dbPTM

IRS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRS2_HUMAN
UniProt AC	Q9Y4H2
Protein Name	Insulin receptor substrate 2
Gene Name	IRS2
Organism	Homo sapiens (Human).
Sequence Length	1338
Subcellular Localization	Cytoplasm, cytosol.
Protein Description	May mediate the control of various cellular processes by insulin..
Protein Sequence	MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPPRHGPP -----CCCCCCCCCC	47.50	27251789
14	Phosphorylation	HGPPGPASGDGPNLN CCCCCCCCCCCCCCC	40.32	28102081
30	Phosphorylation	NNNNNNHSVRKCGYL CCCCCCCCHHHHHHE	26.24	25159151
75	Phosphorylation	PQPPRLEYYESEKKW CCCCCCHHHHHHHHH	19.68	25884760
76	Phosphorylation	QPPRLEYYESEKKWR CCCCCHHHHHHHHHH	12.01	-
78	Phosphorylation	PRLEYYESEKKWRSK CCCHHHHHHHHHHHH	38.30	21815630
111	Phosphorylation	RADAKHKYLIALYTK CCCCCCCEEEEEEEC	11.76	23898821
117	Phosphorylation	KYLIALYTKDEYFAV CEEEEEEECCCEEEE	32.63	20068231
144	Phosphorylation	RALTDLVSEGRAAAG HHHHHHHHHHHHHCC	41.45	20068231
162	Phosphorylation	PAAAPAASCSASLPG CCCCCCHHCCCCCCC	15.65	28348404
164	Phosphorylation	AAPAASCSASLPGAL CCCCHHCCCCCCCHH	20.56	28348404
166	Phosphorylation	PAASCSASLPGALGG CCHHCCCCCCCHHCC	20.85	28348404
184	Phosphorylation	AAGAEDSYGLVAPAT CCCCCCCCCCCCCCC	27.14	18669648
237	Phosphorylation	KLNCEQPSVTLQLMN EEECCCCCEEEEEEE	27.68	25690035
239	Phosphorylation	NCEQPSVTLQLMNIR ECCCCCEEEEEEEEE	17.08	25690035
295	Ubiquitination	LEAMKALKELFEFRP HHHHHHHHHHHHHCC	58.17	21890473
297	Ubiquitination	AMKALKELFEFRPRS HHHHHHHHHHHCCCC	4.82	21890473
304	Phosphorylation	LFEFRPRSKSQSSGS HHHHCCCCCCCCCCC	39.06	20201521
305	Ubiquitination	FEFRPRSKSQSSGSS HHHCCCCCCCCCCCC	54.52	-
306	Phosphorylation	EFRPRSKSQSSGSSA HHCCCCCCCCCCCCC	36.22	29255136
308	Phosphorylation	RPRSKSQSSGSSATH CCCCCCCCCCCCCCC	43.70	29255136
309	Phosphorylation	PRSKSQSSGSSATHP CCCCCCCCCCCCCCC	34.75	22167270
311	Phosphorylation	SKSQSSGSSATHPIS CCCCCCCCCCCCCCC	20.81	23927012
312	Phosphorylation	KSQSSGSSATHPISV CCCCCCCCCCCCCCC	40.49	23927012
314	Phosphorylation	QSSGSSATHPISVPG CCCCCCCCCCCCCCC	30.08	23927012
318	Phosphorylation	SSATHPISVPGARRH CCCCCCCCCCCCCCC	27.06	23927012
334	Phosphorylation	HLVNLPPSQTGLVRR CCCCCCHHHCCCCCC	38.13	17525332
342	Phosphorylation	QTGLVRRSRTDSLAA HCCCCCCCCCCCCCC	29.03	22199227
344	Phosphorylation	GLVRRSRTDSLAATP CCCCCCCCCCCCCCC	31.05	21955146
346	Phosphorylation	VRRSRTDSLAATPPA CCCCCCCCCCCCCCC	21.21	16964243
350	Phosphorylation	RTDSLAATPPAAKCS CCCCCCCCCCCHHCC	24.97	29255136
357	Phosphorylation	TPPAAKCSSCRVRTA CCCCHHCCCCEEEEC	31.59	20068231
358	Phosphorylation	PPAAKCSSCRVRTAS CCCHHCCCCEEEECC	18.53	20068231
363	Phosphorylation	CSSCRVRTASEGDGG CCCCEEEECCCCCCH	31.51	19664994
365	Phosphorylation	SCRVRTASEGDGGAA CCEEEECCCCCCHHH	41.31	29255136
384	Phosphorylation	AAGARPVSVAGSPLS HCCCCCEEECCCCCC	14.66	29255136
388	Phosphorylation	RPVSVAGSPLSPGPV CCEEECCCCCCCCCC	16.96	29255136
391	O-linked_Glycosylation	SVAGSPLSPGPVRAP EECCCCCCCCCCCCC	31.06	23301498
391	Phosphorylation	SVAGSPLSPGPVRAP EECCCCCCCCCCCCC	31.06	29255136
400	Phosphorylation	GPVRAPLSRSHTLSG CCCCCCCCCCCCCCC	30.58	25159151
402	Phosphorylation	VRAPLSRSHTLSGGC CCCCCCCCCCCCCCC	19.90	30576142
404	Phosphorylation	APLSRSHTLSGGCGG CCCCCCCCCCCCCCC	24.70	25159151
406	Phosphorylation	LSRSHTLSGGCGGRG CCCCCCCCCCCCCCC	34.00	25159151
412	Methylation	LSGGCGGRGSKVALL CCCCCCCCCCEEEEE	31.34	24129315
414	Phosphorylation	GGCGGRGSKVALLPA CCCCCCCCEEEEEEC	23.69	21955146
428	O-linked_Glycosylation	AGGALQHSRSMSMPV CCCCHHHHHCCCCCC	17.06	23301498
428	Phosphorylation	AGGALQHSRSMSMPV CCCCHHHHHCCCCCC	17.06	21955146
429	Methylation	GGALQHSRSMSMPVA CCCHHHHHCCCCCCC	33.96	54556893
430	Phosphorylation	GALQHSRSMSMPVAH CCHHHHHCCCCCCCC	20.44	-
432	Phosphorylation	LQHSRSMSMPVAHSP HHHHHCCCCCCCCCC	22.60	-
491	Phosphorylation	GSASASGSPSDPGFM CCCCCCCCCCCCCCC	20.80	29460479
505	Phosphorylation	MSLDEYGSSPGDLRA CCHHHCCCCHHHHHH	32.24	-
506	Phosphorylation	SLDEYGSSPGDLRAF CHHHCCCCHHHHHHH	28.65	30576142
515	Phosphorylation	GDLRAFCSHRSNTPE HHHHHHHCCCCCCCH	18.58	30576142
518	Phosphorylation	RAFCSHRSNTPESIA HHHHCCCCCCCHHHH	39.36	23927012
520	Phosphorylation	FCSHRSNTPESIAET HHCCCCCCCHHHHCC	29.67	29255136
523	Phosphorylation	HRSNTPESIAETPPA CCCCCCHHHHCCCCC	28.44	23927012
527	O-linked_Glycosylation	TPESIAETPPARDGG CCHHHHCCCCCCCCC	26.08	23301498
527	Phosphorylation	TPESIAETPPARDGG CCHHHHCCCCCCCCC	26.08	19664994
540	Phosphorylation	GGGGGEFYGYMTMDR CCCCCCCCCEEECCC	11.75	21945579
542	Phosphorylation	GGGEFYGYMTMDRPL CCCCCCCEEECCCCC	4.31	21945579
544	Phosphorylation	GEFYGYMTMDRPLSH CCCCCEEECCCCCCC	13.87	21945579
550	Phosphorylation	MTMDRPLSHCGRSYR EECCCCCCCCCCCCC	21.29	21945579
560	Phosphorylation	GRSYRRVSGDAAQDL CCCCCCCCCCHHHHH	29.19	29255136
569	Methylation	DAAQDLDRGLRKRTY CHHHHHHHHHHHHEE	54.03	80702151
575	Phosphorylation	DRGLRKRTYSLTTPA HHHHHHHEEECCCCC	22.09	21945579
576	Phosphorylation	RGLRKRTYSLTTPAR HHHHHHEEECCCCCH	13.01	21945579
577	Phosphorylation	GLRKRTYSLTTPARQ HHHHHEEECCCCCHH	20.73	19664994
579	Phosphorylation	RKRTYSLTTPARQRP HHHEEECCCCCHHCC	25.45	21945579
580	Phosphorylation	KRTYSLTTPARQRPV HHEEECCCCCHHCCC	21.90	21945579
591	Phosphorylation	QRPVPQPSSASLDEY HCCCCCCCCCCCCCH	33.03	21945579
592	Phosphorylation	RPVPQPSSASLDEYT CCCCCCCCCCCCCHH	28.67	21945579
594	Phosphorylation	VPQPSSASLDEYTLM CCCCCCCCCCCHHEE	38.00	22322096
598	Phosphorylation	SSASLDEYTLMRATF CCCCCCCHHEEEEEE	12.58	21945579
599	Phosphorylation	SASLDEYTLMRATFS CCCCCCHHEEEEEEC	16.42	21945579
604	Phosphorylation	EYTLMRATFSGSAGR CHHEEEEEECCCCCC	14.15	20166139
606	Phosphorylation	TLMRATFSGSAGRLC HEEEEEECCCCCCCC	27.73	25159151
608	Phosphorylation	MRATFSGSAGRLCPS EEEEECCCCCCCCCC	26.76	29255136
615	Phosphorylation	SAGRLCPSCPASSPK CCCCCCCCCCCCCCC	31.56	21955146
619	Phosphorylation	LCPSCPASSPKVAYH CCCCCCCCCCCEECC	32.11	29255136
620	Phosphorylation	CPSCPASSPKVAYHP CCCCCCCCCCEECCC	30.74	29255136
625	Phosphorylation	ASSPKVAYHPYPEDY CCCCCEECCCCCCCC	13.30	21945579
628	Phosphorylation	PKVAYHPYPEDYGDI CCEECCCCCCCCCCC	13.12	21945579
632	Phosphorylation	YHPYPEDYGDIEIGS CCCCCCCCCCCEECC	18.29	21945579
639	Phosphorylation	YGDIEIGSHRSSSSN CCCCEECCCCCCCCC	22.76	21945579
642	Phosphorylation	IEIGSHRSSSSNLGA CEECCCCCCCCCCCC	29.19	21945579
643	Phosphorylation	EIGSHRSSSSNLGAD EECCCCCCCCCCCCC	37.43	21945579
644	Phosphorylation	IGSHRSSSSNLGADD ECCCCCCCCCCCCCC	25.21	21945579
645	Phosphorylation	GSHRSSSSNLGADDG CCCCCCCCCCCCCCC	37.71	21945579
653	Phosphorylation	NLGADDGYMPMTPGA CCCCCCCCCCCCCCC	12.68	21945579
657	Phosphorylation	DDGYMPMTPGAALAG CCCCCCCCCCCCCCC	16.82	21945579
672	Phosphorylation	SGSGSCRSDDYMPMS CCCCCCCCCCCCCCC	38.88	21945579
675	Phosphorylation	GSCRSDDYMPMSPAS CCCCCCCCCCCCCCC	14.22	21945579
679	Phosphorylation	SDDYMPMSPASVSAP CCCCCCCCCCCCCCC	16.08	21945579
682	Phosphorylation	YMPMSPASVSAPKQI CCCCCCCCCCCCHHH	21.71	21945579
684	Phosphorylation	PMSPASVSAPKQILQ CCCCCCCCCCHHHCC	36.04	21945579
704	Phosphorylation	AAAAAVPSAGPAGPA HHHHHCCCCCCCCCC	38.98	29255136
713	Phosphorylation	GPAGPAPTSAAGRTF CCCCCCCCCCCCCEE	32.86	29255136
714	Phosphorylation	PAGPAPTSAAGRTFP CCCCCCCCCCCCEEC	18.31	29255136
723	Phosphorylation	AGRTFPASGGGYKAS CCCEECCCCCCCCCC	37.90	27251789
727	Phosphorylation	FPASGGGYKASSPAE ECCCCCCCCCCCCCC	13.47	29396449
730	Phosphorylation	SGGGYKASSPAESSP CCCCCCCCCCCCCCC	32.47	22167270
731	Phosphorylation	GGGYKASSPAESSPE CCCCCCCCCCCCCCC	32.75	22167270
735	Phosphorylation	KASSPAESSPEDSGY CCCCCCCCCCCCCCC	53.98	22167270
736	Phosphorylation	ASSPAESSPEDSGYM CCCCCCCCCCCCCCC	24.66	22167270
740	Phosphorylation	AESSPEDSGYMRMWC CCCCCCCCCCCCCCC	30.11	27273156
742	Phosphorylation	SSPEDSGYMRMWCGS CCCCCCCCCCCCCCC	5.86	27273156
749	Phosphorylation	YMRMWCGSKLSMEHA CCCCCCCCEECHHCC	27.56	24719451
752	Phosphorylation	MWCGSKLSMEHADGK CCCCCEECHHCCCCC	26.34	29255136
766	Phosphorylation	KLLPNGDYLNVSPSD CCCCCCCCCCCCHHH	11.11	23663014
770	Phosphorylation	NGDYLNVSPSDAVTT CCCCCCCCHHHCCCC	20.01	25159151
772	Phosphorylation	DYLNVSPSDAVTTGT CCCCCCHHHCCCCCC	30.60	25159151
776	Phosphorylation	VSPSDAVTTGTPPDF CCHHHCCCCCCCCCH	22.64	30175587
777	Phosphorylation	SPSDAVTTGTPPDFF CHHHCCCCCCCCCHH	32.24	30175587
779	Phosphorylation	SDAVTTGTPPDFFSA HHCCCCCCCCCHHHH	29.56	25159151
785	Phosphorylation	GTPPDFFSAALHPGG CCCCCHHHHHCCCCC	16.78	23663014
803	Phosphorylation	RGVPGCCYSSLPRSY CCCCCCCCCCCCCCC	12.84	21945579
804	Phosphorylation	GVPGCCYSSLPRSYK CCCCCCCCCCCCCCC	16.10	21945579
805	Phosphorylation	VPGCCYSSLPRSYKA CCCCCCCCCCCCCCC	18.87	21945579
809	Phosphorylation	CYSSLPRSYKAPYTC CCCCCCCCCCCCCCC	29.10	26356563
810	Phosphorylation	YSSLPRSYKAPYTCG CCCCCCCCCCCCCCC	16.67	26356563
814	Phosphorylation	PRSYKAPYTCGGDSD CCCCCCCCCCCCCCC	21.37	21945579
815	Phosphorylation	RSYKAPYTCGGDSDQ CCCCCCCCCCCCCCC	12.01	21945579
820	Phosphorylation	PYTCGGDSDQYVLMS CCCCCCCCCCEEEEC	29.86	21945579
823	Phosphorylation	CGGDSDQYVLMSSPV CCCCCCCEEEECCCC	10.67	21945579
827	Phosphorylation	SDQYVLMSSPVGRIL CCCEEEECCCCCHHH	27.59	21945579
828	Phosphorylation	DQYVLMSSPVGRILE CCEEEECCCCCHHHH	15.05	21945579
844	Phosphorylation	ERLEPQATPGPSQAA HHCCCCCCCCHHHHH	24.43	26425664
868	Phosphorylation	PPHPVVPSPVRPSGG CCCCCCCCCCCCCCC	25.15	26425664
873	Phosphorylation	VPSPVRPSGGRPEGF CCCCCCCCCCCCCCC	43.23	26425664
891	Phosphorylation	RGRAVRPTRLSLEGL CCCCCCCCCCCCCCC	33.41	25159151
894	Phosphorylation	AVRPTRLSLEGLPSL CCCCCCCCCCCCCCC	22.53	25159151
900	Phosphorylation	LSLEGLPSLPSMHEY CCCCCCCCCCCCCCC	58.94	28270605
903	Phosphorylation	EGLPSLPSMHEYPLP CCCCCCCCCCCCCCC	37.76	28270605
907	Phosphorylation	SLPSMHEYPLPPEPK CCCCCCCCCCCCCCC	8.73	29083192
915	Phosphorylation	PLPPEPKSPGEYINI CCCCCCCCCCCCEEC	49.18	19664994
919	Phosphorylation	EPKSPGEYINIDFGE CCCCCCCCEECCCCC	12.75	23927012
932	Phosphorylation	GEPGARLSPPAPPLL CCCCCCCCCCCCCHH	24.23	23663014
941	Phosphorylation	PAPPLLASAASSSSL CCCCHHHHHHCCCHH	25.08	23663014
944	Phosphorylation	PLLASAASSSSLLSA CHHHHHHCCCHHHHC	30.39	23663014
945	Phosphorylation	LLASAASSSSLLSAS HHHHHHCCCHHHHCC	21.15	23663014
946	Phosphorylation	LASAASSSSLLSASS HHHHHCCCHHHHCCC	23.62	23663014
947	Phosphorylation	ASAASSSSLLSASSP HHHHCCCHHHHCCCC	34.97	23663014
950	Phosphorylation	ASSSSLLSASSPASS HCCCHHHHCCCCHHH	31.25	23663014
952	Phosphorylation	SSSLLSASSPASSLG CCHHHHCCCCHHHCC	33.22	23663014
953	Phosphorylation	SSLLSASSPASSLGS CHHHHCCCCHHHCCC	24.97	25002506
969	Phosphorylation	TPGTSSDSRQRSPLS CCCCCCCHHCCCCHH	32.06	28290473
973	Phosphorylation	SSDSRQRSPLSDYMN CCCHHCCCCHHHHCC	23.12	22167270
976	Phosphorylation	SRQRSPLSDYMNLDF HHCCCCHHHHCCCCC	30.03	29255136
978	Phosphorylation	QRSPLSDYMNLDFSS CCCCHHHHCCCCCCC	5.64	22617229
984	Phosphorylation	DYMNLDFSSPKSPKP HHCCCCCCCCCCCCC	45.45	23663014
985	Phosphorylation	YMNLDFSSPKSPKPG HCCCCCCCCCCCCCC	36.02	25159151
988	Phosphorylation	LDFSSPKSPKPGAPS CCCCCCCCCCCCCCC	41.35	22468782
1007	Phosphorylation	GSLDGLLSPEASSPY CCCCCCCCCCCCCCC	26.24	22468782
1060	Phosphorylation	AQGPGAASSLSSDTG CCCCCHHHHCCCCCC	31.14	25921289
1063	Phosphorylation	PGAASSLSSDTGDNG CCHHHHCCCCCCCCC	28.28	25921289
1082	Phosphorylation	MAFGVAATPPQPIAA EEEEEECCCCCCCCC	26.26	25921289
1100	Phosphorylation	PEAARVASPTSGVKR HHHHCCCCCCCCHHH	26.34	29255136
1102	Phosphorylation	AARVASPTSGVKRLS HHCCCCCCCCHHHHH	35.30	23927012
1103	Phosphorylation	ARVASPTSGVKRLSL HCCCCCCCCHHHHHH	45.00	25159151
1109	Phosphorylation	TSGVKRLSLMEQVSG CCCHHHHHHHHHHHC	29.69	25159151
1115	Phosphorylation	LSLMEQVSGVEAFLQ HHHHHHHHCHHHHHH	36.49	22210691
1134	"N6,N6-dimethyllysine"	PDPHRGAKVIRADPQ CCCCCCCEEEECCCC	40.81	-
1134	Methylation	PDPHRGAKVIRADPQ CCCCCCCEEEECCCC	40.81	-
1148	Phosphorylation	QGGRRRHSSETFSST CCCCCCCCCCCCCCC	28.23	29255136
1149	O-linked_Glycosylation	GGRRRHSSETFSSTT CCCCCCCCCCCCCCE	34.23	23301498
1149	Phosphorylation	GGRRRHSSETFSSTT CCCCCCCCCCCCCCE	34.23	27273156
1151	Phosphorylation	RRRHSSETFSSTTTV CCCCCCCCCCCCEEE	30.66	27273156
1153	Phosphorylation	RHSSETFSSTTTVTP CCCCCCCCCCEEEEC	33.91	29255136
1154	Phosphorylation	HSSETFSSTTTVTPV CCCCCCCCCEEEECC	26.11	29255136
1155	Phosphorylation	SSETFSSTTTVTPVS CCCCCCCCEEEECCC	25.86	29255136
1156	Phosphorylation	SETFSSTTTVTPVSP CCCCCCCEEEECCCH	22.63	29255136
1157	Phosphorylation	ETFSSTTTVTPVSPS CCCCCCEEEECCCHH	23.59	29255136
1159	Phosphorylation	FSSTTTVTPVSPSFA CCCCEEEECCCHHHC	18.84	29255136
1162	Phosphorylation	TTTVTPVSPSFAHNP CEEEECCCHHHCCCC	18.94	29255136
1164	Phosphorylation	TVTPVSPSFAHNPKR EEECCCHHHCCCCCC	27.79	27273156
1170	Methylation	PSFAHNPKRHNSASV HHHCCCCCCCCCCCC	72.16	-
1174	Phosphorylation	HNPKRHNSASVENVS CCCCCCCCCCCEECE	18.78	20201521
1176	Phosphorylation	PKRHNSASVENVSLR CCCCCCCCCEECEEE	29.77	29255136
1181	Phosphorylation	SASVENVSLRKSSEG CCCCEECEEEECCCC	33.76	20201521
1185	Phosphorylation	ENVSLRKSSEGGVGV EECEEEECCCCCCCC	27.47	22167270
1186	Phosphorylation	NVSLRKSSEGGVGVG ECEEEECCCCCCCCC	43.21	22167270
1202	Phosphorylation	GGGDEPPTSPRQLQP CCCCCCCCCCCCCCC	63.18	29255136
1203	Phosphorylation	GGDEPPTSPRQLQPA CCCCCCCCCCCCCCC	24.69	19664994
1221	Phosphorylation	APQGRPWTPGQPGGL CCCCCCCCCCCCCCC	21.89	25159151
1234	Phosphorylation	GLVGCPGSGGSPMRR CCCCCCCCCCCCCCC	25.73	28450419
1237	Phosphorylation	GCPGSGGSPMRRETS CCCCCCCCCCCCCCC	21.03	28450419
1243	Phosphorylation	GSPMRRETSAGFQNG CCCCCCCCCHHHCCC	23.28	24719451
1244	Phosphorylation	SPMRRETSAGFQNGL CCCCCCCCHHHCCCC	22.95	27251275
1253	Phosphorylation	GFQNGLNYIAIDVRE HHCCCCCEEEEECCC	9.21	27642862
1282	Phosphorylation	LPQPGDKSSWGRTRS CCCCCCCCCCCCCCC	35.74	28450419
1283	Phosphorylation	PQPGDKSSWGRTRSL CCCCCCCCCCCCCCH	39.01	28450419
1289	Phosphorylation	SSWGRTRSLGGLISA CCCCCCCCHHHHHHE	30.65	22210691
1320	Phosphorylation	ALPPANTYASIDFLS CCCCCCCHHHHHHHH	9.73	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
304	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
304	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
306	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
306	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
384	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
384	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
388	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
388	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
391	S	Phosphorylation	Kinase	CDK1	P06493	PSP
540	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
577	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
577	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
653	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
675	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
919	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
978	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
1149	S	Phosphorylation	Kinase	PIM1	P11309	PSP
1253	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:28126338
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS3	O14543	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS1	O15524	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	APC/C	-	PMID:32554797

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS1_HUMAN	SOCS1	physical	12228220
P85A_HUMAN	PIK3R1	physical	8910607
PTN11_HUMAN	PTPN11	physical	8910607
P55G_HUMAN	PIK3R3	physical	10417350
P85A_HUMAN	PIK3R1	physical	9334184
EPOR_HUMAN	EPOR	physical	9334184
P85A_HUMAN	PIK3R1	physical	9852124
JAK1_HUMAN	JAK1	physical	7499365
P85A_HUMAN	PIK3R1	physical	12107746
PLCG1_HUMAN	PLCG1	physical	9535722
TYK2_HUMAN	TYK2	physical	8550573
UBF1_HUMAN	UBTF	physical	12554758
ESR1_HUMAN	ESR1	physical	12821935
PK3CA_HUMAN	PIK3CA	physical	12933652
SOCS3_HUMAN	SOCS3	physical	15514089
P85A_HUMAN	PIK3R1	physical	15514089
P85A_HUMAN	PIK3R1	physical	19561084
RPTOR_HUMAN	RPTOR	physical	19561084
PLCG1_HUMAN	PLCG1	physical	22974441
GRB2_HUMAN	GRB2	physical	22974441
DVL2_HUMAN	DVL2	physical	24616100
P85A_HUMAN	PIK3R1	physical	23439647
SIR1_MOUSE	Sirt1	physical	17901049
SIR1_HUMAN	SIRT1	physical	17901049
NEDD4_HUMAN	NEDD4	physical	25879670
PK3CA_HUMAN	PIK3CA	physical	25879670
EPN1_HUMAN	EPN1	physical	25879670
SOCS1_HUMAN	SOCS1	physical	27507812
UBP15_HUMAN	USP15	physical	28126338
UBP7_HUMAN	USP7	physical	28126338
GRB10_HUMAN	GRB10	physical	27742835
MTOR_HUMAN	MTOR	physical	27742835
KS6B1_HUMAN	RPS6KB1	physical	27742835

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRS2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-363 AND SER-391, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730 AND SER-736, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-346; THR-350;SER-365; SER-384; SER-388; SER-391; THR-520; SER-523; THR-527;SER-560; SER-577; THR-579; THR-580; SER-594; SER-608; SER-620;SER-679; SER-731; SER-735; SER-736; SER-770; THR-779; SER-828;SER-894; SER-915; SER-973; SER-1100; SER-1103; SER-1148; SER-1149;THR-1159; SER-1162; SER-1174; SER-1176 AND SER-1203, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-713; SER-770; SER-772;SER-915 AND SER-1176, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388; SER-391; SER-608;SER-915 AND SER-1100, AND MASS SPECTROMETRY.	18088087 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, AND MASSSPECTROMETRY.	17525332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346; THR-350; THR-527;SER-577; THR-580 AND SER-1100, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309; SER-388; SER-391;SER-560 AND SER-1176, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-520; SER-915; SER-1100AND SER-1203, AND MASS SPECTROMETRY.	15302935 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-598; TYR-653; TYR-675;TYR-742 AND TYR-823, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-75; TYR-653; TYR-675;TYR-742 AND TYR-823, AND MASS SPECTROMETRY.	18083107 [Abstract]