TSSK1_HUMAN - dbPTM
TSSK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSSK1_HUMAN
UniProt AC Q9BXA7
Protein Name Testis-specific serine/threonine-protein kinase 1
Gene Name TSSK1B
Organism Homo sapiens (Human).
Sequence Length 367
Subcellular Localization Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. In spermatozoa, present in the sperm head and in the flagellum..
Protein Description Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body..
Protein Sequence MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationAVLKRRGYLLGINLG
HHHHHCCEEEEEECC		9.2822817900
31PhosphorylationAKVKSAYSERLKFNV
HHHHHHHHHHHCEEE		18.8930622161
71PhosphorylationLAMLNHCSIIKTYEI
HHHHHCCCCCEEEEE		21.5724719451
75PhosphorylationNHCSIIKTYEIFETS
HCCCCCEEEEEEECC		18.9127794612
76PhosphorylationHCSIIKTYEIFETSH
CCCCCEEEEEEECCC		11.3027794612
156PhosphorylationNIKLSDFSFSKRCLR
CEEHHHCCCCCHHHC		33.3324719451
158PhosphorylationKLSDFSFSKRCLRDD
EHHHCCCCCHHHCCC		20.2830622161
159AcetylationLSDFSFSKRCLRDDS
HHHCCCCCHHHCCCC		45.1519824351
172PhosphorylationDSGRMALSKTFCGSP
CCCCEEECCCCCCCC		21.80-
174PhosphorylationGRMALSKTFCGSPAY
CCEEECCCCCCCCCC		22.3025693802
178PhosphorylationLSKTFCGSPAYAAPE
ECCCCCCCCCCCCHH		13.9230622161
181PhosphorylationTFCGSPAYAAPEVLQ
CCCCCCCCCCHHHHC		13.4925693802
197PhosphorylationIPYQPKVYDIWSLGV
CCCCCCHHHHHHHHH		14.08-
207PhosphorylationWSLGVILYIMVCGSM
HHHHHHHHHHHHCCC		3.94-
216PhosphorylationMVCGSMPYDDSNIKK
HHHCCCCCCCCCHHH		24.60-
250PhosphorylationGECKDLIYHMLQPDV
HHHHHHHHHHHCCCH		6.6225003641
279PhosphorylationMQPKARGSPSVAINK
CCCCCCCCCCEEECC		14.4023403867
281PhosphorylationPKARGSPSVAINKEG
CCCCCCCCEEECCCC		26.3623403867
290PhosphorylationAINKEGESSRGTEPL
EECCCCCCCCCCCCC		35.87-
291PhosphorylationINKEGESSRGTEPLW
ECCCCCCCCCCCCCC		30.35-
308PhosphorylationEPGSDKKSATKLEPE
CCCCCCCCCCCCCCC		47.0825693802
310PhosphorylationGSDKKSATKLEPEGE
CCCCCCCCCCCCCCC		43.1625693802
326PhosphorylationQPQAQPETKPEGTAM
CCCCCCCCCCCCCCC		59.5925693802
331PhosphorylationPETKPEGTAMQMSRQ
CCCCCCCCCCHHHCC		19.7929978859
336PhosphorylationEGTAMQMSRQSEILG
CCCCCHHHCCHHHHC		15.4129978859
339PhosphorylationAMQMSRQSEILGFPS
CCHHHCCHHHHCCCC		26.0329978859
346PhosphorylationSEILGFPSKPSTMET
HHHHCCCCCCCCCCC		55.7429978859
349PhosphorylationLGFPSKPSTMETEEG
HCCCCCCCCCCCCCC		44.0925693802
350PhosphorylationGFPSKPSTMETEEGP
CCCCCCCCCCCCCCC		27.7925693802
353PhosphorylationSKPSTMETEEGPPQQ
CCCCCCCCCCCCCCC		28.6325693802
364PhosphorylationPPQQPPETRAQ----
CCCCCCCCCCC----		36.7625693802
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSSK1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSSK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSSK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP7C_HUMANHSPA8physical
26186194
HSP76_HUMANHSPA6physical
26186194
HSP72_HUMANHSPA2physical
26186194
EFTU_HUMANTUFMphysical
26186194
CP131_HUMANCEP131physical
26186194
GEPH_HUMANGPHNphysical
26186194
CRBG3_HUMANCRYBG3physical
26186194
BORA_HUMANBORAphysical
26186194
GAPD1_HUMANGAPVD1physical
26186194
SNX24_HUMANSNX24physical
26186194
CRBG3_HUMANCRYBG3physical
28514442
CP131_HUMANCEP131physical
28514442
GEPH_HUMANGPHNphysical
28514442
SNX24_HUMANSNX24physical
28514442
GAPD1_HUMANGAPVD1physical
28514442
HSP7C_HUMANHSPA8physical
28514442
KI67_HUMANMKI67physical
28514442
HSP72_HUMANHSPA2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSSK1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Identification of the sucrose non-fermenting related kinase SNRK, asa novel LKB1 substrate.";
Jaleel M., McBride A., Lizcano J.M., Deak M., Toth R., Morrice N.A.,Alessi D.R.;
FEBS Lett. 579:1417-1423(2005).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION,AUTOPHOSPHORYLATION, PHOSPHORYLATION AT THR-174, AND MUTAGENESIS OFTHR-174.

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