)Phosphorylation-1.04-
319 (in isoform 12)Phosphorylation-4.1526657352
320 (in isoform 11)Phosphorylation-27.8527251275
320 (in isoform 12)Phosphorylation-27.8525159151
320 (in isoform 8)Phosphorylation-27.85-
322 (in isoform 12)Phosphorylation-22.1027251275
322 (in isoform 8)Phosphorylation-22.1024275569
323 (in isoform 2)Phosphorylation-18.22-
323 (in isoform 8)Phosphorylation-18.2224275569
324 (in isoform 4)Phosphorylation-6.4525159151
324 (in isoform 5)Phosphorylation-6.4525159151
325 (in isoform 2)Phosphorylation-52.2827642862
326 (in isoform 4)Phosphorylation-53.0923927012
326 (in isoform 5)Phosphorylation-53.0923927012
327 (in isoform 2)Phosphorylation-32.0124275569
327 (in isoform 8)Phosphorylation-32.0125159151
328 (in isoform 2)Phosphorylation-40.4024275569
330 (in isoform 11)Phosphorylation-43.3627642862
332 (in isoform 11)Phosphorylation-6.5027642862
332 (in isoform 2)Phosphorylation-6.5025159151
334 (in isoform 12)Phosphorylation-10.8324275569
335 (in isoform 11)Phosphorylation-2.1527251275
335 (in isoform 4)Phosphorylation-2.1527174698
335 (in isoform 5)Phosphorylation-2.1527174698
336 (in isoform 12)Phosphorylation-23.4224275569
339 (in isoform 11)Phosphorylation-19.9627251275
339 (in isoform 2)Phosphorylation-19.96-
340 (in isoform 4)Phosphorylation-30.9527251275
340 (in isoform 5)Phosphorylation-30.9527251275
341 (in isoform 4)Phosphorylation-18.2627251275
341 (in isoform 5)Phosphorylation-18.2627251275
342 (in isoform 12)Phosphorylation-5.5522167270
344 (in isoform 12)Phosphorylation-5.4328355574
345 (in isoform 11)Phosphorylation-33.7527251275
346 (in isoform 12)Phosphorylation-57.8128355574
348 (in isoform 4)Phosphorylation-19.98-
348 (in isoform 5)Phosphorylation-19.98-
350 (in isoform 4)Phosphorylation-48.80-
350 (in isoform 5)Phosphorylation-48.80-
351 (in isoform 11)Phosphorylation-12.7427251275
351 (in isoform 12)Phosphorylation-12.7422199227
352 (in isoform 2)Phosphorylation-5.40-
352 (in isoform 4)Phosphorylation-5.4024275569
352 (in isoform 5)Phosphorylation-5.4024275569
353PhosphorylationRDSPRAISFKNGWQM
CCCCCEEECCCHHHH		29.2324719451
353 (in isoform 4)Phosphorylation-29.2324275569
353 (in isoform 5)Phosphorylation-29.2324275569
355 (in isoform 12)Phosphorylation-48.0022199227
357 (in isoform 12)Phosphorylation-19.3122199227
357 (in isoform 4)Phosphorylation-19.3125159151
357 (in isoform 5)Phosphorylation-19.3125159151
358 (in isoform 12)Phosphorylation-8.3122199227
359 (in isoform 11)Phosphorylation-19.6327251275
364 (in isoform 12)Phosphorylation-33.7125159151
364 (in isoform 4)Phosphorylation-33.71-
365 (in isoform 9)Phosphorylation-11.0029507054
366 (in isoform 12)Phosphorylation-53.1723927012
366 (in isoform 3)Phosphorylation-53.1729507054
367 (in isoform 9)Phosphorylation-3.9325159151
368 (in isoform 3)Phosphorylation-4.2625159151
368 (in isoform 9)Phosphorylation-4.2622210691
369PhosphorylationRQNAEIWSSTEETVS
HHHCCHHCCCCCCCC		32.8026074081
369 (in isoform 3)Phosphorylation-32.8022210691
369 (in isoform 9)Phosphorylation-32.8029116813
370PhosphorylationQNAEIWSSTEETVSP
HHCCHHCCCCCCCCC		25.4926074081
370 (in isoform 3)Phosphorylation-25.4929116813
370 (in isoform 9)Phosphorylation-25.4929116813
371PhosphorylationNAEIWSSTEETVSPK
HCCHHCCCCCCCCCC		32.1226074081
371 (in isoform 3)Phosphorylation-32.1229116813
372 (in isoform 9)Phosphorylation-54.3329116813
373 (in isoform 11)Phosphorylation-55.3827251275
373 (in isoform 3)Phosphorylation-55.3829116813
373 (in isoform 9)Phosphorylation-55.3825159151
374PhosphorylationIWSSTEETVSPKIKS
HHCCCCCCCCCCHHC		21.7626074081
374 (in isoform 3)Phosphorylation-21.7625159151
375 (in isoform 12)Phosphorylation-11.8827174698
375 (in isoform 9)Phosphorylation-11.8829116813
376PhosphorylationSSTEETVSPKIKSRS
CCCCCCCCCCHHCCC		28.0926074081
376 (in isoform 3)Phosphorylation-28.0929116813
377 (in isoform 4)Phosphorylation-37.75-
378 (in isoform 11)Phosphorylation-56.0827251275
380 (in isoform 12)Phosphorylation-46.0427251275
381 (in isoform 12)Phosphorylation-32.6627251275
382 (in isoform 8)Phosphorylation-35.9829507054
382 (in isoform 9)Phosphorylation-35.9820068231
383PhosphorylationSPKIKSRSCDDLLND
CCCHHCCCHHHHHCC		29.05-
383 (in isoform 3)Phosphorylation-29.0520068231
384 (in isoform 8)Phosphorylation-4.6025159151
385 (in isoform 8)Phosphorylation-51.3322210691
385 (in isoform 9)Phosphorylation-51.3324275569
386 (in isoform 3)Phosphorylation-58.3324275569
386 (in isoform 8)Phosphorylation-58.3329116813
387 (in isoform 11)Phosphorylation-2.8427251275
387 (in isoform 2)Phosphorylation-2.8429507054
387 (in isoform 8)Phosphorylation-2.8429116813
387 (in isoform 9)Phosphorylation-2.8425159151
388 (in isoform 11)Phosphorylation-9.4527251275
388 (in isoform 12)Phosphorylation-9.45-
388 (in isoform 3)Phosphorylation-9.4525627689
389 (in isoform 2)Phosphorylation-50.8225159151
389 (in isoform 8)Phosphorylation-50.8229116813
390 (in isoform 12)Phosphorylation-58.86-
390 (in isoform 2)Phosphorylation-58.8622210691
390 (in isoform 8)Phosphorylation-58.8625159151
391 (in isoform 2)Phosphorylation-36.7329116813
392 (in isoform 12)Phosphorylation-5.4224275569
392 (in isoform 2)Phosphorylation-5.4229116813
392 (in isoform 8)Phosphorylation-5.4229116813
393 (in isoform 12)Phosphorylation-61.3824275569
394PhosphorylationLLNDDCDSFPDPKVK
HHCCCCHHCCCHHCC		45.0420068231
394 (in isoform 10)Phosphorylation-45.0425159151
394 (in isoform 11)Phosphorylation-45.0427251275
394 (in isoform 2)Phosphorylation-45.0429116813
395 (in isoform 2)Phosphorylation-5.2025159151
397 (in isoform 12)Phosphorylation-54.3525159151
397 (in isoform 2)Phosphorylation-54.3529116813
399 (in isoform 10)Phosphorylation-70.4526437602
399 (in isoform 11)Phosphorylation-70.4527251275
399 (in isoform 8)Phosphorylation-70.4520068231
401 (in isoform 11)Phosphorylation-55.4127251275
402PhosphorylationFPDPKVKSESMGSLL
CCCHHCCCCHHHCCC		37.5828450419
402 (in isoform 11)Phosphorylation-37.5827251275
402 (in isoform 8)Phosphorylation-37.5824275569
403 (in isoform 12)Phosphorylation-38.7424719451
404PhosphorylationDPKVKSESMGSLLCE
CHHCCCCHHHCCCCC		35.2228450419
404 (in isoform 12)Phosphorylation-35.22-
404 (in isoform 2)Phosphorylation-35.2220068231
404 (in isoform 8)Phosphorylation-35.2225159151
407PhosphorylationVKSESMGSLLCEEDS
CCCCHHHCCCCCCCC		14.9928450419
407 (in isoform 2)Phosphorylation-14.9924275569
409 (in isoform 2)Phosphorylation-3.5625159151
412 (in isoform 10)Phosphorylation-67.5926657352
412 (in isoform 4)Phosphorylation-67.5929507054
412 (in isoform 5)Phosphorylation-67.5929507054
413 (in isoform 10)Phosphorylation-42.5925159151
414 (in isoform 4)Phosphorylation-41.4225159151
414 (in isoform 5)Phosphorylation-41.4225159151
415 (in isoform 10)Phosphorylation-67.0027251275
415 (in isoform 4)Phosphorylation-67.0022210691
415 (in isoform 5)Phosphorylation-67.0022210691
416 (in isoform 4)Phosphorylation-62.6229116813
416 (in isoform 5)Phosphorylation-62.6229116813
417PhosphorylationCEEDSKESCPMAWGS
CCCCCCCCCCCCCCC		27.5324719451
417 (in isoform 12)Phosphorylation-27.5324719451
417 (in isoform 4)Phosphorylation-27.5329116813
417 (in isoform 5)Phosphorylation-27.5329116813
419 (in isoform 4)Phosphorylation-25.4629116813
419 (in isoform 5)Phosphorylation-25.4629116813
420 (in isoform 4)Phosphorylation-6.0125159151
420 (in isoform 5)Phosphorylation-6.0125159151
422 (in isoform 4)Phosphorylation-11.0929116813
422 (in isoform 5)Phosphorylation-11.0929116813
426PhosphorylationPMAWGSPYVPEVRSN
CCCCCCCCCCHHHCC		30.2724719451
427 (in isoform 10)Phosphorylation-3.5624275569
429 (in isoform 10)Phosphorylation-40.2824275569
429 (in isoform 4)Phosphorylation-40.2820068231
429 (in isoform 5)Phosphorylation-40.2820068231
432 (in isoform 4)Phosphorylation-49.1424275569
432 (in isoform 5)Phosphorylation-49.1424275569
434 (in isoform 4)Phosphorylation-30.1325159151
434 (in isoform 5)Phosphorylation-30.1325159151
435 (in isoform 10)Phosphorylation-27.3222167270
435 (in isoform 12)Phosphorylation-27.3224719451
437 (in isoform 10)Phosphorylation-28.7128355574
439 (in isoform 10)Phosphorylation-20.3228355574
444 (in isoform 10)Phosphorylation-40.8822199227
448 (in isoform 10)Phosphorylation-37.8022199227
450 (in isoform 10)Phosphorylation-3.7522199227
451 (in isoform 10)Phosphorylation-37.6122199227
452 (in isoform 12)Phosphorylation-6.8824719451
454 (in isoform 12)Phosphorylation-39.8725159151
455 (in isoform 12)Phosphorylation-23.5822210691
456 (in isoform 12)Phosphorylation-1.9429116813
457 (in isoform 10)Phosphorylation-36.0325159151
457 (in isoform 12)Phosphorylation-36.0329116813
459 (in isoform 10)Phosphorylation-3.3923927012
459 (in isoform 12)Phosphorylation-3.3917081983
460 (in isoform 12)Phosphorylation-44.9325159151
462 (in isoform 12)Phosphorylation-51.2129116813
468 (in isoform 10)Phosphorylation-30.7827174698
469 (in isoform 12)Phosphorylation-5.5520068231
472PhosphorylationMNSEVICSVKSRILQ
CCCHHHHHHHHHHHH		22.8125690035
472 (in isoform 12)Phosphorylation-22.8124275569
473 (in isoform 10)Phosphorylation-5.9027251275
474 (in isoform 10)Phosphorylation-20.0927251275
474 (in isoform 12)Phosphorylation-20.0925159151
481 (in isoform 10)Phosphorylation-34.53-
483 (in isoform 10)Phosphorylation-42.17-
485 (in isoform 10)Phosphorylation-41.3624275569
486 (in isoform 10)Phosphorylation-25.8724275569
490 (in isoform 10)Phosphorylation-5.1425159151
491 (in isoform 12)Phosphorylation-41.1124719451
494PhosphorylationKDLLRAWSQCSTEEV
HHHHHHHHHCCCCCC		21.96-
497PhosphorylationLRAWSQCSTEEVPRD
HHHHHHCCCCCCCHH		31.0824076635
522PhosphorylationKLIQKSKSMPNLGDD
HHHHHCCCCCCCCCC		46.7124719451
532PhosphorylationNLGDDMLSPVTLEPP
CCCCCCCCCCCCCCC		15.6424719451
535PhosphorylationDDMLSPVTLEPPQNG
CCCCCCCCCCCCCCC		28.8720068231
545 (in isoform 10)Phosphorylation-37.9329507054
547 (in isoform 10)Phosphorylation-29.9825159151
548 (in isoform 10)Phosphorylation-35.4722210691
549 (in isoform 10)Phosphorylation-11.3629116813
550PhosphorylationLCPKRRFSIEYLLEE
CCCCCCEEHHHHHHH		16.8222817900
550 (in isoform 10)Phosphorylation-16.8229116813
552 (in isoform 10)Phosphorylation-29.0029116813
552 (in isoform 12)Phosphorylation-29.0024719451
553PhosphorylationKRRFSIEYLLEEENQ
CCCEEHHHHHHHHHH		18.2124076635
553 (in isoform 10)Phosphorylation-18.2125159151
555 (in isoform 10)Phosphorylation-8.3429116813
559 (in isoform 2)Phosphorylation-44.60-
562 (in isoform 10)Phosphorylation-23.5820068231
565 (in isoform 10)Phosphorylation-29.6824275569
567 (in isoform 10)Phosphorylation-26.2425627689
573 (in isoform 2)Phosphorylation-28.31-
584 (in isoform 4)Phosphorylation-20.05-
649 (in isoform 12)Phosphorylation-18.4724719451
702PhosphorylationSKLAFLVSPVPFRRK
HHHHHHHCCCCCCCC		23.4824076635
712PhosphorylationPFRRKKNSAPKKQTE
CCCCCCCCCCCHHHH		55.6229496963
718PhosphorylationNSAPKKQTEKAKCKA
CCCCCHHHHHHHHHH		48.6223322592
733PhosphorylationSVFEALDSALKDICD
HHHHHHHHHHHHHHH		36.0323322592
750PhosphorylationKAEKKRGSLPDNSIL
HHHHHHCCCCCCHHH		40.54-
755PhosphorylationRGSLPDNSILHRLIS
HCCCCCCHHHHHHHH		33.63-
838PhosphorylationGALQDRESPRSYSST
CCCCCCCCCCCCCCC		26.8928355574
841PhosphorylationQDRESPRSYSSTLTD
CCCCCCCCCCCCHHH		32.5224501219
842PhosphorylationDRESPRSYSSTLTDM
CCCCCCCCCCCHHHH		14.1226657352
843PhosphorylationRESPRSYSSTLTDMG
CCCCCCCCCCHHHHC		20.3526657352
844PhosphorylationESPRSYSSTLTDMGR
CCCCCCCCCHHHHCC		21.1425072903
845PhosphorylationSPRSYSSTLTDMGRS
CCCCCCCCHHHHCCC		27.9528857561
847PhosphorylationRSYSSTLTDMGRSAP
CCCCCCHHHHCCCCC		24.8328555341
852PhosphorylationTLTDMGRSAPRERRG
CHHHHCCCCCHHHCC		36.5729214152
860PhosphorylationAPRERRGTPEKEKLP
CCHHHCCCCCHHCCC		26.8524732914
875AcetylationAKAVYDFKAQTSKEL
CCEEEEECCCCCCEE		36.3726051181
880AcetylationDFKAQTSKELSFKKG
EECCCCCCEECCCCC		67.0926051181
883PhosphorylationAQTSKELSFKKGDTV
CCCCCEECCCCCCEE		35.7924719451
889PhosphorylationLSFKKGDTVYILRKI
ECCCCCCEEEEEEEC		24.7123312004
891PhosphorylationFKKGDTVYILRKIDQ
CCCCCEEEEEEECCC		9.0623312004
901PhosphorylationRKIDQNWYEGEHHGR
EECCCCCCCCCCCCE		22.93-
915PhosphorylationRVGIFPISYVEKLTP
EEEEEEHHHHHHCCC		24.3024732914
916PhosphorylationVGIFPISYVEKLTPP
EEEEEHHHHHHCCCH		17.2224732914
919AcetylationFPISYVEKLTPPEKA
EEHHHHHHCCCHHHC		47.8426051181
921PhosphorylationISYVEKLTPPEKAQP
HHHHHHCCCHHHCCC		48.1128387310
925AcetylationEKLTPPEKAQPARPP
HHCCCHHHCCCCCCC		59.0826051181
941 (in isoform 11)Phosphorylation-17.6227251275
943 (in isoform 11)Phosphorylation-11.2227251275
944 (in isoform 11)Phosphorylation-2.7127251275
958PhosphorylationADTNVELSLRKGDRV
CCCCEEEEECCCCEE		16.7824719451
976PhosphorylationKRVDQNWYEGKIPGT
EECCCCCCCCCCCCC		23.50-
993PhosphorylationQGIFPVSYVEVVKKN
CCEEEEEEEEEEECC		10.81-
998AcetylationVSYVEVVKKNTKGAE
EEEEEEEECCCCCCC		45.5426051181
1001PhosphorylationVEVVKKNTKGAEDYP
EEEEECCCCCCCCCC		39.47-
1007PhosphorylationNTKGAEDYPDPPIPH
CCCCCCCCCCCCCCC		10.8823312004
1015PhosphorylationPDPPIPHSYSSDRIH
CCCCCCCCCCCCCCC		22.7325159151
1016PhosphorylationDPPIPHSYSSDRIHS
CCCCCCCCCCCCCCC		14.7926657352
1017PhosphorylationPPIPHSYSSDRIHSL
CCCCCCCCCCCCCCC		28.8625159151
1018PhosphorylationPIPHSYSSDRIHSLS
CCCCCCCCCCCCCCC		23.7525159151
1021 (in isoform 11)Phosphorylation-2.8827251275
1023PhosphorylationYSSDRIHSLSSNKPQ
CCCCCCCCCCCCCCC		27.819211900
1025PhosphorylationSDRIHSLSSNKPQRP
CCCCCCCCCCCCCCC		34.5723312004
1026PhosphorylationDRIHSLSSNKPQRPV
CCCCCCCCCCCCCCE		54.9223312004
1028AcetylationIHSLSSNKPQRPVFT
CCCCCCCCCCCCEEE		44.4626051181
1035PhosphorylationKPQRPVFTHENIQGG
CCCCCEEECCCCCCC		28.6326657352
1053PhosphorylationFQALYNYTPRNEDEL
CHHHCCCCCCCHHHH		16.4825159151
1087AcetylationVGTSRRTKFFGTFPG
ECCCCCCEEECCCCC		36.5626051181
1091PhosphorylationRRTKFFGTFPGNYVK
CCCEEECCCCCCCCC		22.8427251275
1096PhosphorylationFGTFPGNYVKRL---
ECCCCCCCCCCC---		17.17-
1115 (in isoform 11)Phosphorylation-27251275
1191 (in isoform 11)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
50YPhosphorylationKinaseABLP00519
PSP
59YPhosphorylationKinaseABLP00519
PSP
164YPhosphorylationKinaseABLP00519
PSP
175YPhosphorylationKinaseABLP00519
PSP
259SPhosphorylationKinasePKACAP17612
PSP
573YPhosphorylationKinaseABLP00519
PSP
-KUbiquitinationE3 ubiquitin ligaseCBLP22681
PMID:12475393
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRBS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRBS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBL_HUMANCBLphysical
15128873
FAK2_HUMANPTK2Bphysical
15128873
DLGP4_HUMANDLGAP4physical
10521485
DLGP1_HUMANDLGAP1physical
10521485
VINC_HUMANVCLphysical
10521485
AFAD_HUMANMLLT4physical
10521485
ABL2_HUMANABL2physical
9211900
ABL1_HUMANABL1physical
9211900
CBL_HUMANCBLphysical
12475393
ABL1_HUMANABL1physical
12475393
SEM6A_HUMANSEMA6Aphysical
12421765
PALLD_HUMANPALLDphysical
16125169
ACTN1_HUMANACTN1physical
16125169
WASF1_HUMANWASF1physical
18559503
PTN12_HUMANPTPN12physical
18559503
ABL1_HUMANABL1physical
18559503
1433Z_HUMANYWHAZphysical
21988832
SRBS2_HUMANSORBS2physical
25416956
EFS_HUMANEFSphysical
25416956
VP37C_HUMANVPS37Cphysical
25416956
SH24A_HUMANSH2D4Aphysical
25416956
ATPF2_HUMANATPAF2physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRBS2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-259; THR-277;SER-299; SER-301 AND SER-302, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND MASSSPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259 AND THR-277, ANDMASS SPECTROMETRY.

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