dbPTM

1433B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	1433B_HUMAN
UniProt AC	P31946
Protein Name	14-3-3 protein beta/alpha
Gene Name	YWHAB
Organism	Homo sapiens (Human).
Sequence Length	246
Subcellular Localization	Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13..
Protein Sequence	MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTMDKSEL -------CCCCHHHH	6.72	22814378
1 (in isoform 2)	Acetylation	-	6.72	22814378
2	Acetylation	------MTMDKSELV ------CCCCHHHHH	33.79	22814378
2	Phosphorylation	------MTMDKSELV ------CCCCHHHHH	33.79	23401153
3 (in isoform 2)	Ubiquitination	-	6.20	-
5	Ubiquitination	---MTMDKSELVQKA ---CCCCHHHHHHHH	34.70	-
5	Acetylation	---MTMDKSELVQKA ---CCCCHHHHHHHH	34.70	23749302
6	Phosphorylation	--MTMDKSELVQKAK --CCCCHHHHHHHHH	31.72	25159151
9 (in isoform 2)	Ubiquitination	-	4.88	21890473
11 (in isoform 1)	Ubiquitination	-	39.75	21890473
11	Acetylation	DKSELVQKAKLAEQA CHHHHHHHHHHHHHH	39.75	25953088
11 (in isoform 2)	Ubiquitination	-	39.75	21890473
11	Ubiquitination	DKSELVQKAKLAEQA CHHHHHHHHHHHHHH	39.75	21890473
13 (in isoform 1)	Ubiquitination	-	56.09	21890473
13	Ubiquitination	SELVQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	22053931
13	Acetylation	SELVQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	26051181
21	Phosphorylation	LAEQAERYDDMAAAM HHHHHHHHHHHHHHH	14.06	6852767
24	Sulfoxidation	QAERYDDMAAAMKAV HHHHHHHHHHHHHHH	2.20	30846556
28	Sulfoxidation	YDDMAAAMKAVTEQG HHHHHHHHHHHHHHC	2.16	30846556
29	Ubiquitination	DDMAAAMKAVTEQGH HHHHHHHHHHHHHCH	34.67	-
32	Phosphorylation	AAAMKAVTEQGHELS HHHHHHHHHHCHHCC	27.70	21601212
39	Phosphorylation	TEQGHELSNEERNLL HHHCHHCCHHHHHHH	38.93	28985074
47	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHHHH	14.10	19664994
49 (in isoform 2)	Ubiquitination	-	13.25	21890473
50	Phosphorylation	RNLLSVAYKNVVGAR HHHHHHHHHHHHCCC	10.84	22617229
51	Ubiquitination	NLLSVAYKNVVGARR HHHHHHHHHHHCCCH	33.26	-
51	Acetylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCH	33.26	23954790
51	Malonylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCH	33.26	26320211
51	Methylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCH	33.26	-
51 (in isoform 1)	Ubiquitination	-	33.26	21890473
59	Phosphorylation	NVVGARRSSWRVISS HHHCCCHHHHHHHHH	28.79	29083192
60	Phosphorylation	VVGARRSSWRVISSI HHCCCHHHHHHHHHH	19.65	7785495
65	Phosphorylation	RSSWRVISSIEQKTE HHHHHHHHHHHHHHH	23.54	27273156
66	Phosphorylation	SSWRVISSIEQKTER HHHHHHHHHHHHHHH	21.01	31437433
68 (in isoform 2)	Ubiquitination	-	48.23	21890473
70 (in isoform 1)	Ubiquitination	-	39.29	21890473
70	Malonylation	VISSIEQKTERNEKK HHHHHHHHHHHHHHH	39.29	26320211
70	Ubiquitination	VISSIEQKTERNEKK HHHHHHHHHHHHHHH	39.29	21890473
70	Acetylation	VISSIEQKTERNEKK HHHHHHHHHHHHHHH	39.29	19608861
71	Phosphorylation	ISSIEQKTERNEKKQ HHHHHHHHHHHHHHH	39.61	28857561
77	Acetylation	KTERNEKKQQMGKEY HHHHHHHHHHHHHHH	39.31	62135809
82	Ubiquitination	EKKQQMGKEYREKIE HHHHHHHHHHHHHHH	46.35	-
82	Acetylation	EKKQQMGKEYREKIE HHHHHHHHHHHHHHH	46.35	26051181
84	Nitrated tyrosine	KQQMGKEYREKIEAE HHHHHHHHHHHHHHH	27.79	-
84	Nitration	KQQMGKEYREKIEAE HHHHHHHHHHHHHHH	27.79	-
84	Phosphorylation	KQQMGKEYREKIEAE HHHHHHHHHHHHHHH	27.79	20049867
87	Ubiquitination	MGKEYREKIEAELQD HHHHHHHHHHHHHHH	36.53	-
105	Ubiquitination	DVLELLDKYLIPNAT HHHHHHHHHCCCCCC	41.76	-
106	Nitrated tyrosine	VLELLDKYLIPNATQ HHHHHHHHCCCCCCC	14.99	-
106	Phosphorylation	VLELLDKYLIPNATQ HHHHHHHHCCCCCCC	14.99	28152594
106	Nitration	VLELLDKYLIPNATQ HHHHHHHHCCCCCCC	14.99	-
115 (in isoform 2)	Ubiquitination	-	54.06	21890473
116	Phosphorylation	PNATQPESKVFYLKM CCCCCCCCCEEEEEE	40.58	31437409
117 (in isoform 1)	Ubiquitination	-	34.40	21890473
117	Ubiquitination	NATQPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	21890473
117	Acetylation	NATQPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	19608861
120	Phosphorylation	QPESKVFYLKMKGDY CCCCCEEEEEECCCH	14.38	7330749
120 (in isoform 2)	Ubiquitination	-	14.38	21890473
122	Acetylation	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	7298879
122	Ubiquitination	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	21890473
122 (in isoform 1)	Ubiquitination	-	27.47	21890473
122 (in isoform 2)	Ubiquitination	-	27.47	21890473
124	Ubiquitination	KVFYLKMKGDYFRYL CEEEEEECCCHHHHH	47.22	21890473
124 (in isoform 1)	Ubiquitination	-	47.22	21890473
127	Phosphorylation	YLKMKGDYFRYLSEV EEEECCCHHHHHHHH	9.91	21253578
130	Phosphorylation	MKGDYFRYLSEVASG ECCCHHHHHHHHHCC	12.51	24927040
132	Phosphorylation	GDYFRYLSEVASGDN CCHHHHHHHHHCCCC	22.53	28152594
136	Phosphorylation	RYLSEVASGDNKQTT HHHHHHHCCCCCCCC	52.43	31437415
138 (in isoform 2)	Ubiquitination	-	57.57	21890473
140	Ubiquitination	EVASGDNKQTTVSNS HHHCCCCCCCCCCCH	54.48	21890473
140 (in isoform 1)	Ubiquitination	-	54.48	21890473
143	Phosphorylation	SGDNKQTTVSNSQQA CCCCCCCCCCCHHHH	21.31	10620507
145	Phosphorylation	DNKQTTVSNSQQAYQ CCCCCCCCCHHHHHH	28.77	28152594
147	Phosphorylation	KQTTVSNSQQAYQEA CCCCCCCHHHHHHHH	19.03	28152594
151	Phosphorylation	VSNSQQAYQEAFEIS CCCHHHHHHHHHHHH	11.53	28152594
157 (in isoform 2)	Ubiquitination	-	6.21	21890473
158 (in isoform 2)	Ubiquitination	-	30.40	21890473
159	Acetylation	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	23954790
159	Ubiquitination	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	-
159	Succinylation	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	23954790
159 (in isoform 1)	Ubiquitination	-	59.42	21890473
160	Ubiquitination	EAFEISKKEMQPTHP HHHHHHHHHCCCCCC	52.18	21890473
160 (in isoform 1)	Ubiquitination	-	52.18	21890473
160	Acetylation	EAFEISKKEMQPTHP HHHHHHHHHCCCCCC	52.18	23236377
162	Sulfoxidation	FEISKKEMQPTHPIR HHHHHHHCCCCCCCC	8.75	30846556
180	Phosphorylation	ALNFSVFYYEILNSP EEEEHHHHHHHHCCH	9.68	-
186	Phosphorylation	FYYEILNSPEKACSL HHHHHHCCHHHHHHH	30.87	20058876
192	Phosphorylation	NSPEKACSLAKTAFD CCHHHHHHHHHHHHH	35.90	26074081
195	Ubiquitination	EKACSLAKTAFDEAI HHHHHHHHHHHHHHH	45.75	22053931
196	Phosphorylation	KACSLAKTAFDEAIA HHHHHHHHHHHHHHH	27.27	27820401
207	Phosphorylation	EAIAELDTLNEESYK HHHHHHHCCCHHHCC	44.07	46155601
212	Phosphorylation	LDTLNEESYKDSTLI HHCCCHHHCCCHHHH	31.16	29523821
213	Phosphorylation	DTLNEESYKDSTLIM HCCCHHHCCCHHHHH	23.30	27259358
216	Phosphorylation	NEESYKDSTLIMQLL CHHHCCCHHHHHHHH	22.44	25850435
217	Phosphorylation	EESYKDSTLIMQLLR HHHCCCHHHHHHHHH	30.36	29255136
228	Phosphorylation	QLLRDNLTLWTSENQ HHHHHCCEEEECCCC	26.89	20873877
231	Phosphorylation	RDNLTLWTSENQGDE HHCCEEEECCCCCCC	29.31	20873877
232	Phosphorylation	DNLTLWTSENQGDEG HCCEEEECCCCCCCC	23.98	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
60	S	Phosphorylation	Kinase	KPCD	Q05655	PhosphoELM
60	S	Phosphorylation	Kinase	PRKCD	P28867	GPS
60	S	Phosphorylation	Kinase	PDK3	Q15120	GPS
60	S	Phosphorylation	Kinase	PDKC	-	PhosphoELM
132	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
186	S	Phosphorylation	Kinase	MAPK8	P45983	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
60	S	Phosphorylation		-
Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 1433B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KINH_HUMAN	KIF5B	physical	17353931
MPRIP_HUMAN	MPRIP	physical	17353931
SRRM2_HUMAN	SRRM2	physical	17353931
IRS2_HUMAN	IRS2	physical	17353931
RAI14_HUMAN	RAI14	physical	17353931
SMAG2_HUMAN	SAMD4B	physical	17353931
BRAF_HUMAN	BRAF	physical	17353931
PI4KB_HUMAN	PI4KB	physical	17353931
UBP8_HUMAN	USP8	physical	17353931
E41L3_HUMAN	EPB41L3	physical	17353931
PARD3_HUMAN	PARD3	physical	17353931
KLC1_HUMAN	KLC1	physical	17353931
AFAD_HUMAN	MLLT4	physical	17353931
RGAP1_HUMAN	RACGAP1	physical	17353931
KIF23_HUMAN	KIF23	physical	17353931
EDC3_HUMAN	EDC3	physical	17353931
ZO2_HUMAN	TJP2	physical	17353931
FOXK1_HUMAN	FOXK1	physical	17353931
MYCPP_HUMAN	DENND4A	physical	17353931
FRYL_HUMAN	FRYL	physical	17353931
S4A7_HUMAN	SLC4A7	physical	17353931
MARK3_HUMAN	MARK3	physical	17353931
NCKP1_HUMAN	NCKAP1	physical	17353931
AKP13_HUMAN	AKAP13	physical	17353931
OSBL3_HUMAN	OSBPL3	physical	17353931
CING_HUMAN	CGN	physical	17353931
RMD3_HUMAN	RMDN3	physical	17353931
RABX5_HUMAN	RABGEF1	physical	17353931
LARP1_HUMAN	LARP1	physical	17353931
CSK21_HUMAN	CSNK2A1	physical	17353931
KS6A1_HUMAN	RPS6KA1	physical	12618428
HDAC4_HUMAN	HDAC4	physical	10869435
WEE1_HUMAN	WEE1	physical	10775038
PTN3_HUMAN	PTPN3	physical	9341175
TTP_HUMAN	ZFP36	physical	11886850
IGF1R_HUMAN	IGF1R	physical	9581554
KCNK3_HUMAN	KCNK3	physical	12437930
TESK1_HUMAN	TESK1	physical	11555644
IRS1_HUMAN	IRS1	physical	9422753
RAF1_HUMAN	RAF1	physical	12360521
KPCZ_HUMAN	PRKCZ	physical	10620507
MLXIP_HUMAN	MLXIP	physical	12446771
MPIP2_HUMAN	CDC25B	physical	10713667
ITB1_HUMAN	ITGB1	physical	11313964
MPIP1_HUMAN	CDC25A	physical	7644510
MDM4_HUMAN	MDM4	physical	16511560
TAU_HUMAN	MAPT	physical	12176984
TSC1_HUMAN	TSC1	physical	12176984
TSC2_HUMAN	TSC2	physical	12468542
TSC2_HUMAN	TSC2	physical	12364343
TSC2_HUMAN	TSC2	physical	16636147
TSC2_HUMAN	TSC2	physical	12176984
ING1_HUMAN	ING1	physical	16581770
HDAC4_HUMAN	HDAC4	physical	10958686
SAMN1_HUMAN	SAMSN1	physical	20478393
EXO1_HUMAN	EXO1	physical	21533173
SKP2_HUMAN	SKP2	physical	19270694
ATPA_HUMAN	ATP5A1	physical	15324660
BRAF_HUMAN	BRAF	physical	15324660
C1QBP_HUMAN	C1QBP	physical	15324660
CSK21_HUMAN	CSNK2A1	physical	15324660
DHX15_HUMAN	DHX15	physical	15324660
GRP78_HUMAN	HSPA5	physical	15324660
HS90B_HUMAN	HSP90AB1	physical	15324660
KINH_HUMAN	KIF5B	physical	15324660
KLC1_HUMAN	KLC1	physical	15324660
MARK3_HUMAN	MARK3	physical	15324660
AFAD_HUMAN	MLLT4	physical	15324660
TSC2_HUMAN	TSC2	physical	15324660
PI4KB_HUMAN	PI4KB	physical	15324660
SRSF3_HUMAN	SRSF3	physical	15324660
SON_HUMAN	SON	physical	15324660
TSC1_HUMAN	TSC1	physical	15324660
UBC_HUMAN	UBC	physical	15324660
WEE1_HUMAN	WEE1	physical	15324660
IRS2_HUMAN	IRS2	physical	15324660
UBP8_HUMAN	USP8	physical	15324660
ZO2_HUMAN	TJP2	physical	15324660
KIF23_HUMAN	KIF23	physical	15324660
S4A7_HUMAN	SLC4A7	physical	15324660
DOCK4_HUMAN	DOCK4	physical	15324660
P85B_HUMAN	PIK3R2	physical	15324660
M3K2_HUMAN	MAP3K2	physical	15324660
SRS10_HUMAN	SRSF10	physical	15324660
NCKP1_HUMAN	NCKAP1	physical	15324660
RNPS1_HUMAN	RNPS1	physical	15324660
AKP13_HUMAN	AKAP13	physical	15324660
STK38_HUMAN	STK38	physical	15324660
TBA3C_HUMAN	TUBA3C	physical	15324660
ST38L_HUMAN	STK38L	physical	15324660
FRYL_HUMAN	FRYL	physical	15324660
E41L3_HUMAN	EPB41L3	physical	15324660
MYCB2_HUMAN	MYCBP2	physical	15324660
MPRIP_HUMAN	MPRIP	physical	15324660
K0930_HUMAN	KIAA0930	physical	15324660
LARP1_HUMAN	LARP1	physical	15324660
SRRM2_HUMAN	SRRM2	physical	15324660
OSBL3_HUMAN	OSBPL3	physical	15324660
RAI14_HUMAN	RAI14	physical	15324660
GAPD1_HUMAN	GAPVD1	physical	15324660
RABX5_HUMAN	RABGEF1	physical	15324660
RGAP1_HUMAN	RACGAP1	physical	15324660
PI3R4_HUMAN	PIK3R4	physical	15324660
LSR_HUMAN	LSR	physical	15324660
SMAG2_HUMAN	SAMD4B	physical	15324660
RGPS2_HUMAN	RALGPS2	physical	15324660
RMD3_HUMAN	RMDN3	physical	15324660
PARD3_HUMAN	PARD3	physical	15324660
ALS2_HUMAN	ALS2	physical	15324660
MEP50_HUMAN	WDR77	physical	15324660
EDC3_HUMAN	EDC3	physical	15324660
RIOK1_HUMAN	RIOK1	physical	15324660
MILK1_HUMAN	MICALL1	physical	15324660
FRMD6_HUMAN	FRMD6	physical	15324660
CRTC2_HUMAN	CRTC2	physical	15324660
TBB5_HUMAN	TUBB	physical	15324660
KSR1_MOUSE	Ksr1	physical	10409742
MP2K1_HUMAN	MAP2K1	physical	10409742
MP2K2_HUMAN	MAP2K2	physical	10409742
RFWD2_HUMAN	RFWD2	physical	21135113
HES1_HUMAN	HES1	physical	21900206
CDN1B_HUMAN	CDKN1B	physical	15057270
H31_HUMAN	HIST1H3A	physical	16246723
EXO1_HUMAN	EXO1	physical	22222486
MPIP3_HUMAN	CDC25C	physical	16205633
BAD_HUMAN	BAD	physical	11697890
RAF1_HUMAN	RAF1	physical	11697890
CBL_HUMAN	CBL	physical	11697890
MDM4_HUMAN	MDM4	physical	18356162
A4_HUMAN	APP	physical	21832049
GRP78_HUMAN	HSPA5	physical	22939629
ACTA_HUMAN	ACTA2	physical	22939629
ATG4B_HUMAN	ATG4B	physical	22939629
ABL1_HUMAN	ABL1	physical	16888623
BMH2_YEAST	BMH2	genetic	22785534
RAF1_HUMAN	RAF1	physical	16093354
CD11B_HUMAN	CDK11B	physical	15883043
KLC2_HUMAN	KLC2	physical	24255178
ABLM1_HUMAN	ABLIM1	physical	24255178
AGAP3_HUMAN	AGAP3	physical	24255178
AKTS1_HUMAN	AKT1S1	physical	24255178
AMPD2_HUMAN	AMPD2	physical	24255178
ANS1A_HUMAN	ANKS1A	physical	24255178
ARAF_HUMAN	ARAF	physical	24255178
ARHG2_HUMAN	ARHGEF2	physical	24255178
CP131_HUMAN	CEP131	physical	24255178
BAD_HUMAN	BAD	physical	24255178
BAIP2_HUMAN	BAIAP2	physical	24255178
BRAF_HUMAN	BRAF	physical	24255178
SPE39_HUMAN	VIPAS39	physical	24255178
KKCC1_HUMAN	CAMKK1	physical	24255178
CBL_HUMAN	CBL	physical	24255178
CCDC6_HUMAN	CCDC6	physical	24255178
MPIP3_HUMAN	CDC25C	physical	24255178
BORG5_HUMAN	CDC42EP1	physical	24255178
CDK16_HUMAN	CDK16	physical	24255178
CDK17_HUMAN	CDK17	physical	24255178
CDK18_HUMAN	CDK18	physical	24255178
CE170_HUMAN	CEP170	physical	24255178
CLAP1_HUMAN	CLASP1	physical	24255178
CLAP2_HUMAN	CLASP2	physical	24255178
NELFB_HUMAN	NELFB	physical	24255178
CRTC2_HUMAN	CRTC2	physical	24255178
CRTC3_HUMAN	CRTC3	physical	24255178
CYFP2_HUMAN	CYFIP2	physical	24255178
CYLD_HUMAN	CYLD	physical	24255178
DCAF7_HUMAN	DCAF7	physical	24255178
DDX6_HUMAN	DDX6	physical	24255178
DEN1A_HUMAN	DENND1A	physical	24255178
MYCPP_HUMAN	DENND4A	physical	24255178
DEN4C_HUMAN	DENND4C	physical	24255178
DOC11_HUMAN	DOCK11	physical	24255178
EDC3_HUMAN	EDC3	physical	24255178
IF4E2_HUMAN	EIF4E2	physical	24255178
E41L3_HUMAN	EPB41L3	physical	24255178
DEMA_HUMAN	DMTN	physical	24255178
EXO1_HUMAN	EXO1	physical	24255178
FA83B_HUMAN	FAM83B	physical	24255178
FOXO3_HUMAN	FOXO3	physical	24255178
GAPD1_HUMAN	GAPVD1	physical	24255178
GBF1_HUMAN	GBF1	physical	24255178
GGYF1_HUMAN	GIGYF1	physical	24255178
GGYF2_HUMAN	GIGYF2	physical	24255178
GRIP1_HUMAN	GRIP1	physical	24255178
HDAC4_HUMAN	HDAC4	physical	24255178
HDAC5_HUMAN	HDAC5	physical	24255178
HDAC7_HUMAN	HDAC7	physical	24255178
HGS_HUMAN	HGS	physical	24255178
SAC2_HUMAN	INPP5F	physical	24255178
IRS2_HUMAN	IRS2	physical	24255178
IRS4_HUMAN	IRS4	physical	24255178
C170B_HUMAN	CEP170B	physical	24255178
K0355_HUMAN	KIAA0355	physical	24255178
K0930_HUMAN	KIAA0930	physical	24255178
K1671_HUMAN	KIAA1671	physical	24255178
M3K21_HUMAN	KIAA1804	physical	24255178
KIF1B_HUMAN	KIF1B	physical	24255178
KIF1C_HUMAN	KIF1C	physical	24255178
KLC4_HUMAN	KLC4	physical	24255178
KSR1_HUMAN	KSR1	physical	24255178
LARP1_HUMAN	LARP1	physical	24255178
LIMA1_HUMAN	LIMA1	physical	24255178
LMO7_HUMAN	LMO7	physical	24255178
LUZP1_HUMAN	LUZP1	physical	24255178
MP2K1_HUMAN	MAP2K1	physical	24255178
MP2K2_HUMAN	MAP2K2	physical	24255178
M3K2_HUMAN	MAP3K2	physical	24255178
MARK1_HUMAN	MARK1	physical	24255178
MARK2_HUMAN	MARK2	physical	24255178
MARK3_HUMAN	MARK3	physical	24255178
MAST2_HUMAN	MAST2	physical	24255178
MTMRC_HUMAN	MTMR12	physical	24255178
NADK_HUMAN	NADK	physical	24255178
NAV1_HUMAN	NAV1	physical	24255178
NCKP1_HUMAN	NCKAP1	physical	24255178
SPN90_HUMAN	NCKIPSD	physical	24255178
NF1_HUMAN	NF1	physical	24255178
PAK4_HUMAN	PAK4	physical	24255178
PARD3_HUMAN	PARD3	physical	24255178
PARP8_HUMAN	PARP8	physical	24255178
F262_HUMAN	PFKFB2	physical	24255178
PHLB2_HUMAN	PHLDB2	physical	24255178
PI4KB_HUMAN	PI4KB	physical	24255178
P3C2A_HUMAN	PIK3C2A	physical	24255178
PKP2_HUMAN	PKP2	physical	24255178
PKHA5_HUMAN	PLEKHA5	physical	24255178
PKHA7_HUMAN	PLEKHA7	physical	24255178
LIPA1_HUMAN	PPFIA1	physical	24255178
LIPB1_HUMAN	PPFIBP1	physical	24255178
PPM1H_HUMAN	PPM1H	physical	24255178
2A5D_HUMAN	PPP2R5D	physical	24255178
PTN13_HUMAN	PTPN13	physical	24255178
PTN14_HUMAN	PTPN14	physical	24255178
PUM1_HUMAN	PUM1	physical	24255178
R3HD1_HUMAN	R3HDM1	physical	24255178
R3HD2_HUMAN	R3HDM2	physical	24255178
RFIP1_HUMAN	RAB11FIP1	physical	24255178
RFIP2_HUMAN	RAB11FIP2	physical	24255178
RAF1_HUMAN	RAF1	physical	24255178
RGPS2_HUMAN	RALGPS2	physical	24255178
RPGF6_HUMAN	RAPGEF6	physical	24255178
NGAP_HUMAN	RASAL2	physical	24255178
REEP4_HUMAN	REEP4	physical	24255178
RICTR_HUMAN	RICTOR	physical	24255178
RTKN_HUMAN	RTKN	physical	24255178
SMAG1_HUMAN	SAMD4A	physical	24255178
SMAG2_HUMAN	SAMD4B	physical	24255178
SPD2A_HUMAN	SH3PXD2A	physical	24255178
SH3R1_HUMAN	SH3RF1	physical	24255178
SH3R3_HUMAN	SH3RF3	physical	24255178
SHKB1_HUMAN	SHKBP1	physical	24255178
SHRM3_HUMAN	SHROOM3	physical	24255178
SI1L2_HUMAN	SIPA1L2	physical	24255178
SI1L3_HUMAN	SIPA1L3	physical	24255178
SK2L2_HUMAN	SKIV2L2	physical	24255178
SRBS1_HUMAN	SORBS1	physical	24255178
SRBS2_HUMAN	SORBS2	physical	24255178
SRGP2_HUMAN	SRGAP2	physical	24255178
STAM1_HUMAN	STAM	physical	24255178
STK3_HUMAN	STK3	physical	24255178
TANC2_HUMAN	TANC2	physical	24255178
TBCD1_HUMAN	TBC1D1	physical	24255178
TB22A_HUMAN	TBC1D22A	physical	24255178
TB22B_HUMAN	TBC1D22B	physical	24255178
TBCD4_HUMAN	TBC1D4	physical	24255178
TBCD5_HUMAN	TBC1D5	physical	24255178
ASPP2_HUMAN	TP53BP2	physical	24255178
TPD53_HUMAN	TPD52L1	physical	24255178
TRI32_HUMAN	TRIM32	physical	24255178
TSC2_HUMAN	TSC2	physical	24255178
TTC28_HUMAN	TTC28	physical	24255178
UH1BL_HUMAN	UHRF1BP1L	physical	24255178
UBP54_HUMAN	USP54	physical	24255178
UBP8_HUMAN	USP8	physical	24255178
VP33B_HUMAN	VPS33B	physical	24255178
WDR62_HUMAN	WDR62	physical	24255178
NELFA_HUMAN	NELFA	physical	24255178
WNK1_HUMAN	WNK1	physical	24255178
1433E_HUMAN	YWHAE	physical	24255178
1433G_HUMAN	YWHAG	physical	24255178
1433F_HUMAN	YWHAH	physical	24255178
1433T_HUMAN	YWHAQ	physical	24255178
1433Z_HUMAN	YWHAZ	physical	24255178
M3K20_HUMAN	ZAK	physical	24255178
ZCHC8_HUMAN	ZCCHC8	physical	24255178
TISD_HUMAN	ZFP36L2	physical	24255178
LRRK2_HUMAN	LRRK2	physical	20642453
MARK3_HUMAN	MARK3	physical	20642453
TSC2_HUMAN	TSC2	physical	12582162
CAZA1_HUMAN	CAPZA1	physical	22863883
PA1B2_HUMAN	PAFAH1B2	physical	22863883
PAK2_HUMAN	PAK2	physical	22863883
6PGD_HUMAN	PGD	physical	22863883
NHRF1_HUMAN	SLC9A3R1	physical	22863883
SPSY_HUMAN	SMS	physical	22863883
DDIT4_HUMAN	DDIT4	physical	18198340
TTP_HUMAN	ZFP36	physical	17170118
DTL_HUMAN	DTL	physical	25154416
FOXK1_HUMAN	FOXK1	physical	26344197
1433G_HUMAN	YWHAG	physical	26344197
PPARG_HUMAN	PPARG	physical	26260846
DACT1_HUMAN	DACT1	physical	21262972
SRPK2_HUMAN	SRPK2	physical	19592491
P53_HUMAN	TP53	physical	17898864

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 1433B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-117, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.	19413330 [Abstract]

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