GAPD1_HUMAN - dbPTM
GAPD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GAPD1_HUMAN
UniProt AC Q14C86
Protein Name GTPase-activating protein and VPS9 domain-containing protein 1
Gene Name GAPVD1
Organism Homo sapiens (Human).
Sequence Length 1478
Subcellular Localization Membrane
Peripheral membrane protein . Endosome . Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Protein Description Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras..
Protein Sequence MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDGESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MVKLDIHTLA
-----CCCEEHHHHH		52.91-
24UbiquitinationRLYVNSEKQLIQRLN
HHHCCCHHHHHHHHC		50.6721890473
24AcetylationRLYVNSEKQLIQRLN
HHHCCCHHHHHHHHC		50.6725953088
24UbiquitinationRLYVNSEKQLIQRLN
HHHCCCHHHHHHHHC		50.67-
24 (in isoform 1)Ubiquitination-50.6721890473
24 (in isoform 2)Ubiquitination-50.6721890473
24 (in isoform 3)Ubiquitination-50.6721890473
24 (in isoform 4)Ubiquitination-50.6721890473
24 (in isoform 5)Ubiquitination-50.6721890473
24 (in isoform 6)Ubiquitination-50.6721890473
36UbiquitinationRLNADVLKTAEKLYR
HHCHHHHHHHHHHHH		45.60-
40UbiquitinationDVLKTAEKLYRTAWI
HHHHHHHHHHHHHHH		48.64-
44PhosphorylationTAEKLYRTAWIAKQQ
HHHHHHHHHHHHHHH		16.8820068231
49AcetylationYRTAWIAKQQRINLD
HHHHHHHHHHCCCCC		37.5226051181
49UbiquitinationYRTAWIAKQQRINLD
HHHHHHHHHHCCCCC		37.52-
49 (in isoform 6)Ubiquitination-37.52-
62PhosphorylationLDRLIITSAEASPAE
CCEEEEECCCCCHHH		17.4429214152
66PhosphorylationIITSAEASPAECCQH
EEECCCCCHHHHHHH		19.0226462736
75AcetylationAECCQHAKILEDTQF
HHHHHHHHHCCCCCC		45.7826051181
80PhosphorylationHAKILEDTQFVDGYK
HHHHCCCCCCCCHHH		17.96-
86PhosphorylationDTQFVDGYKQLGFQE
CCCCCCHHHHCCCCH		7.35-
94PhosphorylationKQLGFQETAYGEFLS
HHCCCCHHHHHHHHH		17.88-
96PhosphorylationLGFQETAYGEFLSRL
CCCCHHHHHHHHHHH		25.30-
101PhosphorylationTAYGEFLSRLRENPR
HHHHHHHHHHHHCCH		34.29-
112PhosphorylationENPRLIASSLVAGEK
HCCHHHHHHHHHCCC		19.7420068231
113PhosphorylationNPRLIASSLVAGEKL
CCHHHHHHHHHCCCC		20.1720068231
147PhosphorylationCIMQEDESYLLQVLR
CCCCCCHHHHHHHHH		33.1420068231
148PhosphorylationIMQEDESYLLQVLRY
CCCCCHHHHHHHHHH		14.9120068231
227PhosphorylationNKLIERFSPSQQEKL
HHHHHHCCHHHHHHH		29.8425159151
229PhosphorylationLIERFSPSQQEKLFG
HHHHCCHHHHHHHHC		43.2125627689
233UbiquitinationFSPSQQEKLFGEKGS
CCHHHHHHHHCCCCH		44.79-
233 (in isoform 6)Ubiquitination-44.79-
238AcetylationQEKLFGEKGSDRFRQ
HHHHHCCCCHHHHHH		65.1819608861
238UbiquitinationQEKLFGEKGSDRFRQ
HHHHHCCCCHHHHHH		65.1819608861
238 (in isoform 6)Ubiquitination-65.18-
253PhosphorylationKVQEMVESNEAKLVA
HHHHHHHCCHHHHHH		28.6728509920
270AcetylationNKFIGYLKQNTYCFP
HHHHHHHHHCCCCCH		32.7723954790
285PhosphorylationHSLRWIVSQMYKTLS
HHHHHHHHHHHHHHC		10.4920860994
288PhosphorylationRWIVSQMYKTLSCVD
HHHHHHHHHHHCCHH		7.9920860994
342SulfoxidationEVARFNLMQVGRLLQ
HHHHHHHHHHHHHHH		2.9628465586
353SulfoxidationRLLQQLAMTGSEEGD
HHHHHHHHHCCCCCC		6.2421406390
356PhosphorylationQQLAMTGSEEGDPRT
HHHHHHCCCCCCCCC		24.25-
365PhosphorylationEGDPRTKSSLGKFDK
CCCCCCHHHCCCCCH		30.1325599653
366PhosphorylationGDPRTKSSLGKFDKS
CCCCCHHHCCCCCHH		42.5725599653
369UbiquitinationRTKSSLGKFDKSCVA
CCHHHCCCCCHHHHH		56.54-
390PhosphorylationIGGRAVETPPLSSVN
ECCCCCCCCCCCCCH		24.4929255136
394PhosphorylationAVETPPLSSVNLLEG
CCCCCCCCCCHHHHC		37.7023403867
395PhosphorylationVETPPLSSVNLLEGL
CCCCCCCCCHHHHCC		23.7821815630
396PhosphorylationETPPLSSVNLLEGLS
CCCCCCCCHHHHCCC		5.4115302935
403PhosphorylationVNLLEGLSRTVVYIT
CHHHHCCCCEEEEEE		36.4426546556
452PhosphorylationPPAKPGKSSSLEMTP
CCCCCCCCCCCCCCC		30.9521945579
453PhosphorylationPAKPGKSSSLEMTPY
CCCCCCCCCCCCCCC		42.2921945579
454PhosphorylationAKPGKSSSLEMTPYN
CCCCCCCCCCCCCCC		35.1321945579
458PhosphorylationKSSSLEMTPYNTPQL
CCCCCCCCCCCCCCC		17.1621945579
460PhosphorylationSSLEMTPYNTPQLSP
CCCCCCCCCCCCCCC		23.6221945579
462PhosphorylationLEMTPYNTPQLSPAT
CCCCCCCCCCCCCCC		13.4321945579
466PhosphorylationPYNTPQLSPATTPAN
CCCCCCCCCCCCCCC		13.7725159151
469PhosphorylationTPQLSPATTPANKKN
CCCCCCCCCCCCCCC		36.3721945579
470PhosphorylationPQLSPATTPANKKNR
CCCCCCCCCCCCCCC		23.6221945579
474AcetylationPATTPANKKNRLPIA
CCCCCCCCCCCCCCC		54.2326051181
482PhosphorylationKNRLPIATRSRSRTN
CCCCCCCCCCCCCCC		29.8726074081
484PhosphorylationRLPIATRSRSRTNML
CCCCCCCCCCCCCCC		30.1926074081
486PhosphorylationPIATRSRSRTNMLMD
CCCCCCCCCCCCCEE		44.7126074081
559 (in isoform 4)Phosphorylation-53.5822468782
562PhosphorylationLHGKPDKTLRFSLCS
CCCCCCCCEEEEEEC		30.4623927012
562 (in isoform 4)Phosphorylation-30.4624275569
566PhosphorylationPDKTLRFSLCSDNLE
CCCCEEEEEECCCCC		23.2529255136
566 (in isoform 4)Phosphorylation-23.2522468782
569PhosphorylationTLRFSLCSDNLEGIS
CEEEEEECCCCCCCC		34.5229255136
576PhosphorylationSDNLEGISEGPSNRS
CCCCCCCCCCCCCCC		47.5625159151
580PhosphorylationEGISEGPSNRSNSVS
CCCCCCCCCCCCCCC		56.5923927012
583PhosphorylationSEGPSNRSNSVSSLD
CCCCCCCCCCCCCEE		37.3928348404
585PhosphorylationGPSNRSNSVSSLDLE
CCCCCCCCCCCEECC		25.3126074081
587PhosphorylationSNRSNSVSSLDLEGE
CCCCCCCCCEECCCC		25.6326074081
588PhosphorylationNRSNSVSSLDLEGES
CCCCCCCCEECCCCC		24.6026074081
642PhosphorylationIRDMMGLTDDRDISE
HHHHHCCCCCCCHHH		30.0827470641
654PhosphorylationISETVSETWSTDVLG
HHHHHHHHHCCCCCC		19.7424275569
656PhosphorylationETVSETWSTDVLGSD
HHHHHHHCCCCCCCC		23.3424275569
662PhosphorylationWSTDVLGSDFDPNID
HCCCCCCCCCCCCCC		30.8322468782
716PhosphorylationETTSEAWSVEVLPSD
CCCCCCEEEEECCCC		18.5626074081
722PhosphorylationWSVEVLPSDSEAPDL
EEEEECCCCCCCCCC		50.0026074081
724PhosphorylationVEVLPSDSEAPDLKQ
EEECCCCCCCCCCCH		39.7426074081
740PhosphorylationERLQELESCSGLGST
HHHHHHHHCCCCCCC		26.6329255136
742PhosphorylationLQELESCSGLGSTSD
HHHHHHCCCCCCCCC		46.4629255136
746PhosphorylationESCSGLGSTSDDTDV
HHCCCCCCCCCCCCH		29.7629255136
747PhosphorylationSCSGLGSTSDDTDVR
HCCCCCCCCCCCCHH		34.0829255136
748PhosphorylationCSGLGSTSDDTDVRE
CCCCCCCCCCCCHHH		34.8829255136
751PhosphorylationLGSTSDDTDVREVSS
CCCCCCCCCHHHHHC		41.1922167270
757PhosphorylationDTDVREVSSRPSTPG
CCCHHHHHCCCCCCC		18.8422167270
758PhosphorylationTDVREVSSRPSTPGL
CCHHHHHCCCCCCCC		54.0822167270
761PhosphorylationREVSSRPSTPGLSVV
HHHHCCCCCCCCEEE		46.2329255136
762PhosphorylationEVSSRPSTPGLSVVS
HHHCCCCCCCCEEEE		24.8629255136
766PhosphorylationRPSTPGLSVVSGISA
CCCCCCCEEEECCCC		26.7922167270
769PhosphorylationTPGLSVVSGISATSE
CCCCEEEECCCCCCC		28.4023927012
772PhosphorylationLSVVSGISATSEDIP
CEEEECCCCCCCCCC		29.0823927012
774PhosphorylationVVSGISATSEDIPNK
EEECCCCCCCCCCHH		26.3423927012
775PhosphorylationVSGISATSEDIPNKI
EECCCCCCCCCCHHH		32.7523927012
787PhosphorylationNKIEDLRSECSSDFG
HHHHHHHHHHCCCCC		50.6925849741
790PhosphorylationEDLRSECSSDFGGKD
HHHHHHHCCCCCCCC		28.9625159151
791PhosphorylationDLRSECSSDFGGKDS
HHHHHHCCCCCCCCC		48.9325159151
798 (in isoform 6)Phosphorylation-30.6827732954
800PhosphorylationFGGKDSVTSPDMDEI
CCCCCCCCCCCHHHH		38.1925627689
800 (in isoform 5)Phosphorylation-38.1925159151
800 (in isoform 6)Phosphorylation-38.1928450419
801PhosphorylationGGKDSVTSPDMDEIT
CCCCCCCCCCHHHHC		19.4225627689
801 (in isoform 5)Phosphorylation-19.4225159151
801 (in isoform 6)Phosphorylation-19.4228450419
808 (in isoform 6)Phosphorylation-16.5327732954
813 (in isoform 6)Phosphorylation-45.99-
819PhosphorylationHQLTSPPSQSESLLA
HHCCCCCCCCHHHHH		50.1224275569
821 (in isoform 5)Phosphorylation-33.2325159151
836 (in isoform 6)Phosphorylation-21.2922210691
837 (in isoform 6)Phosphorylation-7.4222210691
846 (in isoform 6)Phosphorylation-19.3625159151
847PhosphorylationVVRPKVHYARPSHPP
EECCCCCCCCCCCCC		13.8021945579
851PhosphorylationKVHYARPSHPPPDPP
CCCCCCCCCCCCCCC		42.9721945579
860 (in isoform 6)Phosphorylation-6.4822210691
876PhosphorylationARLPNFGSHVLTPAE
CCCCCCCCCCCCHHH		13.2921712546
880PhosphorylationNFGSHVLTPAEMEAF
CCCCCCCCHHHHHHH		21.2622199227
892PhosphorylationEAFKQRHSYPERLVR
HHHHHHCCCHHHHHH		44.5727794612
893PhosphorylationAFKQRHSYPERLVRS
HHHHHCCCHHHHHHC		11.7327251275
896MethylationQRHSYPERLVRSRSS
HHCCCHHHHHHCCCC		33.70-
900PhosphorylationYPERLVRSRSSDIVS
CHHHHHHCCCCCHHH		29.0923927012
902PhosphorylationERLVRSRSSDIVSSV
HHHHHCCCCCHHHHC		33.3429255136
903PhosphorylationRLVRSRSSDIVSSVR
HHHHCCCCCHHHHCC		30.1929255136
907PhosphorylationSRSSDIVSSVRRPMS
CCCCCHHHHCCCCCC		24.3723401153
908PhosphorylationRSSDIVSSVRRPMSD
CCCCHHHHCCCCCCC		14.5623401153
913SulfoxidationVSSVRRPMSDPSWNR
HHHCCCCCCCCCCCC		7.2328183972
914PhosphorylationSSVRRPMSDPSWNRR
HHCCCCCCCCCCCCC		49.4028731282
917PhosphorylationRRPMSDPSWNRRPGN
CCCCCCCCCCCCCCC		41.8128176443
938PhosphorylationPAAAIGATSLVAAPH
HHHHCCCCEEEECCC		19.8523927012
939PhosphorylationAAAIGATSLVAAPHS
HHHCCCCEEEECCCC		21.9523927012
946PhosphorylationSLVAAPHSSSSSPSK
EEEECCCCCCCCCCC		30.7522167270
947PhosphorylationLVAAPHSSSSSPSKD
EEECCCCCCCCCCCC		31.0722167270
948PhosphorylationVAAPHSSSSSPSKDS
EECCCCCCCCCCCCC		37.5422167270
949PhosphorylationAAPHSSSSSPSKDSS
ECCCCCCCCCCCCCC		48.4922167270
950PhosphorylationAPHSSSSSPSKDSSR
CCCCCCCCCCCCCCC		34.8322167270
952PhosphorylationHSSSSSPSKDSSRGE
CCCCCCCCCCCCCCC		51.5522167270
955PhosphorylationSSSPSKDSSRGETEE
CCCCCCCCCCCCCCC		26.1830278072
956PhosphorylationSSPSKDSSRGETEER
CCCCCCCCCCCCCCC		55.2130278072
960PhosphorylationKDSSRGETEERKDSD
CCCCCCCCCCCCCCC		46.0730576142
966PhosphorylationETEERKDSDDEKSDR
CCCCCCCCCCCCCCC		50.4230278072
984PhosphorylationWWRKRFVSAMPKAPI
HHHHHHHHHCCCCCC		19.0124719451
1012PhosphorylationDLGPDRFSTLTDDPS
CCCCCCHHHCCCCCC		24.3320873877
1013PhosphorylationLGPDRFSTLTDDPSP
CCCCCHHHCCCCCCH		30.8525850435
1015PhosphorylationPDRFSTLTDDPSPRL
CCCHHHCCCCCCHHH		38.1430266825
1016 (in isoform 3)Phosphorylation-69.7822167270
1017 (in isoform 3)Phosphorylation-40.1022167270
1019PhosphorylationSTLTDDPSPRLSAQA
HHCCCCCCHHHHHHH		29.6419664994
1019 (in isoform 3)Phosphorylation-29.6422167270
1022 (in isoform 4)Phosphorylation-5.8922167270
1023PhosphorylationDDPSPRLSAQAQVAE
CCCCHHHHHHHHHHH		21.4425159151
1023 (in isoform 4)Phosphorylation-21.4422167270
1025 (in isoform 4)Phosphorylation-29.0222167270
1026 (in isoform 3)Phosphorylation-12.9228796482
1028 (in isoform 3)Phosphorylation-7.6428796482
1029 (in isoform 3)Phosphorylation-9.1828796482
1032 (in isoform 4)Phosphorylation-3.9528796482
1034 (in isoform 4)Phosphorylation-46.4028796482
1035AcetylationVAEDILDKYRNAIKR
HHHHHHHHHHHHHHH		42.5423236377
1035UbiquitinationVAEDILDKYRNAIKR
HHHHHHHHHHHHHHH		42.54-
1035 (in isoform 4)Phosphorylation-42.5428796482
1036PhosphorylationAEDILDKYRNAIKRT
HHHHHHHHHHHHHHC		14.57-
1037 (in isoform 3)Phosphorylation-31.6628796482
1041 (in isoform 3)Phosphorylation-47.4128796482
1043PhosphorylationYRNAIKRTSPSDGAM
HHHHHHHCCCCCCCC		39.7323663014
1043 (in isoform 2)Phosphorylation-39.7322167270
1043 (in isoform 4)Phosphorylation-39.7328796482
1044PhosphorylationRNAIKRTSPSDGAMA
HHHHHHCCCCCCCCC		26.8323663014
1044 (in isoform 2)Phosphorylation-26.8322167270
1046PhosphorylationAIKRTSPSDGAMANY
HHHHCCCCCCCCCCC		48.7419664994
1046 (in isoform 2)Phosphorylation-48.7422167270
1047 (in isoform 4)Phosphorylation-52.8628796482
1053PhosphorylationSDGAMANYESTGDNH
CCCCCCCCCCCCCCC		11.1721945579
1053 (in isoform 2)Phosphorylation-11.1728796482
1055PhosphorylationGAMANYESTGDNHDR
CCCCCCCCCCCCCCC		27.5921945579
1055 (in isoform 2)Phosphorylation-27.5928796482
1056PhosphorylationAMANYESTGDNHDRD
CCCCCCCCCCCCCCC		36.2921945579
1056 (in isoform 2)Phosphorylation-36.2928796482
1064 (in isoform 2)Phosphorylation-6.9328796482
1065PhosphorylationDNHDRDLSSKLLYHS
CCCCCCHHHHEEECC		29.7121945579
1066PhosphorylationNHDRDLSSKLLYHSD
CCCCCHHHHEEECCC		34.3221945579
1068 (in isoform 2)Phosphorylation-6.5728796482
1070PhosphorylationDLSSKLLYHSDKEVM
CHHHHEEECCCCCCC		15.0920068231
1070 (in isoform 6)Phosphorylation-15.0922167270
1071 (in isoform 6)Phosphorylation-29.5022167270
1072PhosphorylationSSKLLYHSDKEVMGD
HHHEEECCCCCCCCC		36.5023186163
1073 (in isoform 6)Phosphorylation-37.5122167270
1080 (in isoform 6)Phosphorylation-25.6528796482
1082PhosphorylationEVMGDGESAHDSPRD
CCCCCCCCCCCCHHH		36.1128985074
1082 (in isoform 6)Phosphorylation-36.1128796482
1083 (in isoform 6)Phosphorylation-13.2528796482
1086PhosphorylationDGESAHDSPRDEALQ
CCCCCCCCHHHHHHH		16.39-
1091 (in isoform 6)Phosphorylation-20.8028796482
1095 (in isoform 6)Phosphorylation-2.0128796482
1096PhosphorylationDEALQNISADDLPDS
HHHHHCCCHHHCCCC		32.9422167270
1102PhosphorylationISADDLPDSASQAAH
CCHHHCCCCHHHHCC		65.2216565220
1103PhosphorylationSADDLPDSASQAAHP
CHHHCCCCHHHHCCC		28.0730266825
1105PhosphorylationDDLPDSASQAAHPQD
HHCCCCHHHHCCCCC		25.0517525332
1113PhosphorylationQAAHPQDSAFSYRDA
HHCCCCCCCCCHHHH		26.4323663014
1116PhosphorylationHPQDSAFSYRDAKKK
CCCCCCCCHHHHHHH		20.9823663014
1117PhosphorylationPQDSAFSYRDAKKKL
CCCCCCCHHHHHHHH		13.1723663014
1130PhosphorylationKLRLALCSADSVAFP
HHHHHHHCCCCCHHH		35.6420873877
1133PhosphorylationLALCSADSVAFPVLT
HHHHCCCCCHHHHCC		18.3020873877
1140PhosphorylationSVAFPVLTHSTRNGL
CCHHHHCCCCCCCCC		17.6420873877
1142PhosphorylationAFPVLTHSTRNGLPD
HHHHCCCCCCCCCCC		24.6720873877
1143PhosphorylationFPVLTHSTRNGLPDH
HHHCCCCCCCCCCCC		22.1320873877
1184PhosphorylationLMAQLQETMRCVCRF
HHHHHHHHHHHHHHC		9.28-
1198UbiquitinationFDNRTCRKLLASIAE
CCCHHHHHHHHHHHH		50.42-
1202PhosphorylationTCRKLLASIAEDYRK
HHHHHHHHHHHHHHH		23.4630576142
1207 (in isoform 6)Ubiquitination-15.00-
1226PhosphorylationRCRQGLQTTQAHLER
HHHHHHHHHHHHHHH		26.3920068231
1227PhosphorylationCRQGLQTTQAHLERL
HHHHHHHHHHHHHHH		15.7020068231
1260PhosphorylationCVRLLLESKEKKIRE
HHHHHHHCHHHHHHH		46.1929083192
1270 (in isoform 6)Ubiquitination-51.27-
1274UbiquitinationEFIQDFQKLTAADDK
HHHHHHHHHHHCCCC		48.04-
1282 (in isoform 3)Ubiquitination-29.3521890473
1288UbiquitinationKTAQVEDFLQFLYGA
CCCCHHHHHHHHHHH		3.5021890473
1288 (in isoform 4)Ubiquitination-3.5021890473
1301 (in isoform 5)Ubiquitination-4.1621890473
1309 (in isoform 2)Ubiquitination-40.1321890473
1327UbiquitinationSVMNRIFKLAFYPNQ
HHHHHHHHHHCCCCC		36.21-
1327 (in isoform 1)Ubiquitination-36.2121890473
1336 (in isoform 6)Ubiquitination-17.6921890473
1353UbiquitinationEHIQRLSKVVTANHR
HHHHHHHHHHHHCCH		45.37-
1356PhosphorylationQRLSKVVTANHRALQ
HHHHHHHHHCCHHHC		25.4025022875
1362 (in isoform 6)Ubiquitination-4.84-
1388UbiquitinationIRTISAYKTPRDKVQ
HHHHHCCCCHHHHHH		52.34-
1389PhosphorylationRTISAYKTPRDKVQC
HHHHCCCCHHHHHHH		15.75-
1393AcetylationAYKTPRDKVQCILRM
CCCCHHHHHHHHHHH		35.1725953088
1393UbiquitinationAYKTPRDKVQCILRM
CCCCHHHHHHHHHHH		35.17-
1397 (in isoform 6)Ubiquitination-1.20-
1402 (in isoform 6)Ubiquitination-16.18-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
902SPhosphorylationKinaseAMPKA1Q13131
PSP
950SPhosphorylationKinaseCDK1P06493
PSP
1012SPhosphorylationKinaseMAP3K7O43318
GPS
1013TPhosphorylationKinaseMAP3K7O43318
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GAPD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GAPD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBL_HUMANCBLphysical
17545148
RASA2_HUMANRASA2physical
26344197
RASA3_HUMANRASA3physical
26344197
RASL1_HUMANRASAL1physical
26344197
1433B_HUMANYWHABphysical
26344197
HSF1_HUMANHSF1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GAPD1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-238, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; SER-466; SER-766;SER-902; SER-1019 AND SER-1096, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; THR-469; THR-747;SER-748; SER-903 AND SER-1019, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; THR-458; SER-466;THR-470; SER-566; SER-569; SER-902; SER-903; SER-1019; SER-1096 ANDSER-1105, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; SER-900 ANDSER-1019, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-569; THR-747; SER-902AND SER-1096, AND MASS SPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1105, AND MASSSPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1096, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742; SER-746; THR-747;SER-748; SER-966 AND SER-1096, AND MASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390, AND MASSSPECTROMETRY.

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