EFS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFS_HUMAN
• UniProt AC: O43281
• Protein Name: Embryonal Fyn-associated substrate
• Gene Name: EFS
• Organism: Homo sapiens (Human).
• Sequence Length: 561
• Protein Description: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity)..
• Protein Sequence: MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQALQFTTLLTSLAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LYDNTAESPQELSFR HHHCCCCCCCHHCCC	29.44	24719451
30 (in isoform 3)	Phosphorylation	-	34.17	28348404
30 (in isoform 2)	Phosphorylation	-	34.17	28348404
30	Phosphorylation	ELSFRRGDVLRVLQR HHCCCCCCHHHHHHC	34.17	24719451
66	Phosphorylation	PANRVKLLPAGPAPK CCCCEEEEECCCCCC	1.96	24719451
70	Phosphorylation	VKLLPAGPAPKPSLS EEEEECCCCCCCCCC	47.71	24719451
123	Phosphorylation	PAGPCPPSPDLIYKI CCCCCCCCCCCEEEE	19.05	25884760
128	Phosphorylation	PPSPDLIYKIPRASG CCCCCCEEEECCCCC	15.34	25884760
129	Phosphorylation	PSPDLIYKIPRASGT CCCCCEEEECCCCCC	38.96	32142685
148	Phosphorylation	PRDALEVYDVPPTAL CCCEEEEECCCCCCE	11.22	25884760
150	Phosphorylation	DALEVYDVPPTALRV CEEEEECCCCCCEEC	3.15	32142685
153	Phosphorylation	EVYDVPPTALRVPSS EEECCCCCCEECCCC	32.05	24505115
154	Phosphorylation	VYDVPPTALRVPSSG EECCCCCCEECCCCC	10.11	32142685
159	Phosphorylation	PTALRVPSSGPYDCP CCCEECCCCCCCCCC	45.10	24719451
160	Phosphorylation	TALRVPSSGPYDCPA CCEECCCCCCCCCCC	37.40	26356563
163	Phosphorylation	RVPSSGPYDCPASFS ECCCCCCCCCCCCCC	33.43	25884760
188	Phosphorylation	PGEDDAPYDVPLTPK CCCCCCCCCCCCCCC	31.15	27642862
193	Phosphorylation	APYDVPLTPKPPAEL CCCCCCCCCCCCHHC	24.17	27642862
194	Phosphorylation	PYDVPLTPKPPAELE CCCCCCCCCCCHHCC	55.64	24719451
205	Phosphorylation	AELEPDLEWEGGREP HHCCCCCCCCCCCCC	51.35	32142685
217	Phosphorylation	REPGPPIYAAPSNLK CCCCCCCCCCCCCHH	11.50	30377224
221	Phosphorylation	PPIYAAPSNLKRASA CCCCCCCCCHHHHHH	50.50	30377224
224	Phosphorylation	YAAPSNLKRASALLN CCCCCCHHHHHHHHH	50.60	24719451
226	Phosphorylation	APSNLKRASALLNLY CCCCHHHHHHHHHHH	9.51	24719451
230	Phosphorylation	LKRASALLNLYEAPE HHHHHHHHHHHHCCH	4.08	24719451
238	Phosphorylation	NLYEAPEELLADGEG HHHHCCHHHHCCCCC	48.28	24719451
253	Phosphorylation	GGTDEGIYDVPLLGP CCCCCCCCCCCCCCC	23.03	-
287	Phosphorylation	LAQLLARSPPPPHRP HHHHHHCCCCCCCCC	35.83	22985185
298	Phosphorylation	PHRPRLPSAESLSRR CCCCCCCCHHHHCCC	49.62	19664994
301	Phosphorylation	PRLPSAESLSRRPLP CCCCCHHHHCCCCCC	31.21	26699800
303	Phosphorylation	LPSAESLSRRPLPAL CCCHHHHCCCCCCCC	35.21	27794612
317	Phosphorylation	LPVPEAPSPSPVPSP CCCCCCCCCCCCCCC	45.09	24117733
319	Phosphorylation	VPEAPSPSPVPSPAP CCCCCCCCCCCCCCC	42.75	28731282
323	Phosphorylation	PSPSPVPSPAPGRKG CCCCCCCCCCCCCCC	33.65	30278072
331	Phosphorylation	PAPGRKGSIQDRPLP CCCCCCCCCCCCCCC	21.80	26657352
372	Phosphorylation	PAGHHNEYEGIPMAE CCCCCCCCCCCCCCC	25.44	26356563
381	Phosphorylation	GIPMAEEYDYVHLKG CCCCCCCCCEEEECC	12.22	25884760
383	Phosphorylation	PMAEEYDYVHLKGMD CCCCCCCEEEECCCC	6.72	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
253	Y	Phosphorylation	Kinase	SRC	P12931	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC6A_HUMAN	TRAPPC6A	physical	16189514
PTN12_HUMAN	PTPN12	physical	9748319
SRC_HUMAN	SRC	physical	8647432
CRK_HUMAN	CRK	physical	8647432
A4_HUMAN	APP	physical	21832049
OSTF1_HUMAN	OSTF1	physical	25416956
TSSK1_HUMAN	TSSK1B	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.